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Fourth Enlightenment Salon – Health Segment: Discussions on GMOs, Calorie Restriction, Genetics, Artificial Sweeteners, CBD

Fourth Enlightenment Salon – Health Segment: Discussions on GMOs, Calorie Restriction, Genetics, Artificial Sweeteners, CBD

Gennady Stolyarov II
Bill Andrews
Bobby Ridge
John Murrieta


This is the second video segment from Mr. Stolyarov’s Fourth Enlightenment Salon. Watch the first segment here.

On July 8, 2018, during his Fourth Enlightenment Salon, Gennady Stolyarov II, Chairman of the U.S. Transhumanist Party, invited John Murrieta, Bobby Ridge, and Dr. Bill Andrews for an extensive discussion about transhumanist advocacy, science, health, politics, and related subjects.

Topics discussed during this installment include the following:

• Why genetically modified organisms (GMOs) are mostly good for you, and most negative perceptions of GMOs should really just be directed at the corporate practices of one company but not genetic modification as a whole.

• What technologies are already aiding the disabled and dramatically extending their capabilities in daily life.

• The role of genetics in longevity and the future of somatic genome editing.

• What the scientific evidence suggests regarding the impact of caloric restriction in humans and other primates.

• CBD and cannabinoids: separating the evidence from the marketing.

• Sierra Sciences’ history of testing over a million compounds for effects on telomerase induction.

• Why artificial sweeteners also should not be maligned, and there is no scientific evidence of their harms.

Join the U.S. Transhumanist Party for free, no matter where you reside by filling out an application form that takes less than a minute. Members will also receive a link to a free compilation of Tips for Advancing a Brighter Future, providing insights from the U.S. Transhumanist Party’s Advisors and Officers on some of what you can do as an individual do to improve the world and bring it closer to the kind of future we wish to see.

Are We Entering The Age of Exponential Growth? – Article by Marian L. Tupy

Are We Entering The Age of Exponential Growth? – Article by Marian L. Tupy

The New Renaissance HatMarian L. Tupy
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In his 1999 book The Age of Spiritual Machines, the famed futurist Ray Kurzweil proposed “The Law of Accelerating Returns.” According to Kurzweil’s law, “the rate of change in a wide variety of evolutionary systems (including but not limited to the growth of technologies) tends to increase exponentially.” I mention Kurzweil’s observation, because it is sure beginning to feel like we are entering an age of colossal and rapid change. Consider the following:

According to The Telegraph, “Genes which make people intelligent have been discovered [by researchers at the Imperial College London] and scientists believe they could be manipulated to boost brain power.” This could usher in an era of super-smart humans and accelerate the already fast process of scientific discovery.

Elon Musk’s SpaceX Falcon 9 rocket has successfully “blasted off from Cape Canaveral, delivered communications satellites to orbit before its main-stage booster returned to a landing pad.” Put differently, space flight has just become much cheaper since main-stage booster rockets, which were previously non-reusable, are also very expensive.

The CEO of Merck has announced a major breakthrough in the fight against lung cancer. Keytruda “is a new category of drugs that stimulates the body’s immune system.” “Using Keytruda,” Kenneth Frazier said, “will extend [the life of lung cancer sufferers] … by approximately 13 months on average. We know that it will reduce the risk of death by 30-40 percent for people who had failed on standard chemo-therapy.”

Also, there has been massive progress in the development of “edible electronics.” New technology developed by Bristol Robotics Laboratory “will allow the doctor to feel inside your body without making a single incision, effectively taking the tips of the doctor’s fingers and transplant them onto the exterior of the [edible] robotic pill. When the robot presses against the interior of the intestinal tract, the doctor will feel the sensation as if her own fingers were pressing the flesh.”

Marian L. Tupy is the editor of HumanProgress.org and a senior policy analyst at the Center for Global Liberty and Prosperity. He specializes in globalization and global wellbeing, and the political economy of Europe and sub-Saharan Africa. His articles have been published in the Financial Times, Washington Post, Los Angeles Times, Wall Street Journal, U.S. News and World Report, The Atlantic, Newsweek, The U.K. Spectator, Weekly Standard, Foreign Policy, Reason magazine, and various other outlets both in the United States and overseas. Tupy has appeared on The NewsHour with Jim Lehrer, CNN International, BBC World, CNBC, MSNBC, Al Jazeera, and other channels. He has worked on the Council on Foreign Relations’ Commission on Angola, testified before the U.S. Congress on the economic situation in Zimbabwe, and briefed the Central Intelligence Agency and the State Department on political developments in Central Europe. Tupy received his B.A. in international relations and classics from the University of the Witwatersrand in Johannesburg, South Africa, and his Ph.D. in international relations from the University of St. Andrews in Great Britain.

This work by Cato Institute is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

Malaria, Sickle-Cell Anemia, and Natural Selection (2003) – Article by G. Stolyarov II

Malaria, Sickle-Cell Anemia, and Natural Selection (2003) – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
July 26, 2014
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Note from the Author: This essay was originally written in 2003 and published on Associated Content (subsequently, Yahoo! Voices) in 2007.  The essay earned over 13,000 page views on Associated Content/Yahoo! Voices, and I seek to preserve it as a valuable resource for readers, subsequent to the imminent closure of Yahoo! Voices. Therefore, this essay is being published directly on The Rational Argumentator for the first time.  ***
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~ G. Stolyarov II, July 26, 2014
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The Genetics Behind the Survival of Sickle-Cell Disease

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This paper explores the genetics behind malaria and sickle-cell anemia, a fascinating case where the presence of an allele for sickle-cell anemia prevents individuals from getting malaria. This effect explains the presence of some natural selection in favor of the sickle-cell anemia allele.
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Alternative versions of a gene are alleles. Each gene resides at a specific chromosome locus. The DNA at that locus, however, can vary somewhat in sequence of nucleotides and information content. Alleles are these possible DNA variations.

Individuals who are homozygous for an allele have both alleles of the same sort, one on each pertinent locus of two homologous chromosomes. Individuals who are heterozygous for an allele have two different alleles, one on each of the homologous chromosomes.

Natural selection through differential reproductive success can cause allele frequencies in a population to change. Disasters or dramatic changes in the environment can also bring about a bottleneck effect whereby the small quantity of individuals remaining does not statistically represent the former population. Thus, the available gene pool has been altered dramatically.

Malaria is a tropical disease transmitted through the bite of a mosquito. The malarial protozoa infect the liver and reproduce, subsequently infecting the victim’s red blood cells and becoming available for transfer to other individuals via another mosquito.

People in Africa or of African descent often carry the sickle-cell anemia allele because heterozygotes for the allele can be protected from malaria while not exhibiting considerable symptoms of sickle-cell anemia. They can survive to reproductive age and transfer the allele to offspring, thus perpetuating the allele’s occurrence in the gene pool.

Natural selection can serve as a mechanism for the survival in heterozygotes of certain recessive alleles which pose great harm to recessive homozygotes. If the allele confers an advantage to a heterozygote that is lacked by the dominant homozygote (which in this case is vulnerable to malaria), this allele can be spread to future generations, since its carriers reach reproductive age with greater likelihood. In a different environment, however, where malaria does not occur frequently or at all, there will be little or no survival advantage from being a carrier of the sickle-cell allele. Although these individuals can still reproduce without great obstacles, they are no longer favored over the homozygous dominant genotype. Thus, in places such as the United States, the sickle-cell allele is not nearly as frequent as in the tropical regions of Africa. Nevertheless, it does occur in a very small percentage of the population of African descent, seeing as insufficient time has passed in order for the allele frequency to decline to negligible amounts.

One of the reasons why sickle-cell disease can still potentially exist in malaria-free environments is the fact that heterozygotes’ normal phenotypes “mask” the existence of the allele within their genotypes. Thus, they can mate with healthy heterozygote partners and produce diseased offspring. Perhaps technological advancement in the near future will enable individuals to learn of their own genotypes and the possibility of transferring such diseases to their children, thus enabling them to make more prudent decisions concerning reproduction. Heterozygotes may choose to marry dominant homozygotes in the United States, or clone themselves in Africa so as to ensure that malaria resistance will be passed to their children without the risk of them acquiring sickle-cell disease.

Yet natural selection does not always function in a perfect or desirable manner. In many experimental cases, introducing just one heterozygote into an area with high rates of malaria death failed to establish the sickle-cell allele. Many factors can account for this, including the possibility that the heterozygote did not transfer the recessive allele to his offspring, or that he died of a cause absolutely unrelated to malaria or sickle-cell anemia prior to transferring the allele to offspring.

An Analysis of Ethical Issues in the Film “Jurassic Park” (2004) – Article by G. Stolyarov II

An Analysis of Ethical Issues in the Film “Jurassic Park” (2004) – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
July 26, 2014
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Note from the Author: This essay was originally written in 2004 and published on Associated Content (subsequently, Yahoo! Voices) in 2007.  The essay earned over 18,000 page views on Associated Content/Yahoo! Voices, and I seek to preserve it as a valuable resource for readers, subsequent to the imminent closure of Yahoo! Voices. Therefore, this essay is being published directly on The Rational Argumentator for the first time.  ***
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~ G. Stolyarov II, July 26, 2014
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The central ethical dilemma of the 1993 Steven Spielberg film, Jurassic Park, hinges on the question of whether man should employ his knowledge of genetics to revive a species that had become extinct as a result of natural processes. The scenario presented by the film is one of utter pandemonium and devastation after carnivorous dinosaurs, such as velociraptors and Tyrannosaurus rex defy security measures and trample on the human-built infrastructure of Jurassic Park. From this arises a more complex series of questions: to what extent should man manipulate genetic information? Which species can he legitimately revive, and which must he refrain from reanimating? At which point is it proper to state that one has taken sufficient precautions against potential threats and proceed with a given project?
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John Hammond is the founder of Jurassic Park, an entrepreneur who wants to give his visitors an absolutely genuine experience in observing revived dinosaurs and omit no element of the Mesozoic era, even the carnivorous dinosaurs that view humans as prey. Hammond introduces a group of scientists to Jurassic Park and seeks to convince them to give their professional endorsement to the endeavor as a means of mollifying his investors. He repeatedly ignores warnings from Dr. Malcolm and others that the situation is likely to go awry and arranges the tour to take place when there is a high likelihood of a storm occurring. In the meantime, Dennis Nedry, who programs the security systems in Jurassic Park, seeks to steal valuable dinosaur embryos and sell them on the black market. In order to escape and cause havoc in Jurassic Park, he disables the security systems and lets the dinosaurs loose during the storm. By the time the security systems are reestablished, the dinosaurs have already penetrated the main compound.

Dr. Ian Malcolm is a chaos theorist who constantly warns that Hammond’s seeming control over the course Jurassic Park will follow is a mere illusion, that there are numerous factors that cannot be foreseen when two species separated by 65 million years of evolutionary history collide. His prediction is realized, as the all-female contingent of dinosaurs finds a way to reproduce by spontaneously changing sex, as their frog DNA permits. Drs. Grant and Sappler, specialists in the fauna and flora of the Mesozoic, display concern about Hammond’s introduction of certain species into the park which would not be able to adapt to an age in which they do not belong and behave as if they were still in the Mesozoic.

In order to protect visitors from the dinosaurs, Jurassic Park possesses a system of security fences and remote feeding, which allows goats and other medium-sized mammals to be airlifted into the dinosaur cages while keeping humans out of harm’s way. Unfortunately, this does not take into account the fact that carnivorous dinosaurs are instructed by their instincts to hunt their prey, not ingest passive critters that are delivered to them. When Nedry disables the security systems, the dinosaurs have their chance to lunge at the tour vans in search of more active, human prey. They have also begun to feed on one another, the velociraptors consuming small dinosaurs and being in turn hunted by T. rex. The velociraptors are the most agile, coordinated, and intelligent of the dinosaurs, and have even learned to open door handles, surprising even the initial skeptics of the Jurassic Park endeavor. During the course of the dinosaurs’ siege of the Jurassic Park compound, Hammond’s hopes to revive Jurassic Park with enhanced security measures are shattered, and the objective of the humans becomes, as Dr. Sappler suggested, to save the lives of those endangered by the catastrophe. Hammond is not thrilled with the destruction of his most ambitious dream, and regretfully eyes the fossilized mosquito at the tip of his cane, but he must eventually come to terms with the reality of his experiment’s failure.

Jurassic Park’s failure results in numerous fatalities, including that of the visiting lawyer, the chief programmer, and the man in charge of feeding and containing the dinosaurs. Other lives are placed on the line, including those of Dr. Grant, Dr. Malcolm, and Hammond’s own grandchildren. Even after security is established, no place on the island is safe, as the velociraptors penetrate into the main compound and a helicopter is summoned to evacuate the survivors. Aside from the human toll, the consequences of leaving an unmonitored dinosaur ecosystem in place are problematic, to say the least. The dinosaurs are able to breed and entrench themselves on the island. The films which follow Jurassic Park explore the situation on the island after humans return to it to face a far stronger and more aggressive dinosaur population. Moreover, The Lost World depicts a threat to the mainland human population as a T. rex is illegally imported into the United States. These problems were, obviously, not foreseen by Hammond and other creators of Jurassic Park.

The creation of Jurassic Park was an attempt at beneficence, intended to grant visitors of all economic standings an experience hitherto closed to them, a glimpse at an era 65 million years in the past. Moreover, Hammond sought to exercise his autonomy in employing scientific knowledge of genetics to engineer new species in order to earn profit and personal satisfaction. However, the principle of nonmaleficence was neglected in this process, since, though Hammond did take security precautions intended to avoid harm to visitors, he did not fully consider other potential threats and carried the project forward without analyzing possible implications of blending dinosaur DNA with that of frogs or subjecting the park’s security to the control of the unstable and unreliable Dennis Nedry.

An alternate course of action to the swift establishment of Jurassic Park would have been to proceed at a more cautious pace and be more discriminatory as to the features included in the park. Herbivorous dinosaurs alone would not have posed a dramatic threat to human lives, and would likely have been docile enough to be contained by the security measures that the park possessed. This is supported by the fact that Dr. Grant and Hammond’s grandchildren were able to pet a gigantic herbivore and only received a burst of mucus in the face.

Moreover, a more selective process for employment at Jurassic Park might have been able to weed out individuals like Nedry, who was principally responsible for security failures. Every field of human existence has its blackguards and deceivers. This does not justify curtailing endeavors in those fields, but it does warrant a more stringent approach toward keeping those individuals out of positions of power.

As for employing the DNA of frogs, it might have been possible to locate a species that does not spontaneously change sex and use its genes to fill the “gaps” in dinosaur DNA. Dr. Malcolm’s ideas of a complex interplay of factors determining the outcome of a given event should not deter individuals from undertaking endeavors as novel and ambitious as Jurassic Park, but the complexity, which I think is perfectly within the grasp of human cognition, does need to be taken into account. This would fit the ethics of principlism, as Jurassic Park already fulfills the standards of beneficence and autonomy, and nonmaleficence can be achieved by taking stricter precautions to control the dinosaurs and the security measures of the park. The principle of justice would necessitate that individuals like Hammond have the right, like all others living in a free country, to use their property and create a profit-making venture (this can be termed comparative justice in a paradigm where the right to free enterprise exists in a majority of cases).

To Accept Aging and Death is to Choose Aging and Death – Article by Reason

To Accept Aging and Death is to Choose Aging and Death – Article by Reason

The New Renaissance Hat
Reason
April 1, 2014
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It is in the nature of things for people to become more accepting of the imperfect state of the world and the flawed human condition with advancing age, to lose that youthful indignation and urge to change all that causes suffering and injustice. We can blame a range of things for this, but I suspect that it has a lot to do with the growth in wealth and connections that occurs over the years for most individuals. Whatever your starting level, on average the 50-year-old you will be in a better place than the 20-year-old you. The gains you have amassed merge with nostalgia in a slow erosion of the desire to tear down walls and shake up your neighbors: things are better for you, and isn’t that a good thing? Not everyone is this way, of course, but it is a dynamic to be aware of in your relationship with the world. It is human nature to measure today against yesterday, and feel good about gains that are relatively large but absolutely small.

Acceptance of death and aging is the mindset I am thinking in particular here. The unpleasant ends of life are dim and distant myths when you are young and vigorous in your search for world-changing causes. It is the rare young individual who is willing to devote his or her life in preparation for a time half a century down the road. The older folk who feel the pressures of time and encroaching frailty are those who have become more accepting, however. To fight aging and work on rejuvenation treatments is an intrinsically hard sell in comparison to many other ventures. The youth think they have time to focus on other matters first, and the old have come to terms.

Nonetheless, with rapid progress in biotechnology year after year the number of people needed to get the job done is falling rapidly. Ten million supporters willing to put in a little time or money (rather than just a wave and a good word) and the careers of a few thousand scientists and biotechnicians is probably more than is needed at this point, a level of support that lies in a similar ballpark to that of the cancer or stem-cell research communities. We are not there yet, though support for scientific, medical approaches to the treatment and prevention of aging has grown in a very encouraging fashion over the past decade. At any time in the next year or so you might see mainstream press articles in noted publications favorably mention the SENS Research Foundation, regenerative medicine, Google’s Calico initiative, and progress in genetic science all in the same few paragraphs.

We are here, where we are, precisely because numerous people retained a youthful fire and verve, and indignation and horror of aging and death. Despite the ever-present opposition from a mainstream that once mocked aging research, these iconoclasts put in the work that has raised funds, created organizations, and changed minds: all seeds for tomorrow’s grand rejuvenation research community. This is a work in progress. But let us take a moment to admire some of the fire from those driving things along at the grassroots level:

Those Critical of Indefinite Life Extension Fear Life

Quote:

Accepting death is in fact choosing it. In the face of recent discoveries and progress in science, medicine, technology – it is a matter of choice. Pretending to be fearless in the face of death isn’t some form of heroism. It isn’t reasonable or courageous. It is quite the opposite. It is taking the easy way out. Let’s repeat it – death really is the easy way out. You fall asleep; you get a bullet; cancer kills you; some choose suicide; some accept aging and its effects as an inexorable given. The hard truth here that we should be prepared to acknowledge is: accepting death is the true cowardice, no matter the circumstances. Fighting it and choosing life is the true courage.

Critics of indefinite life extension, don’t put on a snide, condescending face and tell me that you aren’t afraid of death, because you are, too.

By your own knee-jerk flippancy, reactionary admission, you are also afraid of life. You’re afraid of death, and you’re afraid of life. You say, right to us, all the time, that you don’t want to bear to deal with the drastic changes, you don’t want to live without all your friends and family around, you don’t want to live with war still being a reality anywhere. You can’t stand all the jerks and the dangerous people, and rich people, or tyrants, controlling you for one decade longer than a traditional lifespan. The thought of it makes you want to jump into your grave right now to get away from this big, bad, scary life.

You, my friend, are afraid of life. Living scares you. You think of life and you cower. You see the challenges of life and you’re too scared to face them. You wouldn’t dare form and join teams and initiatives to meet those challenges on the intellectual combat fields of dialectics and action. You don’t have what it takes. Life isn’t for you. It’s not your thing. So love your death, fear your life. Do that if that’s what you want.

I am afraid of death. It scares me to think of losing my life. I value my life. I have no shame in that. That is the reasonable thing to do. What I have shame for is that anybody would think that being afraid of death might possibly be something to mock.

You mock us for being afraid of death. We are afraid of death; it’s a logical and positive thing to be afraid in the face of it. It reminds a person to take action against danger. It’s your being afraid of life that is to be mocked. So stand up and tell us how afraid you are of living. We promise not to look upon you with too much shame, and we promise to lend you a hand if you need help crossing over to the land of reason.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 

This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

23andMe and the FDA’s Travesty of Justice – Video by G. Stolyarov II

23andMe and the FDA’s Travesty of Justice – Video by G. Stolyarov II

Mr. Stolyarov explains that the US Food and Drug Administration has hit a new low in warning the genetic testing service 23andMe to halt sales of its $99 testing kits. The kits are not a drug or medical treatment; they merely provide information and violate no one’s rights. The irrationality of some people is used as an excuse to deny everyone else potentially life-saving information while establishing artificial barriers that would prevent declines in the cost of medical care.

References
– “FDA warns Google-backed 23andMe to halt sales of genetic tests” – Toni Clarke – Reuters – November 25, 2013
23andMe Website
Petition to “overrule the FDA’s decision to bar 23andMe from selling their potentially life-saving diagnostic kits”