Tag Archives: lifespans


Impacts of Indefinite Life Extension: Answers to Common Questions – Video by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II

As a proponent of attaining indefinite human longevity through the progress of medical science and technology, Mr. Stolyarov is frequently asked to address key questions about the effects that indefinite life extension would have on human incentives, behaviors, and societies. Here, he offers his outlook on what some of these impacts would be.

The specific questions addressed are the following:
1. What would be the benefits of life extension?
2. What drawbacks would life extension pose?
3. Would governments ban indefinite life extension if it is achieved?


– “Impacts of Indefinite Life Extension: Answers to Common Questions” – Essay by G. Stolyarov II
Death is Wrong – Illustrated Children’s Book by G. Stolyarov II


Major Mouse Testing Program Crowdfunding Campaign Announcement by International Longevity Alliance

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The New Renaissance HatInternational Longevity Alliance


Editor’s Note: The Rational Argumentator strongly supports the Major Mouse Testing Project crowdfunding campaign, and I have personally pledged $100 to this effort. Furthermore, I am honored that copies of my illustrated children’s book Death is Wrong are being made available as rewards for certain tiers of contributors to this research fundraiser.

~ Gennady Stolyarov II, Editor-in-Chief, The Rational Argumentator, May 11, 2016

The International Longevity Alliance is conducting a crowdfunding campaign to support the investigation of senolytic drugs’ potential to extend life. The team is going to study the combination of three senolytic drugs – Dasatinib, Venetoclax, and Quercetin – in mice, to see if the removal of senescent cells can ensure extended maximum lifespan. With highly devoted scientists and volunteers working for MMTP, the project needs only $60,000 to begin this experiment, as the researchers would need only to buy the mice and pay for their housing, the substances to test, and the battery of tests to analyze health changes.

Will you help to fund this research? Then please go to Lifespan.io, and choose the donation that suits you best and receive the deepest gratitude of the team and a nice useful souvenir to remember your input into the investigation of longevity therapies!

MMTP_Project1_StairFind out more about the International Longevity Alliance here.


A Most Interesting Data Set Covering the Longevity of Polish Elite Athletes Across Much of the 20th Century – Article by Reason

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The New Renaissance HatReason

Today I noticed an open access paper in which the authors examine mortality data for Polish Olympic athletes over the past 90 years or so, and compare it with established historical data for the general population. This blends two topics that are occasionally covered here at Fight Aging!: firstly, the growth in human life expectancy in recent history and its causes, and secondly the topic of how regular exercise and life expectancy interact. It is the present consensus that elite athletes, those at the top of their profession, live longer than the rest of us, but it remains open to debate as to whether this is because more exercise is better, or because very robust people who would have lived longer anyway are more likely to enter the world of professional athletics. Researchers want to map the dose-response curve for exercise, in other words. Even though there is very good, very solid evidence for the benefits of regular moderate exercise versus being sedentary, going beyond that to a more nuanced view of what more or less exercise does for health is a challenging goal given the starting point of statistical snapshots of data from various study populations.

Studying the history of life expectancy isn’t much easier, though there the challenges tend to revolve around the ever-decreasing quality of data as you look further back in time. The 20th century marked transitions from hopeful aspiration to solid accomplishment in all fields of medicine, too many profound advances in the capabilities of medical science and practice to list here. As the decades passed, this important progress focused ever more on treatments for age-related conditions. An individual born in the US in 1900 suffered through the end of the era of poor control of infectious disease, prior to modern antibiotics and antiviral drugs, and likely benefited little from later progress towards better control of heart disease and other common age-related diseases. An individual born in the US in 1950, on the other hand, enjoyed a youth with comparatively little fear of disease, and is probably still alive today, with access to far more capable therapies than existed even a couple of decades ago.

Given all of this, one of the interesting things to note in the analysis of the Polish data is that the elite athletes born in the early 20th century appear to have a lower rate of aging than the general population, as determined by a slower rise in mortality over time, but that this difference between athletes and the average individual is greatly diminished for people born in the latter half of the 20th century. This suggests, roughly, that advances in medicine from 1900 to 1950 had a leveling effect, bringing up the average, preventing early deaths, but doing little to address age-related disease. That said, there is a large variation in results across the range of similar studies, both those that look at the history of longevity, and those that look at populations of athletes at a given time. It is wise to consider epidemiological studies in groups rather than one by one, and look for common themes. Still, this one is a fascinating data set for the way in which it combines historical trends and exercise in the study of aging.

Examining mortality risk and rate of ageing among Polish Olympic athletes: a survival follow-up from 1924 to 2012 – by Yuhui Lin, Antoni Gajewski, and Anna Poznańska


A sedentary lifestyle is associated with the onset of chronic diseases including ischaemic heart disease, type-II diabetes and neurodegenerative diseases. Frequent exercise is perceived as a major behavioural determinant for improved life expectancy and a slower rate of ageing. There is little doubt that frequent exercise is beneficial for individuals’ well-being, and an active lifestyle reduces the risk for chronic diseases. However, it is still uncertain whether the rate of ageing decelerates in response to frequent and intense physical exercise. Our attempt is the first empirical study to show the application of a parametric frailty survival model to gain insights into the rate of ageing and mortality risk for Olympic athletes.

Our participants for this parametric frailty survival analysis were Polish athletes who had participated in the Olympic Games from 1924 to 2010. We assumed that these athletes were elite in their preferred sports expertise, and that they were engaged in frequent, if not intense, physical exercise. The earliest recorded year of birth was 1875, and the latest was in 1982; total N=2305; male=1828, female=477. For reliable estimates, mortality improvements by calendar events and birth cohort had to be taken into consideration to account for the advancements made in medicine and technology. After the consideration of mortality improvements and the statistical power for parametric survival analysis, we restricted our analysis to male athletes born from 1890 to 1959 (M=1273). For reliable estimates, we preassigned recruited athletes into two categorical cohorts: 1890-1919 (Cohort I); 1920-1959 (Cohort II).

Our findings suggest that Polish elite athletes in Cohort I born from 1890-1919 experienced a slower rate of ageing, and had a lower risk for mortality and a longer life-expectancy than the general population from the same birth cohort. It is very unlikely that these survival benefits were gained within a short observational time. Therefore, we argue that participation in frequent sports from young adulthood reduces mortality risk, increases life-expectancy and slows the rate of ageing. The age-specific mortality trajectories of Cohort I elite athletes also suggest frequent exercise can decelerate the rate of ageing by 1% with an achievement of threefold risk reduction in mortality. In comparison with those of the general population, the differences in energy expenditure, behavioural habits, body mass and sports expertise were likely to be the contributing factors to the higher variance in lifespan among elite athletes.

In Cohort II, the estimated rate of ageing is highly similar between elite athletes and the general population, which contradicts our estimates for Cohort I. This may be attributed to mortality improvements from year 1920 onwards in Poland. These mortality improvements have changed individuals’ susceptibilities for different causes of death, which has resulted in an increased variation in lifespan both in the general population and for elite athletes. Interestingly, the comparison of the rate of ageing of elite athletes in Cohort I and II shows a similar rate of ageing. Among the elite athletes, the estimates suggest that Cohort II individuals benefited from a 50% mortality risk reduction as compared with individuals born in Cohort I. The estimated overall mortality risk of the Polish general population is 29% lower in Cohort II than in I.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.
This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.


Impacts of Indefinite Life Extension: Answers to Common Questions – Article by G. Stolyarov II

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Categories: Transhumanism, Tags: , , , , , , , , , , , ,

The New Renaissance Hat
G. Stolyarov II

As a proponent of attaining indefinite human longevity through the progress of medical science and technology, I am frequently asked to address key questions about the effects that indefinite life extension would have on human incentives, behaviors, and societies. Here, I offer my outlook on what some of these impacts would be.

What would be the benefits of life extension?

(1) The greatest benefit of life extension is the continued existence of the individual who remains alive. Each individual – apart from the worst criminals – has incalculable moral value and is a universe of ideas, experiences, emotions, and memories. When a person dies, that entire universe is extinguished, and, to the person who dies, everything is lost and not even a memory remains. It is as if the individual never existed at all. This is the greatest possible loss and should be averted if at all possible. The rest of us, of course, also lose the possible benefits and opportunities of interacting with that individual.

(2) People would be able to accomplish far more with longer lifespans. They could pursue multiple careers and multi-year personal projects and could reliably accumulate enough resources to sustainably enjoy life. They could develop their intellectual, physical, and relational capabilities to the fullest. Furthermore, they would exhibit longer-term orientations, since they could expect to remain to live with the consequences of decisions many decades and centuries from now. I expect that a world of longer-lived individuals would involve far less pollution, corruption, fraud, hierarchical oppression, destruction of other species, and short-term exploitation of other humans. Prudence, foresight, and pursuit of respectful, symbiotic interactions would prevail. People would tend to live in more reflective, measured, and temperate ways instead of seeking to haphazardly cram enjoyment and activity into the tiny slivers of life they have now. At the same time, they would also be more open to experimentation with new projects and ideas, since they would have more time to devote to such exploratory behaviors.

(3) Upon becoming adults, people would no longer live life in strict stages, and the normative societal expectations of “what one should do with one’s life” at a particular stage would relax considerably. If a person at age 80 is biologically indistinguishable from a person at age 20, the strict generational divides of today would dissipate, allowing a much greater diversity of human interactions. People will tend to become more tolerant and cosmopolitan, having more time to explore other ways of living and to understand those who are different from them.

(4) Technological, scientific, and economic progress would accelerate rapidly, because precious intellectual capital would not be lost to the ravages of death and disease. Longer-lived humans would be more likely to invest in projects that would materialize over the course of decades, including space travel and colonization, geo-engineering and terraforming, prevention of asteroid impacts and other natural disasters, safe nuclear disarmament and disposal of nuclear waste, and long-term preservation of the human species. The focus of most intelligent people would shift from meeting quarterly or annual business earnings goals and toward time- and resource-intensive projects that could avert existential dangers to humankind and also expand humanity’s reach, knowledge, and benevolence. The achievement of significant life extension would inspire many intelligent people to try to solve other age-old problems instead of resigning to the perception of their inevitability.

(5) Major savings to health-care systems, both private and governmental, would result if the largest expenses – which occur in the last years of life today, in the attempt to fight a losing battle against the diseases of old age – are replaced by periodic and relatively inexpensive rejuvenation and maintenance treatments to forestall the advent of biological senescence altogether. Health care could truly become about the pursuit of sustainable good health instead of a last-ditch effort against the onslaught of diseases that accompanies old age today. Furthermore, the strain on public pensions would be alleviated as advanced age would cease to be a barrier to work.

What drawbacks would life extension pose?

I do not see true drawbacks to life extension. Certainly, the world and all human societies would change significantly, and there would be some upheaval as old business models and ways of living are replaced by new ones. However, this has happened with every major technological advance in history, and in the end the benefits far outweigh any transitional costs. For the people who remain alive, the avoidance of the greatest loss of all will be well worth it, and the human capacity for adaptation and growth in the face of new circumstances is and has always been remarkable.  Furthermore, the continued presence of individuals from older generations would render this transition far more humane than any other throughout history. After all, entire generations would no longer be swept away by the ravages of time. They could persist and preserve their knowledge and experience as anchors during times of change.

Every day, approximately 150,000 people die, and approximately 100,000 of them die from causes related to senescence. If those deaths can be averted and the advent of indefinite life extension accelerated by even a few days, hundreds of thousands of irreplaceable individual universes would be preserved. This is worth paying even substantial costs in my view, but, fortunately, I think the other – economic and societal – effects that accompany life extension would be overwhelmingly positive as well.

As Death is Wrong, my illustrated children’s book on the prospects for life extension, points out, “Death is the enemy of us all, to be fought with medicine, science, and technology.” The book discusses the benefits of life extension in a language and format accessible to most children of ages 8 or older. Death is Wrong also outlines some common arguments against life extension and reasonable responses to them.  For instance, I respond to the common overpopulation argument as follows: “human population is the highest it has ever been, and most people live far longer, healthier, more prosperous lives than their ancestors did when the Earth’s population was hundreds of times smaller. Technology gives us far more food, energy, and living space than our ancestors had, and the growth in population only gives us more smart people who can create even more technologies to benefit us all. Besides, humans ought to build more settlements on land, on water, underwater, and in space. Space travel could also save the human species if the Earth were hit by a massive asteroid that could wipe out complex life. ” I respond to the boredom argument by stating that, due to human creativity and discovery, the number of possible pursuits increases far faster than the ability of any individual to pursue them. For instance, thousands more books are published every day than a single person could possibly read.


Would governments ban indefinite life extension if it is achieved?

Once life-extending treatments are developed and publicly available, national governments would not be effectively able to ban them, since there will not be a single medicine or procedure that would accomplish indefinite lifespans. Rather, indefinite life extension would be achieved through a combination of treatments, beating back today’s deadliest diseases using techniques that would not be limited in their application to people who explicitly want to live longer. (For instance, people who do not harbor that particular desire but do want to get rid of cancer, heart disease, or Alzheimer’s disease that may afflict them or their loved ones, would also benefit from the same treatments.) These treatments would be as embedded in the healthcare systems of the future as over-the-counter drugs like aspirin and ibuprofen are today; it would be practically impossible to ban them, and countries that did would face massive black markets or people traveling abroad to receive the same treatments.

Furthermore, genuine healthy life extension could be a great fiscal solution for many welfare states today, which are finding themselves with unsustainable burdens pertaining to old-age healthcare and pensions. The majority of health-care costs are expended to keep frail people alive a little bit longer and to fight an expensive and ultimately losing battle against the diseases of old age. The only way dramatic life extension could occur is if regular and relatively inexpensive maintenance (made inexpensive through the exponential progress of information technologies and bio/nanotechnology) prevented the decline of the body to such a stage where expensive, losing battles needed to be fought at all. Replacing the current extremely expensive end-of-life medical care with periodic rejuvenation and maintenance would be a great cost-saver and may avert a major fiscal crisis.

What concerns me is not governments banning life-extension technologies once they are developed, but rather existing political systems (and their associated politically connected established private institutions) creating barriers to the emergence of those technologies in the first place. Most of those barriers are probably inadvertent – for instance, the FDA’s approval process in the United States premised on a model of medicines and treatments that must focus on single diseases rather than the biological aging process as a whole. However, there have been influential “bioethicists”, such as Leon Kass, Daniel Callahan, and Sherwin Nuland, who have explicitly and extensively spoken and written against healthy life extension. It is important to win the contest of ideas so that public opinion does not give encouragement to the “bioconservative” bioethicists who want to use the political process to perpetuate the old cycle of life, death, and decay – where each generation must be swept away by the ravages of senescence. We must stand for life and against age-old rationalizations of our own demise.

This essay may be freely reproduced using the Creative Commons Attribution Share-Alike International 4.0 License, which requires that credit be given to the author, G. Stolyarov II. Find out about Mr. Stolyarov here.


“A Morte é um Erro” – Portuguese Translation of “Death is Wrong” – Translated by Eric Pedro Alvaro – Post by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II

A free PDF version of A Morte é um Erro – the Portuguese translation of Death is Wrong – is now available for download from The Rational Argumentator. You can obtain your copy here and may spread it to Portuguese-speaking audiences as widely as you wish.

A Morte é um Erro was generously translated into Portuguese by Eric Pedro Alvaro.

Death_is_Wrong_Portuguese_CoverPaperback copies of A Morte é um Erro can be purchased in the following venues:



Kindle copies of A Morte é um Erro can be purchased on Amazon for $0.99.


Se você já se perguntou, “Por que as pessoas morrem?” então este livro é para você. A resposta é que não, a morte não é necessária, inevitável ou boa. Na verdade, a morte é um erro. A morte é uma inimiga de todos nós, que deve ser combatida com ciência, medicina e tecnologia. Este livro lhe apresenta os maiores, mais desafiantes e mais revolucionários movimentos para prolongar radicalmente o tempo de vida humano, para que você então simplesmente não precise morrer.

Você aprenderá sobre algumas plantas e animais com um tempo de vida incrivelmente longo, sobre recentes descobertas científicas em relação a ampliação do tempo de vida em humanos, e sobre simples e poderosos argumentos que podem refutar as comuns desculpas para a morte. Se você alguma vez já pensou que a morte é injusta e que ela deve ser derrotada, você não está sozinho. Leia este livro, e se torne parte desta importante busca na história da humanidade.

Este livro foi escrito pelo filósofo e futurólogo Gennady Stolyarov II e ilustrado pela artista Wendy Stolyarov. Com o intuito de lhe mostrar que, não importa quem é você e o que você pode fazer, sempre há uma forma de ajudar humanidade em sua batalha contra morte.


How Anti-Individualist Fallacies Prevent Us from Curing Death – Article by Edward Hudgins

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The New Renaissance HatEdward Hudgins
July 3, 2015

Are you excited about Silicon Valley entrepreneurs investing billions of dollars to extend life and even “cure” death?

It’s amazing that such technologically challenging goals have gone from sci-fi fantasies to fantastic possibilities. But the biggest obstacles to life extension could be cultural: the anti-individualist fallacies arrayed against this goal.

Entrepreneurs defy death

 A recent Washington Post feature documents the “Tech titans’ latest project: Defy death. “ Peter Thiel, PayPal co-founder and venture capitalist, has led the way, raising awareness and funding regenerative medicines. He explains: “I’ve always had this really strong sense that death was a terrible, terrible thing… Most people end up compartmentalizing and they are in some weird mode of denial and acceptance about death, but they both have the result of making you very passive. I prefer to fight it.”

Others prefer to fight as well. Google CEO Larry Page created Calico to invest in start-ups working to stop aging. Oracle’s Larry Ellison has also provided major money for anti-aging research. Google’s Sergey Brin and Facebook’s Mark Zuckerberg both have funded the Breakthrough Prize in Life Sciences Foundation.

Beyond the Post piece we can applaud the education in the exponential technologies needed to reach these goals by Singularity U., co-founded by futurist Ray Kurzweil, who believes humans and machines will merge in the decades to become transhumans, and X-Prize founder Peter Diamandis.

The Post piece points out that while in the past two-thirds of science and medical research was funded by the federal government, today private parties put up two-thirds. These benefactors bring their entrepreneurial talents to their philanthropic efforts. They are restless for results and not satisfied with the slow pace of government bureaucracies plagued by red tape and politics.

“Wonderful!” you’re thinking. “Who could object?”

Laurie Zoloth’s inequality fallacy

 Laurie Zoloth for one. This Northwestern University bioethicist argues that “Making scientific progress faster doesn’t necessarily mean better — unless if you’re an aging philanthropist and want an answer in your lifetime.” The Post quotes her further as saying that “Science is about an arc of knowledge, and it can take a long time to play out.”

Understanding the world through science is a never-ending enterprise. But in this case, science is also about billionaires wanting answers in their lifetimes because they value their own lives foremost and they do not want them to end. And the problem is?

Zoloth grants that it is ”wonderful to be part of a species that dreams in a big way” but she also wants “to be part of a species that takes care of the poor and the dying.” Wouldn’t delaying or even eliminating dying be even better?

The discoveries these billionaires facilitate will help millions of people in the long-run. But her objection seems rooted in a morally-distorted affinity for equality of condition: the feeling that it is wrong for some folks to have more than others—never mind that they earned it—in this case early access to life-extending technologies. She seems to feel that it is wrong for these billionaires to put their own lives, loves, dreams, and well-being first.

We’ve heard this “equality” nonsense for every technological advance: only elites will have electricity, telephones, radios, TVs, computers, the internet, smartphones, whatever. Yes, there are first adopters, those who can afford new things. Without them footing the bills early on, new technologies would never become widespread and affordable. This point should be blindingly obvious today, since the spread of new technologies in recent decades has accelerated. But in any case, the moral essential is that it is right for individuals to seek the best for themselves while respecting their neighbors’ liberty to do the same.

Leon Kass’s “long life is meaningless” fallacy

 The Post piece attributes to political theorist Francis Fukuyama the belief that “a large increase in human life spans would take away people’s motivation for the adaptation necessary for survival. In that kind of world, social change comes to a standstill.”

Nonsense! As average lifespans doubled in past centuries, social change—mostly for the better—accelerated. Increased lifespans in the future could allow individuals to take on projects spanning centuries rather than decades. Indeed, all who love their lives regret that they won’t live to see, experience, and help create the wonders of tomorrow.

The Post cites physician and ethicist Leon Kass who asks: “Could life be serious or meaningful without the limit of mortality?”

Is Kass so limited in imagination or ignorant of our world that he doesn’t appreciate the great, long-term projects that could engage us as individuals seriously and meaningfully for centuries to come? (I personally would love to have the centuries needed to work on terraforming Mars, making it a new habitat for humanity!)

Fukuyama and Kass have missed the profound human truth that we each as individuals create the meaning for our own lives, whether we live 50 years or 500. Meaning and purpose are what only we can give ourselves as we pursue productive achievements that call upon the best within us.

Francis Fukuyama’s anti-individualist fallacy

 The Post piece quotes Fukuyama as saying “I think that research into life extension is going to end up being a big social disaster… Extending the average human life span is a great example of something that is individually desirable by almost everyone but collectively not a good thing. For evolutionary reasons, there is a good reason why we die when we do.”

What a morally twisted reason for opposing life extension! Millions of individuals should literally damn themselves to death in the name of society. Then count me anti-social.

Some might take from Fukuyama’s premise a concern that millions of individuals living to 150 will spend half that time bedridden, vegetating, consuming resources, and not producing. But the life extension goal is to live long with our capacities intact—or enhanced! We want 140 to be the new 40!

What could be good evolutionary reasons why we die when we do? Evolution only metaphorically has “reasons.” It is a biological process that blindly adapted us to survive and reproduce: it didn’t render us immune to ailments. Because life is the ultimate value, curing those ailments rather than passively suffering them is the goal of medicine. Life extension simply takes the maintenance of human life a giant leap further.

Live long and prosper

 Yes, there will be serious ethical questions to face as the research sponsored by benevolent billionaires bears fruit. But individuals who want to live really long and prosper in a world of fellow achievers need to promote human life as the ultimate value and the right of all individuals to live their own lives and pursue their own happiness as the ultimate liberty.

Dr. Edward Hudgins directs advocacy and is a senior scholar for The Atlas Society, the center for Objectivism in Washington, D.C.

Copyright, The Atlas Society. For more information, please visit www.atlassociety.org.


“La mort, c’est mal!” – French Translation of “Death is Wrong” – Translated by Philippe Castonguay – Post by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II
May 16, 2015

La mort, c’est mal! – the French translation of Death is Wrong – is now available for download from The Rational Argumentator. You can obtain your free PDF copy here and may spread it to French-speaking audiences as widely as you wish.

La mort, c’est mal! was generously translated into French by Philippe Castonguay.

Death_is_Wrong_French_CoverPaperback copies of La mort, c’est mal! can be purchased in the following venues:

Createspace – $9.48

Amazon – $9.48

Kindle copies of La mort, c’est mal! can be purchased on Amazon for $0.99.


Si vous avez déjà demandé « pourquoi les gens doivent-ils mourir? » alors ce livre est pour vous. La vérité est que non, la mort n’est ni bonne, ni nécessaire, ni inévitable. En fait, la mort, c’est mal! La mort est notre ennemie à tous et toutes et doit être combattue par la médecine, la science et la technologie. Ce livre vous introduit au plus grand défi de notre espèce, à son mouvement le plus révolutionnaire; celui d’augmenter radicalement l’espérance de vie humaine pour que vous n’ayez plus à mourir, du tout.

Vous trouverez dans ce livre des plantes et des animaux à la longévité spectaculaire, des découvertes scientifiques récentes pavant le chemin vers l’augmentation de la durée des vies humaines, ainsi que de simples, mais puissants arguments pour affronter ceux en faveur de la mort. Si vous avez déjà pensé que la mort était injuste et qu’elle devrait être vaincue, sachez que vous n’êtes pas seul. Lisez ce livre et prenez part à la plus importante quête de l’histoire de l’humanité.

Ce livre a été écrit par le philosophe et futuriste Gennady Stolyarov II et illustré par l’artiste Wendy Stolyarov. Ici, il vous sera démontré que, peu importe qui vous êtes et peu importe vos habiletés, il vous est toujours possible d’aider l’humanité dans sa lutte contre la mort.


Adam Alonzi Interviews G. Stolyarov II on Indefinite Life Extension and “Death is Wrong”

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The New Renaissance Hat
G. Stolyarov II and Adam Alonzi
February 22, 2015

Today I had a pleasant and erudite discussion with Adam Alonzi regarding the feasibility and desirability of attaining indefinite longevity in our lifetimes, as well as Death is Wrong and its impact.


Adam Alonzi’s YouTube Channel
Adam Alonzi Reads Death is Wrong


“Death is Wrong” Reviewed by Robert W. Franson of Troynovant

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Read the excellent new review by science-fiction author and literary essayist Robert W. Franson of Death is Wrong. The review is published on Mr. Franson’s website Troynovant, which offers extensive literary and philosophical analysis.

Here is an excerpt: “Death is Wrong is a short book, clearly written and easy to read. I like the personal approach: it doesn’t talk down and is quite accessible. A striking concept presented quite reasonably and supported matter-of-factly. There are apt quotations from a variety of thinkers, including several of my personal heroes of modern times: Francis Bacon, Benjamin Franklin, Friedrich Nietzsche. These people and some scenes from nature are nicely illustrated by Wendy Stolyarov. For readers who want a little more about the background concepts, there is a brief Appendix discussing the seven basic causes of senescence, such as cell loss and atrophy. There are some links for further learning. It’s a good book, entertaining and thoughtful, and certainly gives us a challenge to think about.


The Plasticity of Aging and Longevity Continues – Article by Reason

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The New Renaissance Hat
December 4, 2014

When looking at most of the past extension of human life since the 1700s the major causes were better sanitation and control of infectious disease, with the largest effects on life expectancy at birth arising from lowered childhood mortality, even though there was also a steady increase in adult life expectancy. When looking back at the late 20th and early 21st century period from a safe distance of a century or so, the similar high level summary of the drivers of life extension will probably focus on greatly increased control over cardiovascular disease and the resulting steep decline in late life mortality due to this cause. There are many other improvements in medicine that have occurred in the past fifty years, but this is the one that stands out if you look at the data.

This period of medical strategy and development is coming to an end, however, and the summary of the next age in medicine with regard to its effects on human longevity will be that this was the time in which researchers started to directly address the processes of aging and, separately, brought cancer largely under medical control. Progress in the future of life expectancy at this point in time is overwhelmingly a matter of success in intervening in the aging process, building biotechnologies to repair the cellular and molecular damage that causes aging and thus prevent or turn back age-related frailty and disease.

If aging is purely a matter of damage we should expect all improvements in long-term health to also extend life to some degree. If there is less damage then the machinery lasts longer – it really is that simple a concept, even though the machinery of our biology is very complex. Studies of changing life expectancy such as the one quoted below continue to find that aging appears to be plastic, and that present trends in reduced old age mortality are continuing in those regions with better access to medical technology. The only limits on life are imposed by a present inability to fix the problems that kill us, and that can be changed by funding the right research:


In high-income countries, life expectancy at age 60 years has increased in recent decades. Falling tobacco use (for men only) and cardiovascular disease mortality (for both men and women) are the main factors contributing to this rise. In high-income countries, avoidable male mortality has fallen since 1980 because of decreases in avoidable cardiovascular deaths. For men in Latin America, the Caribbean, Europe, and central Asia, and for women in all regions, avoidable mortality has changed little or increased since 1980. As yet, no evidence exists that the rate of improvement in older age mortality (60 years and older) is slowing down or that older age deaths are being compressed into a narrow age band as they approach a hypothesised upper limit to longevity.

Link: http://dx.doi.org/10.1016/S0140-6736(14)60569-9

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 

This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

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