Categotry Archives: Announcements

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Fundraiser by Lifespan.io & CellAge: Targeting Senescent Cells With Synthetic Biology

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Categories: Announcements, Science, Transhumanism, Tags: , , , , , , , , , , , , ,

The New Renaissance HatCellAge
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Editor’s Note: The Rational Argumentator and the U.S. Transhumanist Party support Lifespan.io and CellAge in their work towards groundbreaking scientific life-extension research. Finding a way to repair age-related damage to senescent cells would be a fundamental breakthrough for transhumanism, and we offer our best wishes and support for those striving towards these new technologies.

               ~ Gennady Stolyarov II, Editor-in-Chief, The Rational Argumentator, December 11, 2016

From Lifespan.io and CellAge:

Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Furthermore, removing senescent cells from mice has been recently shown to drastically increase mouse healthspan (a period of life free of serious diseases).

Here at CellAge we are working hard to help translate these findings into humans!

CellAge, together with a leading synthetic biology partner, Synpromics, are poised to develop a technology allowing for the identification and removal of harmful senescent cells. Our breakthrough technology will benefit both the scientific community and the general public.

In short, CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies. The most prominently used p16 gene promoter has a number of limitations, for example. First, it is involved in cell cycle regulation, which poses a danger in targeting cells which are not diving but not senescent either, such as quiescent stem cells. Second, organism-wide administration of gene therapy might at present be too dangerous. This means senescent cells only in specific organs might need to be targeted and p16 promoter does not provide this level of specificity. Third, the p16 promoter is not active in all senescent cells. Thus, after therapies utilizing this promoter, a proportion of senescent cells would still remain. Moreover, the p16 promoter is relatively large (2.1kb), making it difficult to incorporate in present gene therapy vehicles. Lastly, to achieve the intended therapeutic effect the strength of p16 promoter to drive therapeutic effect might not be high enough.

CellAge will be constructing a synthetic promoter which has a potential to overcome all of the mentioned limitations. A number of gene therapy companies, including uniQure, AGTC and Avalanche Biotech have successfully targeted other types of cells using this technology. With your help, we will be able to use same technology to develop tools and therapies for accurate senescent cell targeting.

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The Rational Argumentator’s Fourteenth Anniversary Manifesto: Who Is the Western Man?

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Categories: Announcements, Culture, Philosophy, Tags: , , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
August 31, 2016
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Who Is the Western Man?

On the fourteenth anniversary of The Rational Argumentator, it is fitting to consider the tagline that has been featured on TRA since its founding: “A Journal for Western Man”. But who is this Western Man for whom The Rational Argumentator is intended? In 2002, the answer to that question seemed rather apparent for at least a substantial segment of then-prevalent libertarian, conservative, and Objectivist thinkers who, each in their own way, understood the Western Man to stand for the general cultural ideals and noblest aspirations of Western civilization.

Unfortunately, the decade of the 2010s and the past two years especially have seen the rise of a noxious and fundamentally anti-Western, anti-modern, and anti-civilization movement known as the “alt-right”, which has attempted to appropriate the rhetoric of Western culture and even of the Renaissance for itself. The Rational Argumentator will not allow this appropriation to remain unchallenged. TRA stands resolutely in opposition to all forms of bigotry, racism, nativism, misogyny, and any other circumstantially rooted intolerance – all of which are contrary to the ideals of high Western civilization. But at the same time, The Rational Argumentator also cannot cave to the “social justice” campus activism of the far Left, which would have even the very identification of Western culture and civilization banished, lest it offend the ever-more-delicate sensibilities of firebrand youths who resolutely refuse to let knowledge of the external world get in the way of their “feelings” and subjective experiences. TRA will not abandon the Western Man, but will continue to explain what it is that the Western Man represents and why these principles are more important and enduring than any tumultuous, ephemeral, and most likely futile and self-defeating activist movements of our era.

So who is the Western Man? It is a not a particular man from the West. It is not a descriptor limited to a particular subset of individuals based on their birth, skin color, national origin, or even gender. Indeed, my original intent behind the “Western Man” descriptor was specifically to salvage the generic term “man” – meaning an archetypical representative of humankind – from any suggestions that it must necessarily be gender-specific. This subtitle was meant transparently to imply, “Of course, ‘Western Man’ includes women, too!”  Some of the greatest and most courageous Western Men – from Hypatia of Alexandria to Mary Wollstonecraft to Ayn Rand to Ayaan Hirsi Ali – have been women.

A Western Man can have been born anywhere, have any physical features, any age, any gender (or lack of gender identity), any sexual preferences (or lack thereof), any religion (or lack thereof) – as long as he/she/it is a thinking being who accepts the valuable contributions of Western culture and civilization and seeks to build upon them. If self-aware, rational artificial intelligences are developed in the future, or if an intelligent alien species comes into contact with us, these beings could potentially be Western Men as well.

A Western Man will respect and seek to learn from the great philosophy, literature, art, music, natural and social sciences, mathematics, and political theory that flourished in Western societies throughout the past three millennia – although by no means is a Western man required to focus exclusively on ideas that originated in the West. Indeed, Western culture itself has unceasingly interacted with and absorbed the intellectual contributions of Egyptian, Mesopotamian, Arabic, Persian, Indian, Chinese, Korean, and Japanese thinkers and creators – to provide just a few examples. Likewise, a great deal of hope for the future of Western civilization can be found among entrepreneurs in Asia, Africa, and Latin America who have endeavored, with notable success, to spread the technologies of the digital age, construct great buildings, and lift billions of people out of abject poverty and into humane and respectable living standards accompanied by ever-increasing longevity.

A Western Man is someone who embraces the ideal of cosmopolitan universalism – a rejection of circumstantially defined tribalism, of the casting of people as “one of us” or “the other” based on attributes that they did not choose. This cosmopolitan universalism is the product of both a long-evolving philosophical framework and the material abundance that enabled the broadening of what Adam Smith termed our circles of sympathy to encompass ever more people.

The edifice of Western philosophical thought has been built upon by thinkers since the times of Thales, Socrates, and Aristotle – but its greatest intellectual breakthroughs were made during the 18th-century Age of Enlightenment. The Western Men who embraced these ideals were often personally flawed; they were men of their time and constrained by the practical realities and social mores that surrounded them. Some Western Men throughout history have, unfortunately, owned slaves, respected individual liberty only in some instances, or been improperly prejudiced against broad groups of people due to ignorance or gaps in the consistent application of their principles. Nonetheless, the legacy of their work – the notions of universal, inalienable individual rights and the preciousness of each person’s liberty and humanity – has been indispensable for later accomplishments, such as the abolition of slavery, women’s suffrage and liberation, civil and privacy rights, cultural and legal acceptance of homosexuality, and recognition of individual rights for members of religious minorities, atheists, and children. If we are able to see farther and know better than to repeat some of the moral errors of the past, it is because, to paraphrase Sir Isaac Newton, we stand on the shoulders of intellectual giants who paved the way for our embrace of the aforementioned great cultural achievements.

The ideals of peaceful commerce and cultural exchange – indeed, cultural appropriation (in an educated, informed, and deliberate manner) of the best elements of every time, place, and way of life – have resulted in a dramatic reduction in warfare, a general decline in nationalistic and tribal hatreds, and a widespread understanding of the essential humanity of our fellows in all parts of the world. Were it not for the intellectual achievements of Western civilization and the global commercial and industrial networks to which it gave rise, humankind would still be embroiled in a bitter, Hobbesian war of all against all. A Western Man is anyone who gives the essential achievements of modernity their well-deserved recognition and admiration, and who studies and offers justified respect to the forebears and authors of these achievements. A Western Man is also anyone who seeks to build upon these accomplishments and add his, her, or its distinctive bricks to the edifice of human progress.

A Western Man is not a fanatic or a bully, and sees fanatics and bullies as the threats to civilization that they are. A Western Man does not use ideology to stifle peaceful expression or compel others to dutifully “know their place” within some would-be totalitarian static social order. A Western Man knows that some people will disagree with him, her, or it, and they have the right to disagree peacefully. However, they do not have the right to be protected from attempts at persuasion or the presentation of diverse and possibly contrary views.

A Western Man embraces reason as the way to discover more about the external world and about human beings. Reason is not the exclusive province of any subset of people; anyone is capable of it, but it takes training and effort – and great respect for the intellect – to utilize consistently and properly. From reason stem the empirical scientific method, the deductive processes of formal logic and mathematics, and the application of empirical and logical truths to the development of technology which improves the human condition. A Western Man does not vilify technology, but rather sees it as a key driver of human progress and an enabler of moral growth by giving people the time and space which prosperity affords, making possible contemplation of better ways of living and relating to others – a prerogative only available to those liberated from hand-to-mouth subsistence.

The ideal of the Western Man is to maintain the great things which have already been brought into this world, and to create new achievements that further improve human life. There is thus both a conservative and a progressive motive within the Western Man, and they must combine to sustain a rich and vital civilization. A Western Man can go by labels such as “liberal”, “conservative”, “libertarian”, “progressive”, or “apolitical” – as long as they are accompanied by careful thought, study, discernment, work ethic, and an earnest desire to build what is good instead of, out of rage or spite, tearing down whatever exists. Conservation of great achievements and progress in creating new achievements are not antagonists, but rather part of the same essential mode of functioning of the Western Man – transcending petty and often false political antagonisms which needlessly create acrimony among people who should all be working to take civilization to the next level.

The next level of civilization – the unceasing expansion of human potential – is the preoccupation of the Western Man. This – not descending into contrived identitarian antagonisms – is the great project of our era. Building on the philosophical groundwork laid by Enlightenment humanism and its derivatives, a Western Man can explore the next stage of intellectual evolution – that of transhumanism, which promises to liberate humankind from its age-old shackles of death, disease, severe scarcity, Earth-boundedness, and internecine conflict.

Who is the Western Man? If you accept the challenge and the honor of supporting and building upon the great civilization which offers us unparalleled opportunities to create a glorious future for all – then the Western Man can be you.

TRA Statistics and Achievements During Its Fourteenth Year

TRA published 211 regular features during its fourteenth year, a rate of publication comparable to that of the eleventh and thirteenth years, while remaining below the extremely active tenth and twelfth years, as shown in the table below:

TRA Year Regular Features Published Page Views in Year
10th 306 1,302,774
11th 208 1,077,192
12th 314 1,430,226
13th 228 892,082
14th 211 823,968

With slightly less content published during the fourteenth year, and a similar average number of page views per published feature (3,905.06 in the fourteenth year versus 3,912.64 in the thirteenth year), it could be expected that total page views would decline slightly. While TRA did not reach the milestone of 10,000,000 cumulative page views during its fourteenth year, it did come the overwhelming majority of the way toward it. Total lifetime TRA visitation currently stands at 9,892,636 page views. However, I am confident that the 10-million page-view threshold will be exceeded within the next two months.

I have reason to expect that publication activity will again accelerate during TRA’s fifteenth year, although this may not occur immediately. Over the past year, I have been occupied with satisfying some of the last remaining requirements of my actuarial studies, and their successful completion is in sight. In the meantime, I collaborated with ACTEX Publications to produce a major 400-page commercial study guide, Practice Problems in Advanced Topics in General Insurance, for SOA Exam GIADV.

Several large-scale endeavors within the transhumanist and life-extensionist movements were pursued over the past year. TRA’s anniversary (August 31) coincides with the date of formation of the Nevada Transhumanist Party, a non-election-oriented, non-donation-accepting, policy-oriented party that advocates for the widespread adoption of emerging technologies, individual liberty, and the pursuit of indefinite life extension. The Nevada Transhumanist Party has grown to 107 members during its first year and has been a forum for numerous thought-provoking discussions. Nevada Transhumanist Party activities have occurred online via its Facebook page and its hosted video panels, such as the Panel Discussion on Hereditary Religion, a conversation among Transhumanist Libertarians and Socialists, and the panel for International Longevity Day, in collaboration with MILE – the Movement for Indefinite Life Extension – entitled “How Can Life Extension Become as Popular as the War on Cancer?” In-person activities of the Nevada Transhumanist Party included attendance at a university political lecture, a local Libertarian candidate’s campaign event, and RAAD Fest, the largest in-person gathering of life-extension supporters to date, where I personally met and spoke with such luminaries of the life-extension movement as Aubrey de Grey, Bill Andrews, and Zoltan Istvan.

Gradual but fundamental shifts are occurring that will contribute to more frequent and impactful activity on The Rational Argumentator’s pages during its fifteenth year. As the overview of the Western Man in this manifesto indicates, the importance of TRA’s work and ideals remains paramount. TRA will remain a bulwark of thoughtful consistency in an era where it seems entire societies have become unmoored from core principles that are integral to a successful civilization. We will steadfastly champion the virtues of reason and deliberation, discussion and civil debate, individualism and classical liberal tolerance, creation and maintenance. Even when the tumult of current events calls into question the foundations of civilized life, TRA will be here to reaffirm and uphold them.

This essay may be freely reproduced using the Creative Commons Attribution Share-Alike International 4.0 License, which requires that credit be given to the author, G. Stolyarov II. Find out about Mr. Stolyarov here.

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G. Stolyarov II Interviews Demian Zivkovic Regarding the D.N.A. – Gene Therapies Congress

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Categories: Announcements, Science, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II and Demian Zivkovic
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Mr. Stolyarov invited Demian Zivkovic, President of the Institute of Exponential Sciences (IES), to discuss the forthcoming Designing New Advances (D.N.A.) Gene Therapies Congress in Utrecht, The Netherlands.

The interview took place on Sunday, June 19, 2016, at 11 a.m. US Pacific Time. Watch the recording here.

The D.N.A. Congress is scheduled to occur on July 9, 2016, and will feature speakers such as Oliver Medvedik, Aubrey de Grey, Elizabeth Parrish, Keith Comito, and Tatjana Kochetkova. This event receives the strong endorsement of both The Rational Argumentator and the Nevada Transhumanist Party.

Read the announcement of the D. N. A. Congress here.

Contribute to the fundraiser for the D. N. A. Congress on Indiegogo  and Generosity.

DNA_Interview_CoverDemian Zivkovic is the president of the Institute of Exponential Sciences  (Facebook  / Meetup) – an international transhumanist think tank / education institute comprised of a group of transhumanism-oriented scientists, professionals, students, journalists, and entrepreneurs interested in the interdisciplinary approach to advancing exponential technologies and promoting techno-positive thought. He is also an entrepreneur and student of artificial intelligence and innovation sciences and management at the University of Utrecht.

Demian and the IES have been involved in several endeavors, such as organizing lectures on exponential sciences, interviewing experts such as Aubrey de Grey, joining several of Mr. Stolyarov’s futurism panels, and spreading Death is Wrong – Mr. Stolyarov’s illustrated children’s book on indefinite life extension – in The Netherlands.

Demian Zivkovic is a strong proponent of healthy life extension and cognitive augmentation. His interests include hyperreality, morphological freedom advocacy, postgenderism, and hypermodernism. He is currently working on his ambition of raising enough capital to make a real difference in life extension and transhumanist thought.

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D.N.A. Congress Announcement by the Institute of Exponential Sciences

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The New Renaissance HatInstitute of Exponential Sciences
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Editor’s Note: The forthcoming D.N.A. Congress in Utrecht, The Netherlands, hosted by the Institute of Exponential Sciences, devoted to discussions of gene therapies, receives the strong endorsement of both The Rational Argumentator and the Nevada Transhumanist Party. The D.N.A. Congress offers a promising venue to discuss the potential for gene therapies to cure diseases, lengthen lifespans, and improve quality of life for millions of people in the coming years and decades.

~ Gennady Stolyarov II, Editor-in-Chief, The Rational Argumentator, June 5, 2016

D.N.A CONGRESS PRESS RELEASE:

The Institute of Exponential Sciences (IES) has a large announcement to make. We are organising D.N.A – The largest European congress on human gene therapies, featuring speakers such as Aubrey de Grey, Liz Parrish, Oliver Medvedik and others.

Our event has been endorsed by LEAF, Heales VZW, BioViva, SENS Research Foundation, Singularity Network, People Unlimited, The Rational Argumentator, and many others. The event will be covered by national media and will be broadcasted online.

To make this vision a reality, we need your support. Share this message and donate today. Thank you!

IES needs your support to help make this vision a reality. Click here to donate to our crowdfunding campaign.

D.N.A – Designing New Advances: The second large Institute of Exponential Sciences event is coming to Utrecht

 

DNADemian Zivkovic

Utrecht – After a successful event last year in May, the grand congress is ready for a second edition. With a new name, we hope to make exponential sciences more approachable to the general public and bring people in the field closer together. The Institute of Exponential Sciences congress 2016 will be held at RASA podium on the 9th of July. The main theme of the event is gene therapies and cutting-edge applications of such therapies, such as health extension and interventions against human aging. To guarantee a great event, we have invited some of the biggest names in the field. Our guest speakers will be as follows:

Opening the event will be Oliver Medvedik, Ph.D, director of scientific programs at Genspace. Dr. Medvedik has earned his Ph.D at Harvard Medical school in the biomedical and biological sciences program. Since graduating from Harvard, he has worked as a biotechnology consultant, taught molecular biology to numerous undergraduates at Harvard, and mentored two of Harvard’s teams for the international genetically engineered machines competition (IGEM) held annually at M.I.T.

Our second speaker is Aubrey David Nicholas Jasper de Grey, Ph.D, an English author, Chief Science Officer of the SENS Research Foundation, and editor-in-chief of the academic journal Rejuvenation Research. Aubrey de Grey is well known for his focus on regenerative medicine and views on human aging. He will take the stage talking about the applications of current and upcoming technologies and studies which hold the potential to greatly extend our healthy lifespan.

Our third speaker is Tatjana Kochetkova, Ph.D, who is a fellow of the Institute of Exponential Sciences and a bioethicist. Dr. Kochetkova will follow up discussing the ethical and philosophical side of the technology and will address questions of what exponential technologies in biotech mean for society.

Our fourth speaker is Elizabeth Parrish, a fellow of the Institute of Exponential Sciences and the Founder and CEO of BioViva Sciences Inc, a Delaware corporation based in Seattle, WA, with labs and participating clinics in South/Central America where the majority of practical work is carried out. BioViva has been noted for being the first corporation in the world to treat a patient with gene therapy to reverse aging. The woman who wants to genetically engineer you will cover the basics of BioViva’s approach and vision for the the future, as well as the potential that gene therapies hold for radically improving our health and lives in the future.

Our fifth speaker will be Keith Comito, who is the founder and president of the Life Extension Advocacy Foundation (LEAF), a 501(c)(3) non-profit organization and a partner of the Institute of Exponential Sciences. Through LEAF, he operates the crowdfunding platform Lifespan.io, which supports biomedical research aimed at extending healthy human lifespan. He also serves as policy coordinator for the Global Healthspan Policy Institute, which facilitates relationships between researchers and government to advance initiatives in support of healthy life extension.

About Institute of Exponential Sciences

The Institute of Exponential Sciences is an international innovation-oriented think tank, outreach organisation, and networking platform based in the Netherlands, in the city of Utrecht. Its main activities include organising lectures and conferences, providing quality consultancy on innovation and exponential technologies, and collaborating with student organisations and universities in educating the public on the importance of exponential technologies.

It was founded by members of its predecessor, the Arma’thwynn society, which was a student group of like-minded young academics in the Netherlands. After organising events and attracting a very diverse and professional team of entrepreneurs, academics, and journalists, the society decided to move past student politics and make the move towards professionalism.

The Institute of Exponential Sciences is the result of that decision. After organising successful events (the largest of which was their symposium in April, 2015), the Institute of Exponential Sciences formalised its mission and reached out towards a process of international collaboration with other entities which share a techno-positive vision. The institute strives towards excellence in providing the best information and resources related to the issues relevant in the rapidly advancing technological society we live in.

The IES approach is focused on providing interdisciplinary education in the fields of exponential technologies such as artificial intelligence, bio-informatics, gene therapies, 3D-printing, augmented reality, and neural interfacing. We also provide a networking platform which allows entrepreneurs, scientists, journalists, and students to get in touch with others with similar ideas so that they may create the technologies of tomorrow. The IES strives not only to improve the speed of development of these technologies, but also to show the public the amazing possibilities technology provides for society.

IES and the IES logo are either registered trademarks or trademarks of IES Foundation in the Netherlands and/or other countries. All other products and/or services referenced are trademarks of their respective entities.

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Major Mouse Testing Program Crowdfunding Campaign Announcement by International Longevity Alliance

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The New Renaissance HatInternational Longevity Alliance

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Editor’s Note: The Rational Argumentator strongly supports the Major Mouse Testing Project crowdfunding campaign, and I have personally pledged $100 to this effort. Furthermore, I am honored that copies of my illustrated children’s book Death is Wrong are being made available as rewards for certain tiers of contributors to this research fundraiser.

~ Gennady Stolyarov II, Editor-in-Chief, The Rational Argumentator, May 11, 2016

The International Longevity Alliance is conducting a crowdfunding campaign to support the investigation of senolytic drugs’ potential to extend life. The team is going to study the combination of three senolytic drugs – Dasatinib, Venetoclax, and Quercetin – in mice, to see if the removal of senescent cells can ensure extended maximum lifespan. With highly devoted scientists and volunteers working for MMTP, the project needs only $60,000 to begin this experiment, as the researchers would need only to buy the mice and pay for their housing, the substances to test, and the battery of tests to analyze health changes.

Will you help to fund this research? Then please go to Lifespan.io, and choose the donation that suits you best and receive the deepest gratitude of the team and a nice useful souvenir to remember your input into the investigation of longevity therapies!

MMTP_Project1_StairFind out more about the International Longevity Alliance here.

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Publication of “Practice Problems in Advanced Topics in General Insurance” – ACTEX Study Guide by G. Stolyarov II

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Categories: Announcements, Mathematics, Tags: , , , , , , , , , , , , , ,

Practice Problems in Advanced Topics in General Insurance

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Written by Gennady Stolyarov II, ASA, ACAS, MAAA, CPCU, ARe, ARC, API, AIS, AIE, AIAF

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Published by ACTEX Publications
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1st Edition: Spring 2016

 

Students preparing for Society of Actuaries Exam GIADV: Advanced Topics in General Insurance will benefit from Mr. Stolyarov’s latest book, Practice Problems in Advanced Topics in General Insurance. Three options are available for purchase.

ACTEX GIADV Study Guide Cover
Hard-Copy/Electronic Bundle  https://www.actexmadriver.com/product.aspx?id=453107178
Hard Copy  https://www.actexmadriver.com/product.aspx?id=453107176
Electronic  https://www.actexmadriver.com/product.aspx?id=453107177

Comments from the Author: This book of practice problems is the most comprehensive culmination of my efforts to date, and I am pleased to have the opportunity to work with ACTEX Publications to bring all of these resources to candidates in one convenient compilation so that they will spend less time gathering problems from many separate sources. The Spring 2016 edition of this book is approximately 400 pages long and includes 613 practice problems and full solutions. 531 of the problems/solutions are original creations of mine.

This book is structured to align precisely with the five syllabus topics and eight syllabus papers (including the Lee paper, new on the Spring 2016 Exam GIADV syllabus) – each of which has a section of problems devoted to it. The following is a summary breakdown of what you will find:

  Problems by Source
Section (and Syllabus Paper) Original SOA CAS Total
1 (Mack) 21 5 5 31
2 (Venter) 22 4 5 31
3 (Clark LDF) 60 4 6 70
4 (Marshall et al.) 103 4 4 111
5 (Lee) 44 0 12 56
6 (Clark Reinsurance) 139 8 9 156
7 (D’Arcy / Dyer) 99 4 6 109
8 (Mango) 43 4 2 49
TOTAL 531 33 49 613

 

Each section presents all of the problems in succession, followed by the solutions at the end. You are encouraged to attempt each problem on your own and write down or type your solution, and then look at the answer key for step-by-step explanation and/or calculations. As this book is a learning tool, I have provided relevant citations from the syllabus readings for many of the practice problems. Also, I am not an advocate of leaving any problems as unexplained “exercises to the reader.” While each of these problems is intended to be an exercise for you, this book’s purpose is to show you how they can be solved as well – so give each of them your best attempt, but know that detailed answers are available for you to check your work and fill in any gaps that may have prevented you from solving a problem yourself.

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Lifespan Challenge: Support the MitoSENS Mitochondrial Repair Project Research Fundraiser – Video by G. Stolyarov II

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The New Renaissance HatG. Stolyarov II
October 21, 2015
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Mr. Stolyarov, author of “Death is Wrong” and Chief Executive of the Nevada Transhumanist Party (NTP), challenges all members of the NTP and the general public to donate to life-extension research – particularly, the ongoing MitoSENS Mitochondrial Repair Project for which crowdfunding is currently being conducted on Lifespan.io.

LifespanChallengeSign-513x396

References

MitoSENS Mitochondrial Repair Project Description
Updates and Stretch Goals for the MitoSENS Mitochondrial Repair Project
SENS Research Foundation
– “The #LifespanChallenge Starting on October 1 – International Longevity Day” – Article by Keith Comito
Death is Wrong – Official Home Page
Nevada Transhumanist Party – Constitution and Bylaws
Nevada Transhumanist Party – Facebook Page

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BioViva Treats First Patient with Gene Therapy to Reverse Aging – Press Release by Elizabeth Parrish

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Categories: Announcements, Science, Transhumanism, Tags: , , , , , , , , , , , ,

The New Renaissance HatElizabeth Parrish
October 3, 2015
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BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced that the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

Although not generally considered a disease, cellular aging is the leading cause of death in the developed world. Side effects like muscle wasting (sarcopenia), grey hair and memory loss are the well-known hallmarks.

And the aging cell is also responsible for the diseases of aging, including Alzheimer’s disease, heart disease and cancer. BioViva is leading the charge to treat the aging cell and reverse aging. “The aging cell is a key factor that has been overlooked for too long. Companies have put millions of dollars into treating the diseases of aging, such as dementia, frailty, kidney failure and Parkinson’s disease, and we still do not have a cure,” says Parrish.

Until now, no company had tried multiple gene therapies in one person. When asked why BioViva has done so, Parrish says, “Aging involves multiple pathways. We wanted to target more than one for a better outcome.”

Contact
Elizabeth Parrish
lparrish(at)BioVivaSciences(dot)com
http://www.biovivasciences.com

Elizabeth Parrish, CEO of BioViva, is a humanitarian, entrepreneur, and innovator, and is a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of regenerative medicine modalities, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and sits on the board of the International Longevity Alliance (ILA). She is an affiliated member of the Complex Biological Systems Alliance (CBSA), which is a unique platform for Mensa-based, highly gifted persons who advance scientific discourse and discovery.

The mission of the CBSA is to further scientific understanding of biological complexity and the nature and origins of human disease. Elizabeth is the founder of BioTrove Investments LLC and the BioTrove Podcasts, which is committed to offering a meaningful way for people to learn about and fund research in regenerative medicine.  She is also the Secretary of The American Longevity Alliance (ALA), a 501(c)(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular and regenerative medicine.

Editor’s Note: Elizabeth Parrish also made the announcement of this promising human trial at the October 1, 2015, Movement for Indefinite Life Extension (MILE) panel discussion “How Can Life Extension Become as Popular as the War on Cancer?” Watch the discussion here.

~ Gennady Stolyarov II, Editor-in-Chief, The Rational Argumentator, October 3, 2015

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The Rational Argumentator’s Thirteenth Anniversary Manifesto

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Categories: Announcements, Philosophy, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
August 31, 2015
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On August 31, 2015, The Rational Argumentator celebrates a successful end to its thirteenth year of existence. While TRA’s visitation is still recovering from the Yahoo-initiated closure of Yahoo! Voices in 2014, publication activity continues to be abundant. With the addition of Wendy Stolyarov as an Assistant Editor, more rapid and efficient publication of articles is now possible and has been ongoing for several months. As always, TRA continues to emphasize quality of content to set itself apart as a bastion of high intellectualism and thoughtful discourse that resists both information overload and the dumbing-down effects of the “bite-sized” media culture.

Total thirteenth-year visitation for all TRA features was 892,082 page views – compared to 1,430,226 page views during the twelfth year. The 37.6% decline in visitation is explained by the unfortunate closure of Yahoo! Voices (formerly Associated Content) in July 2014, which eliminated a popular channel through which TRA content was previously accessed and read. However, the milestone of 9 million cumulative views was still exceeded during TRA’s thirteenth year. TRA’s lifetime visitation stands at 9,068,668 page views. I am hopeful that, during TRA’s fourteenth year of operation, the 10-million-view threshold will be exceeded due to an increase to visits directly to The Rational Argumentator’s domain. TRA’s thirteenth year was marked by the publication of 228 regular features, compared to 314 regular features published during the twelfth year, 208 regular features published during the eleventh year, and 306 features published during the tenth year.

Growth in special features has also occurred during the thirteenth year, including special pages dedicated to new Minecraft skyscrapers, The Actuary’s Free, Open-Source Study Guide for SOA Exam GIADV: Advanced Topics in General Insurance (the only study guide for this exam known to me to exist at this time), and six of my new musical compositions. Furthermore, all of my past musical compositions have been remastered and are now available on YouTube in a playlist where they can be listed to in chronological order of their composition, accompanied by my works of fractal art or other inspiring imagery. Listeners can now conveniently hear all 82 of my compositions to date from one convenient location, with automatic transitions between individual works.

A significant innovation in TRA’s outreach activities occurred in 2015 in the form of new video panel discussions held via Google Hangouts on Air, where I recorded conversations with a variety of philosophers, technologists, and futurists – including Demian Zivkovic, Peter Rothman, Kyrel Zantonavitch, Franco Cortese (here and here), Adam Alonzi (here and here) and also facilitated discussions among multiple guests regarding how to accelerate technological progress and how to encourage more people to become techno-optimists. A major public-relations success, facilitated by the same means, was the Movement for Indefinite Life Extension (MILE) Demonstration of March 21, 2015, of which I and Wendy Stolyarov hosted the first three-hour segment.

The spread of my most famous work, Death is Wrong, has continued. This children’s book on indefinite life extension, illustrated by Wendy Stolyarov, is now available in four languages: English, Russian, Spanish, and French. The French Edition of Death is Wrong La mort, c’est mal!was published in May 2015 and was made possible due to the generous translation efforts of Philippe Castonguay. We continue to welcome and greatly appreciate any volunteer efforts to translate this vitally important book into as many languages as possible. Since Death is Wrong was made available as a free PDF download, a total of 3,440 copies have been downloaded from TRA directly – and likely, many more have been downloaded from external file-sharing sites to whose data I do not have access. As a result, the electronic versions of the book have now reached over three times more people than the 1,029 paperback copies that were shipped for distribution to children in 14 countries in 2014. I am pleased by this impact, but wish to see it continue and expand by orders of magnitude. The more awareness there is of the feasibility and desirability of reversing senescence and greatly reducing the probability of involuntary death, the more likely the majority of people will recognize the imperative of greatly accelerating technological progress in our lifetimes.

As TRA enters into its fourteenth year, it will continue to be characterized by the quest for permanence and the expansion of its voluminous content base through the publication of additional thoughtful and thought-provoking features. The promotion of individual liberty, rational philosophy, indefinite life extension, and uplifting esthetics will remain hallmarks of TRA’s mission and output. We will continue to exert a positive, enlightening influence on cultural and political discourse, while always adhering to the high standards and unyielding moral principles that have enabled TRA to endure while short-term-oriented publications have faltered. The Rational Argumentator is now among the oldest extant Internet-only publications, and it shall long outlive many of its more ephemeral counterparts.

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International Longevity Day – October 1, 2015 – Press Release by Ilia Stambler

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Categories: Announcements, Science, Transhumanism, Tags: , , , , , , , , , , , , , , , , , ,

The New Renaissance HatIlia Stambler
August 30, 2015

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International-Longevvity-Day Dear friends,

There has been emerging a tradition by longevity researchers and activists around the world to organize events dedicated to promotion of longevity research on or around October 1 – the UN International Day of Older Persons.

This day is sometimes referred to in some parts of the longevity activists community as the “International Longevity Day”. As this is the official UN Day of Older Persons, this provides the longevity research activists a perfect opportunity, perhaps even a perfect “excuse”, to emphasize the importance of aging and longevity research for the development of effective health care for the elderly, in the wide public as well as among decision makers.

The critical importance and the critical need to promote biological research of aging derives from the realization that tackling the degenerative processes and negative biological effects of human aging, at once and in an interrelated manner, can provide the best foundations to find holistic and effective ways for intervention and prevention against age-related ill health. Such an approach has been supported by scientific proofs of concept, involving the evidential increase in healthy lifespan in animal models and the emerging technological capabilities to intervene into fundamental aging processes. The focus on intervention into degenerative aging processes can provide solutions to a number of non-communicable, age-related diseases (such as cancer, heart disease, type 2 diabetes and neurodegenerative diseases), insofar as such diseases are strongly determined by degenerative aging processes (such as chronic inflammation, cross-linkage of macromolecules, somatic mutations, loss of stem cell populations, and others). This approach is likely to decrease susceptibility of the elderly also to communicable, infectious diseases due to improvements in immunity. The innovative, applied results of such research and development will lead to sustainable, economically viable solutions for a large array of age-related medical and social challenges, that may be globally applicable. Furthermore, such research and development should be supported on ethical grounds, to provide equal health care chances for the elderly as for the young.

Therefore it is the societal duty, especially of the professionals in biology, medicine, health care, economy and socio-political organizations, to strongly recommend greater investments, incentives and institutional support for the research and development dealing with the understanding of mechanisms associated with the human biological aging process and translating these insights into safe, affordable and universally available applied technologies and treatments.

October 1 – the International Day of Older Persons — provides the researchers and advocates an opportunity to raise these points and make these demands.

http://www.longevityforall.org/the-critical-need-to-promote-research-of-aging-around-the-world/

In 2013, events during or around that day – ranging from small meetings of friends to seminars and rather large conferences, alongside special publications, distributions of outreach materials (petitions and flyers) and media appearances – were held in over 30 countries, and in 2014 in over 20 countries. (Sometimes the events’ dates vary several days around October 1, or even through the entire month of October, designated as the “International Month of Older Persons” or the “International Longevity Month”, and sometimes the events are organized independently and without prior knowledge of other events, but they are all nonetheless unified by the common action and purpose.)

http://www.longevityforall.org/october-1-international-day-of-older-persons-longevity-day-2013-2014/

Let us maintain and strengthen this tradition! Let us plan and organize a mutually reinforcing network of events worldwide. If you plan to organize an event for that day – either live meetings or on-line publications and promotions – please let know. Together we can create an activism wave of strong impact. 

Following the collection of an impressive number of longevity promoting events worldwide in honor of that day, a general public appeal will be issued, both widely disseminated and addressed to relevant officials, both governmental and supra-governmental. Yet, the strength of the appeal will depend on the strength of all the individual events and actions.

Among the materials for discussion, distribution and promotion, one may use the position paper on the “Critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population”, briefly describing the rationales, technologies and policies needed to promote this research. The position paper is available in 9 languages and can serve as a “universal advocacy paper” both for the grass roots discussions and promotions and for the outreach to officials: http://www.longevityforall.org/the-critical-need-to-promote-research-of-aging-around-the-world/. Also one may use in the preparation a presentation briefly listing some topics in longevity science promotion, such as the feasibility and desirability of achieving healthy longevity and public actions that can be taken to achieve it – http://www.longevityhistory.com/articles/ab7.php – or any other materials of your choice.

So far, events for that day – including meetings, publications and promotions – are already planned to be held around the world, in over 30 countries on 5 continents, including:

In the US, a conference will be held at the headquarters of the International Society on Aging and Disease (ISOAD), at the University of North Texas Health Science Center, in Fort Worth, Texas. This action will be endorsed and promoted by the US Healthspan Campaign (http://www.healthspancampaign.org/).

The Longevity Day action will also be promoted by the US Transhumanist Party, during their campaign tour that coincides with October 1.

Also in the US, online promotions will be held by the MILE campaign and by the Christian Transhumanist Association.

MILE-Panel-Cover

A special promotion will be done by LEAF – Life Extension Advocacy Foundation – via its crowdfunding platform for longevity research (http://www.lifespan.io/).

A fundraising action will be launched on that day for SENS Research Foundation by Fight Aging (https://www.fightaging.org/fund-research/).

In Israel, a seminar will be held in Bar Ilan University, by the Israeli Longevity Alliance. Toward that day, Israeli activists will also freely distribute an e-book on the history of longevity research (http://www.longevityhistory.com/).

In Moscow, Russia, a conference will be organized by the Russian Longevity Alliance. Another large conference will take place in Moscow, on the “Quality of Life of Older Persons”, supported by the Gerontological Society of the Russian Academy of Sciences, focusing on geroprotective substances and therapies.

In Gomel, Byelorussia, at the end of September, a conference will take place on the general subject of Radiobiolgy, at the Institute of Radiobiology of the National Academy of Sciences of Byelorussia, with a leading section on the biology of aging and longevity (“gerontological aspects of man-made factors”).

Another  small conference will take place in New Delhi, India, organized by the Solutions For the Future, with the help of India Future Society, and ISOAD India.

A series of events is planned in Pakistan, by the Pakistan National Academy of Young Scientists and the Universities of Lahore and of Malakand. The newly formed Pakistan Aging Research Society (PARS) organizes an entire month long campaign, “Go for Life” – from September 1 until October 1 – to encourage physical activity of older persons.

In Rome, Italy, a conference will be organized by the Italian Transhumanist Association and the Italian Longevity Alliance.

Additional meetings and promotions are planned by the European Healthy Life Extension Society (HEALES) in Brussels, Belgium, including a Competition for the Best Short Film on Life Extension.

A conference on longevity/life-extension science will be held by the Waag Society – Do It Together Bio in Amsterdam, Netherlands.

In Germany, meetings will be held by two new officially registered political parties that emphasize the development of biomedical research in their programs: in Berlin, by the German Health Research Party and in Stuttgart by the German Transhumanist Party.

An online promotion (videoconference) in Spanish will be organized by the Venezuela Longevity Alliance (together with activists from accross Latin America). A similar videoconference (to be recorded) in Portuguese will be organized for Brazil by the Brazil Longevity Alliance.

A pro-longevity documentary promotion will be done in Helsinki by Longevity Finland – Pitkäikäinen Suomi.

A meeting will be held in Stockholm, Sweden, by Aldrandefonden/Svenska Livsförlängningssällskapet SLFS – Swedish Life Extension Society.

In the UK, the London Futurist community will celebrate longevity research as a part of a discussion of emerging technologies in London.

In Larnaca, Cyprus, the ELPIS Foundation, together with the local gerontological community, will hold a seminar “Health in Older Life” and a local TV show in honor of that day.

In Perth, Australia, a meeting will be held by the “Healthy Longevity Philosophy” society. Another promotion will be done by Science, Technology and the Future society in Melbourne, Australia.

In Kiev, Ukraine, a seminar will be held on behalf of the Kiev Institute of Gerontology of the Ukrainian Academy of Medical Sciences.

In Beijing, China, a meeting will be organized by the Technium community.

In Uganda, the Kasese Freethinkers Sports Academy will educate about the connection between physical activity and longevity.

A mini-seminar will be held in Lekki, Lagos, Nigeria, by Longevity Nigeria group.

In Romania, a conference will be held at Äna Aslan National Institute of Gerontology and Geriatrics, in Bucharest, toward the end of October, with earlier promotions.

In Vietnam, Hanoi, the Vietnam Public Health Association will hold a conference on the Mental Health of the Elderly, emphasizing biomedical research on neurodegenerative diseases.

In Singapore, a seminar on biology of aging will be organized at the National University of Singapore. This will precede a large Biology of Aging Conference organized by the Singapore Immunology Network (A*Star) – not “officially” a part of the “Longevity Day” events, but perhaps of the “Longevity Month.”

At about the same time, the 10th Asia / Oceania Congress of Gerontology and Geriatrics 2015 for “Healthy Aging Beyond Frontiers” will take place in Chiangmai, Thailand, including sections on biology of aging.

In Paris, France, a seminar will be organized at the Biopark Cancer Campus, University Paris Sud.

In South Korea, the Korean Branch of Solutions for the Future will organize a meetup in Seoul.

In Switzerland, Zurich, the Swiss Longevity Alliance will have a presentation on longevity research. This will shortly follow a large international symposium on geroprotectors in Basel.

In Poland, the Warsaw University Students Association will support the organization of a discussion on life extension science.

In Canada, at Huntington University, an event will be held by the Canadian Institute for Studies in Aging (CISA). In Alberta University, Canada, a special discussion on Technology and the Future of Medicine will be dedicated to that day.

In Iran, a study group will be conducted in Tehran on behalf of the Iran Longevity Alliance: http://www.iranlongevity.com/.

Yet another study group will be held in Cairo, Egypt, by the Egypt Longevity Alliance: http://www.egyptplus.org/.

And yet another free discussion of longevity science will take place in Tirana, Albania – the first longevity research activism event in the country.

In Bulgaria, events toward the International Longevity Day will start earlier in September with a conference in Ravda, organized by the University for National and World Economy, Department of Management and BASAGA – Bulgarian Academic Simulation and Gaming Association, including a section on Futurism, Transhumanism and Longevity, and continuing up to the date itself with more live and online discussions and publications and a special appeal in honor of that day.

In Tokyo, Japan, Exponential Technologies Institute will hold a meetup on longevity science in the framework of Tokyo-Singularity-Meetup.

A meeting will be held in the National Library in Tbilisi, Georgia, by activists of the Georgian Longevity Alliance, including presentations on the development of longevity science in Georgia and the world, and debates.

More events and expressions of support are expected to be initiated in the very near time in different countries.

Please add your support and more events and publications for this initiative! If you would like to get involved, please let know!

You are also welcome to promote this initiative on social media:

https://www.facebook.com/events/1017229998296364/

https://www.facebook.com/LongevityDay

Preparations for the next year’s International Longevity Day – October 1 – already started as well. The next global conference of the International Society on Aging and Disease (ISOAD) will take place in Stanford on October 1-2, 2016. The topics will range from interventions for longevity through stem cell research, genetics and systems biology of aging, to public support for aging research. The submission of abstracts and proposals is already started and welcome. And a conference is being planned in Brussels, for September 29-October 1, 2016, by the European Healthy Life Extension Society – Heales.

Hopefully, thanks to these and many other events, in this year and in the years to come, the importance of biological aging and longevity research will gradually become a strong theme of the international healthcare agenda, for the elderly and for the entire population.

Ilia Stambler, PhD.

Outreach coordinator. International Society on Aging and Disease (ISOAD)

http://isoad.org/

ilia.stambler@gmail.com

Thank you!

Ilia Stambler, Ph.D. is an IEET Affiliate Scholar, researcher at Bar-Ilan University, Israel, and activist at the International Longevity Alliance. He is author of A History of Life-Extensionism in the Twentieth Century.
 
He studied biomedical engineering at the Moscow Polytechnical Institute, biology at the Technion, Israel Institute of Technology, and earned his MA in English literature from Bar-Ilan University. He earned his Ph.D. at the Department of Science, Technology, and Society, at Bar-Ilan University. His thesis subject, and his main interest, is the History of Life-Extensionism in the Twentieth Century.
 
In addition, Ilia authored Life extension — a conservative enterprise? Some fin-de-siècle and early twentieth-century precursors of transhumanism, Demonstration for Radical Life Extension in Tel Aviv, and Heroic Power in Thomas Carlyle and Leo Tolstoy, and coauthored Breast cancer detection by Michaelis–Menten constants via linear programming, and Comparative analysis of cell parameter groups for breast cancer detection. Read the full list of his publications!
 
He speaks Hebrew, English, Russian, German, and Yiddish. He is active in the Israeli chapter of Humanity Plus, the Israeli Society for the Biology of Aging, and the International Longevity Alliance.
 
Watch Demonstration for Radical Life Extension in Tel Aviv 5: Ilia Stambler. Read 10 Answers by Ilia Stambler. Visit his Facebook page. Read his Google+ profile and his LinkedIn profile. Read his blog Singularity | Life Extension | Transhumanism (Hebrew).

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