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Private or Governmental Funding for Indefinite Life Extension? – Post by G. Stolyarov II

Private or Governmental Funding for Indefinite Life Extension? – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
March 27, 2013
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I was recently asked to comment on an Immortal Life debate/discussion thread about whether governmental or private approaches to funding and motivating research on indefinite life extension are best.

Mine is definitely a libertarian view. I do not support advocating for government funding for life extension, unless the funding is combined with larger reductions in military spending or other destructive government spending. I discuss this issue in two of my videos:

Eliminating Death – Part 18 – Never Seek Government Funding

Libertarian Life-Extension Reforms – #6 – Medical Research Instead of Military Spending

The danger of government funding of life extension is that it comes with many political strings attached, and may lead life-extension research itself to be shackled by politically influential opponents of technological progress.

The great weakness of politics as a strategy is that it requires consensus among elites and some connection to majority approval, as well as the overcoming of numerous bureaucratic hurdles and obsolete habits. Private action, as long as it is lawful, can simply be pursued irrespective of how many people agree. There is thus much more flexibility and potential for quick deployment with private approaches toward radical life extension.

Private investment into life-extension research can occur in many ways, both for-profit and non-profit, both direct and indirect. Seasteading is indeed a highly promising approach for experimenting with novel medicines and therapies that might take over a decade to be approved by the FDA in the United States or similar “screening” agencies in other countries.

At the same time, Tom Mooney is correct about the need for a grassroots education campaign. By the time radical life extension begins to become a reality, there needs to be a strong current of public opinion supporting it. Otherwise, the “bioconservatives” might just manage to obtain enough support for their agenda to thwart this vital progress.

Libertarian Life-Extension Reforms – Video Series by G. Stolyarov II

Libertarian Life-Extension Reforms – Video Series by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
December 10, 2012
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This video series is derived from Mr. Stolyarov’s essay, “Political Priorities for Achieving Indefinite Life Extension: A Libertarian Approach“. The series highlights each of the proposed areas of pro-liberty life-extension reforms in an effort to spread these ideas and achieve their broader public consideration.

#1 – Repeal FDA Approval Requirements

Mr. Stolyarov discusses the greatest threat to research on indefinite human life extension: the  current requirement in the United States (and analogous requirements elsewhere in the Western world) that drugs or treatments may not be used, even on willing patients, unless approval for such drugs or treatments is received from the Food and Drug Administration (or an analogous national regulatory organization in other countries).

Such prohibitions on the quick development and marketing of potentially life-saving drugs are not only costly and time-consuming to overcome; they are morally unconscionable in terms of the cost in human lives.

#2 – Abolishing Medical Licensing Protectionism

There are too few doctors in the West today – not enough to deliver affordable, life-saving treatments, and certainly not enough to ensure that, when life-extending discoveries are made, they will rapidly become available to all.

Mr. Stolyarov advocates for the elimination of compulsory licensing requirements for medical professionals, and the replacement of such a system by a competing market of private certifications for various “tiers” of medical care.

#3-4 – Abolishing Medical and Software Patent Monopolies

Patents – legal grants of monopoly privilege – artificially raise the cost and the scarcity of new drugs and new software. Mr. Stolyarov recommends allowing free, open competition to apply to these products as well.

#5 – Reestablishing the Doctor-Patient Relationship

The most reliable and effective medical care occurs when both patients and doctors have full sovereignty over medical treatment and payment. A libertarian system is most likely to prolong individual lives and lead to the rapid discovery of unprecedented life-extending treatments.

Mr. Stolyarov presents the case for political reforms that maximize patient choice and free-market experimentation with various methods of payment for and provision of medical services.

#6 – Medical Research Instead of Military Spending

Mr. Stolyarov concludes his series on libertarian life-extension reforms by offering a way to reduce aggregate government spending while also increasing funding for medical research. If government funds are spent on saving and extending lives rather than destroying them, this would surely be an improvement. Thus, while Mr. Stolyarov does not support increasing aggregate government spending to fund indefinite life extension (or medical research generally), he would advocate a spending-reduction plan where vast amounts of military spending are eliminated and some fraction of such spending is replaced with spending on medical research.

Political Priorities for Achieving Indefinite Life Extension: A Libertarian Approach – Article by G. Stolyarov II

Political Priorities for Achieving Indefinite Life Extension: A Libertarian Approach – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
November 22, 2012
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While the achievement of radical human life extension is primarily a scientific and technical challenge, the political environment in which research takes place is extremely influential as to the rate of progress, as well as whether the research could even occur in the first place, and whether consumers could benefit from the fruits of such research in a sufficiently short timeframe. I, as a libertarian, do not see massive government funding of indefinite life extension as the solution – because of the numerous strings attached and the possibility of such funding distorting and even stalling the course of life-extension research by rendering it subject to pressures by anti-longevity special-interest constituencies. (I can allow an exception for increased government medical spending if it comes at the cost of major reductions in military spending; see my item 6 below for more details.) Rather, my proposed solutions focus on liberating the market, competition, and consumer choice to achieve an unprecedented rapidity of progress in life-extension treatments. This is the fastest and most reliable way to ensure that people living today will benefit from these treatments and will not be among the last generations to perish. Here, I describe six major types of libertarian reforms that could greatly accelerate progress toward indefinite human life extension.

1. Repeal of the requirement for drugs and medical treatments to obtain FDA approval before being used on willing patients. The greatest threat to research on indefinite life extension – and the availability of life-extending treatments to patients – is the current requirement in the United States (and analogous requirements elsewhere in the Western world) that drugs or treatments may not be used, even on willing patients, unless approval for such drugs or treatments is received from the Food and Drug Administration (or an analogous national regulatory organization in other countries). This is a profound violation of patient sovereignty; a person who is terminally ill is unable to choose to take a risk on an unapproved drug or treatment unless this person is fortunate enough to participate in a clinical trial. Even then, once the clinical trial ends, the treatment must be discontinued, even if it was actually successful at prolonging the person’s life. This is not only profoundly tragic, but morally unconscionable as well.

As a libertarian, I would prefer to see the FDA abolished altogether and for competing private certification agencies to take its place. But even this transformation does not need to occur in order for the worst current effects of the FDA to be greatly alleviated. The most critical reform needed is to allow unapproved drugs and treatments to be marketed and consumed. If the FDA wishes to strongly differentiate between approved and unapproved treatments, then a strongly worded warning label could be required for unapproved treatments, and patients could even be required to sign a consent form stating that they have been informed of the risks of an unapproved treatment. While this is not a perfect libertarian solution, it is a vast incremental improvement over the status quo, in that hundreds of thousands of people who would die otherwise would at least be able to take several more chances at extending their lives – and some of these attempts will succeed, even if they are pure gambles from the patient’s point of view. Thus, this reform to directly extend many lives and to redress a moral travesty should be the top political priority of advocates of indefinite life extension. Over the coming decades, its effect will be to allow cutting-edge treatments to reach a market sooner and thus to enable data about those treatments’ effects to be gathered more quickly and reliably. Because many treatments take 10-15 years to receive FDA approval, this reform could by itself speed up the real-world advent of indefinite life extension by over a decade.

2. Abolishing medical licensing protectionism. The current system for licensing doctors is highly monopolistic and protectionist – the result of efforts by the American Medical Association in the early 20th century to limit entry into the profession in order to artificially boost incomes for its members. The medical system suffers today from too few doctors and thus vastly inflated patient costs and unacceptable waiting times for appointments. Instead of prohibiting the practice of medicine by all except a select few who have completed an extremely rigorous and cost-prohibitive formal medical schooling, governments in the Western world should allow the market to determine different tiers of medical care for which competing private certifications would emerge. For the most specialized and intricate tasks, high standards of certification would continue to exist, and a practitioner’s credentials and reputation would remain absolutely essential to convincing consumers to put their lives in that practitioner’s hands. But, with regard to routine medical care (e.g., annual check-ups, vaccinations, basic wound treatment), it is not necessary to receive attention from a person with a full-fledged medical degree. Furthermore, competition among certification providers would increase quality of training and lower its price, as well as accelerate the time needed to complete the training. Such a system would allow many more young medical professionals to practice without undertaking enormous debt or serving for years (if not decades) in roles that offer very little remuneration while entailing a great deal of subservience to the hierarchy of some established institution or another. Ultimately, without sufficient doctors to affordably deliver life-extending treatments when they become available, it would not be feasible to extend these treatments to the majority of people. Would there be medical quacks under such a system of privatized certification? There are always quacks, including in the West today – and no regulatory system can prevent those quacks from exploiting willing dupes. But full consumer choice, combined with the strong reputational signals sent by the market, would ensure that the quacks would have a niche audience only and would never predominate over scientifically minded practitioners.

3. Abolishing medical patent monopolies. Medical patents – in essence, legal grants of monopoly for limited periods of time – greatly inflate the cost of drugs and other treatments. Especially in today’s world of rapidly advancing biotechnology, a patent term of 20 years essentially means that no party other than the patent holder (or someone paying royalties to the patent holder) may innovate upon the patented medicine for a generation, all while the technological potential for such innovation becomes glaringly obvious. As much innovation consists of incremental improvements on what already exists, the lack of an ability to create derivative drugs and treatments that tweak current approaches implies that the entire medical field is, for some time, stuck at the first stages of a treatment’s evolution – with all of the expense and unreliability this entails. More appallingly, many pharmaceutical companies today attempt to re-patent drugs that have already entered the public domain, simply because the drugs have been discovered to have effects on a disease different from the one for which they were originally patented. The result of this is that the price of the re-patented drug often spikes by orders of magnitude compared to the price level during the period the drug was subject to competition. Only a vibrant and competitive market, where numerous medical providers can experiment with how to improve particular treatments or create new ones, can allow for the rate of progress needed for the people alive today to benefit from radical life extension. Some may challenge this recommendation with the argument that the monopoly revenues from medical patents are necessary to recoup the sometimes enormous costs that pharmaceutical companies incur in researching and testing the drug and obtaining approval from regulatory agencies such as the FDA. But if the absolute requirement of FDA approval is removed as I recommend, then these costs will plummet dramatically, and drug developers will be able to realize revenues much more quickly than in the status quo. Furthermore, the original developer of an innovation will still always benefit from a first-mover advantage, as it takes time for competitors to catch on. If the original developer can maintain high-quality service and demonstrate the ability to sell a safe product, then the brand-name advantage alone can secure a consistent revenue stream without the need for a patent monopoly.

4. Abolishing software patent monopolies. With the rapid growth of computing power and the Internet, much more medical research is becoming dependent on computation. In some fields such as genome sequencing, the price per computation is declining at a rate even far exceeding that of Moore’s Law. At the same time, ordinary individuals have an unprecedented opportunity to participate in medical research by donating their computer time to distributed computing projects. Software, however, remains artificially scarce because of patent monopolies that have increasingly been utilized by established companies to crush innovation (witness the massively expensive and wasteful patent wars over smartphone and tablet technology). Because most software is not cost-prohibitive even today, the most pernicious effect of software patents is not on price, but on the existence of innovation per se. Because there exist tens of thousands of software patents (many held defensively and not actually utilized to market anything), any inventor of a program that assists in medical, biotechnological, or nanotechnological computations must proceed with extreme caution, lest he run afoul of some obscure patent that is held for the specific purpose of suing people like him out of existence once his product is made known. The predatory nature of the patent litigation system serves to deter many potential innovators from even trying, resulting in numerous foregone discoveries that could further accelerate the rate at which computation could facilitate medical progress. Ideally, all software patents (and all patents generally) should be abolished, and free-market competition should be allowed to reign. But even under a patent system, massive incremental improvements could be made. First, non-commercial uses of a patent should be rendered immune to liability. This would open up a lot of ground for non-profit medical research using distributed computing. Second, for commercial use of patents, a system of legislatively fixed maximum royalties could emerge – where the patent holder would be obligated to allow a competitor to use a particular patented product, provided that a certain price is paid to the patent holder – and litigation would be permanently barred. This approach would continue to give a revenue stream to patent holders while ensuring that the existence of a patent does not prevent a product from coming to market or result in highly uncertain and variable litigation costs.

5. Reestablishing the two-party doctor-patient relationship. The most reliable and effective medical care occurs when the person receiving it has full discretion over the level of treatment to be pursued, while the person delivering it has full discretion over the execution (subject to the wishes of the consumer). When a third party – whether private or governmental – pays the bills, it also assumes the position of being able to dictate the treatment and limit patient choice. Third-party payment systems do not preclude medical progress altogether, but they do limit and distort it in significant ways. They also result in the “rationing” of medical care based on the third party’s resources, rather than those of the patient. Perversely enough, third-party payment systems also discourage charity on the part of doctors. For instance, Medicare in the United States prohibits doctors who accept its reimbursements from treating patients free of charge. Mandates to utilize private health insurance in the United States and governmental health “insurance” elsewhere in the Western world have had the effect of forcing patients to be restricted by powerful third parties in this way. While private third-party payment systems should not be prohibited, all political incentives for third-party medical payment systems should be repealed. In the United States, the pernicious health-insurance mandate of the Affordable Care Act (a.k.a. Obamacare) should be abolished, as should all requirements and political incentives for employers to provide health insurance. Health insurance should become a product whose purchase is purely discretionary on a free market. This reform would have many beneficial effects. First, by decoupling insurance from employment, it would ensure that those who do rely on third-party payments for medical care will not have those payments discontinued simply because they lose their jobs. Second, insurance companies would be encouraged to become more consumer-friendly, since they will need to deal with consumers directly, rather than enticing employers – whose interests in an insurance product may be different from those of their employees. Third, insurance companies would be entirely subject to market forces – including the most powerful consumer protection imaginable: the right of a consumer to exit from a market entirely. Fourth and most importantly, the cost of medical care would decline dramatically, since it would become subject to direct negotiation between doctors and patients, while doctors would be subject to far less of the costly administrative bureaucracy associated with managing third-party payments.

In countries where government is the third-party payer, the most important reform is to render participation in the government system voluntary. The worst systems of government healthcare are those where private alternatives are prohibited, and such private competition should be permitted immediately, with no strings attached. Better yet, patients should be permitted to opt out of the government systems altogether by being allowed to save on their taxes if they renounce the benefits from such systems and opt for a competing private system instead. Over time, the government systems would shrink to basic “safety nets” for the poorest and least able, while standards of living and medical care would rise to the level that ever fewer people would find themselves in need of such “safety nets”. Eventually, with a sufficiently high level of prosperity and technological advancement, the government healthcare systems could be phased out altogether without adverse health consequences to anyone.

6. Replacement of military spending with medical research. While, as a libertarian, I do not consider medical research to be the proper province of government, there are many worse ways for a government to spend its money – for instance, by actively killing people in wasteful, expensive, and immoral wars. If government funds are spent on saving and extending lives rather than destroying them, this would surely be an improvement. Thus, while I do not support increasing aggregate government spending to fund indefinite life extension (or medical research generally), I would advocate a spending-reduction plan where vast amounts of military spending are eliminated and some fraction of such spending is replaced with spending on medical research. Ideally, this research should be as free from “strings attached” as possible and could be funded through outright unconditional grants to organizations working on indefinite life extension. However, in practice it is virtually impossible to avoid elements of politicization and conditionality in government medical funding. Therefore, this plan should be implemented with the utmost caution. Its effectiveness could be improved by the passage of legislation to expressly prohibit the government from dictating the methods, outcomes, or applications of the research it funds, as well as to prohibit non-researchers from acting as lobbyists for medical research. An alternative to this plan could be to simply lower taxes across the board by the amount of reduction in military spending. This would have the effect of returning wealth to the general public, some of which would be spent on medical research, while another portion of these returned funds would increase consumers’ bargaining power in the medical system, resulting in improved treatments and more patient sovereignty.

Announcements and October-November 2012 Update to Resources on Indefinite Life Extension

Announcements and October-November 2012 Update to Resources on Indefinite Life Extension

I expect be unavailable to publish The Rational Argumentator until circa November 22, 2012 – but, in the meantime, various new offerings have been posted for my readers.

In addition, I have recently been impressed by the significant contributions my computer has made to the World Community Grid Help Conquer Cancer distributed computing project. (You can see a presentation by one of the project’s lead scientists, Dr. Igor Jurisica, here.) About a month ago, the Help Conquer Cancer project was enhanced to allow computers’ Graphics Processing Units (GPUs) to assist in the analysis of millions of experiments. My own recently enhanced computer has been participating heavily, which caused my worldwide ranking on World Community Grid to rise within a month from about 60,000th place to 26,744th place (updated every half-day) in terms of credits and 15,795th place in terms of results returned. In addition, for the totality of BOINC distributed computing projects, I have risen to the 98.2932nd percentile and a world rank of 42,446 in terms of total credits and the 99.5634th percentile and a world rank of 10,878 in terms of recent average credit. In the United States, I am ranked at 11,802nd place in terms of total BOINC credit earned.

I expect that my computer will continue to run at full capacity during the upcoming weeks, and indefinitely into the foreseeable future.

For your contemplation and enjoyment, I offer here the list of diverse and fascinating articles and videos that have been included in the Resources on Indefinite Life Extension (RILE) page in October and early November of this year.

Articles

– “Nanoparticles Against Aging” – Science Daily and Asociación RUVID – October 3, 2012

– “Nanoparticles can deliver antiaging therapies” – Brian Wang – The Next Big Future – October 4, 2012

– “A Speculative Order of Arrival for Important Rejuvenation Therapies” – Reason – Fight Aging! – October 4, 2012

– “Therapy will use stem cells to heal heart” – Pauline Tam – October 4, 2012

– “Aubrey de Grey on Longevity Science” – Reason – Fight Aging! – October 5, 2012

– “Predicted sequence of Antiaging rejuvenation” – Brian Wang – The Next Big Future – October 5, 2012

– “Researchers use magnets to cause programmed cancer cell deaths” – Bob Yirka – October 8, 2012 

– “Lilly Alzheimer’s Drug Slows Mental Decline, Study Finds” – Shannon Pettypiece – October 8, 2012

– “Vitamin Variants Could Combat Cancer as Scientists Unravel B12 Secrets” – ScienceDaily and University of Kent – October 8, 2012

– “Human Immortality: Singularity Summit Looks Forward to the Day That Humans Can Live Forever” – Hamdan Azhar – Policymic – October 2012

– “Drug From Chinese ‘Thunder God Vine’ Slays Tumors in Mice” – Drew Armstrong – Bloomberg – October 17, 2012

– “82 Years of Technology Advances; but best yet to come” – Dick Pelletier – Transhumanity.net – October 25, 2012

– “New you by 2022: biotech enhancements will help you ‘grow young’” – Dick Pelletier – Positive Futurist – October 2012

– “Flu Vaccination May Increase Longevity” – Lyle J. Dennis, M.D. – Extreme Longevity – October 29, 2012

– “Dead as a Doornail?” – Peter Rothman – h+ Magazine – November 1, 2012

– “An Outcast Among Peers Gains Traction on Alzheimer’s Cure” – Jeanne Whalen – Wall Street Journal – November 9, 2012

 

Videos

Anthony Atala
Anthony Atala at TEDMED 2009
January 21, 2010

Ray Kurzweil

From Eliza Watson to Passing the Turing Test – Singularity Summit 2011

October 25, 2011

Nikola Danaylov

Ray Kurzweil on Singularity 1 on 1: Be Who You Would Like to Be – October 13, 2012

A Speculative Order of Arrival for Important Rejuvenation Therapies – Article by Reason

A Speculative Order of Arrival for Important Rejuvenation Therapies – Article by Reason

The New Renaissance Hat
Reason
October 6, 2012
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A toolkit for producing true rejuvenation in humans will require a range of different therapies, each of which can repair or reverse one of the varied root causes of degenerative aging. Research is underway for all of these classes of therapy, but very slowly and with very little funding in some cases. The funding situation spans the gamut from that of the stem cell research community, where researchers are afloat in money and interest, to the search for ways to break down advanced glycation endproducts (AGEs), which is a funding desert by comparison, little known or appreciated outside the small scientific community that works in that field.

While bearing in mind that progress in projects with little funding is unpredictable in comparison to that of well-funded projects, I think that we can still take a stab at a likely order of arrival for various important therapies needed to reverse aging. Thus an incomplete list follows, running from the earliest to the latest arrival, with the caveat that it is based on the present funding and publicity situation. If any one of the weakly funded and unappreciated lines of research suddenly became popular and awash with resources, it would probably move up in the ordering:

1) Destruction of Senescent Cells

Destroying specific cells without harming surrounding cells is a well-funded line of research thanks to the cancer community, and the technology platforms under development can be adapted to target any type of cell once it is understood how to target its distinctive features.

The research community has already demonstrated benefits from senescent cell destruction, and there are research groups working on this problem from a number of angles. A method of targeting senescent cells for destruction was recently published, and we can expect to see more diverse attempts at this in the next few years. As soon as one of these can be shown to produce benefits in mice that are similar to the early demonstrations, then senescent cell clearance becomes a going concern: something to be lifted from the deadlocked US regulatory process and hopefully developed quickly into a therapy in Asia, accessed via medical tourism.

2) Selective Pruning and Support of the Immune System

One of the reasons for immune system decline is crowding out of useful immune cells by memory immune cells that serve little useful purpose. Here, targeted cell destruction can also produce benefits, and early technology demonstrations support this view. Again, the vital component is the array of mechanisms needed to target the various forms of immune cell that must be pruned. I expect the same rising tide of technology and knowledge that enables senescent cell targeting will lead to the arrival of immune cell targeting on much the same schedule.

Culling the immune system will likely have to be supported with some form of repopulation of cells. It is already possible to repopulate a patient’s immune system with immune cells cultivated from their own tissues, as demonstrated by the limited number of full immune system reboots carried out to cure autoimmune disorders. Alternatives to this process include some form of tissue engineering to recreate the dynamic, youthful thymus as a source of immune cells – or more adventurous processes such as cultivating thymic cells in a patient’s lymph nodes.

3) Mitochondrial Repair

Our mitochondria sabotage us. There’s a flaw in their structure and operation that causes a small but steadily increasing fraction of our cells to descend into a malfunctioning state that is destructive to bodily tissues and systems.

There are any number of proposed methods for dealing with this component of the aging process – either repairing or making it irrelevant – and a couple are in that precarious state of being just a little more solidity and work away from the point at which they could begin clinical development. The diversity of potential approaches in increasing too. Practical methods are now showing up for ways to put new mitochondria into cells, or target arbitrary therapies to the interior or mitochondria. It all looks very promising.

Further, the study of mitochondria is very broad and energetic, and has a strong presence in many areas of medicine and life science research. While few groups in the field are currently engaged in work on mitochondrial repair, there is an enormous reservoir of potential funding and workers awaiting any method of repair shown to produce solid results.

4) Reversing Stem Cell Aging

The stem cell research field is on a collision course with the issue of stem cell aging. Most of the medical conditions that are best suited to regenerative medicine, tissue engineering, and similar cell based therapies are age-related, and thus most of the patients are old. In order for therapies to work well, there must be ways to work around the issues caused by the aged biochemistry of the patient. To achieve this end, the research community will essentially have to enumerate the mechanisms by which stem cell populations decline and fail with age, and then reverse their effects.

Where stem cells themselves are damaged by age, stem cell populations will have to be replaced. This is already possible for many different types of stem cell, but there are potentially hundreds of different types of adult stem cell – and it is too much to expect for the processes and biochemistry to be very similar in all cases. A great deal of work will remain to be accomplished here even after the first triumphs involving hearts, livers, and kidneys.

Much of the problem, however, is not the stem cells but rather the environment they operate within. This is the bigger challenge: picking out all the threads of signalling, epigenetic change, and cause and effect that leads to quieted and diminished stem cell populations – and the resulting frailty as tissues are increasingly poorly supported. This is a fair sized task, and little more than inroads have been made to date – a few demonstrations in which one stem cell type has been coerced into acting with youthful vigor, and a range of research on possible processes and mechanisms to explain how an aging metabolism causes stem cells to slow down and stop their work.

The stem cell research community is, however, one of the largest in the world, and very well funded. This is a problem that they have to solve on the way to their declared goals. What I would expect to see here is for a range of intermediary stopgap solutions to emerge in the laboratory and early trials over the next decade. These will be limited ways to invigorate a few aged stem cell populations, intended to be used to boost the effectiveness of stem cell therapies for diseases of aging.

Any more complete or comprehensive solution for stem cell aging seems like a longer-term prospect, given that it involves many different stem cell populations with very different characteristics.

5) Clearing Advanced Glycation Endproducts (AGEs)

AGEs cause inflammation and other sorts of mischief through their presence, and this builds up with age. Unfortunately, research on breaking down AGEs to remove their contribution to degenerative aging has been a very thin thread indeed over the past few decades: next to no-one works on it, despite its importance, and very little funding is devoted to this research.

Now on the one hand it seems to be the case that one particular type of AGE – glucosepane – makes up 90% or more the AGEs in human tissues. On the other hand, efforts to find a safe way to break it down haven’t made any progress in the past decade, though a new initiative was launched comparatively recently. This is an excellent example of how minimally funded research can be frustrating: a field can hover just that one, single advance away from largely solving a major problem for years on end. All it takes is the one breakthrough, but the chances of that occurring depend heavily on the resources put into the problem: how many parallel lines of investigation can be followed, how many researchers are working away at it.

This is an excellent candidate for a line of research that could move upward in the order of arrival if either a large source of funding emerged or a plausible compound was demonstrated to safely and aggressively break down glucospane in cell cultures. There is far less work to be done here than to reverse stem cell aging, for example.

6) Clearing Aggregates and Lysomal Garbage

All sorts of aggregates build up within and around cells as a result of normal metabolic processes, causing harm as they grow, and the sheer variety of these waste byproducts is the real challenge. They range from the amyloid that features prominently in Alzheimer’s disease through to the many constituents of lipofuscin that clog up lysosomes and degrade cellular housekeeping processes. At this point in the advance of biotechnology it remains the case that dealing with each of the many forms of harmful aggregate must be its own project, and so there is a great deal of work involved in moving from where we stand today to a situation in which even a majority of the aggregates that build up with age can be removed.

The most promising lines of research to remove aggregates are immunotherapy, in which the immune system is trained or given the tools to to consume and destroy a particular aggregate, and medical bioremediation, which is the search for bacterial enzymes that can be repurposed as drugs to break down aggregates within cells. Immunotherapy to attack amyloid as a treatment for Alzheimer’s is a going concern, for example. Biomedical remediation is a younger and far less funded endeavor, however.

My expectation here is that some viable therapies for some forms of unwanted and harmful metabolic byproducts will emerge in the laboratory over the next decade, but that will prove to be just the start on a long road indeed. From here it’s hard for me to guess at where the 80/20 point might be in clearing aggregates: successfully clearing the five most common different compounds? Or the ten most common? Or twenty? Lipofuscin alone has dozens of different constituent chemicals and proteins, never mind the various other forms of aggregate involved in specific diseases such as Alzheimer’s.

But work is work: it can be surmounted. Pertinently, and again, the dominant issue in timing here is the lack of funding and support for biomedical remediation and similar approaches to clearing aggregates.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

How Government Sort of Created the Internet – Article by Steve Fritzinger

How Government Sort of Created the Internet – Article by Steve Fritzinger

The New Renaissance Hat
Steve Fritzinger
October 6, 2012
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Editor’s Note: Vinton Cerf, one of the individuals whose work was pivotal in the development of the Internet, has responded to this article in the comments below. Read his response here.

In his now-famous “You didn’t build that” speech, President Obama said, “The Internet didn’t get invented on its own. Government research created the Internet so that all the companies could make money off the Internet.”

Obama’s claim is in line with the standard history of the Internet. That story goes something like this: In the 1960s the Department of Defense was worried about being able to communicate after a nuclear attack. So it directed the Advanced Research Projects Agency (ARPA) to design a network that would operate even if part of it was destroyed by an atomic blast. ARPA’s research led to the creation of the ARPANET in 1969. With federal funding and direction the ARPANET matured into today’s Internet.

Like any good creation myth, this story contains some truth. But it also conceals a story that is much more complicated and interesting. Government involvement has both promoted and retarded the Internet’s development, often at the same time. And, despite Obama’s claims, the government did not create the Internet “so all the companies could make money off” it.

The idea of internetworking was first proposed in the early 1960s by computer scientist J. C. R. Licklider at Bolt, Beranek and Newman (BBN). BBN was a private company that originally specialized in acoustic engineering. After achieving some success in that field—for example, designing the acoustics of the United Nations Assembly Hall—BBN branched out into general R&D consulting. Licklider, who held a Ph.D. in psychoacoustics, had become interested in computers in the 1950s. As a vice president at BBN he led the firm’s growing information science practice.

In a 1962 paper Licklider described a “network of networks,” which he called the “Intergalactic Computer Network.” This paper contained many of the ideas that would eventually lead to the Internet. Its most important innovation was “packet switching,” a technique that allows many computers to join a network without requiring expensive direct links between each pair of machines.

Licklider took the idea of internetworking with him when he joined ARPA in 1962. There he met computer science legends Ivan Sutherland and Bob Taylor. Sutherland and Taylor continued developing Licklider’s ideas. Their goal was to create a network that would allow more effective use of computers scattered around university and government laboratories.

In 1968 ARPA funded the first four-node packet-switched network. This network was not part of a Department of Defense (DOD) plan for post-apocalyptic survival. It was created so Taylor wouldn’t have to switch chairs so often. Taylor routinely worked on three different computers and was tired of switching between terminals. Networking would allow researchers like Taylor to access computers located around the country without having dedicated terminals for each machine.

The first test of this network was in October 1969, when Charley Kline, a student at UCLA, attempted to transmit the command “login” to a machine at the Stanford Research Institute. The test was unsuccessful. The network crashed and the first message ever transmitted over what would eventually become the Internet was simply “lo.”

With a bit more debugging the four-node network went live in December 1969, and the ARPANET was born. Over the next two decades the ARPANET would serve as a test bed for internetworking. It would grow, spawn other networks, and be transferred between DOD agencies. For civilian agencies and universities, NSFNET, operated by the National Science Foundation, replaced ARPANET in 1985. ARPANET was finally shut down in February 1990. NSFNET continued to operate until 1995, during which time it grew into an important backbone for the emerging Internet.

For its entire existence the ARPANET and most of its descendants were restricted to government agencies, universities, and companies that did business with those entities. Commercial use of these networks was illegal. Because of its DOD origins ARPANET was never opened to more than a handful of organizations. In authorizing funds for NSFNET, Congress specified that it was to be used only for activities that were “primarily for research and education in the sciences and engineering.”

During this time the vast majority of people were banned from the budding networks. None of the services, applications, or companies that define today’s Internet could exist in this environment. Facebook may have been founded by college students, but it was not “primarily for research and education in the sciences and engineering.”

This restrictive environment finally began to change in the mid-1980s with the arrival of the first dial-up bulletin boards and online services providers. Companies like Compuserve, Prodigy, and AOL took advantage of the home computer to offer network services over POTS (Plain Old Telephone Service) lines. With just a PC and a modem, a subscriber could access email, news, and other services, though at the expense of tying up the house’s single phone line for hours.

In the early 1990s these commercial services began to experiment with connections between themselves and systems hosted on NSFNET. Being able to access services hosted on a different network made a network more valuable, so service providers had to interoperate in order to survive.

ARPANET researchers led by Vint Cerf and Robert Kahn had already created many of the standards that the Internet service providers (ISPs) needed to interconnect. The most important standard was the Transmission Control Protocol/Internet Protocol (TCP/IP). In the 1970s computers used proprietary technologies to create local networks. TCP/IP was the “lingua franca” that allowed these networks to communicate regardless of who operated them or what types of computers were used on them. Today most of these proprietary technologies are obsolete and TCP/IP is the native tongue of networking. Because of TCP/IP’s success Cerf and Kahn are known as “the fathers of the Internet.”

Forced to interoperate, service providers rapidly adopted TCP/IP to share traffic between their networks and with NSFNET. The modern ISP was born. Though those links were still technically illegal, NSFNET’s commercial use restrictions were increasingly ignored.

The early 1990s saw the arrival of the World Wide Web. Tim Berners-Lee, working at the European high energy physics lab CERN, created the Uniform Resource Locator (URL), Hyper-Text Transfer Protocol (HTTP), and Hyper-Text Markup Language (HTML). These three technologies made it easier to publish, locate, and consume information online. The web rapidly grew into the most popular use of the Internet.

Berners-Lee donated these technologies to the Internet community and was knighted for his work in 2004.

In 1993 Mosaic, the first widely adopted web browser, was released by the National Center for Supercomputing Applications (NCSA). Mosaic was the first Internet application to take full advantage of Berners-Lee’s work and opened the Internet to a new type of user. For the first time the Internet became “so easy my mother can use it.”

The NCSA played a significant role in presidential politics. It had been created by the High Performance Computing & Communications Act of 1991 (aka “The Gore Bill”). In 1999 presidential candidate Al Gore cited this act in an interview about his legislative accomplishments,saying, “I took the initiative in creating the Internet.” This comment was shortened to: “I created the Internet” and quickly became a punchline for late-night comedians. This one line arguably cost Gore the presidency in 2000.

The 1992 Scientific and Advanced Technology Act, another Gore initiative, lifted some of the commercial restrictions on Internet usage. By mid-decade all the pieces for the modern Internet were in place.

In 1995, 26 years after its humble beginnings as ARPANET, the Internet was finally freed of government control. NSFNET was shut down. Operation of the Internet passed to mostly private companies, and all prohibitions on commercial use were lifted.

Anarchy, Property, and Innovation

Today the Internet can be viewed as three layers, each with its own stakeholders, business models, and regulatory structure. There are the standards, like TCP/IP, that control how information flows between networks, the physical infrastructure that actually comprises the networks, and the devices and applications that most people see as “the Internet.”

Since the Internet is really a collection of separate networks that have voluntarily joined together, there is no single central authority that owns or controls it. Instead, the Internet is governed by a loose collection of organizations that develop technologies and ensure interoperability. These organizations, like the Internet Engineering Task Force (IETF), may be the most successful anarchy ever.

Anarchy, in the classical sense, means without ruler, not without laws. The IETF demonstrates how well a true anarchy can work. The IETF has little formal structure. It is staffed by volunteers. Meetings are run by randomly chosen attendees. The closest thing there is to being an IETF member is being on the mailing list for a project and doing the work. Anyone can contribute to any project simply by attending the meetings and voicing an opinion. Something close to meritocracy controls whose ideas become part of the standards.

At the physical layer the Internet is actually a collection of servers, switches, and fiber-optic cables. At least in the United States this infrastructure is mostly privately owned and operated by for-profit companies like AT&T and Cox. The connections between these large national and international networks put the “inter” in Internet.

As for-profit companies ISPs compete for customers. They invest in faster networks, wider geographic coverage, and cooler devices to attract more monthly subscription fees. But ISPs are also heavily regulated companies. In addition to pleasing customers, they must also please regulators. This makes lobbying an important part of their business. According to the Center for Responsive Politics’s OpenSecrets website, ISPs and the telecommunications industry in general spend between $55 million and $65 million per year trying to influence legislation and regulation.

When most people think of the Internet they don’t think of a set of standards sitting on a shelf or equipment in a data center. They think of their smart phones and tablets and applications like Twitter and Spotify. It is here that Internet innovation has been most explosive. This is also where government has had the least influence.

For its first 20 years the Internet and its precursors were mostly text-based. The most popular applications, like email, Gopher (“Go for”), and Usenet news groups, had text interfaces. In the 20 years that commercial innovation has been allowed on the Internet, text has become almost a relic. Today, during peak hours, almost half of North American traffic comes from streaming movies and music. Other multimedia services, like video chat and photo sharing, consume much of people’s Internet time.

None of this innovation could have happened if the Internet were still under government control. These services were created by entrepreneurial trial and error. While some visionaries explored the possibilities of a graphically interconnected world as early as the 1960s, no central planning board knew that old-timey-looking photographs taken on ultramodern smart phones would be an important Internet application.

I, Internet

When Obama said the government created the Internet so companies could make money off it, he was half right. The government directly funded the original research into many core networking technologies and employed key people like Licklider, Taylor, Cerf, and Kahn. But after creating the idea the government sat on it for a quarter century and denied access to all but a handful of people. Its great commercial potential was locked away.

For proponents of government-directed research policies, the Internet proves the value of their programs. But government funding might not have been needed to create the Internet. The idea for internetwork came from BBN, a private company. The rise of ISPs in the 1980s showed that other companies were willing to invest in this space. Once the home PC and dial-up services became available, people joined commercial networks by the millions. The economic incentives to connect those early networks probably would have resulted in something very much like today’s Internet even if the ARPANET had never existed.

In the end the Internet rose from no single source. Like Leonard Read’s humble writing instrument, the pencil, no one organization could create the Internet. It took the efforts of thousands of engineers from the government and private sectors. Those engineers followed no central plan. Instead they explored. They competed. They made mistakes. They played.

Eventually they created a system that links a third of humanity. Now entrepreneurs all over the world are looking for the most beneficial ways to use that network.

Imagine where we’d be today if that search could have started five to ten years earlier.

Steve Fritzinger is a freelance writer from Fairfax,Virginia. He is the regular economics commentator on the BBC World Service program Business Daily.

This article was published by The Foundation for Economic Education and may be freely distributed, subject to a Creative Commons Attribution United States License, which requires that credit be given to the author.

The Movement for Indefinite Life Extension: The Next Step for Humankind – Article by G. Stolyarov II

The Movement for Indefinite Life Extension: The Next Step for Humankind – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
July 14, 2012
******************************

An old cliché would have us believe that nothing is inevitable except death and taxes. The Movement for Indefinite Life Extension (MILE) respectfully disagrees. Increasing numbers of people are coming to the conclusion that there is nothing natural or inevitable about the decrepitude and vulnerability that accompanies old age in humans. Nature already offers examples of ways to avoid our predicament. Many other animal species are negligibly senescent; they do not experience significant biological decay with time and have much longer life expectancies than we do. Scientific advances in biotechnology, nanotechnology, medicine, and computing offer humankind the possibility to radically extend lifespans beyond anything seen in history.

Does this sound utopian or unattainable? That depends on your historical perspective. Inventions from the horseless carriage to powered flight were considered impossible by “experts” – until they became reality. Today we drive automobiles and fly on airplanes routinely. In a few decades – with sufficient determination, resources, and public support – we could be living much longer than any of our ancestors, while retaining our youthful vigor and resilience.

Too many people fall prey to the unfortunate status quo bias – the assumption that the way matters happen to be today is the way they have always been and always will be. In fact, colossal changes are possible and happen all around us. Each generation finds itself in a dramatically different world. Chances are that you already lived through the revolution caused by the Internet and personal electronic technology. With the pace of technological, societal, intellectual, and political change accelerating, it is becoming increasingly apparent that the stability of the status quo is an illusion. We are always going somewhere: let us make it the best destination possible, and let us exert every effort to make sure that we get there as individuals.

In a world of accelerating change, our bodies and minds will need to be enhanced and maintained in their prime in order to keep up with the improved knowledge and technology available – and to contribute to further improvements. This virtuous cycle will enable human beings to transcend limitations previously considered insurmountable, and to solve age-old problems: war, poverty, crime, pollution, tyranny, and the existential threat to our species from natural disasters and human follies. The longer people live, the more motivated they will be to think in the long term and to invest in the future. They will know that their actions will have consequences for them personally, not just for remote unspecified descendants. People will have more time to learn and to work – but also more time to enjoy life and follow their dreams. Almost everyone wants the good life. The MILE wants to help make that good life a reality. The job of the MILE is to show a clear path toward radical improvement for good people everywhere.

The MILE embodies a combination of scientific, technological, philosophical, philanthropic, and even esthetic aspirations. Every skill set – from research to public relations – can find an application to the grand goal of indefinite life extension. There is no single leader or hierarchy in the MILE. You can be a leader and an example to others through your work on one of the many fronts in the war on death and decay. The MILE is a tolerant and diverse movement that welcomes a wide range of people and intellectual persuasions. Whatever your age, gender, culture, country of origin, place of residency, religion (or lack thereof), occupation, or lifestyle – as long as you love life and wish to cultivate and lengthen it, the MILE welcomes you. The MILE will deploy an increasing array of tools to help empower you and motivate you to contribute. By joining the MILE, you will not only become part of the most profound improvement in human history – indefinite life extension; you will also enjoy doing it.

The future is in our hands. The innovations of our ancestors made possible our current historically high standards of living. Today we can take the next step and secure the future for those who are alive and wish to remain that way. Death is indeed not inevitable if we deploy knowledge, persistence, and persuasive skill in achieving the needed commitment from humankind.

Update to Resources on Indefinite Life Extension – July 10, 2012

Update to Resources on Indefinite Life Extension – July 10, 2012

TRA’s Resources on Indefinite Life Extension page has been enhanced over the past two months with links to numerous fascinating articles and videos.

Articles

– “Scientists turn skin cells into beating heart muscle” – Kate Kelland – Reuters – May 22, 2012

– “Is Amyloidosis the Limiting Factor for Human Lifespan?” – Lyle J. Dennis, M.D. – Extreme Longevity – May 22, 2012

– “Israeli scientists create beating heart tissue from skin cells” – The Telegraph – May 23, 2012

– “Paralyzed rats walk again in Swiss lab study” – Chris Wickham – MSNBC.com – May 31, 2012

– “New Cancer Drugs Use Body’s Own Defenses” – Ron Winslow – Wall Street Journal – June 1, 2012

– “Bristol immune drug shows promise in three cancers” – Julie Steenhuysen – Reuters – June 2, 2012

– “Prostate cancer drug so effective trial stopped” – Victoria Colliver – San Francisco Chronicle – June 2, 2012

– “New ‘smart bomb’ drug attacks breast cancer, doctors say” – Associated Press – June 3, 2012

– “Alzheimer’s vaccine trial a success” – Karolinska Institutet – June 6, 2012

– “Man Cured of AIDS: ‘I Feel Good’” – Carrie Gann – ABC News – June 8, 2012

– “Artificial Lifeforms Promise Cleaner World, Healthier Humans” – Dick Pelletier – Positive Futurist – June 9, 2012

– “Secret of ageing found: Japanese scientists pave way to everlasting life” – RT – June 9, 2012

– “How aging normal cells fuel tumor growth and metastasis” – Thomas Jefferson University – June 14, 2012

– “People Who Justify Aging are Profoundly Wrong – Aging is Abhorrent” – Maria Konovalenko – Institute for Ethics & Emerging Technologies – June 14, 2012

– “Scientists tie DNA repair to key cell signaling network” – University of Texas Medical Branch at Galveston – June 15, 2012

– “Deciding How We Age as We Age” – Seth Cochran – h+ Magazine – June 19, 2012

– “How we die (in one chart)” – Sarah Kliff – Washington Post – June 22, 2012

– “Modified humans: the most cost-efficient way to colonize space” – Dick Pelletier – Positive Futurist – June 2012

– “Japanese Scientists Grow Human Liver From Stem Cells” – Reuters and Singularity Weblog – June 2012

– “Why Do Naked Mole Rats Live So Long? Do they hold the key to human life extension?” – Maria Konovalenko – Institute for Ethics & Emerging Technologies – June 29, 2012

– “Scientists Develop Alternative to Gene Therapy” – ScienceDaily – Scripps Research Institute – July 1, 2012

– “How to live beyond 100” – Lucy Wallis – BBC News – July 2, 2012

– “Earth 2050-2100: longer lives; new energy; FTL travel; global village” – Dick Pelletier – Positive Futurist – July 3, 2012

– “Scientists discover bees can ‘turn back time,’ reverse brain aging” – Phys.org – Arizona State University – July 3, 2012

– “Secret formula may be key to reverse aging” – Mike Holfeld – Click Orlando – July 4, 2012

– “Is there a biological limit to longevity?” – Aubrey de Grey – KurzweilAI – July 5, 2012

– “Demystifying the immortality of cancer cells” – Medical Xpress – July 5, 2012

– “Suggesting a Test of Rapamycin and Metformin Together” – Reason – FightAging.org – July 5, 2012

– “Earth 2050-2100: Longer Lives; New Energy; FTL Travel; Global Village” – Dick Pelletier – Positive Futurist – July 7, 2012

Videos

Aubrey de Grey

Aubrey de Grey – Aging & Suffering – Interview with Adam Ford – May 31, 2012

Nikola Danaylov (Socrates)

Anders Sandberg on Singularity 1 on 1: We Are All Amazingly Stupid, But We Can Get Better – May 27, 2012

Hugo de Garis on Singularity 1 on 1: Are We Building Gods or Terminators? – June 2012

A Libertarian Transhumanist Critique of Jeffrey Tucker’s “A Lesson in Mortality” – Audio Essay by G. Stolyarov II, Read by Wendy Stolyarov

A Libertarian Transhumanist Critique of Jeffrey Tucker’s “A Lesson in Mortality” – Audio Essay by G. Stolyarov II, Read by Wendy Stolyarov

Mr. Stolyarov, a libertarian transhumanist, offers a rebuttal to the arguments in Jeffrey Tucker’s 2005 essay, “A Lesson in Mortality“.

This essay is read by Wendy Stolyarov.

As a libertarian transhumanist, Mr. Stolyarov sees the defeat of “inevitable” human mortality as the logical outcome of the intertwined forces of free markets and technological progress – the very forces about which Mr. Tucker writes at length.

Read the text of Mr. Stolyarov’s essay here.
Download the MP3 file of this essay here.
Download a vast compendium of audio essays by Mr. Stolyarov and others at TRA Audio.

References

It’s a Jetsons World – Book by Jeffrey Tucker
– “Without Rejecting IP, Progress is Impossible” – Essay by Jeffrey Tucker – July 18, 2010
– “The Quest for Indefinite Life II: The Seven Deadly Things and Why There Are Only Seven” – Essay by Dr. Aubrey de Grey – July 30, 2004
Resources on Indefinite Life Extension (RILE)
– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Essay by G. Stolyarov II

A Libertarian Transhumanist Critique of Jeffrey Tucker’s “A Lesson in Mortality” – Article by G. Stolyarov II

A Libertarian Transhumanist Critique of Jeffrey Tucker’s “A Lesson in Mortality” – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
May 13, 2012
******************************

Jeffrey Tucker is one of my favorite pro-technology libertarian thinkers of our time. In his essays and books (see, for instance, It’s a Jetsons World), Mr. Tucker eloquently draws the connection between free markets and technological progress – and how the power of human creativity within a spontaneous order can overcome the obstructions posed by stagnant political and attitudinal paradigms. Mr. Tucker embraces the innovations of the Internet age and has written on their connection with philosophical debates – such as whether the idea of intellectual property is even practically tenable anymore, now that electronic technology renders certain human creations indefinitely reproducible.

Because I see Mr. Tucker as such an insightful advocate of technological progress in a free-market context, I was particularly surprised to read his 2005 article, “A Lesson in Mortality” – where Mr. Tucker contends that death is an inescapable aspect of the human condition. His central argument is best expressed in his own words: “Death impresses upon us the limits of technology and ideology. It comes in time no matter what we do. Prosperity has lengthened life spans and science and entrepreneurship has made available amazing technologies that have forestalled and delayed it. Yet, it must come.” Mr. Tucker further argues that “Modernity has a problem intellectually processing the reality of death because we are so unwilling to defer to the implacable constraints imposed on us within the material world… To recognize the inevitability of death means confessing that there are limits to our power to manufacture a reality for ourselves.

Seven years is a long time, and I am not aware of whether Mr. Tucker’s views on this subject have evolved since this article was published. Here, I offer a rebuttal to his main arguments and invite a response.

To set the context for his article, Mr. Tucker discusses the deaths of short-lived pets within his family – and how his children learned the lesson to grieve for and remember those whom they lost, but then to move on relatively quickly and to proceed with the business of life – “to think about death only when they must, but otherwise to live and love every breath.” While I appreciate the life-embracing sentiment here, I think it concedes too much to death and decay.

As a libertarian transhumanist, I see the defeat of “inevitable” human mortality as the logical outcome of the intertwined forces of free markets and technological progress. While we will not, at any single instant in time, be completely indestructible and invulnerable to all possible causes of death, technological progress – if not thwarted by political interference and reactionary attitudes – will sequentially eliminate causes of death that would have previously killed millions. This has already happened in many parts of the world with regard to killers like smallpox, typhus, cholera, malaria – and many others. It is not a stretch to extrapolate this progression and apply it to perils such as cancer, heart disease, stroke, Alzheimer’s disease, and ALS. Since human life expectancy has already increased roughly five-fold since the Paleolithic era, it is not inconceivable that – with continued progress – another five-fold or greater increase can be achieved.

As biogerontologist and famous life-extension advocate Dr. Aubrey de Grey points out, the seven basic types of damage involved in human senescence are already known – each for at least thirty years. With advances in computing capacity, as well as accelerating medical discoveries that have already achieved life extension in mice, rats, and other small organisms, there is hope that medical progress will arrive at similar breakthroughs for us within our lifetimes. Once life expectancy begins to increase by more than one year for every year of time that passes, we will have reached longevity escape velocity – a condition where the more we live, the more probability we will have of surviving even longer. In February 2012 I began an online compendium of Resources on Indefinite Life Extension, which tracks ongoing developments in this field and provides access to a wide array of media to show that life extension is not just science fiction, but an ongoing enterprise.

To Mr. Tucker, I pose the question of why he appears to think that despite the technological progress and economic freedom whose benefits he clearly recognizes, there would always be some upper limit on human longevity that these incredibly powerful forces would be unable to breach. What evidence exists for such a limit – and, even if such evidence exists, why does Mr. Tucker appear to assume that our currently finite lifespans are not just a result of our ignorance, which could be remedied in a more advanced and enlightened future? In the 15th century, for instance, humans were limited in their technical knowledge from achieving powered flight, even though visionaries such as Leonardo da Vinci correctly anticipated the advent of flying machines. Imagine if a Renaissance scholar made the argument to da Vinci that, while the advances of the Renaissance have surely produced improvements in art, architecture, music, and commerce, nature still imposes insurmountable limits on humans taking to the skies! “Sure,” this scholar might say, “we can now construct taller and sturdier buildings, but the realm of the birds will be forever beyond our reach.” He might say, paraphrasing Mr. Tucker, “[Early] modernity has a problem intellectually processing the reality of eternally grounded humans because we are so unwilling to defer to the implacable constraints imposed on us within the material world. To recognize the inevitability of human grounding means confessing that there are limits to our power to manufacture a reality for ourselves.” What would have happened to a society that fully accepted such arguments? Perhaps the greatest danger we can visit upon ourselves is to consider a problem so “inevitable” that nothing can be done about it. By accepting this inevitability as a foregone conclusion, we foreclose on the inherently unpredictable possibilities that human creativity and innovation can offer. In other words, we foreclose on a better future.

Mr. Tucker writes that “Whole ideologies have been concocted on the supposition that such constraints [on the material world] do not have to exist. That is the essence of socialism. It is the foundation of US imperialism too, with its cocky supposition that there is nothing force cannot accomplish, that there are no limits to the uses of power.” It is a significant misunderstanding of transhumanism to compare it to either socialism or imperialism. Both socialism and imperialism rely on government force to achieve an outcome deemed to be just or expedient. Transhumanism does not depend on force. While governments can and do fund scientific research, this is not an optimal implementation of transhuman aspirations, since government funding of research is notoriously conservative and reluctant to risk taxpayer funds on projects without short-term, visible payoffs about which politicians can boast. Furthermore, government funding of research renders it easier for the research to be thwarted by taxpayers – such as fundamentalist evangelical Christians – who disagree with the aims of such research. The most rapid technological advances can be achieved on a pure free market, where research is neither subsidized nor restricted by any government.

Moreover, force is an exceedingly blunt instrument. While it can be used to some effect to dispose of criminals and tyrants, even there it is tremendously imperfect and imposes numerous unintended negative consequences. Transhumanism is not about attempting to overcome material constraints by using coercion. It is, rather, about improving our understanding of natural laws and our ability to harness mind and matter by giving free rein to human experimentation in applying these laws.

Transhumanism fully embraces Francis Bacon’s dictum that “Nature, to be commanded, must be obeyed.” This means working within material constraints – including the laws of economics – and making the most of what is possible. But this also means using human ingenuity to push out our material limits. As genetic modification of crops has resulted in vastly greater volumes of food production, so can genetic engineering, rejuvenation therapies, and personalized medicine eventually result in vastly longer human lifespans. Transhumanism is the logical extrapolation of a free-market economy. The closer we get to an unfettered free market, the faster we could achieve the transhuman goals of indefinite life extension, universal wealth, space colonization, ubiquitous erudition and high culture, and the conquest of natural and manmade existential risks.

Mr. Tucker writes that recognizing the inevitability of death “is akin to admitting that certain fundamental facts of the world, like the ubiquity of scarcity, cannot be changed. Instead of attempting to change it, we must imagine social systems that come to terms with it. This is the core claim of economic science, and it is also the very reason so many refuse to acknowledge its legitimacy or intellectual binding power.” It is undeniable that scarcity exists, and that scarcity of some sort will always exist. However, there are degrees of scarcity. Food, for instance, is much less scarce today than in the Paleolithic era, when the earth could support barely more than a million humans. Furthermore, in some realms, such as digital media, Mr. Tucker himself has acknowledged that scarcity is no longer a significant limitation – because of the capacity to indefinitely reproduce works of art, music, and writing. With the proximate advent of technologies such as three-dimensional printing and tabletop nano-manufacturing, more and more goods will begin to assume qualities that more closely resemble digital goods. Then, as now, some physical resources will be required to produce anything – and these physical resources would continue to be subject to the constraints of scarcity. But it is not inconceivable that we would eventually end up in a Star Trek world of replicators that can manufacture most small-scale goods out of extremely cheap basic substances, which would render those goods nearly free to reproduce. Even in such a world, more traditional techniques may be required to construct larger structures, but subsequent advances may make even those endeavors faster, cheaper, and more accessible.

At no point in time would human lifespans be infinite (in the sense of complete indestructibility or invulnerability). A world of scarcity is, however, compatible with indefinite lifespans that do not have an upper bound. A person’s life expectancy at any point in time would be finite, but that finite amount might increase faster than the person’s age. Even in the era of longevity escape velocity, some people would still die of accidents, unforeseen illnesses, or human conflicts. But the motivation to conquer these perils will be greatly increased once the upper limit on human lifespans is lifted. Thus, I expect actual human mortality to asymptotically approach zero, though perhaps without ever reaching zero entirely. Still, for a given individual, death would no longer be an inevitability, particularly if that individual behaves in a risk-averse fashion and takes advantage of cutting-edge advancements. Even if death is always a danger on some level, is it not better to act to delay or prevent it – and therefore to get as much time as possible to live, create, and enjoy?

Mr. Tucker writes: “To discover the fountain of youth is a perpetual obsession, one that finds its fulfillment in the vitamin cults that promise immortality. We create government programs to pay for people to be kept alive forever on the assumption that death is always and everywhere unwarranted and ought to be stopped. There is no such thing as ‘natural death’ anymore; the very notion strikes us as a cop out.” It is true that there are and have always been many dubious remedies, promising longevity-enhancing benefits without any evidence. However, even if false remedies are considered, we have come a long way from the Middle Ages, where, in various parts of the world, powders of gold, silver, or lead – or even poisons such as arsenic – were considered to have life-extending powers. More generally, the existence of charlatans, frauds, snake-oil salesmen, and gullible consumers does not discredit genuine, methodical, scientific approaches toward life extension or any other human benefit. Skepticism and discernment are always called for, and we should always be vigilant regarding “cures” that sound too good to be true. Nobody credible has said that conquering our present predicament of mortality would be easy or quick. There is no pill one can swallow, and there is little in terms of lifestyle that one can do today – other than exercising regularly and avoiding obviously harmful behaviors – to materially lengthen one’s lifespan. However, if some of the best minds in the world are able to utilize some of the best technology we have – and to receive the philosophical support of the public and the material support of private donors for doing so – then this situation may change within our lifetimes. It is far better to live with this hope, and to work toward this outcome, than to resign oneself to the inevitability of death.

As regards government programs, I find no evidence for Mr. Tucker’s assertion that these programs are the reason that people are being kept alive longer. Implicit in that assertion is the premise that, on a fully free market (where the cost of high-quality healthcare would ultimately be cheaper), people would not voluntarily pay to extend the lives of elderly or seriously ill patients to the same extent that they expect such life extension to occur when funded by Medicare or by the national health-care systems in Canada and Europe. Indeed, Mr. Tucker’s assertion here poses a serious danger to defenders of the free market. It renders them vulnerable to the allegation that an unfettered free market would shorten life expectancies and invite the early termination of elderly or seriously ill patients – in short, the classic nightmare scenario of eliminating the weak, sickly, or otherwise “undesirable” elements. This is precisely what a free market would not result in, because the desire to live is extremely strong for most individuals, and free individuals using their own money would be much more likely to put it toward keeping themselves alive than would a government-based system which must ultimately ration care in one way or another.

Mr. Tucker writes: “Thus do we insist on always knowing the ‘cause’ of death, as if it only comes about through an exogenous intervention, like hurricanes, traffic accidents, shootings, and bombs. But even when a person dies of his own accord, we always want to know so that we have something to blame. Heart failure? Well, he or she might have done a bit more exercise. Let this be a lesson. Cancer? It’s probably due to smoking, or perhaps second-hand smoke. Or maybe it was the carcinogens introduced by food manufacturers or factories. We don’t want to admit that it was just time for a person to die.” Particularly as Austrian Economics, of which Mr. Tucker is a proponent, champions a rigorous causal analysis of phenomena, the above excerpt strikes me as incongruous with how rational thinkers ought to approach any event. Clearly, there are no uncaused events; there is nothing inexplicable in nature. Sometimes the explanations may be difficult or complex to arrive at; sometimes our minds are too limited to grasp the explanations at our present stage of knowledge and technological advancement. However, all valid questions are ultimately answerable, and all problems are ultimately solvable – even if not by us. The desire to know the cause of a death is a desire to know the answers to important questions, and to derive value from such answers by perhaps gathering information that would help oneself and others avoid a similar fate. To say that “it was just time for a person to die” explains nothing; it only attempts to fill in the gaps in our knowledge with an authoritative assertion that forecloses on further inquiry and discovery. While this may, to some, be comforting as a way of “moving on” – to me and other transhumanists it is an eminently frustrating way of burying the substance of the matter with a one-liner.

Mr. Tucker also compares death to sleep: “The denial of death’s inevitability is especially strange since life itself serves up constant reminders of our physical limits. Sleep serves as a kind of metaphor for death. We can stay awake working and having fun up to 18 hours, even 24 or 36, but eventually we must bow to our natures and collapse and sleep. We must fall unconscious so that we can be revived to continue on with our life.” While sleep is a suspension of some activities, death and sleep could not be more different. Sleep is temporary, while death is permanent. Sleep preserves significant aspects of consciousness, as well as a continuity of operations for the brain and the rest of the body. While one sleeps, one’s brain is hard at work “repackaging” the contents of one’s memory to prepare one for processing fresh experiences the next day. Death, on the other hand, is not a preparation for anything. It is the cessation of the individual, not a buildup to something greater or more active. In “How Can I Live Forever: What Does or Does Not Preserve the Self”, I describe the fundamental difference between processes, such as sleep, which preserve the basic continuity of bodily functions (and thus one’s unique vantage point or “I-ness”) and processes that breach this continuity and result in the cessation of one’s being. Continuity-preserving processes are fundamentally incomparable to continuity-breaching processes, and thus the ubiquity and necessity of sleep can tell us nothing regarding death.

Mr. Tucker validly notes that the human desire to live forever can manifest itself in the desire to leave a legacy and to create works that outlive the individual. This is an admirable sentiment, and it is one that has fueled the progress of human civilization even in eras when mortality was truly inevitable. I am glad that our ancestors had this motivation to overcome the sense of futility and despair that their individual mortality would surely have engendered otherwise. But we, standing on their shoulders and benefiting from their accomplishments, can do better. The wonders of technological progress within the near term, about which Mr. Tucker writes eloquently and at length, can be extrapolated to the medium and long term in order for us to see that the transhumanist ideal of indefinite life extension is both feasible and desirable. Free markets, entrepreneurship, and human creativity will help pave the way to the advances that could save us from the greatest peril of them all. I hope that, in time, Mr. Tucker will embrace this prospect as the incarnation, not the enemy, of libertarian philosophy and rational, free-market economics.