Browsed by
Tag: Ray Kurzweil

Concepts for Functional Replication of Biological Neurons – Article by Franco Cortese

Concepts for Functional Replication of Biological Neurons – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
May 18, 2013
******************************
This essay is the third chapter in Franco Cortese’s forthcoming e-book, I Shall Not Go Quietly Into That Good Night!: My Quest to Cure Death, published by the Center for Transhumanity. The first two chapters were previously published on The Rational Argumentator as “The Moral Imperative and Technical Feasibility of Defeating Death” and “Immortality: Material or Ethereal? Nanotech Does Both!“.
***

The simplest approach to the functional replication of biological neurons I conceived of during this period involved what is normally called a “black-box” model of a neuron. This was already a concept in the wider brain-emulation community, but I was yet to find out about it. This is even simpler than the mathematically weighted Artificial Neurons discussed in the previous chapter. Rather than emulating or simulating the behavior of a neuron, (i.e, using actual computational—or more generally signal—processing) we (1) determine the range of input values that a neuron responds to, (2) stimulate the neuron at each interval (the number of intervals depending on the precision of the stimulus) within that input-range, and (3) record the corresponding range of outputs.

This reduces the neuron to essentially a look-up-table (or, more formally, an associative array). The input ranges I originally considered (in 2007) consisted of a range of electrical potentials, but later (in 2008) were developed to include different cumulative organizations of specific voltage values (i.e., some inputs activated and others not) and finally the chemical input and outputs of neurons. The black-box approach was eventually seen as being applied to the sub-neuron scale—e.g., to sections of the cellular membrane. This creates a greater degree of functional precision, bringing the functional modality of the black-box NRU-class in greater accordance with the functional modality of biological neurons. (I.e., it is closer to biological neurons because they do in fact process multiple inputs separately, rather than singular cumulative sums at once, as in the previous versions of the black-box approach.) We would also have a higher degree of variability for a given quantity of inputs.

I soon chanced upon literature dealing with MEMS (micro-electro-mechanical systems) and NEMS (nano-electro-mechanical systems), which eventually led me to nanotechnology and its use in nanosurgery in particular. I saw nanotechnology as the preferred technological infrastructure regardless of the approach used; its physical nature (i.e., operational and functional modalities) could facilitate the electrical and chemical processes of the neuron if the physicalist-functionalist (i.e., physically embodied or ‘prosthetic’) approach proved either preferable or required, while the computation required for its normative functioning (regardless of its particular application) assured that it could facilitate the informationalist-functionalist (i.e., computational emulation or simulation) of neurons if that approach proved preferable. This was true of MEMS as well, with the sole exception of not being able to directly synthesize neurotransmitters via mechanosynthesis, instead being limited in this regard to the release of pre-synthesized biochemical inventories. Thus I felt that I was able to work on conceptual development of the methodological and technological infrastructure underlying both (or at least variations to the existing operational modalities of MEMS and NEMS so as to make them suitable for their intended use), without having to definitively choose one technological/methodological infrastructure over the other. Moreover, there could be processes that are reducible to computation, yet still fail to be included in a computational emulation due to our simply failing to discover the principles underlying them. The prosthetic approach had the potential of replicating this aspect by integrating such a process, as it exists in the biological environment, into its own physical operation, and perform iterative maintenance or replacement of the biological process, until such a time as to be able to discover the underlying principles of those processes (which is a prerequisite for discovering how they contribute to the emergent computation occurring in the neuron) and thus for their inclusion in the informationalist-functionalist approach.

Also, I had by this time come across the existing approaches to Mind-Uploading and Whole-Brain Emulation (WBE), including Randal Koene’s minduploading.org, and realized that the notion of immortality through gradually replacing biological neurons with functional equivalents wasn’t strictly my own. I hadn’t yet come across Kurzweil’s thinking in regard to gradual uploading described in The Singularity is Near (where he suggests a similarly nanotechnological approach), and so felt that there was a gap in the extant literature in regard to how the emulated neurons or neural networks were to communicate with existing biological neurons (which is an essential requirement of gradual uploading and thus of any approach meant to facilitate subjective-continuity through substrate replacement). Thus my perceived role changed from the father of this concept to filling in the gaps and inconsistencies in the already-extant approach and in further developing it past its present state. This is another aspect informing my choice to work on and further varietize both the computational and physical-prosthetic approach—because this, along with the artificial-biological neural communication problem, was what I perceived as remaining to be done after discovering WBE.

The anticipated use of MEMS and NEMS in emulating the physical processes of the neurons included first simply electrical potentials, but eventually developed to include the chemical aspects of the neuron as well, in tandem with my increasing understanding of neuroscience. I had by this time come across Drexler’s Engines of Creation, which was my first introduction to antecedent proposals for immortality—specifically his notion of iterative cellular upkeep and repair performed by nanobots. I applied his concept of mechanosynthesis to the NRUs to facilitate the artificial synthesis of neurotransmitters. I eventually realized that the use of pre-synthesized chemical stores of neurotransmitters was a simpler approach that could be implemented via MEMS, thus being more inclusive for not necessitating nanotechnology as a required technological infrastructure. I also soon realized that we could eliminate the need for neurotransmitters completely by recording how specific neurotransmitters affect the nature of membrane-depolarization at the post-synaptic membrane and subsequently encoding this into the post-synaptic NRU (i.e., length and degree of depolarization or hyperpolarization, and possibly the diameter of ion-channels or differential opening of ion-channels—that is, some and not others) and assigning a discrete voltage to each possible neurotransmitter (or emergent pattern of neurotransmitters; salient variables include type, quantity and relative location) such that transmitting that voltage makes the post-synaptic NRU’s controlling-circuit implement the membrane-polarization changes (via changing the number of open artificial-ion-channels, or how long they remain open or closed, or their diameter/porosity) corresponding to the changes in biological post-synaptic membrane depolarization normally caused by that neurotransmitter.

In terms of the enhancement/self-modification side of things, I also realized during this period that mental augmentation (particularly the intensive integration of artificial-neural-networks with the existing brain) increases the efficacy of gradual uploading by decreasing the total portion of your brain occupied by the biological region being replaced—thus effectively making that portion’s temporary operational disconnection from the rest of the brain more negligible to concerns of subjective-continuity.

While I was thinking of the societal implications of self-modification and self-modulation in general, I wasn’t really consciously trying to do active conceptual work (e.g., working on designs for pragmatic technologies and methodologies as I was with limitless-longevity) on this side of the project due to seeing the end of death as being a much more pressing moral imperative than increasing our degree of self-determination. The 100,000 unprecedented calamities that befall humanity every day cannot wait; for these dying fires it is now or neverness.

Virtual Verification Experiments

The various alternative approaches to gradual substrate-replacement were meant to be alternative designs contingent upon various premises for what was needed to replicate functionality while retaining subjective-continuity through gradual replacement. I saw the various embodiments as being narrowed down through empirical validation prior to any whole-brain replication experiments. However, I now see that multiple alternative approaches—based, for example, on computational emulation (informationalist-functionalist) and physical replication (physicalist-functionalist) (these are the two main approaches thus far discussed) would have concurrent appeal to different segments of the population. The physicalist-functionalist approach might appeal to wide numbers of people who, for one metaphysical prescription or another, don’t believe enough in the computational reducibility of mind to bet their lives on it.

These experiments originally consisted of applying sensors to a given biological neuron, and constructing NRUs based on a series of variations on the two main approaches, running each and looking for any functional divergence over time. This is essentially the same approach outlined in the WBE Roadmap, which I was yet to discover at this point, that suggests a validation approach involving experiments done on single neurons before moving on to the organismal emulation of increasingly complex species up to and including the human. My thinking in regard to these experiments evolved over the next few years to also include the some novel approaches that I don’t think have yet been discussed in communities interested in brain-emulation.

An equivalent physical or computational simulation of the biological neuron’s environment is required to verify functional equivalence, as otherwise we wouldn’t be able to distinguish between functional divergence due to an insufficient replication-approach/NRU-design and functional divergence due to difference in either input or operation between the model and the original (caused by insufficiently synchronizing the environmental parameters of the NRU and its corresponding original). Isolating these neurons from their organismal environment allows the necessary fidelity (and thus computational intensity) of the simulation to be minimized by reducing the number of environmental variables affecting the biological neuron during the span of the initial experiments. Moreover, even if this doesn’t give us a perfectly reliable model of the efficacy of functional replication given the amount of environmental variables one expects a neuron belonging to a full brain to have, it is a fair approximator. Some NRU designs might fail in a relatively simple neuronal environment and thus testing all NRU designs using a number of environmental variables similar to the biological brain might be unnecessary (and thus economically prohibitive) given its cost-benefit ratio. And since we need to isolate the neuron to perform any early non-whole-organism experiments (i.e., on individual neurons) at all, having precise control over the number and nature of environmental variables would be relatively easy, as this is already an important part of the methodology used for normative biological experimentation anyways—because lack of control over environmental variables makes for an inconsistent methodology and thus for unreliable data.

And as we increase to the whole-network and eventually organismal level, a similar reduction of the computational requirements of the NRU’s environmental simulation is possible by replacing the inputs or sensory mechanisms (from single photocell to whole organs) with VR-modulated input. The required complexity and thus computational intensity of a sensorially mediated environment can be vastly minimized if the normative sensory environment of the organism is supplanted with a much-simplified VR simulation.

Note that the efficacy of this approach in comparison with the first (reducing actual environmental variables) is hypothetically greater because going from simplified VR version to the original sensorial environment is a difference, not of category, but of degree. Thus a potentially fruitful variation on the first experiment (physical reduction of a biological neuron’s environmental variables) would be not the complete elimination of environmental variables, but rather decreasing the range or degree of deviation in each variable, including all the categories and just reducing their degree.

Anecdotally, one novel modification conceived during this period involves distributing sensors (operatively connected to the sensory areas of the CNS) in the brain itself, so that we can viscerally sense ourselves thinking—the notion of metasensation: a sensorial infinite regress caused by having sensors in the sensory modules of the CNS, essentially allowing one to sense oneself sensing oneself sensing.

Another is a seeming refigurement of David Pearce’s Hedonistic Imperative—namely, the use of active NRU modulation to negate the effects of cell (or, more generally, stimulus-response) desensitization—the fact that the more times we experience something, or indeed even think something, the more it decreases in intensity. I felt that this was what made some of us lose interest in our lovers and become bored by things we once enjoyed. If we were able to stop cell desensitization, we wouldn’t have to needlessly lose experiential amplitude for the things we love.

In the next chapter I will describe the work I did in the first months of 2008, during which I worked almost wholly on conceptual varieties of the physically embodied prosthetic (i.e., physical-functionalist) approach (particularly in gradually replacing subsections of individual neurons to increase how gradual the cumulative procedure is) for several reasons:

The original utility of ‘hedging our bets’ as discussed earlier—developing multiple approaches increases evolutionary diversity; thus, if one approach fails, we have other approaches to try.

I felt the computational side was already largely developed in the work done by others in Whole-Brain Emulation, and thus that I would be benefiting the larger objective of indefinite longevity more by focusing on those areas that were then comparatively less developed.

The perceived benefit of a new approach to subjective-continuity through a substrate-replacement procedure aiming to increase the likelihood of gradual uploading’s success by increasing the procedure’s cumulative degree of graduality. The approach was called Iterative Gradual Replacement and consisted of undergoing several gradual-replacement procedures, wherein the class of NRU used becomes progressively less similar to the operational modality of the original, biological neurons with each iteration; the greater the number of iterations used, the less discontinuous each replacement-phase is in relation to its preceding and succeeding phases. The most basic embodiment of this approach would involve gradual replacement with physical-functionalist (prosthetic) NRUs that in turn are then gradually replaced with informational-physicalist (computational/emulatory) NRUs. My qualms with this approach today stem from the observation that the operational modalities of the physically embodied NRUs seem as discontinuous in relation to the operational modalities of the computational NRUs as the operational modalities of the biological neurons does. The problem seems to result from the lack of an intermediary stage between physical embodiment and computational (or second-order) embodiment.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Bibliography

Embedded Processor. (2013). In Encyclopædia Britannica. Retrieved from http://www.britannica.com/EBchecked/topic/185535/embedded-processor

Jerome, P. (1980). Recording action potentials from cultured neurons with extracellular microcircuit electrodes. Journal or Neuroscience Methods, 2 (1), 19-31.

Wolf, W. & (March 2009). Cyber-physical Systems. In Embedded Computing. Retrieved February 28, 2013 from http://www.jiafuwan.net/download/cyber_physical_systems.pdf

Immortality: Material or Ethereal? Nanotech Does Both! – Article by Franco Cortese

Immortality: Material or Ethereal? Nanotech Does Both! – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
May 11, 2013
******************************

This essay is the second chapter in Franco Cortese’s forthcoming e-book, I Shall Not Go Quietly Into That Good Night!: My Quest to Cure Death, published by the Center for Transhumanity. The first chapter was previously published on The Rational Argumentator as “The Moral Imperative and Technical Feasibility of Defeating Death“.

In August 2006 I conceived of the initial cybernetic brain-transplant procedure. It originated from a very simple, even intuitive sentiment: if there were heart and lung machines and prosthetic organs, then why couldn’t these be integrated in combination with modern (and future) robotics to keep the brain alive past the death of its biological body? I saw a possibility, felt its magnitude, and threw myself into realizing it. I couldn’t think of a nobler quest than the final eradication of involuntary death, and felt willing to spend the rest of my life trying to make it happen.

First I collected research on organic brain transplantation, on maintaining the brain’s homeostatic and regulatory mechanisms outside the body (or in this case without the body), on a host of prosthetic and robotic technologies (including sensory prosthesis and substitution), and on the work in Brain-Computer-Interface technologies that would eventually allow a given brain to control its new, non-biological body—essentially collecting the disparate mechanisms and technologies that would collectively converge to facilitate the creation of a fully cybernetic body to house the organic brain and keep it alive past the death of its homeostatic and regulatory organs.

I had by this point come across online literature on Artificial Neurons (ANs) and Artificial Neural Networks (ANNs), which are basically simplified mathematical models of neurons meant to process information in a way coarsely comparable to them. There was no mention in the literature of integrating them with existing neurons or for replacing existing neurons towards the objective of immortality ; their use was merely as an interesting approach to computation particularly optimal to certain situations. While artificial neurons can be run on general-purpose hardware (massively parallel architectures being the most efficient for ANNs, however), I had something more akin to neuromorphic hardware in mind (though I wasn’t aware of that just yet).

At its most fundamental level, Artificial Neurons need not even be physical at all. Their basic definition is a mathematical model roughly based on neuronal operation – and there is nothing precluding that model from existing solely on paper, with no actual computation going on. When I discovered them, I had thought that a given artificial neuron was a physically-embodied entity, rather than a software simulation. – i.e., an electronic device that operates in a way comparable to biological neurons.  Upon learning that they were mathematical models however, and that each AN needn’t be a separate entity from the rest of the ANs in a given AN Network, I saw no problem in designing them so as to be separate physical entities (which they needed to be in order to fit the purposes I had for them – namely, the gradual replacement of biological neurons with prosthetic functional equivalents). Each AN would be a software entity run on a piece of computational substrate, enclosed in a protective casing allowing it to co-exist with the biological neurons already in-place. The mathematical or informational outputs of the simulated neuron would be translated into biophysical, chemical, and electrical output by operatively connecting the simulation to an appropriate series of actuators (which could range from being as simple as producing electric fields or currents, to the release of chemical stores of neurotransmitters) and likewise a series of sensors to translate biophysical, chemical, and electrical properties into the mathematical or informational form they would need to be in to be accepted as input by the simulated AN.

Thus at this point I didn’t make a fundamental distinction between replicating the functions and operations of a neuron via physical embodiment (e.g., via physically embodied electrical, chemical, and/or electromechanical systems) or via virtual embodiment (usefully considered as 2nd-order embodiment, e.g., via a mathematical or computational model, whether simulation or emulation, run on a 1st-order physically embodied computational substrate).

The potential advantages, disadvantages, and categorical differences between these two approaches were still a few months away. When I discovered ANs, still thinking of them as physically embodied electronic devices rather than as mathematical or computational models, I hadn’t yet moved on to ways of preserving the organic brain itself so as to delay its organic death. Their utility in constituting a more permanent, durable, and readily repairable supplement for our biological neurons wasn’t yet apparent.

I initially saw their utility as being intelligence amplification, extension and modification through their integration with the existing biological brain. I realized that they were categorically different than Brain-Computer Interfaces (BCIs) and normative neural prosthesis for being able to become an integral and continuous part of our minds and personalities – or more properly the subjective, experiential parts of our minds. If they communicated with single neurons and interact with them on their own terms—if the two were operationally indistinct—then they could become a continuous part of us in a way that didn’t seem possible for normative BCI due to their fundamental operational dissimilarity with existing biological neural networks. I also collected research on the artificial synthesis and regeneration of biological neurons as an alternative to ANs. This approach would replace an aging or dying neuron with an artificially synthesized but still structurally and operationally biological neuron, so as to maintain the aging or dying neuron’s existing connections and relative location. I saw this procedure (i.e., adding artificial or artificially synthesized but still biological neurons to the existing neurons constituting our brains, not yet for the purposes of gradually replacing the brain but instead for the purpose of mental expansion and amplification) as not only allowing us to extend our existing functional and experiential modalities (e.g., making us smarter through an increase in synaptic density and connectivity, and an increase in the number of neurons in general) but even to create fundamentally new functional and experiential modalities that are categorically unimaginable to us now via the integration of wholly new Artificial Neural Networks embodying such new modalities. Note that I saw this as newly possible with my cybernetic-body approach because additional space could be made for the additional neurons and neural networks, whereas the degree with which we could integrate new, artificial neural networks in a normal biological body would be limited by the available volume of the unmodified skull.

Before I discovered ANs, I speculated in my notes as to whether the “bionic nerves” alluded to in some of the literature I had collected by this point (specifically regarding BCI, neural prosthesis, and the ability to operatively connect a robotic prosthetic extremity – e.g., an arm or a leg – via BCI) could be used to extend the total number of neurons and synaptic connections in the biological brain. This sprang from my knowledge on the operational similarities between neurons and muscle cells, both of the larger class of excitable cells.

Kurzweil’s cyborgification approach (i.e., that we could integrate non-biological systems with our biological brains to such an extent that the biological portions become so small as to be negligible to our subjective-continuity when they succumb to cell-death, thus achieving effective immortality without needing to actually replace any of our existing biological neurons at all) may have been implicit in this concept. I envisioned our brains increasing in size many times over and thus that the majority of our mind would be embodied or instantiated in larger part by the artificial portion than by the biological portions; the fact that the degree with which the loss of a part of our brain will affect our emergent personalities depends on how big (other potential metrics alternative to size include connectivity and the degree with which other systems depend on that potion for their own normative operation) that lost part is in comparison to the total size of the brain, the loss of a lobe being much worse than the loss of a neuron, follows naturally from this initial premise. The lack of any explicit statement of this realization in my notes during this period, however, makes this mere speculation.

It wasn’t until November 11, 2006, that I had the fundamental insight underlying mind-uploading—that the replacement of existing biological neurons with non-biological functional equivalents that maintain the existing relative location and connection of such biological neurons could very well facilitate maintaining the memory and personality embodied therein or instantiated thereby—essentially achieving potential technological immortality, since the approach is based on replacement and iterations of replacement-cycles can be run indefinitely. Moreover, the fact that we would be manufacturing such functional equivalents ourselves means that we could not only diagnose potential eventual dysfunctions easier and with greater speed, but we could manufacture them so as to have readily replaceable parts, thus simplifying the process of physically remediating any such potential dysfunction or operational degradation, even going so far as to include systems for the safe import and export of replacement components or as to make all such components readily detachable, so that we don’t have to cause damage to adjacent structures and systems in the process of removing a given component.

Perhaps it wasn’t so large a conceptual step from knowledge of the existence of computational models of neurons to the realization of using them to replace existing biological neurons towards the aim of immortality. Perhaps I take too much credit for independently conceiving both the underlying conceptual gestalt of mind-uploading, as well as some specific technologies and methodologies for its pragmatic technological implementation. Nonetheless, it was a realization I arrived at on my own, and was one that I felt would allow us to escape the biological death of the brain itself.

While I was aware (after a little more research) that ANNs were mathematical (and thus computational) models of neurons, hereafter referred to as the informationalist-functionalist approach, I felt that a physically embodied (i.e., not computationally emulated or simulated) prosthetic approach, hereafter referred to as the physicalist-functionalist approach, would be a better approach to take. This was because even if the brain were completely reducible to computation, a prosthetic approach would necessarily facilitate the computation underlying the functioning of the neuron (as the physical operations of biological neurons do presently), and if the brain proved to be computationally irreducible, then the prosthetic approach would in such a case presumably preserve whatever salient physical processes were necessary. So the prosthetic approach didn’t necessitate the computational-reducibility premise – but neither did it preclude such a view, thereby allowing me to hedge my bets and increase the cumulative likelihood of maintaining subjective-continuity of consciousness through substrate-replacement in general.

This marks a telling proclivity recurrent throughout my project: the development of mutually exclusive and methodologically and/or technologically alternate systems for a given objective, each based upon alternate premises and contingencies – a sort of possibilizational web unfurling fore and outward. After all, if one approach failed, then we had alternate approaches to try. This seemed like the work-ethic and conceptualizational methodology that would best ensure the eventual success of the project.

I also had less assurance in the sufficiency of the informational-functionalist approach at the time, stemming mainly from a misconception with the premises of normative Whole-Brain Emulation (WBE). When I first discovered ANs, I was more dubious at that point about the computational reducibility of the mind because I thought that it relied on the premise that neurons act in a computational fashion (i.e., like normative computational paradigms) to begin with—thus a conflation of classical computation with neural operation—rather than on the conclusion, drawn from the Church-Turing thesis, that mind is computable because the universe is. It is not that the brain is a computer to begin with, but that we can model any physical process via mathematical/computational emulation and simulation. The latter would be the correct view, and I didn’t really realize that this was the case until after I had discovered the WBE roadmap in 2010. This fundamental misconception allowed me, however, to also independently arrive at the insight underlying the real premise of WBE:  that combining premise A – that we had various mathematical computational models of neuron behavior – with premise B – that we can perform mathematical models on computers – ultimately yields the conclusion C – that we can simply perform the relevant mathematical models on computational substrate, thereby effectively instantiating the mind “embodied” in those neural operations while simultaneously eliminating many logistical and technological challenges to the prosthetic approach. This seemed both likelier than the original assumption—conflating neuronal activity with normative computation, as a special case not applicable to, say, muscle cells or skin cells, which wasn’t the presumption WBE makes at all—because this approach only required the ability to mathematically model anything, rather than relying on a fundamental equivalence between two different types of physical system (neuron and classical computer). The fact that I mistakenly saw it as an approach to emulation that was categorically dissimilar to normative WBE also helped urge me on to continue conceptual development of the various sub-aims of the project after having found that the idea of brain emulation already existed, because I thought that my approach was sufficiently different to warrant my continued effort.

There are other reasons for suspecting that mind may not be computationally reducible using current computational paradigms – reasons that rely on neither vitalism (i.e., the claim that mind is at least partially immaterial and irreducible to physical processes) nor on the invalidity of the Church-Turing thesis. This line of reasoning has nothing to do with functionality and everything to do with possible physical bases for subjective-continuity, both a) immediate subjective-continuity (i.e., how can we be a unified, continuous subjectivity if all our component parts are discrete and separate in space?), which can be considered as the capacity to have subjective experience, also called sentience (as opposed to sapience, which designated the higher cognitive capacities like abstract thinking) and b) temporal subjective-continuity (i.e., how do we survive as continuous subjectivities through a process of gradual substrate replacement?). Thus this argument impacts the possibility of computationally reproducing mind only insofar as the definition of mind is not strictly functional but is made to include a subjective sense of self—or immediate subjective-continuity. Note that subjective-continuity through gradual replacement is not speculative (just the scale and rate required to sufficiently implement it are), but rather has proof of concept in the normal metabolic replacement of the neuron’s constituent molecules. Each of us is a different person materially than we were 7 years ago, and we still claim to retain subjective-continuity. Thus, gradual replacement works; it is just the scale and rate required that are under question.

This is another way in which my approach and project differs from WBE. WBE equates functional equivalence (i.e., the same output via different processes) with subjective equivalence, whereas my approach involved developing variant approaches to neuron-replication-unit design that were each based on a different hypothetical basis for instantive subjective continuity.

 Are Current Computational Paradigms Sufficient?

Biological neurons are both analog and binary. It is useful to consider a 1st tier of analog processes, manifest in the action potentials occurring all over the neuronal soma and terminals, with a 2nd tier of binary processing, in that either the APs’ sum crosses the threshold value needed for the neuron to fire, or it falls short of it and the neuron fails to fire. Thus the analog processes form the basis of the digital ones. Moreover, the neuron is in an analog state even in the absence of membrane depolarization through the generation of the resting-membrane potential (maintained via active ion-transport proteins), which is analog rather than binary for always undergoing minor fluctuations due to it being an active process (ion-pumps) that instantiates it. Thus the neuron at any given time is always in the process of a state-transition (and minor state-transitions still within the variation-range allowed by a given higher-level static state; e.g., resting membrane potential is a single state, yet still undergoes minor fluctuations because the ions and components manifesting it still undergo state-transitions without the resting-membrane potential itself undergoing a state-transition), and thus is never definitively on or off. This brings us to the first potential physical basis for both immediate and temporal subjective-continuity. Analog states are continuous, and the fact that there is never a definitive break in the processes occurring at the lower levels of the neuron represents a potential basis for our subjective sense of immediate and temporal continuity.

Paradigms of digital computation, on the other hand, are at the lowest scale either definitively on or definitively off. While any voltage within a certain range will cause the generation of an output, it is still at base binary because in the absence of input the logic elements are not producing any sort of fluctuating voltage—they are definitively off. In binary computation, the substrates undergo a break (i.e., region of discontinuity) in their processing in the absence of inputs, and are in this way fundamentally dissimilar to the low-level operational modality of biological neurons by virtue of being procedurally discrete rather than procedurally continuous.

If the premise that the analog and procedurally continuous nature of neuron-functioning (including action potentials, resting-membrane potential, and metabolic processes that form a potential basis for immediate and temporal subjective-continuity) holds true, then current digital paradigms of computation may prove insufficient at maintaining subjective-continuity if used as the substrate in a gradual-replacement procedure, while still being sufficient to functionally replicate the mind in all empirically verifiable metrics and measures. This is due to both the operational modality of binary processing (i.e., lack of analog output) and the procedural modality of binary processing (the lack of temporal continuity or lack of producing minor fluctuations in reference to a baseline state when in a resting or inoperative state). A logic element could have a fluctuating resting voltage rather than the absence of any voltage and could thus be procedurally continuous while still being operationally discrete by producing solely binary outputs.

So there are two possibilities here. One is that any physical substrate used to replicate a neuron (whether via 1st-order embodiment a.k.a prosthesis/physical-systems, or via 2nd-order embodiment a.k.a computational emulation or simulation) must not undergo a break in its operation in the absence of input, because biological neurons do not, and this may be a potential basis for instantive subjective-continuity, but rather must produce a continuous or uninterrupted signal when in a “steady-state” (i.e., in the absence of inputs). The second possibility includes all the premises of the first, but adds that such an inoperative-state signal (or “no-inputs”-state signal) undergo minor fluctuations (because then a steady stream of causal interaction is occurring – e.g., producing a steady signal could be as discontinuous as no signal, like “being on pause”.

Thus one reason for developing the physicalist-functionalist (i.e., physically embodied prosthetic) approach to NRU design was a hedging of bets, in the case that a.) current computational substrates fail to replicate a personally continuous mind for the reasons described above, or b.) we fail to discover the principles underlying a given physical process—thus being unable to predictively model it—but still succeed in integrating them with the artificial systems comprising the prosthetic approach until such a time as to be able to discover their underlying principles, or c.) in the event that we find some other, heretofore unanticipated conceptual obstacle to computational reducibility of mind.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Bibliography

Copeland, J. B. (2008). Neural Network. In The Stanford Encyclopedia of Philosophy (Fall 2008 Edition). Retrieved February 28, 2013. from http://plato.stanford.edu/archives/fall2008/entries/church-turing

Crick, F. (1984 Nov 8-14). Memory and molecular turnover. In Nature, 312(5990)(101). PMID: 6504122

Criterion of Falsifiability, Encyclopædia Britannica. Encyclopædia Britannica Online Academic Edition. Retrieved February 28, 2013, from http://www.britannica.com/EBchecked/topic/201091/criterion-of-falsifiability

Drexler, K. E. (1986). Engines of Creation: The Coming Era of Nanotechnology. New York: Anchor Books.

Grabianowski (2007). How Brain-computer Interfaces Work. Retrieved February 28, 2013, from http://computer.howstuffworks.com/brain-computer-interface.htm

Koene, R. (2011). The Society of Neural Prosthetics and Whole Brain Emulation Science. Retrieved February 28, 2013, from http://www.minduploading.org/

Martins, N. R., Erlhagen, W. & Freitas Jr., R. A. (2012). Non-destructive whole-brain monitoring using nanorobots: Neural electrical data rate requirements. International Journal of Machine Consciousness, 2011. Retrieved February 28, 2013, from http://www.nanomedicine.com/Papers/NanoroboticBrainMonitoring2012.pdf.

Narayan, A. (2004). Computational Methods for NEMS. Retrieved February 28, 2013, from http://nanohub.org/resources/407.

Sandberg, A. & Bostrom, N. (2008). Whole Brain Emulation: A Roadmap, Technical Report #2008-3. Retrieved February 28, 2013, from Whole Brain Emulation: A Roadmap, Technical Report #2008-3.

Star, E. N., Kwiatkowski, D. J. & Murthy, V. N. (2002). Rapid turnover of actin in dendritic spines and its regulation by activity. Nature Neuroscience, 5 , 239-246.

Tsien, J. Z., Rampon, C., Tang,Y.P. & Shimizu, E. (2000). NMDA receptor dependent synaptic reinforcement as a crucial process for memory consolidation. Science, 290 , 1170-1174.

Vladimir, Z. (2013). Neural Network. In Encyclopædia Britannica Online Academic Edition. Retrieved February 28, 2013, from http://www.britannica.com/EBchecked/topic/410549/neural-network

Wolf, W. & (March 2009). Cyber-physical Systems. In Embedded Computing. Retrieved February 28, 2013, from http://www.jiafuwan.net/download/cyber_physical_systems.pdf

 

Liberty Through Long Life – Video by G. Stolyarov II

Liberty Through Long Life – Video by G. Stolyarov II

To maximize their hopes of personally experiencing an amount of personal freedom even approaching that of the libertarian ideal, all libertarians should support radical life extension.

References
– “Liberty Through Long Life” – Essay by G. Stolyarov II –
Resources on Indefinite Life Extension (RILE)
– “Libertarian Life-Extension Reforms” – Video Series – G. Stolyarov II –
– “Massive open online course” – Wikipedia
Mozilla’s Open Badges
– “Open Badges and Proficiency-Based Education: A Path to a New Age of Enlightenment” – Essay by G. Stolyarov II
– “Deep Space Industries” – Wikipedia
– “Planetary Resources” – Wikipedia
The Seasteading Institute
– “Seasteading’s Potential and Challenges: An Overview” — Essay by G. Stolyarov II
– “Seasteading’s Potential and Challenges: An Overview” — Video by G. Stolyarov II
– “Bitcoin” – Wikipedia
– “Benjamin Franklin and the Early Scientific Vision – 1780” – Foundation for Infinite Survival
– “Revisiting the proto-transhumanists: Diderot and Condorcet” – George Dvorsky – Sentient Developments
– “Marquis de Condorcet, Enlightenment proto-transhumanist” – George Dvorsky – IEET
SENS Research Foundation
– “Ray Kurzweil” – Wikipedia

Liberty Through Long Life – Article by G. Stolyarov II

Liberty Through Long Life – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
April 14, 2013
******************************

            It is commonly recognized among libertarians (and some others) that the freedom of individuals to innovate will result in a more rapid rate of technological progress. In “Six Libertarian Reforms to Accelerate Life Extension” I described six liberty-enhancing political changes that would more swiftly bring about the arrival of indefinite human longevity. But, as is less often understood, the converse of this truth also holds. Technological progress in general improves the prospects for liberty and its actual exercise in everyday life. One of the most promising keys to achieving liberty in our lifetimes is to live longer so that we can personally witness and benefit from accelerating technological progress.

            Consider, for example, what the Internet has achieved with respect to expanding the practical exercise of individual freedom of speech. It has become virtually impossible for regimes, including their nominally private “gatekeepers” of information in the mass media and established publishing houses, to control the dissemination of information and the expression of individual opinion. In prior eras, even in countries where freedom of speech was the law of the land, affiliations of the media, by which speech was disseminated, with the ruling elite would serve as a practical barrier for the discussion of views that were deemed particularly threatening to the status quo. In the United States, effective dissent from the established two-party political system was difficult to maintain in the era of the “big three” television channels and a print and broadcast media industry tightly controlled by a few politically connected conglomerates. Now expressing an unpopular opinion is easier and less expensive than ever – as is voting with one’s money for an ever-expanding array of products and services online. The ability of individuals to videotape public events and the behavior of law-enforcement officers has similarly served as a check on abusive behavior by those in power. Emerging online education and credentialing options, such as massive open online courses and Mozilla’s Open Badges, have the power to motivate a widespread self-driven enlightenment which would bring about an increased appreciation for rational thinking and individual autonomy.

            Many other technological advances are on the horizon. The private space race is in full swing, with companies such as SpaceX, Virgin Galactic, Deep Space Industries, and Planetary Resources embarking on ever more ambitious projects. Eventually, these pioneering efforts may enable humans to colonize new planets and build permanent habitats in space, expanding jurisdictional competition and opening new frontiers where free societies could be established. Seasteading, an idea only five years in development, is a concept for building modular ocean platforms where political experimentation could occur and, through competitive pressure, catalyze liberty-friendly innovations on land. (I outlined the potential and the challenges of this approach in an earlier essay.) The coming decades could see the emergence of actual seasteads of increasing sophistication, safety, and political autonomy. Another great potential for increasing liberty comes from the emerging digital-currency movement, of which Bitcoin has been the most prominent exemplar to date. While Bitcoin has been plagued with recent extreme exchange-rate volatility and vulnerability to manipulation and theft by criminal hackers, it can still provide some refuge from the damaging effects of inflationary and redistributive central-bank monetary policy. With enough time and enough development of the appropriate technological infrastructure, either Bitcoin or one of its successor currencies might be able to obtain sufficient stability and reliability to become a widespread apolitical medium of exchange.

            But there is a common requirement for one to enjoy all of these potential breakthroughs, along with many others that may be wholly impossible to anticipate: one has to remain alive for a long time. The longer one remains alive, the greater the probability that one’s personal sphere of liberty would be expanded by these innovations. Living longer can also buy one time for libertarian arguments to gain clout in the political sphere and in broader public opinion. Technological progress and pro-liberty activism can reinforce one another in a virtuous cycle.

            To maximize their hopes of personally experiencing an amount of personal freedom even approaching that of the libertarian ideal, all libertarians should support radical life extension. This sought-after goal of some ancient philosophers, medieval alchemists, Enlightenment thinkers (notably Franklin, Diderot, and Condorcet), and medical researchers from the past two centuries, is finally within reach of many alive today. Biogerontologist Aubrey de Grey of the SENS Research Foundation gives humankind a 50 percent likelihood of reaching “longevity escape velocity” – a condition where increases in life expectancy outpace the rate of human senescence – within 25 years. Inventor, futurist, and artificial-intelligence researcher Ray Kurzweil predicts a radical increase in life expectancy in the 2020s, made possible by advances in biotechnology and nanotechnology, aided by exponentially growing computing power. But, like de Grey and perhaps somewhat unlike Kurzweil, I hold the view that these advances are not inevitable; they rely on deliberate, sustained, and well-funded efforts to achieve them. They rely on support by the general public to facilitate donations, positive publicity, and a lack of political obstacles placed in their way. All libertarians should become familiar with both the technical feasibility and the philosophical desirability of a dramatic, hopefully indefinite, extension of human life expectancies. My compilation of Resources on Indefinite Life Extension (RILE) is a good starting point for studying this subject by engaging with a wide variety of sources, perspectives, and ongoing developments in science, technology, and activism.

            We have only this one life to live. If we fail to accomplish our most cherished goals and our irreplaceable individual universes disappear into oblivion, then, to us, it will be as if those goals were never accomplished. If we want liberty, we should strive to attain it in our lifetimes. We should therefore want those lifetimes to be lengthened beyond any set limit, not just for the sake of experiencing a far more complete liberty, but also for the sake of life itself and all of the opportunities it opens before us.

Common Misconceptions about Transhumanism – Article by G. Stolyarov II

Common Misconceptions about Transhumanism – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
January 26, 2013
******************************

After the publication of my review of Nassim Taleb’s latest book Antifragile, numerous comments were made by Taleb’s followers – many of them derisive – on Taleb’s Facebook page. (You can see a screenshot of these comments here.) While I will only delve into a few of the specific comments in this article, I consider it important to distill the common misconceptions that motivate them. Transhumanism is often misunderstood and maligned by who are ignorant of it – or those who were exposed solely to detractors such as John Gray, Leon Kass, and Taleb himself. This essay will serve to correct these misconceptions in a concise fashion. Those who still wish to criticize transhumanism should at least understand what they are criticizing and present arguments against the real ideas, rather than straw men constructed by the opponents of radical technological progress.

Misconception #1: Transhumanism is a religion.

Transhumanism does not posit the existence of any deity or other supernatural entity (though some transhumanists are religious independently of their transhumanism), nor does transhumanism hold a faith (belief without evidence) in any phenomenon, event, or outcome. Transhumanists certainly hope that technology will advance to radically improve human opportunities, abilities, and longevity – but this is a hope founded in the historical evidence of technological progress to date, and the logical extrapolation of such progress. Moreover, this is a contingent hope. Insofar as the future is unknowable, the exact trajectory of progress is difficult to predict, to say the least. Furthermore, the speed of progress depends on the skill, devotion, and liberty of the people involved in bringing it about. Some societal and political climates are more conducive to progress than others. Transhumanism does not rely on prophecy or mystical fiat. It merely posits a feasible and desirable future of radical technological progress and exhorts us to help achieve it. Some may claim that transhumanism is a religion that worships man – but that would distort the term “religion” so far from its original meaning as to render it vacuous and merely a pejorative used to label whatever system of thinking one dislikes. Besides, those who make that allegation would probably perceive a mere semantic quibble between seeking man’s advancement and worshipping him. But, irrespective of semantics, the facts do not support the view that transhumanism is a religion. After all, transhumanists do not spend their Sunday mornings singing songs and chanting praises to the Glory of Man.

Misconception #2: Transhumanism is a cult.

A cult, unlike a broader philosophy or religion, is characterized by extreme insularity and dependence on a closely controlling hierarchy of leaders. Transhumanism has neither element. Transhumanists are not urged to disassociate themselves from the wider world; indeed, they are frequently involved in advanced research, cutting-edge invention, and prominent activism. Furthermore, transhumanism does not have a hierarchy or leaders who demand obedience. Cosmopolitanism is a common trait among transhumanists. Respected thinkers, such as Ray Kurzweil, Max More, and Aubrey de Grey, are open to discussion and debate and have had interesting differences in their own views of the future. A still highly relevant conversation from 2002, “Max More and Ray Kurzweil on the Singularity“, highlights the sophisticated and tolerant way in which respected transhumanists compare and contrast their individual outlooks and attempt to make progress in their understanding. Any transhumanist is free to criticize any other transhumanist and to adopt some of another transhumanist’s ideas while rejecting others. Because transhumanism characterizes a loose network of thinkers and ideas, there is plenty of room for heterogeneity and intellectual evolution. As Max More put it in the “Principles of Extropy, v. 3.11”, “the world does not need another totalistic dogma.”  Transhumanism does not supplant all other aspects of an individual’s life and can coexist with numerous other interests, persuasions, personal relationships, and occupations.

Misconception #3: Transhumanists want to destroy humanity. Why else would they use terms such as “posthuman” and “postbiological”?

Transhumanists do not wish to destroy any human. In fact, we want to prolong the lives of as many people as possible, for as long as possible! The terms “transhuman” and “posthuman” refer to overcoming the historical limitations and failure modes of human beings – the precise vulnerabilities that have rendered life, in Thomas Hobbes’s words, “nasty, brutish, and short” for most of our species’ past. A species that transcends biology will continue to have biological elements. Indeed, my personal preference in such a future would be to retain all of my existing healthy biological capacities, but also to supplement them with other biological and non-biological enhancements that would greatly extend the length and quality of my life. No transhumanist wants human beings to die out and be replaced by intelligent machines, and every transhumanist wants today’s humans to survive to benefit from future technologies. Transhumanists who advocate the development of powerful artificial intelligence (AI) support either (i) integration of human beings with AI components or (ii) the harmonious coexistence of enhanced humans and autonomous AI entities. Even those transhumanists who advocate “mind backups” or “mind uploading” in an electronic medium (I am not one of them, as I explain here) do not wish for their biological existences to be intentionally destroyed. They conceive of mind uploads as contingency plans in case their biological bodies perish.

Even the “artilect war” anticipated by more pessimistic transhumanists such as Hugo de Garis is greatly misunderstood. Such a war, if it arises, would not come from advanced technology, but rather from reactionaries attempting to forcibly suppress technological advances and persecute their advocates. Most transhumanists do not consider this scenario to be likely in any event. More probable are lower-level protracted cultural disputes and clashes over particular technological developments.

Misconception #4: “A global theocracy envisioned by Moonies or the Taliban would be preferable to the kind of future these traitors to the human species have their hearts set on, because even the most joyless existence is preferable to oblivion.

The above was an actual comment on the Taleb Facebook thread. It is astonishing that anyone would consider theocratic oppression preferable to radical life extension, universal abundance, ever-expanding knowledge of macroscopic and microscopic realms, exploration of the universe, and the liberation of individuals from historical chains of oppression and parasitism. This misconception is fueled by the strange notion that transhumanists (or technological progress in general) will destroy us all – as exemplified by the “Terminator” scenario of hostile AI or the “gray goo” scenario of nanotechnology run amok. Yet all of the apocalyptic scenarios involving future technology lack the safeguards that elementary common sense would introduce. Furthermore, they lack the recognition that incentives generated by market forces, as well as the sheer numerical and intellectual superiority of the careful scientists over the rogues, would always tip the scales greatly in favor of the defenses against existential risk. As I explain in “Technology as the Solution to Existential Risk” and “Non-Apocalypse, Existential Risk, and Why Humanity Will Prevail”,  the greatest existential risks have either always been with us (e.g., the risk of an asteroid impact with Earth) or are in humanity’s past (e.g., the risk of a nuclear holocaust annihilating civilization). Technology is the solution to such existential risks. Indeed, the greatest existential risk is fear of technology, which can retard or outright thwart the solutions to the perils that may, in the status quo, doom us as a species. As an example, Mark Waser has written an excellent commentary on the “inconvenient fact that not developing AI (in a timely fashion) to help mitigate other existential risks is itself likely to lead to a substantially increased existential risk”.

Misconception #5: Transhumanists want to turn people into the Borg from Star Trek.

The Borg are the epitome of a collectivistic society, where each individual is a cog in the giant species machine. Most transhumanists are ethical individualists, and even those who have communitarian leanings still greatly respect individual differences and promote individual flourishing and opportunity. Whatever their positions on the proper role of government in society might be, all transhumanists agree that individuals should not be destroyed or absorbed into a collective where they lose their personality and unique intellectual attributes. Even those transhumanists who wish for direct sharing of perceptions and information among individual minds do not advocate the elimination of individuality. Rather, their view might better be thought of as multiple puzzle pieces being joined but remaining capable of full separation and autonomous, unimpaired function.

My own attraction to transhumanism is precisely due to its possibilities for preserving individuals qua individuals and avoiding the loss of the precious internal universe of each person. As I expressed in Part 1 of my “Eliminating Death” video series, death is a horrendous waste of irreplaceable human talents, ideas, memories, skills, and direct experiences of the world. Just as transhumanists would recoil at the absorption of humankind into the Borg, so they rightly denounce the dissolution of individuality that presently occurs with the oblivion known as death.

Misconception #6: Transhumanists usually portray themselves “like robotic, anime-like characters”.

That depends on the transhumanist in question. Personally, I portray myself as me, wearing a suit and tie (which Taleb and his followers dislike just as much – but that is their loss). Furthermore, I see nothing robotic or anime-like about the public personas of Ray Kurzweil, Aubrey de Grey, or Max More, either.

Misconception #7: “Transhumanism is attracting devotees of a frighteningly high scientific caliber, morally retarded geniuses who just might be able to develop the humanity-obliterating technology they now merely fantasize about. It’s a lot like a Heaven’s Gate cult, but with prestigious degrees in physics and engineering, many millions more in financial backing, a growing foothold in mainstream culture, a long view of implementing their plan, and a death wish that extends to the whole human race not just themselves.

This is another statement on the Taleb Facebook thread. Ironically, the commenter is asserting that the transhumanists, who support the indefinite lengthening of human life, have a “death wish” and are “morally retarded”, while he – who opposes the technological progress needed to preserve us from the abyss of oblivion – apparently considers himself a champion of morality and a supporter of life. If ever there was an inversion of characterizations, this is it. At least the commenter acknowledges the strong technical skills of many transhumanists – but calling them “morally retarded” presupposes a counter-morality of death that should rightly be overcome and challenged, lest it sentence each of us to death. The Orwellian mindset that “evil is good” and “death is life” should be called out for the destructive and dangerous morass of contradictions that it is. Moreover, the commenter provides no evidence that any transhumanist wants to develop “humanity-obliterating technologies” or that the obliteration of humanity is even a remote risk from the technologies that transhumanists do advocate.

Misconception #8: Transhumanism is wrong because life would have no meaning without death.

Asserting that only death can give life meaning is another bizarre contradiction, and, moreover, a claim that life can have no intrinsic value or meaning qua life. It is sad indeed to think that some people do not see how they could enjoy life, pursue goals, and accumulate values in the absence of the imminent threat of their own oblivion. Clearly, this is a sign of a lack of creativity and appreciation for the wonderful fact that we are alive. I delve into this matter extensively in my “Eliminating Death” video series. Part 3 discusses how indefinite life extension leaves no room for boredom because the possibilities for action and entertainment increase in an accelerating manner. Parts 8 and 9 refute the premise that death gives motivation and a “sense of urgency” and make the opposite case – that indefinite longevity spurs people to action by making it possible to attain vast benefits over longer timeframes. Indefinite life extension would enable people to consider the longer-term consequences of their actions. On the other hand, in the status quo, death serves as the great de-motivator of meaningful human endeavors.

Misconception #9: Removing death is like removing volatility, which “fragilizes the system”.

This sentiment was an extrapolation by a commenter on Taleb’s ideas in Antifragile. It is subject to fundamentally collectivistic premises – that the “volatility” of individual death can be justified if it somehow supports a “greater whole”. (Who is advocating the sacrifice of the individual to the collective now?)  The fallacy here is to presuppose that the “greater whole” has value in and of itself, apart from the individuals comprising it. An individualist view of ethics and of society holds the opposite – that societies are formed for the mutual benefit of participating individuals, and the moment a society turns away from that purpose and starts to damage its participants instead of benefiting them, it ceases to be desirable. Furthermore, Taleb’s premise that suppression of volatility is a cause of fragility is itself dubious in many instances. It may work to a point with an individual organism whose immune system and muscles use volatility to build adaptive responses to external threats. However, the possibility of such an adaptive response requires very specific structures that do not exist in all systems. In the case of human death, there is no way in which the destruction of a non-violent and fundamentally decent individual can provide external benefits of any kind worth having. How would the death of your grandparents fortify the mythic “society” against anything?

Misconception #10: Immortality is “a bit like staying awake 24/7”.

Presumably, those who make this comparison think that indefinite life would be too monotonous for their tastes. But, in fact, humans who live indefinitely can still choose to sleep (or take vacations) if they wish. Death, on the other hand, is irreversible. Once you die, you are dead 24/7 – and you are not even given the opportunity to change your mind. Besides, why would it be tedious or monotonous to live a life full of possibilities, where an individual can have complete discretion over his pursuits and can discover as much about existence as his unlimited lifespan allows? To claim that living indefinitely would be monotonous is to misunderstand life itself, with all of its variety and heterogeneity.

Misconception #11: Transhumanism is unacceptable because of the drain on natural resources that comes from living longer.

This argument presupposes that resources are finite and incapable of being augmented by human technology and creativity. In fact, one era’s waste is another era’s treasure (as occurred with oil since the mid-19th century). As Julian Simon recognized, the ultimate resource is the human mind and its ability to discover new ways to harness natural laws to human benefit. We have more resources known and accessible to us now – both in terms of food and the inanimate bounties of the Earth – than ever before in recorded history. This has occurred in spite – and perhaps because of – dramatic population growth, which has also introduced many new brilliant minds into the human species. In Part 4 of my “Eliminating Death” video series, I explain that doomsday fears of overpopulation do not hold, either historically or prospectively. Indeed, the progress of technology is precisely what helps us overcome strains on natural resources.

Conclusion

The opposition to transhumanism is generally limited to espousing some variations of the common fallacies I identified above (with perhaps a few others thrown in). To make real intellectual progress, it is necessary to move beyond these fallacies, which serve as mental roadblocks to further exploration of the subject – a justification for people to consider transhumanism too weird, too unrealistic, or too repugnant to even take seriously. Detractors of transhumanism appear to recycle these same hackneyed remarks as a way to avoid seriously delving into the actual and genuinely interesting philosophical questions raised by emerging technological innovations. These are questions on which many transhumanists themselves hold sincere differences of understanding and opinion. Fundamentally, though, my aim here is not to “convert” the detractors – many of whose opposition is beyond the reach of reason, for it is not motivated by reason. Rather, it is to speak to laypeople who are not yet swayed one way or the other, but who might not have otherwise learned of transhumanism except through the filter of those who distort and grossly misunderstand it. Even an elementary explication of what transhumanism actually stands for will reveal that we do, in fact, strongly advocate individual human life and flourishing, as well as technological progress that will uplift every person’s quality of life and range of opportunities. Those who disagree with any transhumanist about specific means for achieving these goals are welcome to engage in a conversation or debate about the merits of any given pathway. But an indispensable starting point for such interaction involves accepting that transhumanists are serious thinkers, friends of human life, and sincere advocates of improving the human condition.

Fragile Reasoning in Nassim Taleb’s “Antifragile”: An Enlightenment Transhumanist Critique – Article by G. Stolyarov II

Fragile Reasoning in Nassim Taleb’s “Antifragile”: An Enlightenment Transhumanist Critique – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
January 10, 2013
******************************

Never before have I set out to read a book with such high expectations, only to encounter such severe disappointment. As an admirer of Nassim Taleb’s earlier books, Fooled by Randomness and The Black Swan, I expected to find insight and wisdom along similar lines in Antifragile. While Taleb’s latest book does contain some valid observations and a few intriguing general strategies for living, the overwhelming thrust of the book is one of bitter distaste for modernity (and, to a significant extent, technological progress), as well as an abundance of insults for anyone who would disagree with not just with Taleb’s ideas, but with his personal esthetic preferences. While sensible in the realms of finance and (mostly) economics, Taleb’s prescriptions in other fields venture outside of his realms of mastery and, if embraced, would result in a relapse of the barbarisms of premodernity. Perhaps as the outcome of his own phenomenal success, Taleb has become set in his ways and has transitioned from offering some controversial, revolutionary, and genuinely insightful ideas to constructing a static, intolerant, totalistic worldview that rejects deviations in any field of life – and the persons who so deviate.

I am saddened to write this, but I am convinced that Nassim Taleb would find me to be personally repulsive. Not only am I a technology-embracing transhumanist ( a “neomaniac” per Taleb’s vocabulary), and a person who embraces the “nerdification” of society – but I am also an explicit representative and promoter of the legacies of the 18th-century Enlightenment – and a proud suit-and-tie wearer besides. Taleb seethes with contempt for the very trappings of modernity – even for modern formal wear – and repeatedly asserts that nothing valuable can be gleaned from those who wear neckties. As in many other areas, his conclusion-jumping pronouncements exclude the possibility of the world not fitting into his invented categories (with their associated normative spin). On the necktie question, he seems to rule out the very existence of persons like me, who wear neckties not out of any compulsion (my office dress code does not require them), but rather as an esthetic statement arising from sheer personal choice – including, not infrequently, on weekends.

After reading Antifragile, and finding so much of the content in need of a thorough refutation, I have vacillated between writing a book review and a more comprehensive treatise. A short review, I realized, would not do this book justice – but I also did not wish to run the risk of writing a refutation as long as the book itself. The result is this – one of my longest book reviews to date, but written as concisely as the subject matter allows. Here, I seek to comment on many of Taleb’s areas of focus in Antifragile, highlighting both the book’s strengths and its egregious errors.

Antifragile was one of the very few books I ever pre-ordered, as Taleb, until about a month ago, held a place among my most admired contemporary thinkers – along with such luminaries as Steven Pinker, Ray Kurzweil, Aubrey de Grey, Max More, and Ron Paul. Taleb’s writings on the fragility of the contemporary financial system were simply brilliant and highlighted the systemic weaknesses of a “house of cards” built upon highly sophisticated but over-optimized models that relied on the unrealistic stability of the status quo and the absence of extremely disruptive “black swan” events. I expected that Antifragile would discuss ways to survive and prosper in a black-swan-dominated world – a question that has been at the forefront of my mind since at least 2006, when I personally observed some “six-sigma” events on the stock market and – after reducing my losses to manageable levels – have refused to participate in that particular economy-wide casino since.  While Antifragile does provide skeletal discussions of some valuable approaches (such as the “barbell” strategy, on which I will comment more below), the majority of the book’s focus is negative: a harsh criticism of the institutions, ideas, and people whom Taleb considers insufficiently antifragile or “fragilizing”. One of Taleb’s favorite terms throughout the book is “fragilista” – used to describe financial modelers, politicians, and intellectuals of a rationalist frame of mind. The term – aside from creating vague and completely irrelevant associations with left-wing Nicaraguan terrorists – also poisons the metaphorical well with regard to the people and approaches criticized by Taleb.

More generally, the book is pervaded by an undercurrent of anti-intellectualism, mocking those who use structured, explicit knowledge to interpret the world. This is rather odd, because Taleb himself is clearly an intellectual and a “nerd” of the sort he derides; his philosophical and historical allusions – and his expertise in mathematical finance (despite his criticisms thereof) – give away that fact. Fat Tony of Brooklyn, Taleb’s fictional representative of the non-intellectual person who relies on “empirical” heuristics and is able to become rich by occasionally betting against “suckers,” would not have kept the company of people like Taleb. No matter how much rhetorical contempt Taleb shows for those who engage in abstract reasoning, he cannot escape being one of them – and no amount of insults directed at his own kind will get him an iota of respect from those whose character traits he glorifies.

An antifragile system or entity, per Taleb’s definition, is one that benefits from volatility instead of succumbing to it. Beyond mere robustness, which withstands volatility intact, antifragility is the derivation of advantage from volatility. The concept itself is an intriguing one, but Taleb makes a crucial error in assuming that most antifragility is normatively preferable. He does make an exception for “antifragility at others’ expense” – but only in a limited context. For instance, he is outraged at career intellectuals who do not have “skin in the game” and do not suffer for making wrong predictions or recommendations (more on this later) – but he explicitly praises the antifragility of biological evolution, a process that has resulted in the brutal deaths of most organisms and the extinction of about 99.9% of all species in history. Even within his premise that modernity contains “fragilizing” elements, Taleb presupposes that fragility is necessarily undesirable. Yet a beautiful vase is fragile – as is, for that matter, an individual organism. Fragility is no justification for dismissing or opposing an area of existence that has other intrinsic merits. Perhaps the proper response to certain kinds of fragility is extra care in the preservation of the fragile – as shown, for example, in the raising of children and small animals.

When Taleb argues that post-Enlightenment civilization is fragile, he may be partly right – at least in the sense that such civilization requires the steady, conscious application of human intellect to maintain. Every generation must master the scientific, technological, and ethical accomplishments of the generations before it and amplify these accomplishments; this is the essence of progress. This mastery of civilization entails precisely the “nerdification” (i.e., sophisticated, refined, self-aware intellectualism) that Taleb scorns in favor of “empirical” heuristics that may have arisen out of premodern superstition in as great (or greater) a proportion as out of practical wisdom passed down throughout the ages. Steven Pinker, whose magnum opus The Better Angels of Our Nature I would glowingly recommend (and whose work Taleb has unfairly maligned, though Pinker’s response to Taleb is worth reading), illustrates convincingly that not only peacefulness but virtually every other characteristic of civilized human beings has improved dramatically over the past several centuries – and most remarkably over the past several decades. Nothing suggests that this improvement is an inexorable law of history, however; it is possible for anti-civilizing influences to take hold and for humanity to degenerate into the barbarism that characterized much of its past. In that sense, civilization may be considered fragile – but so eminently worth preserving and expanding, for it makes possible the good life for good individuals.

Unfortunately, Taleb has included himself among the influences that would undo many of the essential gains that humanity has achieved since the 18th-century Enlightenment. Taleb repeatedly references the “wisdom of the ancients” (the stoic Seneca is his favorite) and conflates the “natural” (a term from which he excludes human design and technology) with the desirable. Taleb praises the heuristics he sees in traditional religious systems (e.g., elaborate Greek Orthodox fasting rituals) while completely overlooking the massive horrors many traditional (i.e., premodern) religious systems perpetrated when persecuting dissenters, inspiring bloody wars of conquest, and establishing totalitarian regimes when combined with secular authority. The Enlightenment brought about a conscious questioning of religious (and all authority-based) traditions and commandments and resulted in the adoption of rigorous scientific inquiry in the pursuit of discovery and innovation. Taleb is wary of modern medicine because of possible “iatrogenic” effects (where the treatment itself causes most of the harm), and he even questions the genuineness and desirability of massive rises in life expectancy during the 20th and early 21st centuries. While there is some merit to balancing the anticipated benefits and possible side effects of medical treatments – and while Taleb may be right that certain fields may take treatment too far, especially as regards overprescription of psychotropic drugs to children – Taleb’s discussion of “iatrogenics” is mostly anecdotal and reliant on studies from much earlier periods in medicine (e.g., the death of George Washington in 1799 and a study on children in 1930).  The virtual eradication of smallpox, polio, tuberculosis, cholera, and the bubonic plague from the Western world by scientific medicine are utterly ignored by Taleb – as are the substantial declines in cancer death rates over the past 50 years, and the accomplishments of the Green Agricultural Revolution in averting the starvation of billions, which would have occurred if only “natural” agricultural techniques (i.e., techniques employed before some arbitrary historical cutoff date) had been utilized.

There may be some merit to Taleb’s advice of avoiding medical treatment for minor conditions (where the iatrogenic effects of treatment allegedly predominate) and letting the body heal itself, while being willing to undertake radical treatments for extreme, life-threatening conditions. However, context in medical care matters too greatly to make sweeping generalizations. A fairly small skin lesion, which does not interfere with day-to-day functioning, may, after all, be the beginning of a deadly cancer, for which no self-healing mechanism exists. In medicine especially, the “empirical” heuristics championed by Taleb must give way to careful and systematic scientific study. After all, most premodern cultures relied on “traditional” heuristics for millennia, with disastrous results; such reliance can be called folk medicine. One only needs to consider the “traditional” Eastern “remedies” based on the superstition that one will become like the creature one eats – or “traditional” Western Medieval bleeding and surgical practices – to realize how much progress modern scientific medicine has actually made.

While a reader of Fooled by Randomness and The Black Swan might have inferred libertarian and individualist tendencies in Taleb’s writing, Antifragile, unfortunately, sets the record straight: Taleb opposes “too much” individual flourishing and freedom. He reserves his bitterest venom for transhumanism, which is the logical outcome of a libertarian society in which technological progress is given free rein. Taleb’s reverence for “nature” and “the ancients” trumps his skepticism of centralized regimentation – as his ideas on life extension and freedom of speech illustrate. He writes, “I felt some deep disgust – as would any ancient – at the efforts of ‘singularity’ thinkers (such as Ray Kurzweil) who believe in humans’ potential to live forever. Note that if I had to find the anti-me, the person with diametrically opposite ideas and lifestyle on the planet, it would be that Ray Kurzweil fellow. It is not just neomania. While I propose removing offensive elements from people’s diets (and lives), he works by adding, popping close to two hundred pills daily. Beyond that, these attempts at immortality leave me with deep moral revulsion.” Taleb says little of substance to support this “deep moral revulsion” – beyond repeating the same tired, hackneyed old arguments about “making room for others” by dying – as if the life of the individual had no inherent value and could be justifiably expended for an alleged greater good. Taleb does not address Kurzweil’s arguments about the exponential progress of computing and other technologies, and the logical extrapolation of such progress within the coming decades. In short, he says nothing about why he would consider Kurzweil to be mistaken, or what about Kurzweil’s lifestyle and ambitions he considers destructive. Taleb’s rudely expressed opposition to transhumanism seems to be primarily driven by emotional revulsion or, to be more charitable, a conflict of values. Additionally, Taleb does not seem to understand the movement that he criticizes. He assumes that extended longevity would be accompanied by extended frailty and senescence, whereas true radical life extension would only be possible if biological youth could be prolonged through periodic rejuvenation of the organism. Moreover, Taleb is, at heart, a collectivist who embraces the sacrifice of the individual to the tribe. He writes, “I am not here to live forever, as a sick animal. Recall that the antifragility of a system comes from the mortality of its components – and I am part of that larger population called humans. I am here to die a heroic death for the sake of the collective, to produce offspring (and prepare them for life and provide for them), or eventually, books – my information, that is, my genes, the antifragile in me, should be the ones seeking immortality, not me.”

The biggest disappointment I experienced when reading Antifragile was the realization I came to upon reading the above-quoted passage. This book was never about helping make the individual antifragile. The preservation of a human being in a volatile and uncertain world – and the attempt to equip a human being to flourish in the face of such volatility and uncertainty – were never Taleb’s key aims. Taleb’s views on antifragility are, indeed, not particularly helpful to me in my goal to discover strategies that would preserve, fortify, and enrich the individual in an often hostile, and, in many ways, fundamentally unpredictable world which lacks any manner of built-in justice outside of what humans, through their ingenuity and will, can implement. Taleb would have both of us (and everyone else) be sacrificed for the sake of an unspecified “collective” – as if some abstraction, be it “nature”, evolution, or “the whole”, has value in and of itself, apart from its constituent individuals. Yet it is precisely this sort of collectivism that enables inhuman atrocities, from mass executions of “the other” to suicide bombings for a “greater cause”. Taleb does not intend to advocate armed violence, but his rhetoric on heroism, “dying heroically”, and self-sacrifice eerily resembles the pronouncements of many a totalitarian regime, inquisitorial sect, or band of nationalistic or religious terrorists. The good life – the comfortable life of peace, productive work, and self-fulfillment – does not seem to be his objective.

In several sections devoted to having “doxastic commitment” or “soul in the game”, Taleb glorifies the idea of leaving no way out in the event of one’s failure – forgetting that much true learning is iterative and often occurs through a trial-and-error process. If one is not allowed to recover from failure and change one’s approach (without crippling personal cost), then this learning will be preempted, and the individual will be destroyed instead. Taleb glorifies, for instance, the poet Almutanabbi, who died senselessly in the attempt to realize the ideals about which he wrote. But it is far more impressive to live in furtherance of one’s ideals than to die for them – particularly since living requires one to reevaluate one’s views in light of emerging evidence and continual reflection.

Taleb is no more a friend of individual liberty than of technological progress. As a consequence of his view that intellectuals should have “skin in the game”, he insists that they should personally suffer the adverse consequences of their recommendations. Indeed, he would implement his scheme of penalties to the detriment of legal protections for freedom of speech. While criticizing the financial rating agencies’ misclassification of toxic assets as “AAA” securities, he remarks that “they benefit from the protection of free speech – the ‘First Amendment’ so ingrained in American habits. My humble proposal: one should say whatever he wants, but one’s portfolio needs to line up with it.” Elsewhere, Taleb proposes that individuals be held legally liable for the damage that their predictions and recommendations result in if followed by others. He ignores that not all individuals have the assets to even invest in a portfolio. Are the poor and middle class to be deprived of the ability to express their opinions or speculate about the economic future (even if such speculation is without much basis), simply because they do not have much “skin” to put into the “game”? Furthermore, establishing any legal liability for expression of opinion would have a chilling effect on legitimate and valuable ideas – since the very threat or prospect of a lawsuit may serve as a deterrent to publishing or even verbal expression in front of someone who disagrees. For someone so insistent on individual moral responsibility, Taleb ignores the responsibility of the recipient of ideas to actively judge and interpret them. Just as there exist sleazy marketers, so there exist peddlers of philosophical falsehoods, and sometimes those falsehoods result in personal gains for their advocates. Yet the responsibility of the sensible, rational individual is to filter out truth from falsehood using his own mind. No prohibition, no regime of penalties, no prior restraint can protect people from themselves. Such restrictions can only prevent people from cultivating the habits of autonomous thought which are the surest safeguards against charlatans and demagogues of every stripe. Taleb is too concerned about punishing the false prophets, and insufficiently concerned about elevating the general level of reasoning and discourse by means of positive persuasion, dissemination of true information, and technological innovation that alters people’s incentives and the balance of power.

Taleb even departs from the libertarian advocacy of free trade and (genuine) globalization. While he acknowledges the theoretical validity of some specialization and the law of comparative advantage, he sees the global division of labor as vulnerable to volatility in the system. He argues that a change in conditions in one part of the world now has a far greater ability to adversely impact all other parts of the world – because the division of labor is so finely tuned. This is a fair argument for redundancy in economic systems – e.g., having “backup” institutions which could supply a good or service if the original supplier is unavailable due to an unexpected disruption. However, Taleb errs when assuming that businesses pursuing their rational self-interests under a truly free arrangement of global commerce would not already attempt to implement such redundancies. Supply-chain risk, for instance, is commonly discussed by representatives of multinational businesses and their insurers, who have a stake in preventing supply disruptions. Overreliance on any one economic partnership may indeed be imprudent – but does Taleb believe that businessmen with true “skin in the game” – billions of their own dollars – would be oblivious to the need for redundancy? Taleb makes no case for why free trade – in essence, the voluntary exchange of goods and services among individuals without regard for national origins or boundaries – would create a systemic lack of redundancy. A stronger argument could be made for how the current politicized environment of trade – a mixture of freedom and elaborate controls achieved by means of treaties and retaliatory protectionism – would produce insufficient redundancy and overdependence on those precious channels of international trade that remain permitted. But the solution to this problem would be more options – more channels for foreign trade – not fewer. Autarky certainly will not do, as it brings about its own massive vulnerabilities. One only need consider the consequences of a famine in a region which is not allowed to import food from abroad. Trade creates redundancy by allowing access to goods and services from all over the world, instead of just one minor segment thereof.

The nonlinear responses to volatility described in Antifragile are valid in principle. A system responds in a concave fashion if the harm to the system from a change in conditions is more than linear relative to that change (i.e., an accelerating harm). A system responds in a convex fashion if it is able to reap benefits from volatility in a more-than-linear accumulation. Taleb proposes that it is possible for certain systems to be concave or convex in both directions – being harmed by or benefiting from a shift in conditions either way. It is also possible for systems to be convex over some regions of inputs, and concave over others – e.g., a human immune system or a body engaging in exercise. Taleb does not, however, provide many tools to actually determine the inflection points within any particular system. Although he praises “empirical” heuristics for doing so – especially heuristics passed down through the ages – he provides absolutely no support to conclude that those heuristics do not overshoot the desirable levels of any given characteristics. To use the example he provides of religious fasting customs, even if one can be generous and suppose some benefit to the fasting (of which I am not altogether convinced), what evidence is there that the specific schedule and duration of fasts is optimal? Could not scientific investigation uncover a better way, and explain its workings in a rational, evidence-based manner, without recourse to superstition or ancestral hand-waving?  Furthermore, Taleb does not consider that the “wisdom of the ancients” may not have developed through the careful evolutionary process he describes – but rather comes to us as a warped reflection of some very recent generation’s interpretation of ancient practices – which themselves were altered by numerous political authorities, ideological movements, and idiosyncratic historical events in order to fulfill some very context-specific (and not necessarily virtuous or life-affirming) aim. To get a sense of how this has happened to distort prevailing conceptions of the past, one needs only to consider the early history of Christianity – where doctrine was often promoted or suppressed based on the temporal interest of Roman and Byzantine emperors and their officials – or the extensive revisionism performed by the 19th-century Romantics with regard to the Middle Ages. Taleb himself romanticizes antiquity (including the ancient Middle East), overlooking the incessant wars, disease, filth, vulgarity, persecution, and ideological totalism that characterized many pre-Enlightenment societies (e.g., the totalitarianism of Ancient Sparta or Calvin’s Geneva – which made even the USSR seem like a paragon of liberty and progress by comparison).

Taleb’s contempt for wealth, and praise for attitudes that part with wealth lightly, betray the fact that he has never been in danger of losing his material comfort. Growing up in a prosperous , respected, and intellectual Lebanese family, Taleb moved to the United States and made a fortune as a trader, which he later magnified by selling his books. If he expresses contempt for the material well-being he sees around him, and a nostalgic longing for an idealized past, it is because he cannot truly envision what premodernity was actually like. Perhaps, because he greatly underrates the transformative effects of technological progress, Taleb’s image of premodernity is of a slightly rustic incarnation of our present world – except one in which people mostly avoid doctors and editors, walk on rocky landscapes in foot-shaped shoes, eat “paleo” diets, quote from Seneca’s dialogues, and occasionally engage in bloody contests over fine points of poetry, philosophy, and theology – just to show how much “skin in the game” they have with regard to their beliefs. Taleb neglects the possibility that only recently has life become remotely comfortable and quasi-meritocratic, while premodernity was a mostly uninterrupted stretch of miseries, cruelties, superstitions, prejudicial hatreds, and filth (punctuated by a few refined characters like Aristotle – whom Taleb maligns – and Seneca – people who were remarkable for their time and are remembered precisely because they stood out so far above their contemporaries). A small elite has always been super-wealthy (by the standards of their time) in every era and in every society, but it is an all-too-common mistake to imagine oneself in the position of a historical member of the elite (e.g., someone who would have read Seneca, or Seneca himself) rather than a common peasant or slave – which is the far more probable fate for a randomly chosen premodern person. The casual dismissal of wealth as not particularly important would not have been articulated by people toiling from sunrise to sunset in order to grow crops for their feudal overlords and be given a small fraction of the resulting harvest in order not to starve. Nor is this attitude particularly helpful to people who might have been interested in cultivating personal antifragility so as to prevent themselves from becoming poor.

The most useful personal advice in Antifragile concerns the so-called “barbell strategy” for minimizing the downside of volatility while benefiting from the upside. The strategy involves putting most of one’s resources into an ultra-safe, ultra-conservative course of action, while devoting the rest to a diversified speculation, but in such a manner that the entire speculative amount can be lost without significant harm. An example of this approach would be keeping 90% of one’s money as cash or gold, and investing the remaining 10% into five different startup companies; each startup firm could fail – and many do – but it is also possible for a startup company to succeed tremendously and bring orders of magnitude of profit. If all the startup firms fail, then one has had a 10% loss – but this does not have to be ruinous if one is not hyper-leveraged. Taleb is also correct about the highly fragilizing effects of debt and recommends avoidance of indebtedness where possible. This is sound advice, greatly needed in a country where everything from everyday consumption to the purchase of big-ticket items to intangible “investments” such as formal education is often purchased on credit. Debt introduces fragility by amplifying the financial pain of volatility. A marginal drop in income could be endured by a debt-free person with savings, but would result in a leveraged person losing everything. Taleb’s advice here may not always be perfectly realizable – as not every person can afford to invest any percentage of his assets with the ability to continue living well if those assets were lost. Furthermore, mortgage debt is extremely difficult to avoid for a person without sizable initial wealth; other debt, however, is generally avoidable.

While Antifragile has some virtues, Taleb should not have dismissed or derided his editors. If carefully confined to the realms of finance and economics, Antifragile might have been an illuminating and positive book on net. As matters stand, however, Taleb has managed to gratuitously insult practically everybody who might have been sympathetic to his previously articulated views – including the libertarians, transhumanists, and rationalist natural-law thinkers who would have found much to agree with in Fooled by Randomness and The Black Swan. Taleb even classifies Friedrich Hayek among the rationalists whom he dismisses: “We may be drawn to think that Friedrich Hayek would be in that antifragile, antirationalist category. […] But Hayek missed the notion of optionality as a substitute for the social planner. In a way, he believed in intelligence, but as a distributed or collective intelligence – not in optionality as a replacement for intelligence. […] Finally, John Gray, the contemporary political philosopher and essayist who stands against human hubris and has been fighting the prevailing ideas that the Enlightenment is a panacea – treating a certain category of thinkers as Enlightenment fundamentalists. […] Gray worked in an office next to Hayek and told me that Hayek was quite a dull fellow, lacking playfulness – hence optionality.” And there was the gratuitous insult again. Very well. We Enlightenment rationalists and technoprogressives will be happy to accept Hayek as one of us – along with Socrates, Aristotle, and Ayn Rand (for whose fan Taleb should not be mistaken, as he tells us in a footnote). Taleb can have Seneca, Almutanabbi, John Gray, and Fat Tony. We remain in good company without them.

Non-Apocalypse, Existential Risk, and Why Humanity Will Prevail – Video by G. Stolyarov II

Non-Apocalypse, Existential Risk, and Why Humanity Will Prevail – Video by G. Stolyarov II

Doomsday predictions are not only silly but bring about harmful ways of approaching life and the world. Mr. Stolyarov expresses his view that there will never be an end of the world, an end of humanity, or an end of civilization. While some genuine existential risks do exist, most of them are not man-made, and even the man-made risks are largely in the past.

References

– “Transhumanism and the 2nd Law of Thermodynamics” – Video by G. Stolyarov II

Announcements and October-November 2012 Update to Resources on Indefinite Life Extension

Announcements and October-November 2012 Update to Resources on Indefinite Life Extension

I expect be unavailable to publish The Rational Argumentator until circa November 22, 2012 – but, in the meantime, various new offerings have been posted for my readers.

In addition, I have recently been impressed by the significant contributions my computer has made to the World Community Grid Help Conquer Cancer distributed computing project. (You can see a presentation by one of the project’s lead scientists, Dr. Igor Jurisica, here.) About a month ago, the Help Conquer Cancer project was enhanced to allow computers’ Graphics Processing Units (GPUs) to assist in the analysis of millions of experiments. My own recently enhanced computer has been participating heavily, which caused my worldwide ranking on World Community Grid to rise within a month from about 60,000th place to 26,744th place (updated every half-day) in terms of credits and 15,795th place in terms of results returned. In addition, for the totality of BOINC distributed computing projects, I have risen to the 98.2932nd percentile and a world rank of 42,446 in terms of total credits and the 99.5634th percentile and a world rank of 10,878 in terms of recent average credit. In the United States, I am ranked at 11,802nd place in terms of total BOINC credit earned.

I expect that my computer will continue to run at full capacity during the upcoming weeks, and indefinitely into the foreseeable future.

For your contemplation and enjoyment, I offer here the list of diverse and fascinating articles and videos that have been included in the Resources on Indefinite Life Extension (RILE) page in October and early November of this year.

Articles

– “Nanoparticles Against Aging” – Science Daily and Asociación RUVID – October 3, 2012

– “Nanoparticles can deliver antiaging therapies” – Brian Wang – The Next Big Future – October 4, 2012

– “A Speculative Order of Arrival for Important Rejuvenation Therapies” – Reason – Fight Aging! – October 4, 2012

– “Therapy will use stem cells to heal heart” – Pauline Tam – October 4, 2012

– “Aubrey de Grey on Longevity Science” – Reason – Fight Aging! – October 5, 2012

– “Predicted sequence of Antiaging rejuvenation” – Brian Wang – The Next Big Future – October 5, 2012

– “Researchers use magnets to cause programmed cancer cell deaths” – Bob Yirka – October 8, 2012 

– “Lilly Alzheimer’s Drug Slows Mental Decline, Study Finds” – Shannon Pettypiece – October 8, 2012

– “Vitamin Variants Could Combat Cancer as Scientists Unravel B12 Secrets” – ScienceDaily and University of Kent – October 8, 2012

– “Human Immortality: Singularity Summit Looks Forward to the Day That Humans Can Live Forever” – Hamdan Azhar – Policymic – October 2012

– “Drug From Chinese ‘Thunder God Vine’ Slays Tumors in Mice” – Drew Armstrong – Bloomberg – October 17, 2012

– “82 Years of Technology Advances; but best yet to come” – Dick Pelletier – Transhumanity.net – October 25, 2012

– “New you by 2022: biotech enhancements will help you ‘grow young’” – Dick Pelletier – Positive Futurist – October 2012

– “Flu Vaccination May Increase Longevity” – Lyle J. Dennis, M.D. – Extreme Longevity – October 29, 2012

– “Dead as a Doornail?” – Peter Rothman – h+ Magazine – November 1, 2012

– “An Outcast Among Peers Gains Traction on Alzheimer’s Cure” – Jeanne Whalen – Wall Street Journal – November 9, 2012

 

Videos

Anthony Atala
Anthony Atala at TEDMED 2009
January 21, 2010

Ray Kurzweil

From Eliza Watson to Passing the Turing Test – Singularity Summit 2011

October 25, 2011

Nikola Danaylov

Ray Kurzweil on Singularity 1 on 1: Be Who You Would Like to Be – October 13, 2012

Update to Resources on Indefinite Life Extension – July 10, 2012

Update to Resources on Indefinite Life Extension – July 10, 2012

TRA’s Resources on Indefinite Life Extension page has been enhanced over the past two months with links to numerous fascinating articles and videos.

Articles

– “Scientists turn skin cells into beating heart muscle” – Kate Kelland – Reuters – May 22, 2012

– “Is Amyloidosis the Limiting Factor for Human Lifespan?” – Lyle J. Dennis, M.D. – Extreme Longevity – May 22, 2012

– “Israeli scientists create beating heart tissue from skin cells” – The Telegraph – May 23, 2012

– “Paralyzed rats walk again in Swiss lab study” – Chris Wickham – MSNBC.com – May 31, 2012

– “New Cancer Drugs Use Body’s Own Defenses” – Ron Winslow – Wall Street Journal – June 1, 2012

– “Bristol immune drug shows promise in three cancers” – Julie Steenhuysen – Reuters – June 2, 2012

– “Prostate cancer drug so effective trial stopped” – Victoria Colliver – San Francisco Chronicle – June 2, 2012

– “New ‘smart bomb’ drug attacks breast cancer, doctors say” – Associated Press – June 3, 2012

– “Alzheimer’s vaccine trial a success” – Karolinska Institutet – June 6, 2012

– “Man Cured of AIDS: ‘I Feel Good’” – Carrie Gann – ABC News – June 8, 2012

– “Artificial Lifeforms Promise Cleaner World, Healthier Humans” – Dick Pelletier – Positive Futurist – June 9, 2012

– “Secret of ageing found: Japanese scientists pave way to everlasting life” – RT – June 9, 2012

– “How aging normal cells fuel tumor growth and metastasis” – Thomas Jefferson University – June 14, 2012

– “People Who Justify Aging are Profoundly Wrong – Aging is Abhorrent” – Maria Konovalenko – Institute for Ethics & Emerging Technologies – June 14, 2012

– “Scientists tie DNA repair to key cell signaling network” – University of Texas Medical Branch at Galveston – June 15, 2012

– “Deciding How We Age as We Age” – Seth Cochran – h+ Magazine – June 19, 2012

– “How we die (in one chart)” – Sarah Kliff – Washington Post – June 22, 2012

– “Modified humans: the most cost-efficient way to colonize space” – Dick Pelletier – Positive Futurist – June 2012

– “Japanese Scientists Grow Human Liver From Stem Cells” – Reuters and Singularity Weblog – June 2012

– “Why Do Naked Mole Rats Live So Long? Do they hold the key to human life extension?” – Maria Konovalenko – Institute for Ethics & Emerging Technologies – June 29, 2012

– “Scientists Develop Alternative to Gene Therapy” – ScienceDaily – Scripps Research Institute – July 1, 2012

– “How to live beyond 100” – Lucy Wallis – BBC News – July 2, 2012

– “Earth 2050-2100: longer lives; new energy; FTL travel; global village” – Dick Pelletier – Positive Futurist – July 3, 2012

– “Scientists discover bees can ‘turn back time,’ reverse brain aging” – Phys.org – Arizona State University – July 3, 2012

– “Secret formula may be key to reverse aging” – Mike Holfeld – Click Orlando – July 4, 2012

– “Is there a biological limit to longevity?” – Aubrey de Grey – KurzweilAI – July 5, 2012

– “Demystifying the immortality of cancer cells” – Medical Xpress – July 5, 2012

– “Suggesting a Test of Rapamycin and Metformin Together” – Reason – FightAging.org – July 5, 2012

– “Earth 2050-2100: Longer Lives; New Energy; FTL Travel; Global Village” – Dick Pelletier – Positive Futurist – July 7, 2012

Videos

Aubrey de Grey

Aubrey de Grey – Aging & Suffering – Interview with Adam Ford – May 31, 2012

Nikola Danaylov (Socrates)

Anders Sandberg on Singularity 1 on 1: We Are All Amazingly Stupid, But We Can Get Better – May 27, 2012

Hugo de Garis on Singularity 1 on 1: Are We Building Gods or Terminators? – June 2012

Update to Resources on Indefinite Life Extension – May 19, 2012

Update to Resources on Indefinite Life Extension – May 19, 2012

TRA’s Resources on Indefinite Life Extension page has been enhanced over the past month with links to numerous fascinating articles and videos.

Articles

– “New Laser For Neurosurgery Allows Greater Precision And Efficiency For Removal Of Complex Turmors” – ScienceDaily – January 28, 2009

– “Tiny Particles May Help Surgeons by Marking Brain Tumors” – ScienceDaily – April 29, 2010

– “Tagging Tumors With Gold: Scientists Use Gold Nanorods to Flag Brain Tumors” – ScienceDaily – October 12, 2011

– “Immortal worms defy aging” – KurzweilAI – February 29, 2012

– “Earth 2512: humans embrace their technologies; reach for the stars” – Dick Pelletier – Positive Futurist – April 2012

– “Teenager Invents Anti-Aging, Disease-Fighting Compound Using Tree Nanoparticles” – Science 2.0 – May 8, 2012

– “A Libertarian Transhumanist Critique of Jeffrey Tucker’s ‘A Lesson in Mortality’” – G. Stolyarov II – May 13, 2012

– “Gene therapy for aging-associated decline” – KurzweilAI – May 16, 2012

– “Breakthrough in Gene Therapy Holds Great Promise” – Joshua Lipana – The Objective Standard – May 16, 2012

Videos

Aubrey de Grey – Debate with Colin Blakemore: “This house wants to defeat ageing entirely”

Part 1 – Main Debate 

Part 2 – Audience Q&A

The Sheldonian Theatre, Oxford University – April 28, 2012

Aziz Aboobaker

Neverending DNA and Immortal Worms – February 27, 2012

G. Stolyarov II

The Real War – and Why Inter-Human Wars Are a Distraction – March 15, 2012

A Libertarian Transhumanist Critique of Jeffrey Tucker’s “A Lesson in Mortality” – May 15, 2012