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Squishy Machines: Bio-Cybernetic Neuron Hybrids – Article by Franco Cortese

Squishy Machines: Bio-Cybernetic Neuron Hybrids – Article by Franco Cortese

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The New Renaissance Hat
Franco Cortese
May 25, 2013
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This essay is the eighth chapter in Franco Cortese’s forthcoming e-book, I Shall Not Go Quietly Into That Good Night!: My Quest to Cure Death, published by the Center for Transhumanity. The first seven chapters were previously published on The Rational Argumentator under the following titles:
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By 2009 I felt the major classes of physicalist-functionalist replication approaches to be largely developed, producing now only potential minor variations in approach and procedure. These developments consisted of contingency plans in the case that some aspect of neuronal operation couldn’t be replicated with alternate, non-biological physical systems and processes, based around the goal of maintaining those biological (or otherwise organic) systems and processes artificially and of integrating them with the processes that could be reproduced artificially.

2009 also saw further developments in the computational approach, where I conceptualized a new sub-division in the larger class of the informational-functionalist (i.e., computational, which encompasses both simulation and emulation) replication approach, which is detailed in the next chapter.

Developments in the Physicalist Approach

During this time I explored mainly varieties of the cybernetic-physical functionalist approach. This involved the use of replicatory units that preserve certain biological aspects of the neuron while replacing certain others with functionalist replacements, and other NRUs that preserved alternate biological aspects of the neuron while replacing different aspects with functional replacements. The reasoning behind this approach was twofold. The first was that there was a chance, no matter how small, that we might fail to sufficiently replicate some relevant aspect(s) of the neuron either computationally or physically by failing to understand the underlying principles of that particular sub-process/aspect. The second was to have an approach that would work in the event that there was some material aspect that couldn’t be sufficiently replicated via non-biological physically embodied systems (i.e., the normative physical-functionalist approach).

However, these varieties were conceived of in case we couldn’t replicate certain components successfully (i.e., without functional divergence). The chances of preserving subjective-continuity in such circumstances are increased by the number of varieties we have for this class of model (i.e., different arrangements of mechanical replacement components and biological components), because we don’t know which we would fail to functionally replicate.

This class of physical-functionalist model can be usefully considered as electromechanical-biological hybrids, wherein the receptors (i.e., transporter proteins) on the post-synaptic membrane are integrated with the artificial membrane and in coexistence with artificial ion-channels, or wherein the biological membrane is retained while the receptor and ion-channels are replaced with functional equivalents instead. The biological components would be extracted from the existing biological neurons and reintegrated with the artificial membrane. Otherwise they would have to be synthesized via electromechanical systems, such as, but not limited to, the use of chemical stores of amino-acids released in specific sequences to facilitate in vivo protein folding and synthesis, which would then be transported to and integrated with the artificial membrane. This is better than providing stores of pre-synthesized proteins, due to more complexities in storing synthesized proteins without decay or functional degradation over storage-time, and in restoring them from their “stored”, inactive state to a functionally-active state when they were ready for use.

During this time I also explored the possibility of using the neuron’s existing protein-synthesis systems to facilitate the construction and gradual integration of the artificial sections with the existing lipid bilayer membrane. Work in synthetic biology allows us to use viral gene vectors to replace a given cell’s constituent genome—and consequently allowing us to make it manufacture various non-organic substances in replacement of the substances created via its normative protein-synthesis. We could use such techniques to replace the existing protein-synthesis instructions with ones that manufacture and integrate the molecular materials constituting the artificial membrane sections and artificial ion-channels and ion-pumps. Indeed, it may even be a functional necessity to gradually replace a given neuron’s protein-synthesis machinery with protein-synthesis-based machinery for the replacement, integration and maintenance of the non-biological sections’ material, because otherwise those parts of the neuron would still be trying to rebuild each section of lipid bilayer membrane we iteratively remove and replace. This could be problematic, and so for successful gradual replacement of single neurons, a means of gradually switching off and/or replacing portions of the cell’s protein-synthesis systems may be required.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

How Can I Live Forever?: What Does and Does Not Preserve the Self – Video by G. Stolyarov II

How Can I Live Forever?: What Does and Does Not Preserve the Self – Video by G. Stolyarov II

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When we seek indefinite life, what is it that we are fundamentally seeking to preserve? Mr. Stolyarov discusses what is necessary for the preservation of “I-ness” – an individual’s direct vantage point: the thoughts and sensations of a person as that person experiences them directly.

Once you are finished with this video, you can take a quiz and earn the “I-ness” Awareness Open Badge.

Reference

– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Essay by G. Stolyarov II

Thoughts on Zoltan Istvan’s “The Transhumanist Wager” – A Review – Video by G. Stolyarov II

Thoughts on Zoltan Istvan’s “The Transhumanist Wager” – A Review – Video by G. Stolyarov II

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Zoltan Istvan’s new novel The Transhumanist Wager has been compared to Ayn Rand’s Atlas Shrugged. But to what extent are the books alike, and in what respects? In this review, Mr. Stolyarov compares and contrasts the two novels and explores the question of how best to achieve radical life extension and general technological progress for the improvement of the human condition.

References

– The Transhumanist Wager Official Page
– “Thoughts on Zoltan Istvan’s ‘The Transhumanist Wager’: A Review” – Article by G. Stolyarov II
– Guilio Prisco’s Review of The Transhumanist Wager
– “Larry Page wants to ‘set aside a part of the world’ for unregulated experimentation” – Nathan Ingraham – The Verge – May 15, 2013
– Zoltan Istvan’s Reddit AMA

Thoughts on Zoltan Istvan’s “The Transhumanist Wager”: A Review – Article by G. Stolyarov II

Thoughts on Zoltan Istvan’s “The Transhumanist Wager”: A Review – Article by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II
May 18, 2013
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Zoltan Istvan’s new novel The Transhumanist Wager has been compared to Ayn Rand’s Atlas Shrugged. (See, for instance, Giulio Prisco’s review.) But to what extent are the books alike, and in what respects? To be sure, the story and the writing style are gripping, the characters are vivid, and the universe created by Istvan gave me an experience highly reminiscent of my reading of Atlas Shrugged more than a decade ago. Even this alone allows me to highly recommend The Transhumanist Wager as a work of literary art – a philosophical thriller. Moreover, the didactic purpose of the novel, its interplay of clearly identified good and evil forces, and its culmination in an extensive speech where the protagonist elaborates on his philosophical principles (as well as its punctuation by multiple smaller speeches throughout) provide clear parallels to Atlas Shrugged.

Giulio Prisco calls the philosophy of The Transhumanist Wager’s protagonist, Jethro Knights, “an extreme, militant version of the radically libertarian formulation of transhumanism”. However, this is the area where I perceive the most significant departure from the parallels to Atlas Shrugged. Ayn Rand’s philosophy of Objectivism (which she did not like to be called “libertarian”, though it was in essence) has the principle of individual rights and the rejection of the initiation of force at its ethical core. Galt’s Gulch in Atlas Shrugged was formed by a withdrawal of the great thinkers and creators from the world of those who exploited and enslaved them. However, there was no active conquest of that world by Rand’s heroes; rather, without the men of the mind, the power structures of the world simply fell apart on their own accord.

Jethro Knights creates his own seasteading nation, Transhumania, a fascinating haven for innovation and a refuge for transhumanist scientists oppressed by their governments and targeted by religious fundamentalist terrorism. The concept of an autonomous bastion of innovation is timely and promising; it was echoed by the recent statements from Larry Page of Google in favor of setting aside a part of the world to allow for unbridled experimentation. Transhumania, due to its technological superiority, spectacularly beats back a hostile invasion by the combined navies of the world. It is when the Transhumanians go on the offensive that the parallels to Galt’s Gulch cease. Instead of letting the non-transhumanist world crumble or embrace transhumanism on its own accord, Jethro Knights conquers it, destroys all of its political, religious, and cultural centerpieces, and establishes a worldwide dictatorship – including some highly non-libertarian elements, such as compulsory education, restrictions on reproduction, and an espousal of the view that even some human beings who have not initiated force may not have an inviolate right to their lives, but are rather judged on their “usefulness” – however defined (perhaps, in the case of Transhumania, usefulness in advancing the transhumanist vision as understood by Jethro Knights). Jethro Knights permits a certain degree of freedom – enough to sustain technological progress, high standards of living, and due process in the resolution of everyday disputes – but, ultimately, all of the liberties in Transhumania are contingent on their compatibility with Jethro’s own philosophy; they are not recognized as absolute rights even for those who disagree. John Galt would have been gentler. He would have simply withdrawn his support from those who would not deal with him as honest creators of value, but he would have left them to their own devices otherwise, unless they initiated force against him and against other rational creators of value.

The outcome of The Transhumanist Wager is complicated by the fact that Jethro’s militancy is the direct response to the horrific acts of terrorism committed by religious fundamentalists at the behest of Reverend Belinas, who also has considerable behind-the-scenes influence on the US government in the novel. Clearly, the anti-transhumanists were the initiators of force for the majority of the novel, and, so long as they perpetrated acts of violence against pro-technology scientists and philosophers, they were valid targets for retaliation and neutralization – just like all terrorists and murderers are. For the majority of the book, I was, without question, on Jethro’s side when it came to his practice, though not always his theory – but it was upon reading about the offensive phase of his war that I came to differ in both, especially since Transhumania had the technological capacity to surgically eliminate only those who directly attacked it or masterminded such attacks, thereafter leaving the rest of the world powerless to destroy Transhumania, but also free to come to recognize the merits of radical life extension and general technological progress on its own in a less jarring, perhaps more gradual process. An alternative scenario to the novel’s ending could have been a series of political upheavals in the old nations of the world, where the leaders who had targeted transhumanist scientists were recognized to be thoroughly wasteful and destructive, and were replaced by neutral or techno-progressive politicians who, partly for pragmatic reasons and partly arising out of their own attraction to technology, decided to trade with Transhumania instead of waging war on it.

Jethro’s concept of the “omnipotender” is a vision of the individual seeking as much power as he can get, ultimately aiming to achieve power over the entire universe. It is not clear whether power in this vision means simply the ability to achieve one’s objectives, or control in a hierarchical sense, which necessarily involves the subordination of other intelligent beings. I support power in the sense of the taming of the wilderness and the empowerment of the self for the sake of life’s betterment, but not in the sense of depriving others of a similar prerogative. Ayn Rand’s vision of the proper rationally egoistic outlook is extremely clear on the point that one must neither sacrifice oneself to others nor sacrifice others to oneself. Istvan’s numerous critical references to altruism and collectivism clearly express his agreement with the first half of that maxim – but what about the second? Jethro’s statements that he would be ready to sacrifice the lives of even those closest to him in order to achieve his transhumanist vision certainly suggest that the character of Jethro might not give others the same sphere of inviolate action that he would seek for himself. Of course, Jethro also dismisses as a contrived hypothetical the suggestion that such sacrifice would be necessary (at least, in Jethro’s view, for the time being), and I agree. Yet a more satisfying response would have been not that he is ready to make such a sacrifice, but that the sacrifice itself is absolutely not required for individual advancement by the laws of reality, and therefore it is nonsensical to even acknowledge its possibility. Jethro gave his archenemy, Belinas, far too much of a philosophical concession by even picking sides in the false dichotomy between self-sacrifice to others and the subjugation of others to oneself.

Perhaps the best way to view The Transhumanist Wager is as a cautionary tale of what might happen if the enemies of technological progress and radical life extension begin to forcefully clamp down on the scientists who try to make these breakthroughs happen. A climate of violence and terror, rather than civil discourse and an embrace of life-enhancing progress, will breed societal interactions that follow entirely different rules, and produce entirely different incentives, from those which allow a civilized society to smoothly function and advance. I hope that we, at least in the Western world, can avoid a scenario where those different rules and incentives take hold.

I am a transhumanist, but I am also a humanist, in the sense that I see the advancement of humanity and the improvement of the human condition as the desired aims of technological progress. In this sense, I am fond of the reference to the goal of transhumanists as the achievement of a “humanity plus”. Transhumanism is and ought to be, fundamentally, a continuation of the melioristic drive of the 18th-century Enlightenment, ridding man of the limitations and terrible sufferings which have historically been considered part of necessary “human nature” but which are, in reality, the outcome of the contingent material shortcomings with which our species happened to be burdened from its inception. Will it be possible to entice and persuade enough people to embrace the transhumanist vision voluntarily? I certainly hope so, since even a sizable minority of individuals would suffice to drive forward the technological advances which the rest of humanity would embrace for other, non-philosophical reasons.

In the absence of a full-fledged embrace of this humanistic vision of transhumanism, at the very least I hope that it would be possible to “sneak around” the common objections and restrictions and achieve a technological fait accompli through the dissemination of philosophically neutral tools, such as the Internet and mobile devices, that enhance individual opportunities and alter the balance of power between individuals and institutions. In this possible future, some of the old “cultural baggage” – as Jethro would refer to it – would most likely remain – including religions, which are among the hardest cultural elements for people to give up. However, this “baggage” itself would gradually evolve in its essential outlook and impact upon the world, much like Western Christianity today is far gentler than the Christianity of the 3rd, 11th, or 17th centuries. Perhaps, instead of fighting transhumanism, some representatives of old cultural labels will attempt to preserve their own relevance amidst transhuman-oriented developments. This will require reinterpreting doctrines, and will certainly engender fierce debate within many religious, political, and societal circles. However, there may yet be hope that the progressive wings of each of these old institutions and ideologies (“progressive” in the sense of being open to progress, not to be mistaken for any current partisan affiliation) will do the equivalent work to that entailed in a transhumanist revolution, except in a gradual, peaceful, seamless manner.

Yet, on the other hand, the immense urgency of achieving life extension is, without question, a sentiment I strongly identify with. Jethro’s experience, early in the novel, of stepping on a defective mine has autobiographical parallels to Istvan’s own experience in Vietnam. A brush with death certainly highlights the fragility of life and the urgency of pursuing its continuation. Pausing to contemplate that, were it not for a stroke of luck at some prior moment, one could be dead now – and all of the vivid and precious experiences one is having could one day be snuffed out, with not even a memory remaining – certainly motivates one to think about what the most direct, the most effective means of averting such a horrific outcome would be. Will a gradual, humane, humanistic transition to a world of indefinite life extension work out in time for us? What can we do to make it happen sooner? Can we do it within the framework of the principles of libertarianism in addition to those of transhumanism? Which approaches are the most promising at present, and which, on the other hand, could be counterproductive? How do we attempt to enlist the help of the “mainstream” world while avoiding or overcoming its opposition? For me, reading The Transhumanist Wager provided further impetus to keep asking these important, open, and as of yet unresolved questions – in the hopes that someday the ambition to achieve indefinite life extension in our lifetimes will give rise to a clear ultra-effective strategy that can put this most precious of all goals in sight.

The Moral Imperative and Technical Feasibility of Defeating Death – Article by Franco Cortese

The Moral Imperative and Technical Feasibility of Defeating Death – Article by Franco Cortese

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The New Renaissance Hat
Franco Cortese
May 5, 2013
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Consume my heart away; sick with desire
And fastened to a dying animal
It knows not what it is; and gather me
Into the artifice of eternity.
Once out of nature I shall never take
My bodily form from any natural thing,
But such a form as Grecian goldsmiths make
Of hammered gold and gold enameling
To keep a drowsy Emperor awake;
Or set upon a golden bough to sing
To lords and ladies of Byzantium
Of what is past, or passing, or to come.

~ W. B. Yeats

“The original is unfaithful to the translation.“

~ Jorge Luis Borges

“Whatever can be repaired gradually without destroying the original whole is, like the vestal fire, potentially eternal.“

~ Francis Bacon, A History of Life and Death, 1638

I became both Immortalist and Transhumanist long before I knew such designations existed. In 2006, at age 14, I conceived of both the extreme desirability and technical feasibility of ending death, without any knowledge of the proposals for immortality already extant. I thought I was the only one in the world who saw both the utter, belligerent waste of death, and our ability to technologically defeat it. I was dumbfounded that humanity wasn’t attacking the problem like any other preventable source of widespread suffering. I saw that the end of death was not only desirable but a moral imperative.
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If we have the power to make it happen, or have even a chance at doing so, yet fail to even try for reasons of inertia, incredulity, or indifference, then we are condemning massive amounts of real people to unnecessary death by our inaction. I felt a moral obligation to work on conceptual development of the various pragmatic aspects required  to physically realize indefinite longevity until I was old enough to physically put these developments into practice – i.e., do experiments and design physical systems. I worked on my grand project, as I thought of it, from August 2006 until May 2010, at which time I discovered multiple other approaches to indefinite longevity being actively developed (initially through Kurzweil’s The Singularity is Near), and even multiple antecedents of my own approach, I felt less of an imperative to continue active conceptual development on these procedures. I was happy to find the existing Immortalist movement, of course; I stopped not out of resentment for having been anteceded, but rather out of newfound assurance that the defeat of death didn’t lay solely in my hands.

I had worked for 4 years on conceptual designs and approaches to indefinite life extension – designs that I was planning on building and experimentally verifying in my young adulthood, whether through normative medical research and academia or through a privately funded venture, thinking that I would have more of a success than if I came to the world as a teenager with these ideas, as they were. By 2010, 4 years into the project, I discovered that others were seeking the defeat of death through technological intervention as well, and that many of the specific ideas I had come up with were already out and in the world.

My original approach involved transplanting the organic brain into a full cybernetic body. Over the next few months I collected research on experiments in organic brain transplantation done with salamanders, dogs, and monkeys , on maintaining the brain’s homeostatic and regulatory mechanisms outside the body and on a host of prosthetic and robotic technologies which I saw as developmentally converging to allow the creation of a fully cybernetic body. I soon realized that this approach was problematic; while the brain typically dies as a consequence of its homeostatic and regulatory mechanisms (i.e. heart and lungs failing), it would still fall prey to cell death if it remained organic, even if such regulatory mechanisms were maintained technologically.

This obstacle led to my conceiving the essential gestalt of uploading – the gradual replacement of neurons with functional equivalents that preserve each original neuron’s relative location and connection – three months later. Although my original approach was prosthetic (i.e., physically embodied functional equivalents of neurons), I eventually saw computational models as being preferable for their comparatively higher speed and ease of modification and/or modulation.

I discovered that Brain-Emulation and Connectomics (or Mind-Uploading more informally) was an existing discipline not long after conceiving of the idea, but at the time thought that various aspects required for gradual replacement (and thus for real immortality, and not the creation of an immortal double, were undeveloped in regard to how the computational models would communicate and maintain functional equilibrium with the existing biological neurons. If we seek to replace biological neurons with artificial equivalents, once we have a simulation of a given neuron in a computer outside the body, how is that simulated neuron to communicate with the biological neurons still inside that biological body, and vice versa? My solution was the use of initially MEMS (micro-electro-mechanical systems) but later NEMS (nano-electro-mechanical-systems) to detect biophysical properties via sensors and translate them into computational inputs, and likewise to translate computational output into biophysical properties via electrical actuators and the programmed release of chemical stores (essentially stored quantities of indexed chemicals to be released upon command). While the computational hardware could hypothetically be located outside the body, communicating wirelessly to corresponding in-vivo sensors and actuators, I saw the replacement of neurons with enclosed in-vivo computational hardware in direct operative connection with its corresponding sensors and actuators as preferable. I didn’t realize until 2010 that this approach—the use of NEMS to computationally model the neurons, to integrate (i.e., construct and place) the artificial neurons and translate to biophysical signals into computational signals and vice versa—was already suggested by Kurzweil and conceptually developed more formally by Robert Freitas, and when I did, I felt that I didn’t really have much to present that hadn’t already been conceived and developed.

However, since then I’ve come to realize some significant distinctions between my approach and Brain-Emulation, and that besides being an interesting story that helps validate the naturality of Immortalism’s premises (that indefinite longevity is a physically realizable state, and thus technologically realizable –  and what can be considered the “strong Immortalist” claim: that providing people the choice of indefinite longevity if it were realizable is a moral imperative), I had several novel notions and conceptions which might prove useful to the larger community working and thinking on these topics.

While this project began as a means of indefinite longevity, it took on Transhumanist concerns within days of its conception. A cybernetic body not only frees one from the strictures of death, but also from the limitations of a static body designed for a static environment. Freed from our flesh, we could comfortably bear any extremes of Earth or beyond; interchange our bodily designs with the nonchalance of attire; and continuously, on a daily basis, take charge of what it means for us to be. I envisioned extreme phenotypic diversity as undermining racism and prejudices, an explosion of intelligence and happiness consequent of finally taking the stuff of our being into our own hands, the newfound availability of heretofore unrealized modalities of being, experience, thought, morality, and abilities realized through the technological extension and enhancement of the mind.

By 2007, I was calling this philosophy “Enhancism”, which I designated as the thesis that enhancement is the principal underlying both human nature and evolutionary nature. Regardless of what constitutes an “enhancement”, the fact that we strive to reach idealized objectives and grow toward what we envision as better versions of our selves and our world exemplifies enhancement as the underlying driver and primal force that makes up Mind, Man, and Humanity. The objective or “optimization target” isn’t important – what is important is the act of designating an objective as better, and then striving in a fit of fiery thrusts toward it.

I never saw this imperative of improving ourselves using all available means as a move away from humanity, but rather as a natural extension and continuation of what has always best designated us as human. I realized that self-directed modification of both body and mind were not only both possible and desirable, but a natural extension of what humanity has been doing since long before the very concept of “humanity” existed. I had arrived at the essential premises and conclusions of both Immortalism and Transhumanism without exposure to existing forms of either. Indeed, this was even before I started reading science fiction!

I think this observation undermines what I feel to be a common misconception of outside of Transhumanist circles – that Transhumanism and Immortalism are fringe movements for statistical outliers with idiosyncratic interests. I think that this rather adds credence to rebuttal that Transhumanism and Immortalism exemplify the modern embodiment of all we’ve ever been; that they are not founded upon grandiose and overly contingent axioms, but rather on the respective premises that life is good and so should be extended for as long as possible and that we are more likely to create a better world and better selves than we are to find them already given.

If the underlying logic behind Immortalism and Transhumanism can be independently arrived at by a 14-year-old without any knowledge of historical or extant forms of either, then how removed from the human concerns of the majority can they really be? If they relied on a host of contingent hopes and deviant memetic baggage – if their claims or conclusions were overly complicated in any way – how could they be arrived at so readily and fluidly by an adolescent?

I also unwittingly recapitulated many specific Transhumanist objectives throughout the course of my “grand project”, as I had thought of it at the time. My approach of gradually replacing the neurons in the brain with functional equivalents would necessitate control over the processes exhibited by the replacements. This would allow us to actively and consciously control the variables and metrics determining neuronal behavior, not only modifying ourselves through the integration of additional NRUs (neuron-replication-units) or NRU-networks, but also through active modification and real-time modulation of the NRUs that would by then underlie our existing mental and experiential modalities, having replaced our existing biological neurons.

Within the first year of the project, I had conceived of using these new capabilities to make ourselves smarter (an unwitting recapitulation of intelligence-amplification), of making ourselves more ethical (an unwitting recapitulation of moral engineering, explored by such thinkers as James Hughes, Julian Savulescu and Asher Seidel, among others), and of actively making ourselves happier, or rather of eliminating those normative biological aspects that bias us needlessly towards unhappiness (an unwitting variant of David Pearce’s hedonistic imperative), and the exchange of real-time perception and memory deeper and of higher fidelity than sensory memories, essentially extending to thoughts, emotions, and indeed all experiential modalities available to us.

One could imagine my surprise upon finding Transhumanism and Immortalism as existing disciplines and movements; I felt as though I had borne a son and gone away for a day only to return and find him grown up – and that I was never his biological father to begin with.

The fact that both Transhumanist (i.e., enhancement, self-modification and self-modulation) and Immortalist concerns and conceptions developed concurrently throughout my work also reifies their having a shared gestalt. While they are not mutually inclusive (you can be one without being the other), they do share some strong similarities. They both eschew biological and naturalistic limitations, exalt autonomy and the provision of rights, and spring from a legitimate glorification of life and self.

The last point I would like to make here is one that I think helps subvert the superficial claim that Transhumanist or Immortalist objectives are essentially selfish concerns. At 14 I had no personal stake in trying to end death as fast as possible; both ending death and increasing our ability to better determine who we are and what we can do were from day one for the world and for broader humanity – particularly for those who didn’t have the majority of the rest of their lives to live: the 100,000 people who succumb to bitter finitude each day. I think most other Transhumanist and Immortalist thinkers would agree that any positive future involves broad access to both longevity treatments and to the latest means of improving and realizing ourselves.

None of these naïve misinterpretations are real concerns to Transhumanist and Immortalist communities, except in regards to the degree with which they prevent people from digging deep enough to discover their stark insubstantiality. While they may be so off-base as to make their fallaciousness readily obvious to members of either community, and thus a seeming non-issue, I think the way in which they engender public misconceptions about Transhumanism and Immortalism validates our need to dispel them. Transhumanism is the only humanism; it exemplifies the very heart of what makes us human. The “trans” and the “human” in Transhumanism can only signify each other, for to be human is to strive to become more than human. I’ve thought this from the beginning, and this is a direction that my thinking – while having developed significantly since the practical work described here – is still oriented toward.

I wonder how many others there are out there like me, yet to approach the world with their vast extrapersonal visions of self-directed self-realization, yet to find the daring to throw their raucous good works in the face of this world that deserves better than to simply die quietly and unquestioningly, without revolt; others who, like me, saw that to try and change the world for the better is the very namesake of Man; who’ve crafted star-spangled dreams as large and as belligerently righteous as ending death and taking definite control of our ever-indefinite and indefinitive selves.

To every riled child who has ever had a vision larger than himself but that he has been too afraid to reveal, who has ever dreamt of bounding past the boundaries of present and toward the real prize, who has ever felt a dire need to make Man more than he is: I call thee out of the whorlworks and into the world! Come, show us what you’ve done!

What follows in my subsequent essays is first a broad overview of my work in this area from 2006 to 2010 (at which time I had discovered enough Immortalist antecedents to stop actively working on conceptual varieties of techno-immortality), first in terms of my methodology for achieving indefinite longevity (i.e., my work in uploading or brain-emulation proper), and then in terms of the enhancement and modification side, focusing on similarities and differences between my vision and those developed in Transhumanism and Immortalism.

While this essay is largely personal and introductory, I think the fact of my independently arriving at many of the conceptual premises and conclusions of Transhumanism and Immortalism, and under different terms, also reifies the more substantial claim that Transhumanism isn’t as far-out as is normatively presumed—or perhaps rather that the “human” isn’t as right-here as is commonly supposed. For that curious creature of clamorous self-determination called Man is most familiar with unfamiliarity, and most at home in alien dendritic jungles, for having gone so far out as to come back around again.

While in 2010 I thought most of my ideas in regards to practical approaches to immortality as already conceived, I now see some differences between my approach and other conceptions of brain-emulation. One is the conceptual development of physical/prosthetic approaches to neuron replication and replacement (i.e., prosthetics on the cellular scale) in addition to strictly computational approaches. Another is several novel approaches to preserving both immediate subjective-continuity (that is, the ability to have subjective experience, sometimes called sentience – as opposed to sapience, which denotes our higher cognitive capacities like abstract thinking, thus humans have sentience and sapience while most non-mammals are thought to lack sapience but possess sentience) and temporal subjective-continuity (the property of feeling like the same subjective person as you did yesterday, or a week ago, or 10 years ago – despite the fact that all of the molecules constituting your brain are gone, having been replaced with identical molecules through metabolism – via molecular turnover rather than full-cell replacement – over the course of a seven-year period) through a gradual (neuron) replacement procedure that are to my knowledge yet to be explored by the wider techno-immortalist community and brain-emulation discipline, respectively.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Bibliography

(June 2012). International Journal of Machine Consciousness, 4 (1).

Browne, M. W. (2011). From science fiction to science: ‘the whole body transplant’. Retrieved February 28, 2013 from http://www.nytimes.com/1998/05/05/science/essay-from-science-fiction-to-science-the-whole-body-transplant.html

Demikhov, V. P. & (1962).Experimental transplantation of vital organs. Basil Haigh, transl. New York: Consultant’s Bureau Enterprises, Inc.

Grabianowski (2007). How Brain-computer Interfaces Work. Retrieved February 28, 2013 from http://computer.howstuffworks.com/brain-computer-interface.htm

Hickey, L. P. (2011). The brain in a vat argument. Internet encyclopedia of philosophy, 2011. Retrieved February 28, 2013 from http://www.iep.utm.edu/brainvat/

Kurzweil, R. (2005). The Singularity is Near. Penguin Books, p. 63-67.

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Life Extension and Risk Aversion – Video by G. Stolyarov II

Life Extension and Risk Aversion – Video by G. Stolyarov II

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Mr. Stolyarov explains that living longer renders people more hesitant to risk their lives, for the simple reason that they have many more years to lose than their less technologically endowed ancestors.

References
– “Life Extension and Risk Aversion” – Essay by G. Stolyarov II
– “Life expectancy variation over time” – Wikipedia
– Life Expectancy Graphs – University of Oregon
– History of Life Expectancy – WorldLifeExpectancy.com
– “Steven Pinker” – Wikipedia
– “The Better Angels of Our Nature” – Wikipedia
– “FBI Statistics Show Major Reduction in Violent Crime Rates” – WanttoKnow.info
– “List of motor vehicle deaths in U.S. by year” – Wikipedia
– “Prevalence of tobacco consumption” – Wikipedia
– “Human error accounts for 90% of road accidents” – Olivia Olarte – AlertDriving.com
– “Autonomous car” – Wikipedia
– “Iterative Learning versus the Student-Debt Trap” – Essay and Video by G. Stolyarov II

Life Extension and Risk Aversion – Article by G. Stolyarov II

Life Extension and Risk Aversion – Article by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II
April 28, 2013
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A major benefit of longer lifespans is the cultivation of a wide array of virtues. Prudence and forethought are among the salutary attributes that the lengthening of human life expectancies – hopefully to the point of eliminating any fixed upper bound – would bring about.

Living longer renders people more hesitant to risk their lives, for the simple reason that they have many more years to lose than their less technologically endowed ancestors.

This is not science fiction or mere speculation; we see it already. In the Western world, average life expectancies increased from the twenties and thirties in the Middle Ages to the early thirties circa 1800 to the late forties circa 1900 to the late seventies and early eighties in our time. As Steven Pinker writes in his magnum opus, The Better Angels of Our Nature, the overall trend in the Western world (in spite of temporary spikes of conflict, such as the World Wars) has been toward greater peace and increased reluctance of individuals to throw their lives away in armed struggles for geopolitical gain. Long-term declines in crime rates, automobile fatalities, and even smoking have accompanied (and contributed to) rises in life expectancy. Economic growth and improvements in the technologies of production help as well. If a person has not only life but material comfort to lose, this amplifies the reluctance to undertake physical risks even further.

Yet, with today’s finite lifespans, most individuals still find a non-negligible degree of life-threatening risk in their day-to-day endeavors to be an unavoidable necessity. Most people in the United States need to drive automobiles to get to work – in spite of the risk of sharing the road with incompetent, intoxicated, or intimidating other drivers. Over 30,000 people perish every year in the United States alone as a result of that decision. While the probability for any given individual of dying in an automobile accident is around 11 in 100,000 (0.011%) per year, this is still unacceptably high. How would a person with several centuries, several millennia, or all time ahead of him feel about this probability? Over a very long time, the probability of not encountering such a relatively rare event asymptotically approaches zero. For instance, at today’s rate of US automobile fatalities, a person living 10000 years would have a probability of (1 – 0.00011)^10000 = 0.3329 – a mere 33.29% likelihood – of not dying in an automobile accident! If you knew that a problem in this world had a two-thirds probability of killing you eventually, would you not want to do something about it?

Of course, the probabilities of tragic events are not fixed or immutable. They can be greatly affected by individual choices – our first line of defense against life-threatening risks. Well-known risk-management strategies for reducing the likelihood of any damaging event include (1) avoidance (not pursuing the activity that could cause the loss – e.g., not driving on a rugged mountain road – but this is not an option in many cases), (2) loss prevention (undertaking measures, such as driving defensively, that allow one to engage in the activity while lowering the likelihood of catastrophic failure), and (3) loss reduction (undertaking measures, such as wearing seat belts or driving in safer vehicles, that would lower the amount of harm in the event of a damaging incident). Individual choices, of course, cannot prevent all harms. The more fundamental defense against life-threatening accidents is technology. Driving itself could be made safer by replacing human operators, whose poor decisions cause over 90% of all accidents, with autonomous vehicles – early versions of which are currently being tested by multiple companies worldwide and have not caused a single accident to date when not manually driven.

Today, forward-thinking technology companies such as Google are driving the autonomous-vehicle revolution ahead. There is, unfortunately, no large clamor by the public for these life-saving cars yet. However, as life expectancies lengthen, that clamor will surely be heard. When we live for centuries and then for millennia, we will view as barbarous the age when people were expected to take frightening risks with their irreplaceable existences, just to make it to the office every morning. We will see the attempt to manually operate a vehicle as a foolish and reckless gamble with one’s life – unless one is a professional stunt driver who would earn millions in whatever future currency will then exist.

But living longer will accomplish more than just a changed perspective toward the risks presently within our awareness. Because of our expanded scope of personal interest, we will begin to be increasingly aware of catastrophes that occur at much longer intervals than human lifespans have occupied to date. The impacts of major earthquakes and volcano eruptions, recurring ice ages, meteor strikes, and continental drift will begin to become everyday concerns, with far more individuals devoting their time, money, and attention to developing technological solutions to these hitherto larger-than-human-scale catastrophes. With even more radically lengthened lifespans, humans will be motivated to direct their efforts, including the full thrust of scientific research, toward overcoming the demise of entire solar systems. In the meantime, there would be less tolerance for any pollution that could undermine life expectancies or the long-term sustainability of a technological infrastructure (which, of course, would be necessary for life-extension treatments to continue keeping senescence at bay). Thus, a society of radical life extension will embrace market-generated environmentally friendly technologies, including cleaner energy sources, reuse of raw materials (for instance, as base matter for 3D printing and nanoscale fabrication), and efficient targeting of resources toward their intended purposes (e.g., avoidance of wasted water in sprinkler systems or wasted paper in the office).

When life is long and good, humans move up on the hierarchy of needs. Not starving today ceases to be a worry, as does not getting murdered tomorrow. The true creativity of human faculties can then be directed toward addressing the grand, far more interesting and technologically demanding, challenges of our existence on this Earth.

Some might worry that increased aversion to physical risk would dampen human creativity and discourage people from undertaking the kinds of ambitious and audacious projects that are needed for technological breakthroughs to emerge and spread. However, aversion to physical risk does not entail aversion to other kinds of risk – social, economic, or political. Indeed, social rejection or financial ruin are not nearly as damaging to a person with millennia ahead of him as they are to a person with just a few decades of life left. A person who tries to run an innovative business and fails can spend a few decades earning back the capital needed to start again. Today, few entrepreneurs have that second chance. Most do not even have a first chance, as the initial capital needed for a groundbreaking enterprise is often colossal. Promising ideas and a meritorious character do not guarantee one a wealthy birth, and thus even the best innovators must often start with borrowed funds – a situation that gives them little room to explore the possibilities and amplifies their ruin if they fail.  The long-lived entrepreneurs in a world of indefinite life extension would tend to earn their own money upfront and gradually go into business for themselves as they obtain the personal resources to do so. This kind of steady, sustainable entry into a line of work allows for a multitude of iterations and experiments that maximize the probability of a breakthrough.

Alongside the direct benefits of living longer and the indirect benefits of the virtues cultivated thereby, indefinite life extension will also produce less stressful lives for most. The less probability there is of dying or becoming seriously injured or ill, the easier one can breathe as one pursues day-to-day endeavors of self-improvement, enjoyment, and productive work. The less likely a failure is to rob one of opportunities forever, the more likely humans will be to pursue the method of iterative learning and to discover new insights and improved techniques through a beneficent trial-and-error process, whose worst downsides will have been curtailed through technology and ethics. Life extension will lead us to avoid and eliminate the risks that should not exist, while enabling us to safely pursue the risks that could benefit us if approached properly.

Liberty Through Long Life – Video by G. Stolyarov II

Liberty Through Long Life – Video by G. Stolyarov II

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To maximize their hopes of personally experiencing an amount of personal freedom even approaching that of the libertarian ideal, all libertarians should support radical life extension.

References
– “Liberty Through Long Life” – Essay by G. Stolyarov II –
– Resources on Indefinite Life Extension (RILE) –
– “Libertarian Life-Extension Reforms” – Video Series – G. Stolyarov II –
– “Massive open online course” – Wikipedia
– Mozilla’s Open Badges
– “Open Badges and Proficiency-Based Education: A Path to a New Age of Enlightenment” – Essay by G. Stolyarov II
– “Deep Space Industries” – Wikipedia
– “Planetary Resources” – Wikipedia
– The Seasteading Institute
– “Seasteading’s Potential and Challenges: An Overview” — Essay by G. Stolyarov II
– “Seasteading’s Potential and Challenges: An Overview” — Video by G. Stolyarov II
– “Bitcoin” – Wikipedia
– “Benjamin Franklin and the Early Scientific Vision – 1780” – Foundation for Infinite Survival
– “Revisiting the proto-transhumanists: Diderot and Condorcet” – George Dvorsky – Sentient Developments
– “Marquis de Condorcet, Enlightenment proto-transhumanist” – George Dvorsky – IEET
– SENS Research Foundation
– “Ray Kurzweil” – Wikipedia

Liberty Through Long Life – Article by G. Stolyarov II

Liberty Through Long Life – Article by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II
April 14, 2013
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            It is commonly recognized among libertarians (and some others) that the freedom of individuals to innovate will result in a more rapid rate of technological progress. In “Six Libertarian Reforms to Accelerate Life Extension” I described six liberty-enhancing political changes that would more swiftly bring about the arrival of indefinite human longevity. But, as is less often understood, the converse of this truth also holds. Technological progress in general improves the prospects for liberty and its actual exercise in everyday life. One of the most promising keys to achieving liberty in our lifetimes is to live longer so that we can personally witness and benefit from accelerating technological progress.

            Consider, for example, what the Internet has achieved with respect to expanding the practical exercise of individual freedom of speech. It has become virtually impossible for regimes, including their nominally private “gatekeepers” of information in the mass media and established publishing houses, to control the dissemination of information and the expression of individual opinion. In prior eras, even in countries where freedom of speech was the law of the land, affiliations of the media, by which speech was disseminated, with the ruling elite would serve as a practical barrier for the discussion of views that were deemed particularly threatening to the status quo. In the United States, effective dissent from the established two-party political system was difficult to maintain in the era of the “big three” television channels and a print and broadcast media industry tightly controlled by a few politically connected conglomerates. Now expressing an unpopular opinion is easier and less expensive than ever – as is voting with one’s money for an ever-expanding array of products and services online. The ability of individuals to videotape public events and the behavior of law-enforcement officers has similarly served as a check on abusive behavior by those in power. Emerging online education and credentialing options, such as massive open online courses and Mozilla’s Open Badges, have the power to motivate a widespread self-driven enlightenment which would bring about an increased appreciation for rational thinking and individual autonomy.

            Many other technological advances are on the horizon. The private space race is in full swing, with companies such as SpaceX, Virgin Galactic, Deep Space Industries, and Planetary Resources embarking on ever more ambitious projects. Eventually, these pioneering efforts may enable humans to colonize new planets and build permanent habitats in space, expanding jurisdictional competition and opening new frontiers where free societies could be established. Seasteading, an idea only five years in development, is a concept for building modular ocean platforms where political experimentation could occur and, through competitive pressure, catalyze liberty-friendly innovations on land. (I outlined the potential and the challenges of this approach in an earlier essay.) The coming decades could see the emergence of actual seasteads of increasing sophistication, safety, and political autonomy. Another great potential for increasing liberty comes from the emerging digital-currency movement, of which Bitcoin has been the most prominent exemplar to date. While Bitcoin has been plagued with recent extreme exchange-rate volatility and vulnerability to manipulation and theft by criminal hackers, it can still provide some refuge from the damaging effects of inflationary and redistributive central-bank monetary policy. With enough time and enough development of the appropriate technological infrastructure, either Bitcoin or one of its successor currencies might be able to obtain sufficient stability and reliability to become a widespread apolitical medium of exchange.

            But there is a common requirement for one to enjoy all of these potential breakthroughs, along with many others that may be wholly impossible to anticipate: one has to remain alive for a long time. The longer one remains alive, the greater the probability that one’s personal sphere of liberty would be expanded by these innovations. Living longer can also buy one time for libertarian arguments to gain clout in the political sphere and in broader public opinion. Technological progress and pro-liberty activism can reinforce one another in a virtuous cycle.

            To maximize their hopes of personally experiencing an amount of personal freedom even approaching that of the libertarian ideal, all libertarians should support radical life extension. This sought-after goal of some ancient philosophers, medieval alchemists, Enlightenment thinkers (notably Franklin, Diderot, and Condorcet), and medical researchers from the past two centuries, is finally within reach of many alive today. Biogerontologist Aubrey de Grey of the SENS Research Foundation gives humankind a 50 percent likelihood of reaching “longevity escape velocity” – a condition where increases in life expectancy outpace the rate of human senescence – within 25 years. Inventor, futurist, and artificial-intelligence researcher Ray Kurzweil predicts a radical increase in life expectancy in the 2020s, made possible by advances in biotechnology and nanotechnology, aided by exponentially growing computing power. But, like de Grey and perhaps somewhat unlike Kurzweil, I hold the view that these advances are not inevitable; they rely on deliberate, sustained, and well-funded efforts to achieve them. They rely on support by the general public to facilitate donations, positive publicity, and a lack of political obstacles placed in their way. All libertarians should become familiar with both the technical feasibility and the philosophical desirability of a dramatic, hopefully indefinite, extension of human life expectancies. My compilation of Resources on Indefinite Life Extension (RILE) is a good starting point for studying this subject by engaging with a wide variety of sources, perspectives, and ongoing developments in science, technology, and activism.

            We have only this one life to live. If we fail to accomplish our most cherished goals and our irreplaceable individual universes disappear into oblivion, then, to us, it will be as if those goals were never accomplished. If we want liberty, we should strive to attain it in our lifetimes. We should therefore want those lifetimes to be lengthened beyond any set limit, not just for the sake of experiencing a far more complete liberty, but also for the sake of life itself and all of the opportunities it opens before us.

Join the Movement for Indefinite Life Extension: The Most Forward-Thinking Minds Are Not Alone – Video by G. Stolyarov II

Join the Movement for Indefinite Life Extension: The Most Forward-Thinking Minds Are Not Alone – Video by G. Stolyarov II

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​Help humankind defeat senescence and death by joining the Movement for Indefinite Life Extension (MILE). The MILE offers a way to gauge awareness of and support for indefinite life extension. One of the easiest and most important ways you can begin to make a difference in helping bring indefinite life extension about is to (1) go to the MILE Facebook page, (2) like the MILE on Facebook, (3) read and share the many informational, scientific, and philosophical pieces made available daily on the MILE page, and (4) spread the word to your friends and acquaintances who are already sympathetic to indefinite life extension.

References

– The MILE Facebook Page or http://themile.info

– “Join the Movement for Indefinite Life Extension: The Most Forward-Thinking Minds Are Not Alone” – Essay by G. Stolyarov II

– Supporter of Indefinite Life Extension Open Badge

– Open Badges on Indefinite Life Extension

– Resources on Indefinite Life Extension (RILE)

– Rosetta@home

– Folding@home

– World Community Grid