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What It Will Be Like to Be an 85-Year-Old in the 2070s – Article by Scott Emptage

What It Will Be Like to Be an 85-Year-Old in the 2070s – Article by Scott Emptage

Scott Emptage

I will be 85 sometime in the early 2070s. It seems like a mirage, an impossible thing, but the future eventually arrives regardless of whatever you or I might think about it. We all have a vision of what it is to be 85 today, informed by our interactions with elder family members, if nothing else. People at that age are greatly impacted by aging. They falter, their minds are often slowed. They are physically weak, in need of aid. Perhaps that is why we find it hard to put ourselves into that position; it isn’t a pleasant topic to think about. Four decades out into the future may as well be a science-fiction novel, a faraway land, a tale told to children, for all the influence it has on our present considerations. There is no weight to it.

When I am 85, there will have been next to no senescent cells in my body for going on thirty years. I bear only a small fraction of the inflammatory burden of older people of past generations. I paid for the products of companies descended from Oisin Biotechnologies and Unity Biotechnology, every few years wiping away the accumulation of senescent cells, each new approach more effective than the last. Eventually, I took one of the permanent gene therapy options, made possible by biochemical discrimination between short-term beneficial senescence and long-term harmful senescence, and then there was little need for ongoing treatments. Artificial DNA machinery floats in every cell, a backup for the normal mechanisms of apoptosis, triggered by lingering senescence.

When I am 85, the senolytic DNA machinery will be far from the only addition to my cells. I underwent a half dozen gene therapies over the years. I picked the most useful of the many more that were available, starting once the price fell into the affordable-but-painful range, after the initial frenzy of high-cost treatments subsided into business as usual. My cholesterol transport system is enhanced to attack atherosclerotic lesions, my muscle maintenance and neurogenesis operate at levels far above what was once a normal range for my age, and my mitochondria are both enhanced in operation and well-protected against damage by additional copies of mitochondrial genes backed up elsewhere in the cell. Some of these additions were rendered moot by later advances in medicine, but they get the job done.

When I am 85, my thymus will be as active as that of a 10-year-old child. Gene and cell therapies were applied over the past few decades, and as a result my immune system is well-gardened, in good shape. A combination of replacement hematopoietic stem cells, applied once a decade, the enhanced thymus, and periodic targeted destruction of problem immune cells keeps at bay most of the age-related decline in immune function, most of the growth in inflammation. The downside is that age-related autoimmunity has now become a whole lot more complex when it does occur, but even that can be dealt with by destroying and recreating the immune system. By the 2030s this was a day-long procedure with little accompanying risk, and the price fell thereafter.

When I am 85, atherosclerosis will be curable, preventable, and reversible, and that will have been the case for a few decades. There are five or six different viable approaches in the marketplace, all of which basically work. I used several of their predecessors back in the day, as well. Most people in the wealthier parts of the world have arteries nearly free from the buildup of fat and calcification. Cardiovascular disease with age now has a very different character, focused more failure of tissue maintenance and muscle strength and the remaining small portions of hypertension that are still problematic for some individuals. But that too can be effectively postponed through a variety of regenerative therapies.

When I am 85, there will be an insignificant level of cross-linking in most of my tissues, as was the case since my early 60s. My skin has the old-young look of someone who went a fair way down the path before being rescued. Not that I care much about that – I’m much more interested in the state of my blood vessels, the degree to which they are stiff and dysfunctional. That is why removal of cross-links is valuable. That is the reason to keep on taking the yearly treatments of cross-link breakers, or undergo one of the permanent gene therapies to have your cells produce protective enzymes as needed.

When I am 85, I will have a three-decade patchwork history of treatments to partially clear this form of amyloid or that component of lipofuscin. I will not suffer Alzheimer’s disease. I will not suffer any of the common forms of amyloidosis. They are controlled. There is such a breadth of molecular waste, however: while the important ones are addressed, plenty more remain. This is one of the continuing serious impacts to the health of older individuals, and a highly active area of research and development.

When I am 85, I will be the experienced veteran of several potentially serious incidences of cancer, all of which were identified early and eradicated by a targeted therapy that produced minimal side-effects. The therapies evolve rapidly over the years: a bewildering range of hyper-efficient immunotherapies, as well as treatments that sabotage telomere lengthening or other commonalities shared by all cancer cells. They were outpatient procedures, simple and quick, with a few follow-up visits, so routine that they obscured the point that I would be dead several times over without them. The individual rejuvenation technologies I availed myself of over the years were narrowly focused, not perfect, and not available as early as I would have liked. Cancer is an inevitable side-effect of decades of a mix of greater tissue maintenance and unrepaired damage.

Do we know today what the state of health of a well-kept 85-year-old will be in the 2050s? No. It is next to impossible to say how the differences noted above will perform in the real world. They are all on the near horizon, however. The major causes of age-related death today will be largely controlled and cured in the 2050s, at least for those in wealthier regions. If you are in your 40s today, and fortunate enough to live in one of those wealthier region, then it is a given that you will not die from Alzheimer’s disease. You will not suffer from other common age-related amyloidosis conditions. Atherosclerosis will be reliably controlled before it might kill you. Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development. Your immune system will be restored and bolstered. The stem cells in at least your bone marrow and muscles will be periodically augmented. The cross-links that cause stiffening of tissues will be removed. Scores of other issues in aging process, both large and small, will have useful solutions available in the broader medical marketplace. We will all live longer and in better health as a result, but no-one will be able to say for just how long until this all is tried.

Scott Emptage is an anti-aging activist in the United Kingdom. 

Can Toyota and Reason Overcome Blindness? – Article by Edward Hudgins

Can Toyota and Reason Overcome Blindness? – Article by Edward Hudgins

The New Renaissance HatEdward Hudgins

If you’ve shut your eyes at the ugly spectacle of political and cultural decline around you, look in the right direction and you’ll see what’s best in the world, including innovations from Toyota that are helping the visually impaired.

Technology helping the blind see

The research department at the world-class auto maker is doing more than designing Priuses. It recently unveiled Project BLAID, a shoulder and neck-worn device that can help guide visually-impaired folks through building interiors with cameras, speakers and other technology. This is just one nice bit of good news in a world where the media is ruled by “if it bleeds, it leads.” This is one of many innovations in a world that is being transformed by exponential technologies.

For example, in January an Australian research team at Monash University announced development of another system to help the blind that it will test soon. It bypasses the eyeball, which is often damaged beyond use in blind people, and uses a pair of glasses that feeds visual data directly into the brain. At this time that technology at best would give blind people very limited vision, only enough to let them maneuver around like the Toyota technology does. But it’s a start.

Technology helping the deaf hear

Let’s remember that in recent decades, some 190,000 deaf individuals have received cochlear implants. These devises do not simply amplify sound as do hearing aids. They translate sound into electrical impulses that directly stimulate the cochlear nerve in the ear so the individuals can hear. It is estimated that around 150,000 children are born each year with hearing impairment so serious that they could benefit from such implants.

So as the costs of these implants decrease, we will see the gradual elimination of the ago-old scourge of deafness just as the blight of blindness will gradually disappear from list of human woes as companies like Toyota continue their work.

Reason as the cure

The proximate cause of all this good news is the exponential increase in information processing capability, usually called “Moore’s law.” Since the mid-1960s the capacities of semiconductors have doubled every eighteen months. A capacity of 1,000 at that time is 2,000,000,000 today. That means not only the advent of laptops, tablets, and smart phones but also medical devises that would have been thought science fiction decades ago.

But what is really behind these achievements is a moral code that treats rationality as our highest virtue and human achievement as our highest purpose. It is a commitment by individuals to objective reasoning and to understanding the world so that they can control it to enhance human life and flourishing. And it is a joy that individuals take in the process of understanding and creating.

Ayn Rand called machines “the frozen form of living intelligence.” Do you want to live in a world from which blindness and other illnesses or physical defeats are banished? Then fight for this morality of reason.

Dr. Edward Hudgins directs advocacy and is a senior scholar for The Atlas Society, the center for Objectivism in Washington, D.C.

Copyright The Atlas Society. For more information, please visit

Indefinite Life Extension: The Pay is $Infinity – Article by Eric Schulke

Indefinite Life Extension: The Pay is $Infinity – Article by Eric Schulke

The New Renaissance Hat
Eric Schulke
September 22, 2014

World awareness of indefinite-life-extension research increases the percentage of people who will then want to contribute to its success. When we inform the mainstream of most of the industrialized world and beyond, about the people, projects, and organizations working directly and indirectly toward indefinite life extension, then a percentage of that world – which is a lot of people at even a fraction of 1% – will be helping to execute the projects that need to be completed to see if we can make this happen.

It looks like we can make indefinite life extension happen, and in more of our lifetimes. All arrows point to the probability of this occurring. We can stop a lot of things that are like the diseases and damages that cause aging already. There are ways to move genes around to cure some diseases; other diseases have been fixed by delivery of proteins in ingenious ways. We can move material between various nuclei, tag specific neurons, custom-make enzymes, do intricate work on the nano-scale, create amazing new methods and mechanisms for working in our cells, and there are countless other inventions. The numbers of them are increasing in fields across the spectrum by the day.

There are also dozens of organizations with countless projects that are working directly toward indefinite life extension every day. Begin contributing to the research and the support structures that help this all excel. Stand up for your life by getting involved. There is seriously way too much to know and experience in this universe to be laying around in a graveyard for eternity.

Everything that humans do is about striving for sustainability and development. Our elders are among the most important capital that we have. Humans, are as far as we can see, among the universe’s most important capital. We can’t afford to “let the universe down”, so to speak, by letting our negligence cause it to lose any of the extraordinary phenomena of sentience that it has produced.  Do you know how long it took it to do that? Do you know how many times it failed to do that across the universe?

You are an important asset to reality, and you are dying, being killed by aging, disease, and biological frailty, and so are all the people around you. You are under attack by mechanisms that are working to kill you at all times. There is not a day that goes by that they don’t drag you closer to your grave. Some of us aren’t able to help ourselves, because those people are dead now. You are still alive, you can still help yourself. There is still a chance for you. You are still able to continue taking part in the marvels and wonders of the universe. Seize the opportunity. Seriously, what more do you want? How much is enough to entice you to stay? What more could you ask for? How much can a person voluntarily throw away? The journey, work, and fun are profoundly fulfilling, and the pay is $infinity.

Come on, let’s get going. We want you on our teams. Be a leader to your peers on this issue. Don’t procrastinate or let your anxiety about talking to people about it let them down. All you have to do is lead them to the extensive networks of indefinite-life-extension projects and organizations. We have the tools and insights to convince people over time, if you would only give them that first chance. A new thought opens a person’s mind more by allowing that person to collect, think about and sort through more insights related to it. Every wave of people that joins us makes it that much easier to get the next and bigger wave to join in. This is critical. Get the people around you to read and think about the various facets of this life-and-death reality, and join its groups and websites. Subscribe to the Movement for Indefinite Life Extension page here to get a lot of core information about organizations, events, activism opportunities, and related topics.

Remember now: when the percentage of world awareness of this cause goes up, then indefinite life extension, if it is possible, will get here faster.

Eric Schulke was a director at LongeCity during 2009-2013. He has also been an activist with the Movement for Indefinite Life Extension and other causes for over 13 years.

ALS, SENS, and Ice Buckets (or Lack Thereof) – Video by Gennady Stolyarov II and Wendy Stolyarov

ALS, SENS, and Ice Buckets (or Lack Thereof) – Video by Gennady Stolyarov II and Wendy Stolyarov

The New Renaissance Hat
G. Stolyarov II and Wendy Stolyarov
August 28, 2014

Gennady Stolyarov II and Wendy Stolyarov, author and illustrator of Death is Wrong, respond to the ALS Ice Bucket Challenge.


Evidence of Donation to ALS Association
Evidence of Donation to SENS Research Foundation
ALS Association
SENS Research Foundation
Eternal Life Fan Club Website
Eternal Life Fan Club on Facebook
Death is Wrong Official Home Page

SENS or Cryonics?: My Answer to a Hypothetical Choice – Video by G. Stolyarov II

SENS or Cryonics?: My Answer to a Hypothetical Choice – Video by G. Stolyarov II

If Mr. Stolyarov had $1 billion to donate to life extension, would he donate it to SENS (Strategies for Engineered Negligible Senescence) or cryonics? Find out his answer.

– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Essay by G. Stolyarov II
– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Video by G. Stolyarov II
SENS Research Foundation Website
– “Kim Suozzi Cryogenically Preserved After Battle With Brain Cancer” – Huffington Post – January 22, 2013

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life.

– “Calico and the Paradigm Shift in the War on Death” – Article by G. Stolyarov II
– “Google announces Calico, a new company focused on health and well-being” – Google Press Release – September 18, 2013
– “TIME Feature: CSO Aubrey de Grey on Google’s Newly Launched Anti-Aging Initiative” – SENS Research Foundation – September 18, 2013
– “Google’s Calico: the War on Aging Has Truly Begun” – Aubrey de Grey – TIME Magazine – September 18, 2013
SENS Research Foundation

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 19, 2013

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life. Unlike the cautious, short-term orientation of many more conventional manufacturers of drugs and medical devices, Google’s philosophy of making investments with possible immense payoffs in the distant future offers tremendous hope that this company will be around through the many years it will take to engage in the search for promising treatments and their subsequent testing.

 Aubrey de Grey, one of the chief strategists and key intellectual innovators in the escalating war on senescence, has written that Calico signals that the war on aging has truly begun. De Grey emphasizes that it is no longer necessary to persuade most of academia that this war is a worthwhile endeavor: “With Google’s decision to direct its astronomical resources to a concerted assault on aging, that battle may have been transcended: once financial limitations are removed, curmudgeons no longer matter.” As with its remarkable advances in autonomous vehicles, mobile operating systems, and wearable computing, Google does not need to ask the permission of the entire world to explore the possibilities. Rather, it can simply achieve the breakthroughs, whose momentum and adoption naysayers would be powerless to halt.

Funding has always been a major bottleneck for true life-extending research, but now the resources of Google, as well as the highly skilled researchers who will surely be recruited by Calico, will enable this bottleneck to be overcome. Few details about the company are yet available, and it is likely that several years will elapse before major discoveries are announced. However, the barrier to mainstream acceptability of the war on senescence has been breached. Once significant successes are announced, other companies will hopefully shed some of their current caution and will seek to profit from the burgeoning field of longevity research. A few other companies still may even try to emulate Calico before any results are announced – just so as to remain competitive with Google and stay ahead of the pack, in their view.

The key to the success of any sustainable enterprise focused on life-extension research is to recognize that the sole pursuit of profits next quarter or next year is not a viable strategy for altering the status quo in radical ways. Great innovations require great leaps outside the norm. Such leaps are not often immediately rewarded financially by the broader market, which is why much of the longevity research to date has been sponsored by non-profit institutions such as the SENS Research Foundation and various universities. However, a prudent, forward-looking pursuit of profit can take the radical alteration of the status quo to the next level, by harnessing the immensely powerful motive of self-interest for the purpose of improving human lives. In this case, the improvement from gains to human longevity – and hopefully the ultimate defeat of senescence altogether – would be so immense as to be humankind’s crowning achievement. Google develops technologies with the eventual intent of marketing them to millions of consumers, and the success of Calico would be a triumph not just for longevity research but for the dissemination of cures to age-related diseases, and perhaps to senescence itself.

While anyone of sufficient intellectual courage can have a long-term vision and projects aimed at advancing that vision, Google has the distinct advantage of an extremely viable business in the present, which continues to bring in short-term revenues so that Calico does not need to be concerned with profits next quarter or next year. Instead, Calico will be able to survive on the profits of Google’s many ongoing operations, while devoting the time and effort of world-class researchers to pursuing all of the explorations, experiments, and tests that are needed to ultimately develop marketable cures. Once the cures are out there, though, the profits could be unprecedented, because life is the most precious, the most fundamental value we humans have. Any entity that discovers a way to transcend the current frailties of old age and push back or remove the current limits on human lifespans will become fabulously wealthy beyond comparison.

May Calico usher in Adam Smith’s invisible hand in the realm of longevity medicine – a hand that pushes back senescence and death and creates a world where health and wealth are ours to enjoy indefinitely.

Computer Games, Distributed Computing, and Life Extension – Video by G. Stolyarov II

Computer Games, Distributed Computing, and Life Extension – Video by G. Stolyarov II

Imagine if it were possible to help cure disease and lengthen human lifespans simply by playing one’s computer games of choice. Here, Mr. Stolyarov describes a concept for doing just that, and he welcomes efforts from any of you to help bring it about.

Remember to LIKE, FAVORITE, and SHARE this video in order to spread rational discourse on this issue.

Support these video-creation efforts by donating here and here.

– “Computer Games, Distributed Computing, and Life Extension” – Article by G. Stolyarov II – The Rational Argumentator
Article and discussion on
Mr. Stolyarov’s Page of Distributed Computing Statistics
World Community Grid
Human Proteome Folding
Help Conquer Cancer
– “Public Solves Protein Structure” – Jef Akst – The Scientist – September 18, 2011
– “ALS Cause and Protein-Folding Prediction – Thoughts on Two Impressive Scientific Discoveries ” – Video by G. Stolyarov II – September 20, 2011

Computer Games, Distributed Computing, and Life Extension – Article by G. Stolyarov II

Computer Games, Distributed Computing, and Life Extension – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
February 26, 2013

Imagine if it were possible to help cure disease and lengthen human lifespans simply by playing one’s computer games of choice. Here, I describe a concept for doing just that, and I welcome efforts from any readers to help bring it about.

To make a practical, concrete difference in accelerating the advent of radical human life extension, one of the most powerful contributions a layman (non-biologist, non-doctor, non-engineer) can make is to donate idle computer time to distributed computing projects focused on biomedical research. Immensely promising distributed computing endeavors include Rosetta@home, Folding@home, and World Community Grid’s Human Proteome Folding and Help Conquer Cancer projects.  I am a major participant in many of these projects. (I rank in the 98.6th percentile for all distributed computing users by total credit and in the 99.5th percentile by recent average credit.) My computer runs these projects almost nonstop, and I have even made several upgrades, partly to enhance my contribution.  Distributed computing enables scientific research to occur at rates and scales previously inconceivable. Researchers utilize thousands of computers worldwide to perform incredible numbers of complex calculations that they could not have processed in their labs alone.

Billions of computers now exist, and it seems so easy to just download a distributed computing client and let it run while the computer is idle. The computer owner does not need to be technically knowledgeable about the field of research in order to make a positive and direct contribution. Yet participation in distributed computing projects is still orders of magnitude below where it should be. For instance, as of February 23, 2013, Folding@home has 1,674,431 all-time donors of computer resources; the front page suggests that 167,833 computers are currently active in the project. Rosetta@home has 355,661 total donors, while World Community Grid has 401,270. The number of people worldwide who care about advancing medical research is surely far larger than this.

 Yet even an easy task like installing a distributed computing client may be beyond the comfort zone of many people with busy, often hectic, lives. If these people take time out of their day for activities not related to their primary occupations, they will do so because they find those activities entertaining, relaxing, or both. Computer games are an immensely popular example; they directly engage hundreds of millions of people worldwide for hundreds of billions of hours every year. If this level of contribution were made to distributed computing projects, we would see the pace of research accelerate tenfold or more.

There is already one game, FoldIt, that attempts to utilize human creativity to directly address one challenge related to life extension: the prediction of protein-folding configurations. FoldIt’s users have even had some success where computer algorithms have not. However, FoldIt’s gameplay is not for everyone, just like any particular genre of computer game will attract some enthusiastic users but will leave others indifferent.

To radically increase the use of distributed computing, I recommend a new approach: the design of computer games that automatically run distributed computing projects in the background when they are played. Players would not need to acquire the game with the purpose of contributing to research projects; their primary motivation should be to enjoy the game. However, one of the marketing points in the game’s favor could be that it would enable people to make a meaningful contribution to research while they enjoyed themselves. Such games would not need to be related to the subject of the research at all; they could be about absolutely anything, and there could be numerous games of this sort made to appeal to a wide variety of consumer demographics. Indeed, creators of existing games could work on ways to link them to distributed computing clients and use this to emphasize their companies’ philanthropic side.

Each game could include an option to activate the distributed computing client even if the game is not being played. In this way, players who come to enjoy their participation in distributed computing projects could extend that participation beyond their gaming sessions. On the other hand, a lot of players would acquire the game just to play it, while being only peripherally aware of the distributed computing aspect. However, their consent to the distributed computing would be a part of the usage agreement associated with the game. They would contribute to important biomedical research by default, just like all of us contribute to the carbon dioxide available to the Earth’s plants simply by exhaling.

I am not a programmer myself, but I strongly encourage any programmer and/or game developer reading this article to develop this proposed connection between any game and a distributed computing project. This concept should be in the public domain, and, to the extent this is possible under current law, I hereby release any original ideas or concepts in this article into the public domain in full. I seek no monetary profit or even credit from such undertakings (though I would be extremely happy to be informed of efforts to implement them). I will benefit considerably if the implementation of this idea radically accelerates life-extension research, and this benefit would certainly be enough for me.  It is in my best interest for numerous parallel, competing, or collaborative efforts to arise in this area, and for many people to try variations on this idea.

I also welcome input from those who can anticipate some of the technical details and challenges of developing games of this sort. For instance, I would be interested in insights regarding the potential ease or difficulty of integrating a distributed computing client with another program. At present, I anticipate that most of the challenges would be technical, rather than legal, since BOINC, one of the most popular clients, is free software released under a GNU Lesser General Public License. My strong recommendation is for any efforts in this area to have an open-source character, welcoming contributions from all parties in order to make the vast benefits of this project realizable. At least some of the games created as a result could be made freely downloadable, so as to entice more people into obtaining them with nothing to lose.

The idea is now out there. I urge you to help make it happen in any way you are able.