Tag Archives: interview

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Nevada Transhumanist Party Interview on the EMG Radio Show – November 7, 2016

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Categories: Politics, Technology, Transhumanism, Tags: , , , , , , , , , , , , , , , , ,

The New Renaissance HatG. Stolyarov II
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On November 7, 2016, Mr. Stolyarov had his first radio interview as Chief Executive of the Nevada Transhumanist Party. The EMG Radio Show on 91.5 The Rebel HD-2, hosted by Andre’ Haynes, interviewed Mr. Stolyarov for about 10 minutes on the mission of the Nevada Transhumanist Party and transhumanist views on emerging technologies – such as artificial wombs, designer babies, artificial intelligence, and life extension.

The interview begins at 2:00 in the video.

This recording was reproduced with permission from the EMG Radio Show.

Download the interview recording here.

Visit the Nevada Transhumanist Party page here.

Join the Nevada Transhumanist Party Facebook group here.

Find out about Mr. Stolyarov here.

NTP-Logo-9-1-2015

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An Interview with Kelsey Moody of Ichor Therapeutics, Bringing a SENS Therapy for Macular Degeneration to the Clinic – Article by Reason

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Categories: Science, Transhumanism, Tags: , , , , , , , , , , , , , , , ,

The New Renaissance HatReason
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As I mentioned last week, earlier this year Fight Aging! invested a modest amount in the Ichor Therapeutics initiative to develop a treatment for macular degeneration, joining a number of other amateur and professional investors in helping to get this venture started. The approach taken here is based on the results of research carried out at the Methuselah Foundation and SENS Research Foundation over much of the past decade, funded by philanthropists and the support of our community of longevity science enthusiasts. This is how we succeed in building the future: medical science in the laboratory leads to medical development in startup companies, each new stage bringing treatments capable of repairing specific forms of age-related molecular damage that much closer to the clinic.

Ichor Therapeutics is one of a growing number of success stories to emerge from the SENS rejuvenation research community. Young scientists, advocates, and donors involved in earlier projects – years ago now – have gone on to build their own ventures, while retaining an interest in stepping up to do something meaningful to help bring an end to aging. Back in 2010, Kelsey Moody worked on the LysoSENS project to find ways to break down damaging metabolic waste in old tissues; fast-forward six years, and he is the now the CEO of a successful small biotechnology company with a great team, taking that very same technology and putting it to good use. I recently had the chance to ask Kelsey a few questions about the future of SENS rejuvenation research, as well as how the Ichor scientists intend to construct a new class of therapy for macular degeneration, one based on removing one of the root causes of the condition.

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Who are the people behind Ichor Therapeutics? How did you meet and decide that this was the thing to do? Why macular degeneration as a target?

People have always been the focus of Ichor. Since day one we have worked to create a positive environment that cultivates a product-oriented research focus and emphasizes autonomy and personal accountability for work. As a result, ambitious self-starters tend to find their way to Ichor and remain here. However, we recognized early on that just filling a lab with a bunch of blue-eyed bushy tailed young up-and-comers is not sufficient to develop a robust, mature, translational pipeline. We have augmented our team with a number of critical staff members who are seasoned pharma operators, including our Quality Assurance Director and General Counsel.

Age-related macular degeneration (AMD) was chosen as a target because we believe it is the closest SENS therapy to the clinic. While we obviously have an interest in providing cures for the patients suffering from AMD and are attracted to the large market opportunities such a treatment could bring, our broader interest is in validating the entire SENS paradigm. We believe that Aubrey de Grey continues to receive excessive criticism because nothing spun out of SENS has ever made it into a legitimate pre-clinical pipeline, much less to the bedside. However, this does not mean he is wrong. Our goal is to be the first group to bring a SENS inspired therapy into the clinic and in doing so, silence critics and generate new energy and capital for this cause.

I understand there’s a lengthy origin story for the approach you are taking to treat AMD; it’d be great to hear some of it.

Our approach to treating AMD is based on the hypothesis that cellular junk that accumulates over the lifespan significantly contributes to the onset and progression of AMD. Our goal is to periodically reduce the burden of the junk so it never accumulates to levels sufficient to induce pathology. The strategy to accomplish this calls for the identification of enzymes that can break down the junk in a physiological setting, and the engineering of these enzymes such that they can break down the target in the correct organelle of the correct cell without appreciable collateral damage to healthy cells or tissue.

Methuselah Foundation and SENS Research Foundation did excellent work in establishing this program nearly a decade ago. They successfully identified a number of candidate enzymes that could break down the molecular junk, but reported that the targeting systems evaluated failed to deliver these enzymes to the appropriate organelles and cells. My group reevaluated these findings, and discovered that these findings were flawed. The delivery failure could be entirely attributed to a subtle, yet highly significant difference between how the target cells behave outside of the body as compared to inside the body. It turned out that the approach was in fact valid, it was the cell based assay that had been used that was flawed. This discovery was striking enough that SENS Research Foundation provided Ichor with funding and a material and technology transfer agreement to reassess the technology, and over $700,000 in directed program investments and grants have been received in the last year or two.

You recently completed a round of funding for the AMD work; what is the plan for the next year or so?

The new funds will allow us to develop a portfolio of enzyme therapy candidates to treat AMD. We will obtain critical data necessary to secure follow-on investment including in vitro studies (cell culture studies to confirm mechanism of action and cytotoxicity) and pivotal proof-of-concept in vivo studies, such as toxicity, PK/PD (how long the enzyme stays in the body and where), and efficacy. We will also be restructuring the company (reincorporating an IP holding company in Delaware, ensuring all contracts are up to date and audited) and ensuring our IP position is on solid footing (licensing in several related patents from existing collaborators, and filing several provisional patents from our intramural work). Collectively, we believe these efforts will position us to obtain series A for investigational new drug (IND) enabling pre-clinical studies.

You’ve been involved in the rejuvenation research community for quite some time now. What is your take on the bigger picture of SENS and the goal of ending aging?

This is a loaded question. What I can say is that the medical establishment has made great progress in the treatment of infectious disease through the development of antibiotics, vaccines, and hygiene programs. However, similar progress has not been realized for the diseases of old age, despite exorbitant expenditures. I have chosen to work in this space because I think a different approach is necessary, and it is here that I believe my companies and I can be the most impactful. I think SENS provides a good framework within which to ask and answer questions.

What do you see as the best approach to getting nascent SENS technologies like this one out of the laboratory and into the clinic?

We need more people who fully understand, in a highly detailed way, what a real translational path looks like. To take on projects like this, being a good scientist is not enough. We need people who can speak business, science, medicine, and legal, and apply these diverse disciplines to a well articulated, focused product or problem. There is no shortage of people who partially understand some of these, but the details are not somewhat important – they are all that matter for success in this space.

Another area is for investors. Some of the projects that come across my desk for review are truly abysmal, yet I have seen projects that are clearly elaborate hoaxes or outright scams (to anyone who has stepped foot in a laboratory) get funded to the tune of hundreds of thousands of dollars or more. While it is perfectly reasonable for high net worth individuals to gamble on moon shots in the anti-aging space (and I am ever grateful for the investors who have taken such a gamble on us) even aggressive development strategies should have some basis in reality. This is especially true as more and more high tech and internet investors move into the space.

If this works stupendously well, what comes next for Ichor Therapeutics?

I really want to get back into stem-cell research, but I basically need a blank check and a strong knowledge of the regulatory path to clinic before I feel comfortable moving into the space. A successful AMD exit would accomplish both of these goals, and position us to pivot to cell-based therapies.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

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G. Stolyarov II Interviews Demian Zivkovic Regarding the D.N.A. – Gene Therapies Congress

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Categories: Announcements, Science, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II and Demian Zivkovic
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Mr. Stolyarov invited Demian Zivkovic, President of the Institute of Exponential Sciences (IES), to discuss the forthcoming Designing New Advances (D.N.A.) Gene Therapies Congress in Utrecht, The Netherlands.

The interview took place on Sunday, June 19, 2016, at 11 a.m. US Pacific Time. Watch the recording here.

The D.N.A. Congress is scheduled to occur on July 9, 2016, and will feature speakers such as Oliver Medvedik, Aubrey de Grey, Elizabeth Parrish, Keith Comito, and Tatjana Kochetkova. This event receives the strong endorsement of both The Rational Argumentator and the Nevada Transhumanist Party.

Read the announcement of the D. N. A. Congress here.

Contribute to the fundraiser for the D. N. A. Congress on Indiegogo  and Generosity.

DNA_Interview_CoverDemian Zivkovic is the president of the Institute of Exponential Sciences  (Facebook  / Meetup) – an international transhumanist think tank / education institute comprised of a group of transhumanism-oriented scientists, professionals, students, journalists, and entrepreneurs interested in the interdisciplinary approach to advancing exponential technologies and promoting techno-positive thought. He is also an entrepreneur and student of artificial intelligence and innovation sciences and management at the University of Utrecht.

Demian and the IES have been involved in several endeavors, such as organizing lectures on exponential sciences, interviewing experts such as Aubrey de Grey, joining several of Mr. Stolyarov’s futurism panels, and spreading Death is Wrong – Mr. Stolyarov’s illustrated children’s book on indefinite life extension – in The Netherlands.

Demian Zivkovic is a strong proponent of healthy life extension and cognitive augmentation. His interests include hyperreality, morphological freedom advocacy, postgenderism, and hypermodernism. He is currently working on his ambition of raising enough capital to make a real difference in life extension and transhumanist thought.

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Third Interview of Gennady Stolyarov II and Wendy Stolyarov by Roen Horn of the Eternal Life Fan Club – May 2, 2015

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Categories: Justice, Philosophy, Politics, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II and Wendy Stolyarov
September 6, 2015
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ELFC_DIW_Third_InterviewNote by Mr. Stolyarov: On May 2, 2015, a hot spring day in Roseville, California, Wendy Stolyarov and I visited Roen Horn of the Eternal Life Fan Club and had a lengthy discussion with him on a wide variety of subjects: life extension, our illustrated children’s book Death is Wrong, healthcare policy, criminal punishment, and the political prospects of the Transhumanist Party and third parties in general. This was Roen’s third interview with us (watch the first and second interviews as well), and his skillfully edited recording offers a glimpse into its best segments. This conversation occurred approximately four months before Wendy and I took the step to found the Nevada Transhumanist Party, but my comments in this interview are a good example of the evolution of my thinking in this direction, as I was already inclined toward endorsing Zoltan Istvan’s 2016 Presidential run.

Watch the interview here.

Join the Nevada Transhumanist Party here.

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G. Stolyarov II Interviews Adam Alonzi Regarding Emerging Biotech Research

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Categories: Science, Transhumanism, Tags: , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II and Adam Alonzi
August 28, 2015
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On August 23, 2015, Mr. Stolyarov invited Adam Alonzi to share the insights he was able to glean from many recent discussions with biotechnology entrepreneurs and researchers. Mr. Alonzi was able to subsequently edit some of his remarks to remedy the technical issues with audio quality during the broadcast. His edited version appears below.

See the original interview recording:

Adam Alonzi is the author of Praying for Death and A Plank in Reason. He is also a futurist, inventor, DIY enthusiast, biotechnologist, programmer, molecular gastronomist, consummate dilletante and columnist at The Indian Economist. Read his blog here. Listen to his podcasts at http://adamalonzi.libsyn.com.

Adam Alonzi’s Interviews
Elizabeth Parrish – BioViva
Alex Zhavoroknov – InSilico Medicine
Maria Konovalenko – Science for Life Extension Foundation and Longevity Cookbook
Luis Arana – Robots Without Borders

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Second Interview of Gennady Stolyarov II and Wendy Stolyarov by Roen Horn of the Eternal Life Fan Club – November 27, 2014

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Categories: Art, Philosophy, Science, Self-Improvement, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II and Wendy Stolyarov II
November 27, 2014
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ELFC_DIW_Second_Interview
 

Today Wendy Stolyarov and I had an excellent second interview and conversation with Roen Horn of the Eternal Life Fan Club. We discussed our recent activities related to the life-extension movement, the impact of “Death is Wrong”, and many philosophical and practical ideas surrounding the pursuit of indefinite longevity.

Watch the recorded interview here.

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The Continued Momentum of “Death is Wrong” in August-September 2014 – Post by G. Stolyarov II

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Categories: Economics, Philosophy, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
September 25, 2014
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GSII_Age_5_QuoteI am pleased to report that, through late August and September 2014, the momentum of Death is Wrong has continued.

An excellent and entertaining recent interview of me was done by Leonardo Nunes Ricucci on La República Democrática de Leo, where we discussed Death is Wrong, transhumanism, indefinite life extension, risk management, and related topics. You can listen to the podcast and download an MP3 file of the episode here.

On September 6, 2014, Roen Horn of the Eternal Life Fan Club interviewed Wendy and me about Death is Wrong and related arguments for life extension and technological progress. The interview was extensive, and many subjects were discussed. Watch it here.

Here is the video trailer that was posted two days in advance of the interview.

Roen has been doing excellent work in recording his Death is Wrong book giveaways on video. Here is a quick video of his second giveaway of a book to a family with four children.

The book has continued to play a role in discussions of longevity and future remedies to the ravages of senescence. Here is a great post by Will Muessig of Unity Politics, mentioning Death is Wrong and refuting Ezekiel Emanuel’s deeply fallacious recent article about why age 75 is a good age to die.

I am also pleased to have had my thoughts included in “Cyborgs: The truth about human augmentation” – an excellent new article by Frank Swain on BBC Future. Mr. Swain had previously interviewed me about Death is Wrong, which led to his article “How to live forever” being published by BBC Future in April 2014. This time Mr. Swain asked me to help debunk common myths about human augmentation, and was happy to share my vision of “a future in which a thousand augmented flowers bloom” and in which augmentations will help people live longer, more fulfilling lives as well.

The continued infusion of the ideas of indefinite life extension into publicly prominent discussions was one of my key aims in writing Death is Wrong. Just like our book-distribution campaign, this aim is being fulfilled right now, and it will hopefully keep paying cultural dividends to the longevity movement for months and years to come.

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Mr. Stolyarov Interviewed by La República Democrática de Leo About “Death is Wrong”

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Categories: Education, Philosophy, Transhumanism, Tags: , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
August 30, 2014
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Listen to the excellent and entertaining recent interview of me by Leonardo Nunes Ricucci on La República Democrática de Leo, where we discuss my children’s book Death is Wrong, transhumanism, indefinite life extension, risk management, and related topics.

You can listen to the podcast and download an MP3 file of the episode at https://soundcloud.com/rdleo/ep-33

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Gennady Stolyarov II Interviewed on Transhumanism by Rebecca Savastio of Guardian Liberty Voice

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Categories: Technology, Transhumanism, Tags: , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
May 26, 2014
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Rebecca Savastio of Guardian Liberty Voice has published an excellent interview with me, which mentions Death is Wrong in its introduction and delves into various questions surrounding transhumanism and emerging technologies. In my responses, I also make reference to writings by Ray Kurzweil, Max More, Julian Simon, and Singularity Utopia. Additionally, I cite my 2010 essay, “How Can I Live Forever: What Does and Does Not Preserve the Self“.
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I was pleased to be able to advocate in favor of transformative technological progress on multiple fronts.
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Read Ms. Savastio’s article containing the interview: “Gennady Stolyarov on Transhumanism, Google Glass, Kurzweil, and Singularity“.

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Gennady and Wendy Stolyarov Interviewed by Justin Loew of LongeCity Regarding “Death is Wrong”

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Categories: Art, Education, Philosophy, Science, Technology, Transhumanism, Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II
April 16, 2014
Recommend this page.
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Justin Loew of LongeCity recently interviewed me and my wife Wendy Stolyarov regarding our illustrated children’s book Death is Wrong and our Indiegogo campaign to spread this book to 1000 children, free of cost to them. The audio broadcast of our excellent conversation has been posted on this thread on the LongeCity forum. Here is a link to the MP3 file: http://www.longecity.org/media/LongeCityPodcast_Stolyarov2014_A01.mp3.

Gennady and Wendy Stolyarov

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