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Jason Hope on Philanthropy – Article by Reason

Jason Hope on Philanthropy – Article by Reason

The New Renaissance Hat
November 30, 2015

Jason Hope, you might recall, has provided half a million dollars in research funding to the SENS Research Foundation, used to establish a SENS laboratory at Cambridge in order to push forward with the Foundation’s AGE-breaker program. AGE-breakers are drugs or other treatments capable of breaking down advanced glycation end-products (AGEs). These are a class of metabolic waste product that accumulate in our tissues to cause significant harm that includes the progressive loss of elasticity in skin and blood vessels.

There is, on the whole, far too little work undertaken today on AGE-breaker treatments in comparison to the benefits that a treatment could bring. What little research has taken place over the past twenty years unfortunately produced no effective therapies. As it turned out the AGEs that are important in short-lived laboratory animals are not the same at all as those that are important in humans – something that would have been challenging to identify until comparatively recently, and which resulted in promising animal studies that then went nowhere in commercial trials.

Now, however, researchers know that the vast majority of all AGEs in human tissues consist of just one type, called glucosepane – so the way is open for bold philanthropists and forward-looking researchers to build therapies that will be effective in removing this contribution to degenerative aging. Glucospane removal is one of the areas in which the SENS Research Foundation and its backers pick up the slack, undertaking important rejuvenation research that is neglected by the mainstream, even though it was exactly the mainstream research community that produced all of the studies and evidence that demonstrate the important role of glucospane in aging.

In any case, I should point out that Jason Hope runs a website and blog in which he discusses his take on philanthropy and his support for research aimed at extending healthy human life and rejuvenating the old. This makes for an interesting follow-on from yesterday’s post on big philanthropy. More folk of this ilk would certainly be a good thing, and I’m always pleased to see more of the better connected people in this world of ours speaking openly of their support for rejuvenation biotechnology.



Philanthropy has become a big focus for me. The organizations I have chosen to stand behind have come from many facets of my life. One of my passions has become the research done at the SENS Research Foundation. Their involvement in anti aging is not just about wanting to live forever. It’s about creating a longer, better quality of life.

Foundations like SENS are taking a different approach to anti-aging. They are focused on finding cures for disease that break down the body and thus cause us to age faster than we should. Disease like Alzheimer’s and heart and lung disease affect all functions of the body. Traditional medicine looks at treating these diseases after they happen. We want to focus on stopping these diseases from ever happening. We have spent so much time focused on medication for treating disease and not enough time on preventing that disease from ever happening.

By supporting scientific research that thrives through innovation and is not afraid to challenge the modern school of thought we will continue to break down walls.

A 21st-Century Philanthropic Model For Philanthropy


Can you conceive of a world without age-related disease, disability and suffering? What about a world in which it’s possible for the average person to live 120 healthy years? While it may sound like a utopian dream, such a world is the exact goal of some of society’s most brilliant scientists and visionary leaders. At this very minute, groundbreaking work is underway at universities across the globe as researchers attempt to apply regenerative medicine to age-related disease through the repair of damage to tissue, cells and molecules within the body. While this research couldn’t be possible without the leadership of the world’s wealthiest philanthropists, it also relies upon the collective power of everyday people who have joined forces in their commitment to a better quality of life for all.

Traditionally, big ticket donors have been the primary target for fundraising programs. Research has consistently shown that the bulk of donor funds come from a small percentage of the wealthiest donors: in fact, a full 75 percent of funds raised come from gifts of over $1 million.

Instead of resigning themselves solely to the influence of the individual, non-profits are turning to the collective power of a group. The MFoundation’s “The 300 Pledge” fundraising campaign is an exciting example of this method in practice. The 300 Pledge asks 300 funders to commit $1,000 a year for 25 years toward critical research aimed at ending age-related diseases. When broken down, this goal is manageable for many households: just $3 a day or $85 a month – less than your daily tab at Starbucks. Obviously, the model is working: to date, 291 people have taken up the challenge, with nine spots remaining.

As evidenced by the magnificent philanthropy of people like Peter Thiel, Bill Gates and others like them, it’s obvious that one person can make a difference. However, fundraising challenges, like MFoundation’s “The 300,” also demonstrate the power of a dedicated group of people to foster real world change for the billions of people living in the world today as well as the generations that follow. In doing so, those who take up the challenge create a unique and world-altering legacy for themselves.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 

This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on

SENS Research Foundation Joins the Global #GivingTuesday Movement – Press Release by SENS Research Foundation

SENS Research Foundation Joins the Global #GivingTuesday Movement – Press Release by SENS Research Foundation

The New Renaissance Hat
SENS Research Foundation
November 28, 2015
Every Dollar Contributed Up to the First $5,000 Will Be Quadrupled, Turning into $20,000.

MOUNTAIN VIEW, Calif. — November 24, 2015 — The SENS Research Foundation (SRF), a non-profit organization focused on transforming the way the world researches and treats age-related disease, has joined #GivingTuesday, a global day of giving that harnesses the collective power of individuals, communities and organizations to encourage philanthropy and celebrate generosity worldwide. Every dollar donated to SRF up to the first $5,000 will be quadrupled, making every dollar raised turn into $20,000.

Occurring this year on December 1, #GivingTuesday is held annually on the Tuesday after Thanksgiving (in the U.S.) and the widely recognized shopping events Black Friday and Cyber Monday to kick-off the holiday giving season and inspire people to collaborate in improving their local communities and to give back in impactful ways to the charities and causes they support.

SENS Research Foundation is aiming to reach a goal of $20,000 with the help of contributors who have pledged to match each dollar raised up to the first $5,000. The Croeni Foundation, a philanthropic organization dedicated to giving, the environment and health, has pledged to match the first $5,000 raised dollar for dollar. The foundation gave SRF an unrestricted $5,000 earlier this year, as well. Aubrey de Grey, CSO of SENS Research Foundation, has offered a dollar for dollar matching challenge up to $5,000. And Fight Aging! will match every dollar up to $125,000 through December 31, 2015. Fight Aging! encourages the development of medical technologies, lifestyles, and other means to help people live comfortably, healthily, and capably for as long as they desire.

“We are looking forward to participating in #GivingTuesday for a second year, and offer our thanks to Jan Croeni and the Croeni Foundation, as well as Aubrey de Grey and Fight Aging! for their support,” said Jerri Barrett, vice president of outreach, SENS Research Foundation. “Today’s cost for the treatment and care of chronic diseases of aging costs around $40,000 per second and will only continue to go up, as we spend more money per patient, while the number of patients is increasing. As a society, we need to change our ways and start treating age-related diseases more intelligently. The funds we raise on #GivingTuesday will help facilitate our efforts to do just that, as we work to continue learning how to prevent or reverse age-related diseases.”

Those who are interested in joining SENS Research Foundation’s #GivingTuesday initiative can donate at To learn more about #GivingTuesday participants and activities or to join the celebration of giving, please visit:

About SENS Research Foundation (SRF)

SENS Research Foundation is a 501(c)(3) nonprofit that works to research, develop, and promote comprehensive regenerative medicine solutions for the diseases of aging. SRF is focused on a damage repair paradigm for treating the diseases of aging, which it advances through scientific research, advocacy, and education. SENS Research Foundation supports research projects at universities and institutes around the world with the goal of curing such age-related diseases as heart disease, cancer, diabetes and Alzheimer’s disease. Educating the public and training researchers to support a growing regenerative medicine field are also major endeavors of the organization that are being accomplished though advocacy campaigns and educational programs. For more information, visit

Media Contact:
Jerri Barrett

ALS, SENS, and Ice Buckets (or Lack Thereof) – Video by Gennady Stolyarov II and Wendy Stolyarov

ALS, SENS, and Ice Buckets (or Lack Thereof) – Video by Gennady Stolyarov II and Wendy Stolyarov

The New Renaissance Hat
G. Stolyarov II and Wendy Stolyarov
August 28, 2014

Gennady Stolyarov II and Wendy Stolyarov, author and illustrator of Death is Wrong, respond to the ALS Ice Bucket Challenge.


Evidence of Donation to ALS Association
Evidence of Donation to SENS Research Foundation
ALS Association
SENS Research Foundation
Eternal Life Fan Club Website
Eternal Life Fan Club on Facebook
Death is Wrong Official Home Page

Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
October 4, 2013

As part of my escalating efforts to advance the prospects of radical life extension through my individual actions, I have donated $50 to an ambitious new crowdfunding project to research longevity-enhancing treatments in mice.

This international project, undertaken by researchers at the Kiev Institute of Gerontology and supported by the Methuselah Foundation and the SENS Research Foundation, has an Indiegogo fundraising page, titled “I am a little mouse and I want to live longer!”, where contributions can be made.

I am proud to donate to this effort to support longevity research through crowdfunding. This project allows those of us who seek longer lifespans, and who wish to advance the science that will get us there, to contribute directly in a manner whereby each of us can make a sizable fraction of the difference for this research effort. I look forward to the great work that this project will accomplish. Achieving statistically significant mouse life extension in the near future could trigger massive public interest and the influx of major research funds to attain increasingly ambitious life-extension goals in higher-order mammals, culminating in us.

The project has already raised $8,673 and has 16 days remaining to reach its $15,000 goal. The Methuselah Foundation will match each $1,000 given with an equivalent donation – so it is possible to double one’s impact by contributing funds to this research effort.

Be a Patron of a New Classical Composition: Melody, Harmony, and Dignity Guaranteed!

Be a Patron of a New Classical Composition: Melody, Harmony, and Dignity Guaranteed!

I am initiating an ambitious new experiment for funding new rational classical composition via Kickstarter. Please see the Kickstarter page for this project here.

For a combined pledge of $150, I will create a new classical composition of at least 3 minutes in length. The person contributing the plurality of funds will be able to have the composition bear his/her name. (For instance, if your name is Smith, and I compose a rondo, it would be called the Smith Rondo, Op. 70 – or you could choose a different name of appropriate dignity.) Any donor would be able to recommend whether the composition be predominantly in a major or a minor key – as well as the key itself (e.g., C major, A minor, etc.). (Note: Secondary themes or variations on the main theme may depart from the main key if this would reinforce the integrity and develop the intricacy of the composition.) If a majority of donors favors a particular key, I will write the piece in that key.

Once composed, the work would be released online for free download and streaming and would be licensed as Creative Commons. The creation of art and music through distributed patronage, as well as the subsequent free availability of such work, can liberate both creators and the consuming public and unleash a new era of high culture for vast numbers of people. No matter who you are, you can be a patron of classical music in this electronic age.

The composition will be created electronically using Finale 2011 software – probably using several pianos, but other instruments may be incorporated as well. Finale 2011 can create sound quality closely resembling a human performance on a traditional instrument. At the same time, electronic playback can enable the composition to possess speed and virtuosity beyond the abilities of a human performer.

I am asking for combined donations of $150 as compensation for the time in composing this work. I anticipate that the process will take about 5 hours of complete focus, and so I would be compensated at $30 per hour. I can create the composition within at most one week after the funding goal has been reached.

If you have any questions or recommendations about this project, please feel free to e-mail me at


I have composed 69 works to date and have developed a distinctive style that respects centuries of Western musical tradition while taking advantage of the new possibilities of electronic composition. My philosophy of composition holds that music must be (i) orderly and rational, (ii) pleasant to the ear, and (iii) elevating in its content and in the motivation it confer upon the listener.

I can promise the following:

– A directed, rational, thought-provoking, and pleasant melody.

– Sophisticated accompaniment and variation.

– Harmonies that please: No unresolved dissonance, “shock value,” expressionism, debasement, or noise.

You can find some of my freely available compositions on this YouTube playlist.

I particularly recommend my most recent works:

Rondo #2, Op. 65

Progress Amidst a Crisis, Op. 66

Rondo #3, Op. 67

Rondo #4, Op. 68

Baroque Composition for Piano and Organ, Op. 69

All of my compositions are available for free download as MP3 files on this page.

Thank you for your consideration and, hopefully, your patronage.