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U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019

U.S. Transhumanist Party Discussion Panel – Burbank, California – August 24, 2019

Johannon Ben Zion
Gennady Stolyarov II
Arin Vahanian
Charles Holsopple


On August 24, 2019, many leading transhumanists gathered in Burbank, California, to commemorate the publication of The Transhumanism Handbook. Subsequent to the seminar and book-signing event marking that occasion, the U.S. Transhumanist Party / Transhuman Party (USTP) held a discussion panel hosted by Chairman Gennady Stolyarov II and featuring Director of Marketing Arin Vahanian and USTP Presidential Primary candidates Johannon Ben Zion and Charles Holsopple. Subjects of conversation included assessments of the public’s receptiveness to transhumanist ideas, approaches toward spreading transhumanism, common misconceptions and challenges to overcome, as well as the upcoming Presidential primary election, for which voting will begin on September 22, 2019.

Find out more about The Transhumanism Handbook.

Join the U.S. Transhumanist Party for free, no matter where you reside. Those who join by September 22, 2019, will be eligible to vote in the upcoming USTP Presidential Primary.

See the USTP Platform here.

Read Mr. Stolyarov’s chapter in The Transhumanism Handbook – entitled “The United States Transhumanist Party and the Politics of Abundance” – for free here.

Jason Hope on Philanthropy – Article by Reason

Jason Hope on Philanthropy – Article by Reason

The New Renaissance Hat
Reason
November 30, 2015
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Jason Hope, you might recall, has provided half a million dollars in research funding to the SENS Research Foundation, used to establish a SENS laboratory at Cambridge in order to push forward with the Foundation’s AGE-breaker program. AGE-breakers are drugs or other treatments capable of breaking down advanced glycation end-products (AGEs). These are a class of metabolic waste product that accumulate in our tissues to cause significant harm that includes the progressive loss of elasticity in skin and blood vessels.

There is, on the whole, far too little work undertaken today on AGE-breaker treatments in comparison to the benefits that a treatment could bring. What little research has taken place over the past twenty years unfortunately produced no effective therapies. As it turned out the AGEs that are important in short-lived laboratory animals are not the same at all as those that are important in humans – something that would have been challenging to identify until comparatively recently, and which resulted in promising animal studies that then went nowhere in commercial trials.

Now, however, researchers know that the vast majority of all AGEs in human tissues consist of just one type, called glucosepane – so the way is open for bold philanthropists and forward-looking researchers to build therapies that will be effective in removing this contribution to degenerative aging. Glucospane removal is one of the areas in which the SENS Research Foundation and its backers pick up the slack, undertaking important rejuvenation research that is neglected by the mainstream, even though it was exactly the mainstream research community that produced all of the studies and evidence that demonstrate the important role of glucospane in aging.

In any case, I should point out that Jason Hope runs a website and blog in which he discusses his take on philanthropy and his support for research aimed at extending healthy human life and rejuvenating the old. This makes for an interesting follow-on from yesterday’s post on big philanthropy. More folk of this ilk would certainly be a good thing, and I’m always pleased to see more of the better connected people in this world of ours speaking openly of their support for rejuvenation biotechnology.

Philanthropy

Quote:

Philanthropy has become a big focus for me. The organizations I have chosen to stand behind have come from many facets of my life. One of my passions has become the research done at the SENS Research Foundation. Their involvement in anti aging is not just about wanting to live forever. It’s about creating a longer, better quality of life.

Foundations like SENS are taking a different approach to anti-aging. They are focused on finding cures for disease that break down the body and thus cause us to age faster than we should. Disease like Alzheimer’s and heart and lung disease affect all functions of the body. Traditional medicine looks at treating these diseases after they happen. We want to focus on stopping these diseases from ever happening. We have spent so much time focused on medication for treating disease and not enough time on preventing that disease from ever happening.

By supporting scientific research that thrives through innovation and is not afraid to challenge the modern school of thought we will continue to break down walls.

A 21st-Century Philanthropic Model For Philanthropy

Quote:

Can you conceive of a world without age-related disease, disability and suffering? What about a world in which it’s possible for the average person to live 120 healthy years? While it may sound like a utopian dream, such a world is the exact goal of some of society’s most brilliant scientists and visionary leaders. At this very minute, groundbreaking work is underway at universities across the globe as researchers attempt to apply regenerative medicine to age-related disease through the repair of damage to tissue, cells and molecules within the body. While this research couldn’t be possible without the leadership of the world’s wealthiest philanthropists, it also relies upon the collective power of everyday people who have joined forces in their commitment to a better quality of life for all.

Traditionally, big ticket donors have been the primary target for fundraising programs. Research has consistently shown that the bulk of donor funds come from a small percentage of the wealthiest donors: in fact, a full 75 percent of funds raised come from gifts of over $1 million.

Instead of resigning themselves solely to the influence of the individual, non-profits are turning to the collective power of a group. The MFoundation’s “The 300 Pledge” fundraising campaign is an exciting example of this method in practice. The 300 Pledge asks 300 funders to commit $1,000 a year for 25 years toward critical research aimed at ending age-related diseases. When broken down, this goal is manageable for many households: just $3 a day or $85 a month – less than your daily tab at Starbucks. Obviously, the model is working: to date, 291 people have taken up the challenge, with nine spots remaining.

As evidenced by the magnificent philanthropy of people like Peter Thiel, Bill Gates and others like them, it’s obvious that one person can make a difference. However, fundraising challenges, like MFoundation’s “The 300,” also demonstrate the power of a dedicated group of people to foster real world change for the billions of people living in the world today as well as the generations that follow. In doing so, those who take up the challenge create a unique and world-altering legacy for themselves.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

SENS Research Foundation Joins the Global #GivingTuesday Movement – Press Release by SENS Research Foundation

SENS Research Foundation Joins the Global #GivingTuesday Movement – Press Release by SENS Research Foundation

The New Renaissance Hat
SENS Research Foundation
November 28, 2015
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Every Dollar Contributed Up to the First $5,000 Will Be Quadrupled, Turning into $20,000.
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MOUNTAIN VIEW, Calif. — November 24, 2015 — The SENS Research Foundation (SRF), a non-profit organization focused on transforming the way the world researches and treats age-related disease, has joined #GivingTuesday, a global day of giving that harnesses the collective power of individuals, communities and organizations to encourage philanthropy and celebrate generosity worldwide. Every dollar donated to SRF up to the first $5,000 will be quadrupled, making every dollar raised turn into $20,000.

Occurring this year on December 1, #GivingTuesday is held annually on the Tuesday after Thanksgiving (in the U.S.) and the widely recognized shopping events Black Friday and Cyber Monday to kick-off the holiday giving season and inspire people to collaborate in improving their local communities and to give back in impactful ways to the charities and causes they support.

SENS Research Foundation is aiming to reach a goal of $20,000 with the help of contributors who have pledged to match each dollar raised up to the first $5,000. The Croeni Foundation, a philanthropic organization dedicated to giving, the environment and health, has pledged to match the first $5,000 raised dollar for dollar. The foundation gave SRF an unrestricted $5,000 earlier this year, as well. Aubrey de Grey, CSO of SENS Research Foundation, has offered a dollar for dollar matching challenge up to $5,000. And Fight Aging! will match every dollar up to $125,000 through December 31, 2015. Fight Aging! encourages the development of medical technologies, lifestyles, and other means to help people live comfortably, healthily, and capably for as long as they desire.

“We are looking forward to participating in #GivingTuesday for a second year, and offer our thanks to Jan Croeni and the Croeni Foundation, as well as Aubrey de Grey and Fight Aging! for their support,” said Jerri Barrett, vice president of outreach, SENS Research Foundation. “Today’s cost for the treatment and care of chronic diseases of aging costs around $40,000 per second and will only continue to go up, as we spend more money per patient, while the number of patients is increasing. As a society, we need to change our ways and start treating age-related diseases more intelligently. The funds we raise on #GivingTuesday will help facilitate our efforts to do just that, as we work to continue learning how to prevent or reverse age-related diseases.”

Those who are interested in joining SENS Research Foundation’s #GivingTuesday initiative can donate at www.sens.org/donate. To learn more about #GivingTuesday participants and activities or to join the celebration of giving, please visit: http://www.givingtuesday.org/

About SENS Research Foundation (SRF)

SENS Research Foundation is a 501(c)(3) nonprofit that works to research, develop, and promote comprehensive regenerative medicine solutions for the diseases of aging. SRF is focused on a damage repair paradigm for treating the diseases of aging, which it advances through scientific research, advocacy, and education. SENS Research Foundation supports research projects at universities and institutes around the world with the goal of curing such age-related diseases as heart disease, cancer, diabetes and Alzheimer’s disease. Educating the public and training researchers to support a growing regenerative medicine field are also major endeavors of the organization that are being accomplished though advocacy campaigns and educational programs. For more information, visit www.sens.org.

Media Contact:
Jerri Barrett
408-204-7229
jerri.barrett@sens.org

Google Life Sciences to Fund Heart Disease Program – Article by Reason

Google Life Sciences to Fund Heart Disease Program – Article by Reason

The New Renaissance Hat
Reason
November 22, 2015
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An interesting next step from Google Life Sciences: they are putting forward $50 million in search of a laboratory to propose a program that pushes forward the state of the art in research and treatment of heart disease. Spent over ten years, that would produce an organization about the present size of the SENS Research Foundation, or a tenth of the Buck Institute, for purposes of comparison – and smaller than many of the research groups presently dedicated to the study of heart disease. So this is a sizable and welcome investment in medical research, but the significance is overhyped by the reporting organization here; no-one is going to cure heart disease with a $50 million project, since heart disease is caused by aging, and in the most general sense. This is an effort to change the funding landscape, stir things up, and make some progress.

If you walk through the list of forms of cell and tissue damage that causes degenerative aging, near every one of them contributes to structural failure of the cardiovascular system. The loss of stem cell activity and consequent decline in repair of tissues is only one of these: oxidized lipids that contribute to atherosclerosis in blood vessel walls; extracellular cross-links stiffen blood vessel walls and cause hypertension and consequent structural weakening in the heart; senescent cells wreck havoc on all the tissues they accumulate in; transthyretin amyloids that accumulate with age are implicated in heart disease via their ability to clog the cardiovascular system; and the loss of lysosomal function in long-lived cells, including those of the heart, progressively damages their function. Curing heart disease, removing it from the picture, requires treatments that effectively address near all of the causes of aging.

Quote from “Google Aims a $50 Million Moonshot at Curing Heart Disease” by Davey Alba, WIRED, November 16, 2015:

Cardiovascular disease people on Earth than anything else – over 17 million a year, and the number keeps going up. Of those deaths, more than 40 percent is due to coronary heart disease. Medicine has drugs that can treat it and practices that can help prevent it, but nobody really knows what causes it or how to cure it. Now, Google and the American Heart Association aim to change that by dropping a $50 million funding bomb on the problem. And as you might expect from a Silicon Valley giant that believes in moving fast and breaking things – an approach that hasn’t always transferred well to basic scientific research – the company isn’t spreading the money around. Google Life Sciences and the AHA said the money would go to one team over five years. “Traditional research funding models are often incremental and piecemeal, making it difficult to study a long-term, multifaceted subject. AHA and Google Life Sciences have committed to a bold new approach.”

The AHA, already the largest funder of cardiovascular research in the US outside of the federal government, says the program will be its most heavily funded initiative in nearly a century. Applications begin in January and if all goes according to plan, they’ll be due by February 14th. (Valentine’s Day. Get it?) If you want the $50 million, your idea has to fit on a single page. And Google won’t take a financial or intellectual property stake in the results. The organizations hope that the program will accelerate the field of heart research much like Google’s self-driving car eventually compelled the entire automobile industry to follow its lead.

Link: http://www.wired.com/2015/11/google-aims-a-50-million-moonshot-at-curing-heart-disease/

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

Pursuing the Outcomes of a Free Market – Video by G. Stolyarov II

Pursuing the Outcomes of a Free Market – Video by G. Stolyarov II

What hope is there to actually achieve the ideals of liberty in our lifetimes? There is a promising approach, encapsulated in the following method. Ask yourself: What results would a fully free market, functioning in accordance with the principles of liberty and individual rights, bring about? Now go pursue those results directly, through your individual actions, without waiting for the system to change.

References:
The Musical Compositions of G. Stolyarov II
– “Occupy Wall Street activists buy $15m of Americans’ personal debt” – Adam Gabbatt – The Guardian – November 12, 2013

Pursuing the Outcomes of a Free Market – Article by G. Stolyarov II

Pursuing the Outcomes of a Free Market – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
November 13, 2013
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            Those of us who love liberty wish to see a free-market society in our lifetimes. But, as a near-term prospect, a society even approximating a thorough respect of individual rights and free exchange is not on the horizon. The best liberty-oriented activism, culminating in the passionate, motivated support for Ron Paul during his 2012 Presidential campaign, has only gained the ideas of liberty the sympathy of perhaps 15% of the United States population, with the ability to attract perhaps a few more percentage points in tactical alliances on specific issues. This is not enough to catalyze system-wide change and turn around the steadily deteriorating political situation. Probably the best near-term hope for the system is some semblance of the 1990s – a glorious time for liberty by comparison to today! This could be achieved if enough people are galvanized to oppose and overturn NSA surveillance, meaningless foreign wars, and the never-ending domestic “wars” on drugs and terror, which have always ultimately turned into wars on innocent, law-abiding Americans. Such an outcome would produce a sigh of relief from the liberty-minded, but it still would not be close to a free market; it would just be somewhat sane and non-totalitarian.

            But if persuasion has not succeeded in convincing even a plurality of the population (at least for now) and if political change in the near term would mostly consist of reversing the most blatant, egregious travesties of justice, then what hope is there to actually achieve the ideals of liberty in our lifetimes? There is a promising approach, encapsulated in the following method. Ask yourself: What results would a fully free market, functioning in accordance with the principles of liberty and individual rights, bring about? Now go pursue those results directly, through your individual actions, without waiting for the system to change.

            Yes, there are limits to this approach. One limit is the law, whose prohibitions and mandates today will certainly constrain certain beneficial courses of action that would have been possible on the free market, while requiring people to spend their time on other courses of action that the free market would have rendered unnecessary. Yet the approach I propose can still do considerable good within the bounds of current laws in any political system less oppressive than that of Oceania in George Orwell’s 1984. Another limit is that the outcomes of a fully free market are not entirely foreseeable. Future discoveries and innovations by free individuals are the currently unseen benefits of voluntary action and exchange, and we cannot always anticipate them in advance. Even with this recognition, though, it is possible to reasonably anticipate that a free market would uplift human beings materially, intellectually, morally, and culturally. People in a free society would be more prosperous, more knowledgeable (and better able to distinguish good ideas from bad), less inclined to aggression against their fellow men, and more inclined to refined tastes (as a result of increased prosperity, leisure time, and sense that life is generally good).

            Direct, peaceful, lawful action by individuals today can bring about many of the results of a free market even without a free market being legally in place or supported by the majority of people. Furthermore, such results can be brought about by actions that are themselves fully consistent with free-market principles, since they would be entirely voluntary and respectful of the rights of others. There is one catch: the activities that would be profitable on a free market would not necessarily be so today. Their cost would need to be absorbed using one’s own resources, and one would need to consider the outcome not a loss, or even a sub-optimal profit, but rather a moral profit that outweighs the material cost, including the opportunity cost, in time and money.

            To give an example, I compose classically inspired music and give recordings away for free online using a Creative Commons license. In a free market, which over time would uplift the tastes of the general public, the production of high music (which would be simultaneously sophisticated and appealing to the human ear) would be much more remunerative than it is today, and the likes of Justin Bieber and Miley Cyrus would be relegated to the ever-thinning ranks of the dregs of society. This hypothesis is supported by history: in prior, far less prosperous but economically freer eras, composers of high music were often seen as celebrities, with Wolfgang Amadeus Mozart, Felix Mendelssohn, Giuseppe Verdi, and Johann Strauss II being just a few examples. Today, creators of good music have to content themselves with far less remuneration than the dubious pop idols, manufactured by politically connected and protected record labels. However, no one inhibits the freedom to compose, and the available tools for doing so are more impressive than ever before. Voluntary private action can increase the abundance of newly produced high culture in music, art, and literature. Similarly, voluntary private research initiatives, ranging from the humanities to mathematics to DIY biology, can hasten the rate of meaningful discoveries in order to more closely approximate the pace of intellectual and technological progress that would occur in a free market. With the hyper-empowerment made  possible through recent electronic technologies, the opportunities for any individual to make a difference in a field today exceed those available to large laboratories, academic departments, workshops, and orchestras in the mid-20th century. Thus, one person with free-market sympathies, acting on his own time with his own resources, can often achieve more than teams of people working through established institutions using old patterns of production, whose obsolescence is becoming glaringly obvious to anyone who pays attention.

            As an added bonus, creating free-market outcomes in accordance with free-market principles will, in any system, highlight the benefits and possibilities of voluntary, private action to those who might otherwise be unconvinced. It appears to me, from observation and experience, that theoretical and abstract arguments for the benefits of liberty are not sufficient to persuade anyone who is not already extremely theoretically inclined – a tiny minority of the human population. For everyone else, practical demonstrations of how freedom would work are far more powerful than the most finely honed theory of liberty. Probably, the majority of people would only come to support free markets once liberty-minded people have, de facto, built an entire free market around them by informally approximating its outcomes and workings. At that time, achieving a formal free market would just be a matter of “flipping the switch” on the entire system and amending the laws (with popular consent) to recognize the kind of societal order that would have already formed in practice.

            Interestingly enough, Rolling Jubilee, a more recent initiative by the Occupy movement, has valuable lessons to teach free-market advocates regarding the approach of pursuing desired outcomes directly. No, I am not referring to physical occupations of public places, but rather the efforts to purchase consumer debt on the secondary market (at deep discounts) and subsequently to abolish such debt, freeing consumers of its burden.  While the economic ideas of members of the Occupy movement often differ from free-market views, this initiative has achieved an objective that free-market advocates should find salutary: the reduction of the total outstanding amount of consumer debt, much of which was the result of a credit bubble fueled by the reckless inflationary monetary policy of the Federal Reserve. Furthermore, much today’s outstanding consumer debt is an outcome of cultural malaise brought about by generations of unfreedom, as a result of which a condition of financial dependency has come to predominate instead of self-reliance and the robustness to contingencies that can only come about due to a buffer of present owned resources. Freer-market cultures tend to be more contemptuous of reliance on personal debt, and it is thus reasonable to expect the total amount of debt on a free market to be less than exists today. The Occupy movement did not wait for authoritative permission, or for majority agreement, or for system-wide change. Rather, members pooled their resources and, by paying $400,000, managed to annul $14 million of consumer debt. It is a drop in the bucket of the entire problem, to be sure, but it is also an invaluable proof of concept for the project of massive societal transformation through voluntary, private action.

            Direct, peaceful, law-abiding action to bring about the outcomes of a free market would also help in another crucial respect by rehabilitating the image of free markets in the eyes of skeptics. The outcome of the course of action I propose would not be profit maximization in the present day; indeed, it would often require working for free on one’s own time and engaging in acts that would be considered charitable or philanthropic by professed opponents of the market. Even businesses that espouse free-market ideas could join in on this project and pursue practices that, while they may not capture every morsel of profit out there for the taking, are more in accord with how a free market would behave. Such businesses could, for instance, voluntarily renounce lobbying for special privileges and barriers to entry that would keep competitors out of the market.  They could also spend resources to improve workplace conditions and surrounding neighborhoods in order to better approximate how workplaces and neighborhoods would look under a prosperous free market. Furthermore, internal salary schedules in such businesses could be based on an approximation of meritocracy as it would emerge on a free market, which would often mean higher compensation for innovative and talented employees (irrespective of age, origin, past socioeconomic circumstances, or connections), resulting in greater retention, improved morale, better products, and long-term competitive advantages for the business that undertakes such a step. To certain onlookers, these behaviors might seem consistent with what is today called “corporate social responsibility” – and perhaps they would be. But by engaging in these practices in the name of striving toward a free-market ideal, liberty-minded businessmen could perhaps for the first time break through to capture the hearts and minds of many present-day detractors.

            What outcomes do you think would be achieved by a free market but are deficient today? Now go work to make them happen.