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Fifth Enlightenment Salon – Discussions on Longevity, Gene Therapy, Overcoming Disabilities, Animal Lifespans, Education, and Privacy

Fifth Enlightenment Salon – Discussions on Longevity, Gene Therapy, Overcoming Disabilities, Animal Lifespans, Education, and Privacy

Gennady Stolyarov II
Bill Andrews
James Kohagen
Bobby Ridge
John Murrieta


On October 13, 2018, in the spirit of the Age of Enlightenment and its furtherance today, Gennady Stolyarov II, Bill Andrews, James Kohagen, Bobby Ridge, and John Murrieta met for the fifth interdisciplinary discussion – hosted by Mr. Stolyarov – on science, culture, education, advocacy, and policy. Subjects discussed included the following:

– The recent RAAD Fest 2018 in San Diego
– Developments in the field of gene therapy
– Advances in epidural stimulation for treating and overcoming spinal-cord injuries
– Long-lived organisms and their similarities and dissimilarities to humans
– How animal experiments can become more humane
– How contemporary science still has far to go to accumulate even fairly basic information about certain organisms
– How the study of lifespans can be included in educational curricula starting at early childhood
– Whether privacy will remain in a more technologically interconnected future.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute.

Find out about Death is Wrong – the illustrated children’s book on indefinite life extension.

Fourth Enlightenment Salon – Health Segment: Discussions on GMOs, Calorie Restriction, Genetics, Artificial Sweeteners, CBD

Fourth Enlightenment Salon – Health Segment: Discussions on GMOs, Calorie Restriction, Genetics, Artificial Sweeteners, CBD

Gennady Stolyarov II
Bill Andrews
Bobby Ridge
John Murrieta


This is the second video segment from Mr. Stolyarov’s Fourth Enlightenment Salon. Watch the first segment here.

On July 8, 2018, during his Fourth Enlightenment Salon, Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, invited John Murrieta, Bobby Ridge, and Dr. Bill Andrews for an extensive discussion about transhumanist advocacy, science, health, politics, and related subjects.

Topics discussed during this installment include the following:

• Why genetically modified organisms (GMOs) are mostly good for you, and most negative perceptions of GMOs should really just be directed at the corporate practices of one company but not genetic modification as a whole.

• What technologies are already aiding the disabled and dramatically extending their capabilities in daily life.

• The role of genetics in longevity and the future of somatic genome editing.

• What the scientific evidence suggests regarding the impact of caloric restriction in humans and other primates.

• CBD and cannabinoids: separating the evidence from the marketing.

• Sierra Sciences’ history of testing over a million compounds for effects on telomerase induction.

• Why artificial sweeteners also should not be maligned, and there is no scientific evidence of their harms.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute. Members will also receive a link to a free compilation of Tips for Advancing a Brighter Future, providing insights from the U.S. Transhumanist Party’s Advisors and Officers on some of what you can do as an individual do to improve the world and bring it closer to the kind of future we wish to see.

Fourth Enlightenment Salon – Gennady Stolyarov II, Bill Andrews, Bobby Ridge, and John Murrieta Discuss Transhumanist Outreach and Curing Disabilities

Fourth Enlightenment Salon – Gennady Stolyarov II, Bill Andrews, Bobby Ridge, and John Murrieta Discuss Transhumanist Outreach and Curing Disabilities

Gennady Stolyarov II
Bill Andrews
Bobby Ridge
John Murrieta


On July 8, 2018, during his Fourth Enlightenment Salon, Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, invited John Murrieta, Bobby Ridge, and Dr. Bill Andrews for an extensive discussion about transhumanist advocacy, science, health, politics, and related subjects. In this first of several installments from the Fourth Enlightenment Salon, the subjects of conversation include the following:

• The U.S. Transhumanist Party’s recent milestone of 1,000 members and what this portends for outreach toward the general public regarding the meaning of transhumanism and the many ways in which emerging technologies help make life better.

• The new channel – Science-Based Species – launched by Bobby and John to spread basic knowledge about transhumanism, key thinkers in the movement, and advances on the horizon.

• How today’s technologies to assist the disabled are already transhumanist in their effects, and how technologies already in development can liberate humans from disability altogether. John Murrieta’s story is one of transhumanism literally saving a life – and one of the most inspiring examples of how transhumanism translates into human well-being now and in the future.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute. Members will also receive a link to a free compilation of Tips for Advancing a Brighter Future, providing insights from the U.S. Transhumanist Party’s Advisors and Officers on some of what you can do as an individual do to improve the world and bring it closer to the kind of future we wish to see.

Why Do We Advocate for Rejuvenation Research? – Article by Reason

Why Do We Advocate for Rejuvenation Research? – Article by Reason

The New Renaissance Hat
Reason
November 24, 2014
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Yesterday, I had occasion to spend six hours or so in the emergency room of a medical center largely focused on treating serious conditions that are most prevalent in old people. A part of that experience by necessity involved listening to the comings, goings, and conversations of those present. These are not private places: they are typically divided visually by screens but with no way to avoid overhearing the staff and patients. The people there are generally not too concerned about privacy in the immediate sense in any case, having far more pressing matters to focus upon.

So, by proxy, one gets to experience small and somewhat wrenching slices of other people’s lives. It is very easy for even those who follow aging research and speak up for rejuvenation treatments to forget just how hard it is to be very old. It’s one thing to know about the catalog of pain, suffering, and loss of capabilities, the conditions we’d like to find ways to turn back, and another to watch it in action. It is, really, a terrible thing to be frail.

A fellow was brought in a little while after I arrived, a 90-something man who looked a lot better on the exterior than perhaps your mental picture of a 90-something individual might be. Tall, and surprisingly lacking in wrinkles stretched out on the rolling gurney under blankets, a mess of cables, and an oxygen mask. That he had fallen was what I heard from the conversation of the medics, and was in pain. He cried out several times as he was moved from the gurney. It took some time and care to do it without hurting him more, given his weakness.

He seemed confused at first, but that was just my misperception: you try being 90 and in pain some time and see how well you do while you’re being moved around and told to hold this and let go of that. The fellow answered the bevy of questions the receiving staff had for him, but the thing that caught at me was the time he took with the answers, and the questions he just missed. He was coherent, even quite sharp at times, not on any more painkillers than a handful of Tylenol, as I later heard, but he clearly struggled with something that we younger folk all take for granted: parse the question, find the information, form up a reply and speak it. Cognitive ability in all these areas becomes ever less efficient with old age, and there’s something hollowing about hearing what is clearly a capable guy set back for a dozen seconds by a short question about one of the details of his fall. The medic repeated the question a few times and in different ways, which was clearly just making the information overload worse.

It sticks with you to be the observer in this situation and clearly and suddenly realize that one day that faltering older person will be you, trying and often failing to force your mind into the necessary connections rapidly enough for the younger people around you. I know this, but knowing it and having it reinforced by being there are two very different things. An aged person is no less intelligent, far more experienced, wiser and all the rest, but the damage to the structure of the brain that occurs even in those without dementia means that making use of all of that in the way it deserves is near insurmountable.

The fellow’s 60-something daughter arrived a little later to provide support and fill in more of the details. A story was conveyed in bits and pieces: that he was near blind now, and just about too frail to walk safely, even with a frame. The blindness explained a great deal of what had sounded to my ignorant ears as confusion in the earlier part of the fellow’s arrival: we assume all too many things about those around us, such as the use of sight in an unfamiliar environment, or the ability to walk, or think quickly – and all of this is taken from us by aging. The fellow lived with his wife still, and she was of a similar age to him. His wife was not there because she herself was too frail to be undertaking even a short trip at such short notice. That seemed to me a harsh blow on top of the rest of what old age does to you. At some point you simply cannot do everything you’d want to as a partner. You are on the sidelines and at the point at which your other half is most likely to die, you are most likely unable to be there.

In this case the fellow was in no immediate danger by the sound of it. By good luck this was in no way likely to be a fatal accident, but rather another painful indignity to be endured as a part of the downward spiral of health and ability at the end of life. Once you get to the point at which simply moving from room to room bears a high risk of accident, and this is by no means unusual for a mentally capable person in their 90s, then it really is just a matter of time before you cannot live for yourself with only minimal assistance.

When talking with his daughter while he waited on a doctor and medical assistants to come and go with tests and updates, the fellow was much faster in his responses, though this was interrupted by a series of well-meaning but futile attempts to ease his pain by changing his position, each as much an ordeal as the move from the gurney had been. The conversation between father and daughter had the sense of signposts on well-worn paths, short exchanges that recapitulated the high points of many discussions that had come before. She wanted her father to move into an assisted living facility, and this fall was the latest in a line of examples as to why it was past the time for this – she simply could not provide all of the support needed on her own. She wasn’t even strong enough herself to be able to safely get him back up on his feet after a fall. He was concerned about cost and the difficulties of moving, uncertainties and change. They went back and forth on this for a while. “We have to accept that it’s just going to be more expensive as we get older,” she said at one point, and he replied “I think you’re getting the picture now,” and laughed. There wasn’t much to laugh about, but we can all do it here and there under these circumstances. I believe it helps.

I walked out of there after my six hours of hurry up and wait was done. They were still there, and whenever it is he leaves to go home it is unlikely it will be on his own two feet. But this is a scene I’ll no doubt be revisiting at some point in the future, some decades from now, playing the other role in this small slice of life. What comes around goes around, but I’d like it to be different for me, and more importantly to be different for millions of others a lot sooner than my old age arrives.

Which leads to this: why does Fight Aging! exist? Why do we do this? Why advocate, why raise funds for research programs into ways to treat aging that may take decades to pay off? We do this because we can help to create a future in which there will be no more emergency rooms like the one I visited, no conversations about increasing disability, no pain, and no struggles to answer questions as quickly as one used to. No profound frailty. All these things will be removed by the advent of therapies that can effectively repair the causes of aging, curing and preventing frailty and age-related disease, and the sooner this happens the more people will be spared.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

A Review of the Penny Marshall Film “Awakenings” (2004) – Article by G. Stolyarov II

A Review of the Penny Marshall Film “Awakenings” (2004) – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
July 26, 2014
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Note from the Author: This essay was originally written in 2004 and published on Associated Content (subsequently, Yahoo! Voices) in 2007.  The essay earned over 2,600 page views on Associated Content/Yahoo! Voices, and I seek to preserve it as a valuable resource for readers, subsequent to the imminent closure of Yahoo! Voices. Therefore, this essay is being published directly on The Rational Argumentator for the first time.  
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~ G. Stolyarov II, July 26, 2014

**

Today, films about handicaps and diseases occur occasionally. One example is A Beautiful Mind, which features schizophrenia. Certainly, this is not a topic that is featured as often as the common themes of war/action, romance, and comedy, perhaps due to the greater subtlety involved in the dignity of characters who exhibit serious illnesses and the supreme mastery needed of film directors and actors who would wish to convey it. Too often a majority of individuals tend to be repulsed by the sight of individuals on screen whose bodily functions so evidently and so seriously deviate from health. A film about a disease would need to overcome this ingrained repulsion and portray the patients as genuinely attractive, important, and interesting individuals.

Penny Marshall does this with Awakenings (1990) through her depiction of Leonard as an eager connoisseur of books and toy models, as well as Leonard’s intellectual deliberations about the nature of life. Leonard’s mind is exposed in a manner that welcomes the audience to explore his personality, rather than be repelled by his defects.

The various plots of the film are integrated skillfully. For example, the conflict between Dr. Sayer and the hospital establishment constantly undermines his relationship with his patients, as the hospital always holds and often acts on its financial reservations, and, in the ultimate escalation of its insensitivity, denies Leonard’s harmless request to take a walk alone. This brings about Leonard’s deep spite and his orchestration of a rebellion of the patients against both the hospital and Dr. Sayer. Additionally, Leonard’s conversations with Dr. Sayer and his ultimate relapse into immobility convince Sayer to finally express his affections for Eleanor Costello and take advantage of the opportunity to enjoy a caring relationship in full health. Another plot concerns Leonard’s relationship with his mother, who had been his principal caretaker, and who becomes dismayed by Leonard’s interest in and association with Paula. This tension is resolved when Leonard is incapacitated once again, as both his mother and Paula attend to his welfare.

My primary exposure to Robin Williams has been through comedy films such as Mrs. Doubtfire, while Robert De Niro is familiar from action films like The Untouchables. The roles played by both actors in this film are unusual for them, but this is necessitated by the very nature and content of the film. Nevertheless, De Niro did resemble his Al Capone role when, as Leonard, he orchestrated the uprising of patients in the hospital and recruited a ganglike following for himself, endangering and humiliating Dr. Sayer with it. This may have been a deliberate decision on Penny Marshall’s part, as De Niro is known to play well the roles of gang bosses, but that episode was without question an exception to Leonard’s personality rather than the rule. De Niro has been put into a role of an admirable, thoughtful individual, which he has shown to play as well as that of a detestable gangster.

The most memorable secondary character in the film is the female doctor on the hospital board who stated to Leonard when he sought permission to go for a walk, “Are you aware that you are expressing a subconscious disdain for us?” To this Leonard replied, in demonstration of his mental autonomy, “How can I be aware of it if it is subconscious?” This doctor, to me, symbolized a hospital establishment that did not view Leonard and other post-encephalitic patients as fully human and employed pseudo-intellectual sophisms to justify restrictions placed on the patients from some of the most rudimentary and innocent undertakings of human existence.

The visit to an earlier setting of the 1920s presents a stark contrast in appearance and lifestyles with the main setting of the film. The clothing and vehicle styles of Leonard’s childhood are far different from the era of his awakening, and bring about the need for Leonard to adapt to an entirely new world and “catch up” on forty years of change. The effect of this is the creation of an understanding within the audience of just how long Leonard had been incapacitated and how torturous this period had been for him. The historical setting of the 1960s is in itself expressed well through the screams of anti-war protesters near the hospital area, as well as the ragged and often suggestive fashions of people encountered on the streets. One particular scene, of Dr. Sayer and Leonard passing by a dazed bum on the street poses an intense contrast between Leonard, who, having been separated from life for so long, is eager to savor every moment of health and competence, and this apparently young hippie who is deliberately ruining his health and viewing life with a dull contempt.

Leonard awakens literally, from decades of immobility, but also intellectually, being able to reveal his insights and values to the world with immense expressive power which he had hitherto lacked. Dr. Sayer awakens to the idea of enjoying health and competence while they are still available and opening oneself to new opportunities rather than shying away from them. The hospital staff and the sponsors of the project to treat the patients are guided by Leonard and Dr. Sayer into understanding the patients’ full humanity and dignity, as well as appreciating the ability to perform rudimentary life-affirming tasks, such as taking walks or merely speaking, that patients such as Leonard have been deprived of and yearned for greatly. The lesson derived across the board, especially by the audience, is that living must be performed deliberately, without allowing boredom with mundane routine to overshadow an appreciation for and actualization of one’s fundamental ability to extract the most from one’s relationships and undertakings. The audience can awaken to the fact that life is far more colorful than it is often portrayed in a culture that stresses routine, and much more of it can be explored than is customarily taken advantage of.

Healthy, Peaceful Death Does Not Exist – Article by Advocate of Negligible Senescence

Healthy, Peaceful Death Does Not Exist – Article by Advocate of Negligible Senescence

The New Renaissance Hat
Advocate of Negligible Senescence
May 26, 2014
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ANS_Saved_Near_Death

Most people want to die of in their sleep, in peace, of old age, without pain and surrounded by their family and loved ones after achieving success and after having done something worthwhile.But the facts suggest, that such a peaceful end is granted to very few people, while most people have to endure different disabilities and diseases associated with aging and terrible pain and decreased function, performance, and the lack of joy coming with it.The Global Burden of Disease (GBD) project originated in 1990 in a collaboration between the World Health Organization, Harvard School of Public Health, the Institute for Health Metrics and Evaluation (IHME), and the World Bank.

The focus of the Global Burden of Disease Study is to provide a detailed statistical analysis of the impact of diseases leading to death and disability across various regions around the world. The purpose of the study is to reveal gaps between current and ideal health circumstances and develop strategies to reduce this gap.

The 2010 Global Burden of Disease study reveals a significant shift in the nature of disease worldwide. There has been a significant increase in chronic disease worldwide. This is due to demographics of aging, and the subsequent increase of age-related disease.

Worldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults.

As life expectancy has increased, the number of healthy years lost to disability has also increased in most countries, consistent with the expansion of morbidity hypothesis, which has implications for health planning and health-care expenditure.One of the key findings reveals that we are living longer, but under an increased burden of chronic disease that impairs our quality of life.These results are distressing: men can expect to spend an average of 9.2 years and women 11.5 years with some form of a chronic disability. In other words, during the last decade of lives, on average, our quality of life might become significantly impaired by the presence of a chronic disease.

The paradox, then – the fact that people want to be actively saved if they are near or at the moment of death, but also want to die peacefully – seems to be rooted in a pretty profound medical illiteracy.

Healthy people don’t die in their sleep, “peacefully” or otherwise. You don’t hear about too many 25-year-olds dying suddenly of heart attacks or strokes during their nightly slumber.

When people in their twenties die, it’s usually considered tragic. When babies are found dead in their cribs, it’s referred to by a name (“Sudden Infant Death Syndrome”). But when elderly people die, in bed or otherwise, there tends to be a curious tone of, “Well, at least they went peacefully.”

The increase in life expectancy and the resulting growth of the elderly population are also thought to be driving up the number of elderly people with disabilities.

Typically in the case of dying in your sleep due to old age, an autopsy can determine exactly what went wrong, or what stopped working. For example, your heart could simply get tired and stop beating, because it’s been working hard for the past eighty or ninety years.

The phrase “natural causes” or dying “of old age” is a very strange one really. Ultimately what it means is that someone who dies of natural causes, dies of aging in a way that has not been given an additional name; so really it’s just a matter of terminology. The difference is between dying of “natural causes” and dying of some other specifically named thing that doesn’t really often affect young adults.

Searching for a cure for age-related ill health, a problem that kills more people than all other causes combined, is a moral imperative. The Advocate for Negligible Senescence publishes articles that discuss and educate the public about research to combat senescence. See the Advocate’s Facebook page.