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Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life.

References
– “Calico and the Paradigm Shift in the War on Death” – Article by G. Stolyarov II
– “Google announces Calico, a new company focused on health and well-being” – Google Press Release – September 18, 2013
– “TIME Feature: CSO Aubrey de Grey on Google’s Newly Launched Anti-Aging Initiative” – SENS Research Foundation – September 18, 2013
– “Google’s Calico: the War on Aging Has Truly Begun” – Aubrey de Grey – TIME Magazine – September 18, 2013
SENS Research Foundation

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 19, 2013
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Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life. Unlike the cautious, short-term orientation of many more conventional manufacturers of drugs and medical devices, Google’s philosophy of making investments with possible immense payoffs in the distant future offers tremendous hope that this company will be around through the many years it will take to engage in the search for promising treatments and their subsequent testing.

 Aubrey de Grey, one of the chief strategists and key intellectual innovators in the escalating war on senescence, has written that Calico signals that the war on aging has truly begun. De Grey emphasizes that it is no longer necessary to persuade most of academia that this war is a worthwhile endeavor: “With Google’s decision to direct its astronomical resources to a concerted assault on aging, that battle may have been transcended: once financial limitations are removed, curmudgeons no longer matter.” As with its remarkable advances in autonomous vehicles, mobile operating systems, and wearable computing, Google does not need to ask the permission of the entire world to explore the possibilities. Rather, it can simply achieve the breakthroughs, whose momentum and adoption naysayers would be powerless to halt.

Funding has always been a major bottleneck for true life-extending research, but now the resources of Google, as well as the highly skilled researchers who will surely be recruited by Calico, will enable this bottleneck to be overcome. Few details about the company are yet available, and it is likely that several years will elapse before major discoveries are announced. However, the barrier to mainstream acceptability of the war on senescence has been breached. Once significant successes are announced, other companies will hopefully shed some of their current caution and will seek to profit from the burgeoning field of longevity research. A few other companies still may even try to emulate Calico before any results are announced – just so as to remain competitive with Google and stay ahead of the pack, in their view.

The key to the success of any sustainable enterprise focused on life-extension research is to recognize that the sole pursuit of profits next quarter or next year is not a viable strategy for altering the status quo in radical ways. Great innovations require great leaps outside the norm. Such leaps are not often immediately rewarded financially by the broader market, which is why much of the longevity research to date has been sponsored by non-profit institutions such as the SENS Research Foundation and various universities. However, a prudent, forward-looking pursuit of profit can take the radical alteration of the status quo to the next level, by harnessing the immensely powerful motive of self-interest for the purpose of improving human lives. In this case, the improvement from gains to human longevity – and hopefully the ultimate defeat of senescence altogether – would be so immense as to be humankind’s crowning achievement. Google develops technologies with the eventual intent of marketing them to millions of consumers, and the success of Calico would be a triumph not just for longevity research but for the dissemination of cures to age-related diseases, and perhaps to senescence itself.

While anyone of sufficient intellectual courage can have a long-term vision and projects aimed at advancing that vision, Google has the distinct advantage of an extremely viable business in the present, which continues to bring in short-term revenues so that Calico does not need to be concerned with profits next quarter or next year. Instead, Calico will be able to survive on the profits of Google’s many ongoing operations, while devoting the time and effort of world-class researchers to pursuing all of the explorations, experiments, and tests that are needed to ultimately develop marketable cures. Once the cures are out there, though, the profits could be unprecedented, because life is the most precious, the most fundamental value we humans have. Any entity that discovers a way to transcend the current frailties of old age and push back or remove the current limits on human lifespans will become fabulously wealthy beyond comparison.

May Calico usher in Adam Smith’s invisible hand in the realm of longevity medicine – a hand that pushes back senescence and death and creates a world where health and wealth are ours to enjoy indefinitely.

Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy – Article by Franco Cortese

Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
August 21, 2013
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When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e., that many are seeking healthy life extension, a.k.a. “aging gracefully”, instead of more comprehensive methods of indefinite life extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally verifying the various, sometimes mutually exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.
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This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.
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There is no definitive timespan that it will take to achieve indefinitely extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely Extended Life, per unit of time or effort, by advocating the desirability, ethicality, and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives.

In order to get funding, we need to demonstrate with explicit clarity just how much we want it, and that we can do so while minimizing potentially negative societal repercussions like overpopulation. We must do our best to vehemently invalidate the Deathist clichés that promulgate the sentiment that Life Extension is dangerous or unethical. It needn’t be either, nor is it necessarily likely to be either.

Some think that spending one’s time deliberating the potential issues that could result from greatly increased lifespans and the ways in which we could mitigate or negate them won’t make a difference until greatly increased lifespans are actually achieved. I disagree. While any potentially negative repercussions of RLE (like overpopulation) aren’t going to happen until RLE is achieved, offering solution paradigms and ways in which we could negate or mitigate such negative repercussions decreases the time we have to wait for it by increasing the degree with which the wider public feels it to be desirable, and that it can very well be done safely and ethically. Those who are against radical life extension are against it either because they think it is infeasible (in which case being “against” it may be too strong a descriptor) or because they have qualms relating to its ethicality or its safety. More people openly advocating against it would mean a higher public perception of its undesirability. Whether RLE is eventually achieved via private industry or via government-subsidized research initiatives, we need to create the public perception that it is widely desired before either government or industry will take notice.

The sentiment that that the best thing we can do is simply live healthily and wait until progress is made seems to be fairly common as well. People have the feeling that researchers are working on it, that it will happen if it can happen, and that waiting until progress is made is the best course to take. Such lethargy will not help Radical Longevity in any way. How long we have to wait for RLE is a function of how much effort we put into it. And in this article I argue that how much funding and attention RLE receives is by and large a function of how widespread the public perception of its feasibility and desirability is.

This isn’t simply about our individual desire to live longer. It might be easier to hold the sentiment that we should just wait it out until it happens if we only consider its impact on the scale of our own individual lives. Such a sentiment may also be aided by the view that greatly longer lives would be a mere advantage, nice but unnecessary. I don’t think this is the case. I argue that the technological eradication of involuntary death is a moral imperative if there ever was one. If how long we have to wait until RLE is achieved depends on how vehemently we demand it and on how hard we work to create the public perception that longer life is widely longed-for, then to what extent are 100,000 lives lost potentially needlessly every day while we wait on our hands? One million people will die a wasteful and involuntary death in the next 10 days: one million real lives. This puts the Deathist charges of inethicality in a ghostly new light. If advocating the desirability, feasibility, and radical ethicality of RLE can hasten its implementation by even a mere 10 days, then one million lives that would have otherwise been lost will have been saved by the efforts of RLE advocates, researchers and fiscal supporters. Seen in this way, working toward RLE may very well be the most ethical and humanitarian way you could spend your time, in terms of the number of lives saved and/or the amount of suffering prevented.

This is a contemporary problem that we can have a direct impact on. People intuitively assume that we won’t achieve indefinitely extended life until far in the future. This makes them conflate any lives saved by indefinitely extended lifespans with lives yet to come into existence. This makes them see involuntary death as a problem of the future, rather than a problem of today. But more people than I’ve ever known will die tomorrow, from causes that are physically possible to obviate and ameliorate – indeed, from causes that we have potential and conceptual solutions for today.
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I have attempted to show in this article that advocating RLE should be considered as “working toward it” to as great an extent as directly funding it or performing direct research on it is considered as “working toward it”. Advocacy has greater potential to increase its widespread desirability than direct work or funding does, and increasing both its desirability and the public perception of its desirability has more potential to generate increased funding and research-attention for RLE than direct funding or research does. Advocacy thus has the potential to contribute to the arrival of RLE and hasten its implementation just as much, if not more so (as I have attempted to argue in this article), than practical research or direct funding does. This should motivate people to help create the momentous momentum we need to really get the ball rolling. To be an RLE advocate is to be an RLE worker. Involuntary death from age-associated, physically remediable causes is the largest source of death, destruction, and suffering today.  Don’t you want to help prevent the most widespread source of death and of suffering in existence today?  Don’t you want to help mitigate the most pressing moral concern not only of today, but of the entirety of human history – namely physically remediable involuntary death?

Then advocate the technological eradication of involuntary death. Advocate the technical feasibility, extreme desirability, and blatant ethicality of indefinitely extending life. Death is a cataclysm. We need not sanctify the seemingly inevitable any longer. We need not tell ourselves that death is somehow a good thing, or something we can do nothing about, in order to live with the “fact” of it any longer. Soon it won’t be fact of life. Soon it will be artifact of history. Life may not be ipso facto valuable according to some philosophies of value – but life is a necessary precondition for any sort of value whatsoever. Death is dumb, dummy! An incontrovertible waste convertible into nothing! A negative-sum blight! So if you want to contribute to the problems of today, if you want to help your fellow man today, then stand proud and shout loud, “Doom to Arbitrary Duty and Death to  Arbitrary Death!” at every crowd cowed by the seeming necessity of death.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Get Your “Supporter of Indefinite Life Extension” Open Badge

Get Your “Supporter of Indefinite Life Extension” Open Badge

The Rational Argumentator is now offering a free Open Badge to any individual who supports the concept of indefinite human life extension. To claim the badge, click here.

This badge was designed by Wendy Stolyarov, whose art you can see here, here, and here.

If you would like to find out more about Open Badges and the empowering role they can have in producing a new Age of Enlightenment, read this essay.

You would need a free account with Mozilla Backpack to receive the badge. And, of course, you would need to think that indefinite human life extension is desirable. That is all!

You would receive the badge for being a supporter of extending human lifespans beyond any fixed limit. Indefinite human life extension includes the defeat of senescence and other diseases, and the achievement of indefinite youthfulness. While indefinite life extension would not make people indestructible and would not eradicate all causes of death, it would nonetheless lift the “inevitable” death sentence that currently hangs over us all.  Indefinite life extension could be achieved in the future through advances in medical technology, including biotechnology, nanotechnology, and information technology.

Even thinking favorably of indefinite life extension is a courageous, forward-thinking, and highly beneficial attitude to take. Enjoy your reward!