Productivity Enhancement – Video Series by G. Stolyarov II

Productivity Enhancement – Video Series by G. Stolyarov II

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The New Renaissance Hat
G. Stolyarov II
June 2, 2013
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In this series on productivity enhancement, taken from Mr. Stolyarov’s e-book The Best Self-Help is Free, Mr. Stolyarov discusses the fundamental nature of productivity and approaches by which any person can become more productive.

This series is based on Chapters 7-14 of The Best Self-Help is Free.

Part 1 – What is Productivity?

The most reliable way to achieve incremental progress in your life is by addressing and continually improving your own productivity. Productivity constitutes the difference between a world in which life is nasty, brutish, and short and one in which it is pleasant, civilized, and ever-increasing in length.

Part 2 – Reason and the Decisional Component of Productivity

In order to properly decide what ought to be produced, man can ultimately consult only one guide: his rational faculty.

Part 3 – Perfectionism — The Number One Enemy of Productivity

Perfectionism engenders a pervasive sense of futility in its practitioner and mentally inhibits him from pursuing further productive work.

Part 4 – Quantification and Productivity Targets

Quantification enables an individual to set productivity targets for himself and to escape underachievement on one hand and perfectionism on the other.

Part 5 – Habit and the Elimination of the Quality-Quantity Tradeoff

A common fallacy presumes that there is a necessary tradeoff between the quantity of work produced and the quality of that work. By this notion, one can either produce a lot of mediocre units of output or a scant few exceptional ones. While this might be true in some cases, it overlooks several important factors.

Part 6 – The Importance of Frameworks for Productivity

Time-saving, productivity-enhancing frameworks can be applied on a personal level to enable one to overcome the human mind’s limited ability to hold and process multiple pieces of information simultaneously.

Part 7 – The Benefits of Repetition to Productivity

One of the most reliable ways to reduce the amount of mental effort per unit of productive output is to create many extremely similar units of output in succession. Mr. Stolyarov discusses the advantages of structuring one’s work so as to perform many similar tasks in close succession.

Part 8 – Making Accomplishments Work for You

Producing alone is not enough. If you just let your output lie around accumulating dust or taking up computer memory, it will not boost your overall well-being. Your accomplishments can help procure health, reputation, knowledge, safety, and happiness for you — if you think about how to put them to use.

Iraq Collapse Shows Bankruptcy of Interventionism – Article by Ron Paul

Iraq Collapse Shows Bankruptcy of Interventionism – Article by Ron Paul

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The New Renaissance Hat
Ron Paul
June 2, 2013
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May was Iraq’s deadliest month in nearly five years, with more than 1,000 dead – both civilians and security personnel — in a rash of bombings, shootings and other violence. As we read each day of new horrors in Iraq, it becomes more obvious that the US invasion delivered none of the promised peace or stability that proponents of the attack promised.

Millions live in constant fear, refugees do not return home, and the economy is destroyed. The Christian community, some 1.2 million persons before 2003, has been nearly wiped off the Iraqi map. Other minorities have likewise disappeared. Making matters worse, US support for the Syrian rebels next door has drawn the Shi’ite-led Iraqi government into the spreading regional unrest and breathed new life into extremist elements.

The invasion of Iraq opened the door to Al-Qaeda in Iraq, which did not exist beforehand, while simultaneously strengthening the hand of Iran in the region. Were the “experts” who planned for and advocated the US attack really this incompetent?

Ryan Crocker, who was US Ambassador to Iraq from 2007-2009, still speaks of the Iraqi “surge” as a great reconciliation between Sunni and Shi’ite in Iraq. He wrote recently that “[t]hough the United States has withdrawn its troops from Iraq, it retains significant leverage there. Iraqi forces were equipped and trained by Americans, and the country’s leaders need and expect our help.” He seems alarmingly out of touch with reality.

It is clear now that the “surge” and the “Iraqi Awakening” were just myths promoted by those desperate to put a positive spin on the US invasion, which the late General William Odom once called, “the greatest strategic disaster in American history.” Aircraft were loaded with $100 dollar bills to pay each side to temporarily stop killing US troops and each other, but the payoff provided a mere temporary break. Shouldn’t the measure of success of a particular policy be whether it actually produces sustained positive results?

Now we see radical fighters who once shot at US troops in Iraq have spilled into Syria, where they ironically find their cause supported by the US government! Some of these fighters are even greeted by visiting US senators.

The US intervention in Iraq has created ever more problems. That is clear. The foreign policy “experts” who urged the US attack on Iraq now claim that the disaster they created can only be solved with more interventionism! Imagine a medical doctor noting that a particular medication is killing his patient, but to combat the side effect he orders an increase in dosage of the same medicine. Like this doctor, the US foreign policy establishment is guilty of malpractice. And, I might add, this is just what the Fed does with monetary policy.

From Iraq to Libya to Mali to Syria to Afghanistan, US interventions have an unbroken record of making matters far worse. Yet regardless of the disasters produced, for the interventionists a more aggressive US foreign policy is the only policy they offer.

We must learn the appropriate lessons from the disaster of Iraq. We cannot continue to invade countries, install puppet governments, build new nations, create centrally planned economies, engage in social engineering, and force democracy at the barrel of a gun. The rest of the world is tired of US interventionism, and the US taxpayer is tired of footing the bill for US interventionism. It is up to all of us to make it very clear to the foreign-policy establishment and the powers that be that we have had enough and will no longer tolerate empire-building. We should be more confident in ourselves and stop acting like an insecure bully.

Ron Paul, MD, is a former three-time Republican candidate for U. S. President and Congressman from Texas.

This article is reprinted with permission.

Choosing the Right Scale for Brain Emulation – Article by Franco Cortese

Choosing the Right Scale for Brain Emulation – Article by Franco Cortese

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The New Renaissance Hat
Franco Cortese
June 2, 2013
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This essay is the ninth chapter in Franco Cortese’s forthcoming e-book, I Shall Not Go Quietly Into That Good Night!: My Quest to Cure Death, published by the Center for Transhumanity. The first eight chapters were previously published on The Rational Argumentator under the following titles:
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The two approaches falling within this class considered thus far are (a) computational models that model the biophysical (e.g., electromagnetic, chemical, and kinetic) operation of the neurons—i.e., the physical processes instantiating their emergent functionality, whether at the scale of tissues, molecules and/or atoms, and anything in between—and (b) abstracted models, a term which designates anything that computationally models the neuron using the (sub-neuron but super-protein-complex) components themselves as the chosen model-scale (whereas the latter uses for its chosen model-scale the scale at which physical processes emergently instantiating those higher-level neuronal components exist, such as the membrane and individual proteins forming the transmembrane protein-complexes), regardless of whether each component is abstracted as a normative-electrical-component analogue (i.e., using circuit diagrams in place of biological schematics, like equating the lipid bilayer membrane with a capacitor connected to a variable battery) or mathematical models in which a relevant component or aspect of the neuron becomes a term (e.g., a variable or constant) in an equation.

It was during the process of trying to formulate different ways of mathematically (and otherwise computationally) modeling neurons or sub-neuron regions that I laid the conceptual embryo of the first new possible basis for subjective-continuity: the notion of operational isomorphism.

A New Approach to Subjective-Continuity Through Substrate Replacement

There are two other approaches to increasing the likelihood of subjective-continuity, each based on the presumption of two possible physical bases for discontinuity, that I explored during this period. Note that these approaches are unrelated to graduality, which has been the main determining factor impacting the likelihood of subjective-continuity considered thus far. The new approaches consist of designing the NRUs so as to retain the respective postulated physical bases for subjective-continuity that exist in the biological brain. Thus they are unrelated to increasing the efficacy of the gradual-replacement procedure itself, instead being related to the design requirements of functional-equivalents used to gradually replace the neurons that maintain immediate subjective-continuity.

Operational Isomorphism

Whereas functionality deals only with the emergent effects or end-product of a given entity or process, operationality deals with the procedural operations performed so as to give rise to those emergent effects. A mathematical model of a neuron might be highly functionally equivalent while failing to be operationally equivalent in most respects. Isomorphism can be considered a measure of “sameness”, but technically means a 1-to-1 correspondence between the elements of two sets (which would correspond with operational isomorphism) or between the sums or products of the elements of two sets (which would correspond with functional isomorphism, using the definition of functionality employed above). Thus, operational isomorphism is the degree with which the sub-components (be they material as in entities or procedural as in processes) of the two larger-scale components, or the operational modalities possessed by each respective collection of sub-components, are equivalent.

To what extent does the brain possess operational isomorphism? It seems to depend on the scale being considered. At the highest scale, different areas of the nervous system are classed as systems (as in functional taxonomies) or regions (as in anatomical taxonomies). At this level the separate regions (i.e., components of a shared scale) differ widely from one another in terms of operational-modality; they process information very differently from the way other components on the same scale process information. If this scale was chosen as the model-scale of our replication-approach and the preceding premise (that the physical basis for subjective-continuity is the degree of operational isomorphism between components at a given scale) is accepted, then we would in such a case have a high probability of replicating functionality, but a low probability of retaining subjective-continuity through gradual replacement. This would be true even if we used the degree of operational isomorphism between separate components as the only determining factor for subjective-continuity, and ignored concerns of graduality (e.g., the scale or rate—or scale-to-rate ratio—at which gradual substrate replacement occurs).

Contrast this to the molecular scale, where the operational modality of each component (being a given molecule) and the procedural rules determining the state-changes of components at this scale are highly isomorphic. The state-changes of a given molecule are determined by molecular and atomic forces. Thus if we use an informational-functionalist approach, choose a molecular scale for our model, and accept the same premises as the first example, we would have a high probability of both replicating functionality and retaining subjective-continuity through gradual replacement because the components (molecules) have a high degree of operational isomorphism.

Note that this is only a requirement for the sub-components instantiating the high-level neural regions/systems that embody our personalities and higher cognitive faculties such as the neocortex — i.e., we wouldn’t have to choose a molecular scale as our model scale (if it proved necessary for the reasons described above) for the whole brain, which would be very computationally intensive.

So at the atomic and molecular scale the brain possesses a high degree of operational isomorphism. On the scale of the individual protein complexes, which collectively form a given sub-neuronal component (e.g., ion channel), components still appear to possess a high degree of operational isomorphism because all state-changes are determined by the rules governing macroscale proteins and protein-complexes (i.e., biochemistry and particularly protein-protein interactions); by virtue of being of the same general constituents (amino acids), the factors determining state-changes at this level are shared by all components at this scale. The scale of individual neuronal components, however, seems to possess a comparatively lesser degree of operational isomorphism. Some ion channels are ligand-gated while others are voltage-gated. Thus, different aspects of physicality (i.e., molecular shape and voltage respectively) form the procedural-rules determining state-changes at this scale. Since there are now two different determining factors at this scale, its degree of operational isomorphism is comparatively less than the protein and protein-complex scale and the molecular scale, both of which appear to have only one governing procedural-rule set. The scale of individual neurons by contrast appears to possess a greater degree of operational isomorphism; every neuron fires according to its threshold value, and sums analog action-potential values into a binary output (i.e., neuron either fires or does not). All individual neurons operate in a highly isomorphic manner. Even though individual neurons of a given type are more operationally isomorphic in relation to each other than with a neuron of another type, all neurons regardless of type still act in a highly isomorphic manner. However, the scale of neuron-clusters and neural-networks, which operate and communicate according to spatiotemporal sequences of firing patterns (action-potential patterns), appears to possess a lesser degree of operational isomorphism compared to individual neurons, because different sequences of firing patterns will mean a different thing to two respective neural clusters or networks. Also note that at this scale the degree of functional isomorphism between components appears to be less than their degree of operational isomorphism—that is, the way each cluster or network operates is more similar in relation to each other than is their actual function (i.e., what they effectively do). And lastly, at the scale of high-level neural regions/systems, components (i.e., neural regions) differ significantly in morphology, in operationality, and in functionality; thus they appear to constitute the scale that possesses the least operational isomorphism.

I will now illustrate the concept of operational isomorphism using the physical-functionalist and the informational-functionalist NRU approaches, respectively, as examples. In terms of the physical-functionalist (i.e., prosthetic neuron) approach, both the passive (i.e., “direct”) and CPU-controlled sub-classes, respectively, are operationally isomorphic. An example of a physical-functionalist NRU that would not possess operational isomorphism is one that uses a passive-physicalist approach for the one type of component (e.g., voltage-gated ion channel) and a CPU-controlled/cyber-physicalist approach [see Part 4 of this series] for another type of component (e.g., ligand-gated ion channel)—on that scale the components act according to different technological and methodological infrastructures, exhibit different operational modalities, and thus appear to possess a low degree of operational isomorphism. Note that the concern is not the degree of operational isomorphism between the functional-replication units and their biological counterparts, but rather with the degree of operational isomorphism between the functional-replication units and other units on the same scale.

Another possibly relevant type of operational isomorphism is the degree of isomorphism between the individual sub-components or procedural-operations (i.e., “steps”) composing a given component, designated here as intra-operational isomorphism. While very similar to the degree of isomorphism for the scale immediately below, this differs from (i.e., is not equivalent to) such a designation in that the sub-components of a given larger component could be functionally isomorphic in relation to each other without being operationally isomorphic in relation to all other components on that scale. The passive sub-approach of the physical-functionalist approach would possess a greater degree of intra-operational isomorphism than would the CPU-controlled/cyber-physicalist sub-approach, because presumably each component would interact with the others (via physically embodied feedback) according to the same technological and methodological infrastructure—be it mechanical, electrical, chemical, or otherwise. The CPU-controlled sub-approach by contrast would possess a lesser degree of intra-operational-isomorphism, because the sensors, CPU, and the electric or electromechanical systems, respectively (the three main sub-components for each singular neuronal component—e.g., an artificial ion channel), operate according to different technological and methodological infrastructures and thus exhibit alternate operational modalities in relation to eachother.

In regard to the informational-functionalist approach, an NRU model that would be operationally isomorphic is one wherein, regardless of the scale used, the type of approach used to model a given component on that scale is as isomorphic with the ones used to model other components on the same scale as is possible. For example, if one uses a mathematical model to simulate spiking regions of the dendritic spine, then one shouldn’t use a non-mathematical (e.g., strict computational-logic) approach to model non-spiking regions of the dendritic spine. Since the number of variations to the informational-functionalist approach is greater than could exist for the physical-functionalist approach, there are more gradations to the degree of operational isomorphism. Using the exact same branches of mathematics to mathematically model the two respective components would incur a greater degree of operational isomorphism than if we used alternate mathematical techniques from different disciplines to model them. Likewise, if we used different computational approaches to model the respective components, then we would have a lesser degree of operational isomorphism. If we emulated some components while merely simulating others, we would have a lesser degree of operational isomorphism than if both were either strictly simulatory or strictly emulatory.

If this premise proves true, it suggests that when picking the scale of our replication-approach (be it physical-functionalist or informational-functionalist), we choose a scale that exhibits operational isomorphism—for example, the molecular scale rather than the scale of high-level neural-regions, and that we don’t use widely dissimilar types of modeling techniques to model one component (e.g., a molecular system) than we do for another component on the same scale.

Note that unlike operational-continuity, the degree of operational isomorphism was not an explicit concept or potential physical basis for subjective-continuity at the time of my working on immortality (i.e., this concept wasn’t yet fully fleshed out in 2010), but rather was formulated in response to going over my notes from this period so as to distill the broad developmental gestalt of my project; though it appears to be somewhat inherent (i.e., appears to be hinted at), it hasn’t been explicitized until relatively recently.

The next chapter describes the rest of my work on technological approaches to techno-immortality in 2010, focusing on a second new approach to subjective-continuity through a gradual-substrate-replacement procedure, and concluding with an overview of the ways my project differs from the other techno-immortalist projects.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Tapping the Transcendence Drive – Article by D.J. MacLennan

Tapping the Transcendence Drive – Article by D.J. MacLennan

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The New Renaissance Hat
D. J. MacLennan
June 2, 2013
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What do we want? No, I mean, what do we really want?

Your eyes flick back and forth between your smartphone and your iPad; your coffee cools on the dusty coaster beside the yellowing PC monitor; you momentarily look to the green vista outside your window but don’t fully register it; Facebook fade-scrolls the listless postings of tens of phase-locked ‘friends’, while the language-association areas of your brain chisel at your clumsy syntax, relentlessly sculpting it down to the 140-character limit of your next Twitter post.

The noise, the noise; the pink and the brown, the blue and the white. What do we want? How do we say it?

As I am a futurist, it’s understandable that people sometimes ask me what I can tell them about the future. What do I say? How about, “Well, it won’t be the same as the past”? On many levels, this is an unsatisfying answer. But, importantly, it is neither a stupid nor an empty one. If it sounds a bit Zen, that is only because people as used to a mode of thinking about the future that has it looking quite a lot like the past but with more shiny bits and bigger (and much flatter) flatscreens.

What I prefer to say, when there is more time available for the conversation, is, “It depends on what you, and others, want, and upon what you do to get those things.” Another unsatisfying response?

Where others see shiny stuff, I see the physical manifestations of drives. After all, what are Facebook, Twitter, and iPads but manifestations of drives? Easy, isn’t it? We can now glibly state that Twitter and Facebook are manifestations of the drive to communicate, and that the iPad is a manifestation of the desire to possess shiny stuff that does a slick job of enabling us to better pursue our recreational, organizational, and communicational drives.

There are, however, problems with this way of looking at drives. If, for example, we assume, based on the evidence we see from the boom in the use of communication technologies, that people have a strong drive to stay in touch with each other, we will simply churn out more and more of the same kinds of communication devices and platforms. If, on the other hand, we look at what is the overarching drive driving the desire to communicate, we can better address the real needs of the end user.

PongAs another example, we look back to early computer gaming. What was the main drive of the teenager playing Pong on Atari’s first arcade version of the game, released in 1972? If you asked this question to an impartial observer in 1972, they might well have opined that the fun of Pong stemmed from the fact that it was like table tennis; table tennis is fun, so a bleepy digital version of it in a big yellow box should also be fun. While not completely incorrect, such an opinion would be based solely upon the then-current gaming context. In following the advice of such an observer, an arcade-game manufacturer might have invested, and probably lost, an enormous amount of money in producing more and more electronic versions of simple tabletop games. But, fortunately for the computer-game industry, many manufacturers realized that the fun of arcade games was largely in the format, and so began to abandon the notion that they should be digital representations of physical games.

If we jump to a modern MMORPG game involving player avatars, such as World of Warcraft, we find a situation radically different from that which prevailed in 1972, but I would argue that many observers still make the same kinds of mistakes in extrapolating the drives of the players. It’s all about “recreation” and “role-playing”, right?

I think that many technology manufacturers underestimate and misunderstand our true drives. I admit to being an optimist on such matters, but what if, just for a moment, we assume that the drives of technology-obsessed human beings (even the ones playing Angry Birds, or posting drunken nonsense on Facebook) are actually grand and noble ones? What if we really think about what it is that they are trying to do? Now we begin to get somewhere. We can then see the Facebook postings as an individual’s yearning for registration of his or her existence; a drive towards self-actualization with a voice augmented beyond the hoarse squeak of the physical one. We can see individuals’ appreciation of the clean lines of their iPads as a desire for rounded-corner order in a world of filth and tangle. We can see their enjoyment of moving their avatar around World of Warcraft as the beginnings of a massive stretching of their concept of self, to a point where it might break open and merge colorfully with the selves of others.

E-Book Reader

One hundred and forty characters: I know it doesn’t look much like a drive for knowledge and transcendence, but so what? Pong didn’t look much like Second Life; the telegraph didn’t look much like the iPad. The past is a poor guide to the future. A little respect for, and more careful observation of, what might be the true drives of the technology-obsessed would, I think, help us to create a future enhanced by enabling technologies, and not one awash with debilitating noise.

D.J. MacLennan is a futurist writer and entrepreneur, and is signed up with Alcor for cryonic preservation. He lives in, and works from, a modern house overlooking the sea on the coast of the Isle of Skye, in the Highlands of Scotland.

See more of D.J.’s writing at extravolution.com and futurehead.com.

“Common Core” Nationalizes and Dumbs Down Public School Curriculum – Article by Ron Paul

“Common Core” Nationalizes and Dumbs Down Public School Curriculum – Article by Ron Paul

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The New Renaissance Hat
Ron Paul
June 1, 2013
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In addition to shredding civil liberties, launching a utopian global war for democracy, and going on a spending spree that would make LBJ blush, the so-called “conservative” Bush administration dramatically increased federal control over education via the “No Child Left Behind” act. During my time in Congress I heard nothing but complaints about this law from teachers, administrators, and, most importantly, students and parents. Most of the complaints concerned No Child Left Behind’s testing requirements, which encouraged educators to “teach to the test.”

Sadly, but not surprisingly, instead of improving education by repealing No Child Left Behind’s testing and other mandates, the Obama administration is increasing national control over schools via the “Common Core” initiative. Common Core is a new curriculum developed by a panel of so-called education experts. The administration is trying to turn Common Core into a national curriculum by offering states increased federal education funding if they impose Common Core’s curriculum on their public schools. This is yet another example of the government using money stolen from the people to bribe states into obeying federal dictates.

Critics of Common Core say it “dumbs down” education by replacing traditional English literature with “informational texts”. So students will read such inspiring materials as studies by the Federal Reserve Bank of San Francisco, the EPA’s “Recommended Levels of Insulation,” and “Invasive Plant Inventory” by California’s Invasive Plant Council. It is doubtful that reading federal reports will teach students the habits of critical thinking and skepticism of government that the Founders considered essential to maintaining a free republic.

Like Obamacare, Common Core (now dubbed “ObamaCore” by some) has sparked a backlash in the states, leading some to propose legislation forbidding state participation in the scheme. I hope these efforts lead to states not just opting out of Common Core, but out of No Child Left Behind and all other federal education programs as well.

Parents can also effectively “opt out” of programs like Common Core by seeking alternatives to government education. It is no coincidence that, as federal control over education increases, the quality of public education has declined and more parents have chosen to homeschool.

To support these parents, I have established my own homeschool curriculum. Unlike Common Core, we do not dumb down any of our offerings. Instead, the goal is to provide students with a rigorous education in history, math, English, foreign languages, and other core subjects necessary to a well-rounded education. Unlike the top-down model of nationalized education, the homeschool curriculum is deigned to encourage maximum input from parents and students. While the curriculum will reflect my belief, and interest, in Austrian economics, libertarian political theory, and the history of the struggle against centralized coercive power, the curriculum is being carefully designed to not show bias toward any one religion. I hope all parents of any faith—or no religious belief at all—will feel comfortable using the curriculum.

I believe it is important for those of us concerned with education and liberty to fight our battles locally. We must oppose further encroachment on the autonomy of local public schools and work to roll-back existing interference, while encouraging and supporting the growth of homeschooling and other alternative education movements. The key to restoring quality education is to replace the bureaucratic control of education with a free market in education. Parents should have the freedom to select the type of education that best suits their child’s unique needs.

Ron Paul, MD, is a former three-time Republican candidate for U. S. President and Congressman from Texas.

This article is reprinted with permission.

A Brief History of Western Liberalism – Article by Kyrel Zantonavitch

A Brief History of Western Liberalism – Article by Kyrel Zantonavitch

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Kyrel Zantonavitch
June 1, 2013
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This is a brief history of the philosophy and culture of liberalism. It describes a life-style and civilization which lifts human beings far above that of animals, chimpanzees, hominids, and even tribalist hunter-gatherers. Liberalism features man at his best. Liberals are clear-thinking and rational men: natural, sound, healthy, happy, uplifted, and heroic.

Liberalism is a fundamental category of philosophy and life-style – something broad and general. It constitutes a definitive concept – beyond which one cannot venture or improve – like life, happiness, greatness, transcendence, virtue, beauty, pleasure, thought, reality, existence, and the universe. Liberalism’s subsidiary concepts are also ultimate and final: rationality, egoism, and liberty.

In the story of mankind, first come bonobos, then semi-human Homo habilis, then primitive man Homo erectus, then highly advanced Neanderthals, then truly intelligent and impressive Cro-Magnons – who used their 100 IQs to exterminate their brutish competitors, invent sophisticated arrow technology, and make art such as those Venus statues and cave paintings.

By 9000 BC the last Ice Age ended, and humans immediately converted from hunter-gatherers to rancher-farmers. After domesticating multitudinous plants and animals, by 3300 BC human beings further cultivated them with irrigation on their new private property, backed by their revolutionary social institution called government. By 1700 BC men had well-established written laws, well-developed literature and art, easy personal transportation using horses, and elaborate international trade using sophisticated great ships.

All of this constituted impressive advances in humans’ quality of life; but none of it constituted philosophical or cultural liberalism.

Finally, by about 600 BC, the ancient Greeks created the indescribably magnificent phenomenon of Western liberalism. They invented rationality or “Greek reason” or syllogistic logic – or pure thought or epistemology. This is usually described as “the discovery of science and philosophy.”

But along with the stunning and wondrous epistemology of reason – naturally and inevitably and inherently – came the ethics of individualism, and the politics of freedom.

All of this can be fairly, accurately, and usefully denominated as the thought-system and life-style of Western liberalism – of liberal philosophy and culture, especially as exemplified by Aristotle, Epicurus, and Zeno the Stoic. These three theorists, ironically, were labelled by their intellectual opponents as “dogmatic.” This was not because these scientifically minded open debaters claimed to know everything based on faith, but because they claimed to know anything at all based on evidence and analysis.

By the 100s BC in Greece, the general ideology of liberalism was well-established in the middle and upper classes. Then the Romans conquered the Greeks and within a century made liberalism their own. They even advanced the noble ideas and ideals a bit, with such thinkers as Cicero, Lucretius, Virgil, Horace, and Aurelius.

But skepticism of reason ascended rapidly by the 200s AD, and with it came the decline of the greatest country in human history. The new phenomenon of monotheism began to dominate in the 300s AD, especially Christianity or “Plato for the masses.” By the middle of the 400s, the philosophy and culture of liberalism were dead, and so was Rome. A long, terrible Dark Age ensued.

This irrational, illiberal nightmare of Western civilization lasted for a millennium. The wretched and depraved philosophy of Jesus ruined everything.

But a bit of reason and hope came back into the world in the 1100s of northwest Europe with the mini-Renaissance. High-quality Greek thinkers were gradually reintroduced. Then came the 1300s and the Italian Renaissance.

By the 1500s a whole Europe-wide Renaissance began with France’s conquest of northern Italy. The French brought their reborn art and philosophy to everyone in the West. The beautiful general philosophy of liberalism ascended still higher while the ghastly evils of fundamentalist skepticism, Platonism, monotheism, and Christianity declined. The classical liberal era was brought about by radical and heroic innovators like Francis Bacon, John Locke, Voltaire, Adam Smith, and Thomas Jefferson.

The late 1700s Enlightenment and Age of Reason in Britain, France, Holland, and America featured liberalism at its height. But it was gradually and massively undermined by the irrational, nonsensical philosophers Bishop Berkeley, David Hume, Jean-Jacques Rousseau, Immanuel Kant, and Friedrich Hegel.

During and after the 1790s the French Revolution went astray and embraced ideological dogmatism, and self-sacrifice to the cause. It also converted itself into an early version of modern communism; as well as the false, evil, and illiberal ideologies of right-wing conservatism and left-wing progressivism. In the art world this was manifested by the slightly but definitely irrational Romantic movement of 1800-1850. Paintings started to turn ugly again.

Socialism and communism fairly quickly went into high gear after Karl Marx’s Communist Manifesto of 1848. Religion also somewhat revived in the late 1800s. These two monstrous ideologies backed the moral ideal of self-destruction, or the “Judeo-Christian ethic,” or, even better, the “religio-socialist ethic.” The fin de siècle of the 1890s was the giddy, despairing, hopeless, lost end of a noble era in the West – a dynamic, heroic, rational, liberal era.

A practical, real-world, irrational, illiberal dystopia was achieved in the mid-1900s with Stalin, Hitler, and Mao. Later in the 1900s there were Pol Pot, Idi Amin, Ayatollah Khomeini, and countless other despots. Illiberalism reached a hellish trough around 1985.

Then came Ronald Reagan in America, Margaret Thatcher in Britain, Mikhail Gorbachev in Russia, and Deng Xiaoping in China. These four political semi-revolutionaries, in four leading nations, used their governments to change world culture in a liberal direction.

These liberal leaders emerged on the world scene because theory always precedes practice, and the theory of liberalism began to rise again – at least intellectually, and in certain recherché circles – around the early 1900s. It began anew with Austrian economic thinkers like Ludwig von Mises, Henry Hazlitt, and Friedrich Hayek. In addition to the dry, mechanical realm of economics, these three addressed the fields of politics and sociology – and even ethics and epistemology. They filled in many of the gaps, and corrected many of the weaknesses and failures, of Locke, Smith, and company.

The Austrians also attacked the communism, socialism, and progressivism of Woodrow Wilson, Franklin Roosevelt, and Lyndon Johnson, among others. And they taught the fiery intellectual novelist Ayn Rand.

Rand converted from fiction to philosophy from the late 1950s to the late 1970s. She was by far the most liberal thinker in the history of man. She created the philosophy of Objectivism. Ayn Rand advanced human knowledge about as much as Bacon, Locke, Voltaire, Smith, and Jefferson combined.

Sadly, however, Rand undercut her liberal ideology with a heavy atmosphere and subtext of cultism and religiosity in her propaganda movement. This was understandable, considering how revolutionary and hated her philosophy was, but hardly rational or legitimate.

However, Rand died in 1982, and a highly rational and non-religious organization, organized around her discoveries, emerged in 1989. This brought the world Objectivism as a thought-system, not a belief-system; and Objectivism as a rational, benevolent, effective philosophy – not an irrational, malicious, weird cult.

There are currently three separate but related avant-garde liberal ideological movements: Austrian economics, libertarian politics, and Objectivist philosophy. All three are tiny but, based on historical intellectual standards, seemingly growing solidly.

Pure liberalism – a pure, clean, complete comprehension that reason was 100% right in epistemology, individualism was 100% right in ethics, and freedom was 100% right in politics – began in the early 21st century. Randroid illiberalism began to die out. A New Enlightenment is about to begin.

Kyrel Zantonavitch is the founder of The Liberal Institute  (http://www.liberalinstitute.com/) and a writer for Rebirth of Reason (http://www.rebirthofreason.com). He can be contacted at zantonavitch@gmail.com.

Mitochondrially Targeted Antioxidant SS-31 Reverses Some Measures of Aging in Muscle – Article by Reason

Mitochondrially Targeted Antioxidant SS-31 Reverses Some Measures of Aging in Muscle – Article by Reason

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The New Renaissance Hat
Reason
May 26, 2013
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Originally published on the Fight Aging! website.

Antioxidants of the sort you can buy at the store and consume are pretty much useless: the evidence shows us that they do nothing for health, and may even work to block some beneficial mechanisms. Targeting antioxidant compounds to the mitochondria in our cells is a whole different story, however. Mitochondria are swarming bacteria-like entities that produce the chemical energy stores used to power cellular processes. This involves chemical reactions that necessarily generate reactive oxygen species (ROS) as a byproduct, and these tend to react with and damage protein machinery in the cell. The machinery that gets damaged the most is that inside the mitochondria, of course, right at ground zero for ROS production. There are some natural antioxidants present in mitochondria, but adding more appears to make a substantial difference to the proportion of ROS that are soaked up versus let loose to cause harm.

If mitochondria were only trivially relevant to health and longevity, this wouldn’t be a terribly interesting topic, and I wouldn’t be talking about it. The evidence strongly favors mitochondrial damage as an important contribution to degenerative aging, however. Most damage in cells is repaired pretty quickly, and mitochondria are regularly destroyed and replaced by a process of division – again, like bacteria. Some rare forms of mitochondrial damage persist, however, eluding quality-control mechanisms and spreading through the mitochondrial population in a cell. This causes cells to fall into a malfunctioning state in which they export massive quantities of ROS out into surrounding tissue and the body at large. As you age, ever more of your cells suffer this fate.

In recent years a number of research groups have been working on ways to deliver antioxidants to the mitochondria, some of which are more relevant to future therapies than others. For example gene therapies to boost levels of natural mitochondrial antioxidants like catalase are unlikely to arrive in the clinic any time soon, but they serve to demonstrate significance by extending healthy life in mice. A Russian research group has been working with plastinquinone compounds that can be ingested and then localize to the mitochondria, and have shown numerous benefits to result in animal studies of the SkQ series of drug candidates.

US-based researchers have been working on a different set of mitochondrially targeted antioxidant compounds, with a focus on burn treatment. However, they recently published a paper claiming reversal of some age-related changes in muscle tissue in mice using their drug candidate SS-31. Note that this is injected, unlike SkQ compounds:

Mitochondrial targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

Quote:

Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here we demonstrate that a single treatment with the mitochondrial targeted peptide SS-31 restores in vivo mitochondrial energetics to young levels in aged mice after only one hour.

Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg/kg of SS-31. Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and 31 P magnetic resonance spectroscopy. Age-related declines in resting and maximal mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP) were rapidly reversed after SS-31 treatment, while SS-31 had no observable effect on young muscle.

These effects of SS-31 on mitochondrial energetics in aged muscle were also associated with a more reduced glutathione redox status and lower mitochondrial [ROS] emission. Skeletal muscle of aged mice was more fatigue resistant in situ one hour after SS-31 treatment and eight days of SS-31 treatment led to increased whole animal endurance capacity. These data demonstrate that SS-31 represents a new strategy for reversing age-related deficits in skeletal muscle with potential for translation into human use.

So what is SS-31? If look at the publication history for these authors you’ll find a burn-treatment-focused open-access paper that goes into a little more detail and a 2008 review paper that covers the pharmacology of the SS compounds:

Quote:

The SS peptides, so called because they were designed by Hazel H. Sezto and Peter W. Schiler, are small cell-permeable peptides of less than ten amino acid residues that specifically target to inner mitochondrial membrane and possess mitoprotective properties. There have been a series of SS peptides synthesized and characterized, but for our study, we decided to use SS-31 peptide (H-D-Arg-Dimethyl Tyr-Lys-Phe-NH2) for its well-documented efficacy.

Studies with isolated mitochondrial preparations and cell cultures show that these SS peptides can scavenge ROS, reduce mitochondrial ROS production, and inhibit mitochondrial permeability transition. They are very potent in preventing apoptosis and necrosis induced by oxidative stress or inhibition of the mitochondrial electron transport chain. These peptides have demonstrated excellent efficacy in animal models of ischemia-reperfusion, neurodegeneration, and renal fibrosis, and they are remarkably free of toxicity.

Given the existence of a range of different types of mitochondrial antioxidant and research groups working on them, it seems that we should expect to see therapies emerge into the clinic over the next decade. As ever, the regulatory regime will ensure that they are only approved for use in treatment of specific named diseases and injuries such as burns, however. It’s still impossible to obtain approval for a therapy to treat aging in otherwise healthy individuals in the US, as the FDA doesn’t recognize degenerative aging as a disease. The greatest use of these compounds will therefore occur via medical tourism and in a growing black market for easily synthesized compounds of this sort.

In fact, any dedicated and sufficiently knowledgeable individual could already set up a home chemistry lab, download the relevant papers, and synthesize SkQ or SS compounds. That we don’t see this happening is, I think, more of a measure of the present immaturity of the global medical tourism market than anything else. It lacks an ecosystem of marketplaces and review organizations that would allow chemists to safely participate in and profit from regulatory arbitrage of the sort that is ubiquitous in recreational chemistry.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Squishy Machines: Bio-Cybernetic Neuron Hybrids – Article by Franco Cortese

Squishy Machines: Bio-Cybernetic Neuron Hybrids – Article by Franco Cortese

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The New Renaissance Hat
Franco Cortese
May 25, 2013
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This essay is the eighth chapter in Franco Cortese’s forthcoming e-book, I Shall Not Go Quietly Into That Good Night!: My Quest to Cure Death, published by the Center for Transhumanity. The first seven chapters were previously published on The Rational Argumentator under the following titles:
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By 2009 I felt the major classes of physicalist-functionalist replication approaches to be largely developed, producing now only potential minor variations in approach and procedure. These developments consisted of contingency plans in the case that some aspect of neuronal operation couldn’t be replicated with alternate, non-biological physical systems and processes, based around the goal of maintaining those biological (or otherwise organic) systems and processes artificially and of integrating them with the processes that could be reproduced artificially.

2009 also saw further developments in the computational approach, where I conceptualized a new sub-division in the larger class of the informational-functionalist (i.e., computational, which encompasses both simulation and emulation) replication approach, which is detailed in the next chapter.

Developments in the Physicalist Approach

During this time I explored mainly varieties of the cybernetic-physical functionalist approach. This involved the use of replicatory units that preserve certain biological aspects of the neuron while replacing certain others with functionalist replacements, and other NRUs that preserved alternate biological aspects of the neuron while replacing different aspects with functional replacements. The reasoning behind this approach was twofold. The first was that there was a chance, no matter how small, that we might fail to sufficiently replicate some relevant aspect(s) of the neuron either computationally or physically by failing to understand the underlying principles of that particular sub-process/aspect. The second was to have an approach that would work in the event that there was some material aspect that couldn’t be sufficiently replicated via non-biological physically embodied systems (i.e., the normative physical-functionalist approach).

However, these varieties were conceived of in case we couldn’t replicate certain components successfully (i.e., without functional divergence). The chances of preserving subjective-continuity in such circumstances are increased by the number of varieties we have for this class of model (i.e., different arrangements of mechanical replacement components and biological components), because we don’t know which we would fail to functionally replicate.

This class of physical-functionalist model can be usefully considered as electromechanical-biological hybrids, wherein the receptors (i.e., transporter proteins) on the post-synaptic membrane are integrated with the artificial membrane and in coexistence with artificial ion-channels, or wherein the biological membrane is retained while the receptor and ion-channels are replaced with functional equivalents instead. The biological components would be extracted from the existing biological neurons and reintegrated with the artificial membrane. Otherwise they would have to be synthesized via electromechanical systems, such as, but not limited to, the use of chemical stores of amino-acids released in specific sequences to facilitate in vivo protein folding and synthesis, which would then be transported to and integrated with the artificial membrane. This is better than providing stores of pre-synthesized proteins, due to more complexities in storing synthesized proteins without decay or functional degradation over storage-time, and in restoring them from their “stored”, inactive state to a functionally-active state when they were ready for use.

During this time I also explored the possibility of using the neuron’s existing protein-synthesis systems to facilitate the construction and gradual integration of the artificial sections with the existing lipid bilayer membrane. Work in synthetic biology allows us to use viral gene vectors to replace a given cell’s constituent genome—and consequently allowing us to make it manufacture various non-organic substances in replacement of the substances created via its normative protein-synthesis. We could use such techniques to replace the existing protein-synthesis instructions with ones that manufacture and integrate the molecular materials constituting the artificial membrane sections and artificial ion-channels and ion-pumps. Indeed, it may even be a functional necessity to gradually replace a given neuron’s protein-synthesis machinery with protein-synthesis-based machinery for the replacement, integration and maintenance of the non-biological sections’ material, because otherwise those parts of the neuron would still be trying to rebuild each section of lipid bilayer membrane we iteratively remove and replace. This could be problematic, and so for successful gradual replacement of single neurons, a means of gradually switching off and/or replacing portions of the cell’s protein-synthesis systems may be required.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

The Extraordinary Business of Life – Article by Sanford Ikeda

The Extraordinary Business of Life – Article by Sanford Ikeda

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The New Renaissance Hat
Sanford Ikeda
May 25, 2013
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I heard it again from this year’s commencement speaker: the common mistake of thinking economics is just about business and making money. I know I’m not the only economics teacher who every year has to disabuse his students (and many of his own colleagues from other disciplines) of that same error.

Economics is not business administration or accounting. Economics is a science that studies how people interact when the means at their disposal are scarce in relation to their ends. That includes business, of course, but a whole lot more as well.

Where Does That Notion Come From?

Well, for starters, perhaps from one of the greatest economists in history, Alfred Marshall. He opens his highly influential textbook, first published in 1890, with this statement:

“Political Economy or Economics is a study of mankind in the ordinary business of life; it examines that part of individual and social action which is most closely connected with the attainment and with the use of the material requisites of wellbeing.” (Emphasis added)

This definition more or less prevailed until 1932, when another British economist, Lionel Robbins, defined economic science as being concerned with an aspect of all human action insofar as it involves making choices, not with a part of individual action. Economics, in other words, is the science of choice. Its starting point is not the “material requisites of wellbeing” but a person’s subjective valuation of her circumstances. Ludwig von Mises got it, which is why he called his magnum opus, simply, Human Action.

Similarly, Libertarianism Isn’t Pro-Business

An equally common mistake is to think that supporters of the free market are “pro-business” and favor so-called crony capitalism. But a consistent free-market supporter is neither pro-business nor anti-business, pro-labor nor anti-labor. A free market to us is what happens when you safeguard private property, free association, and consistent governance and then just leave people alone.

Part of the misunderstanding here might stem from the term “free market” itself. Since people tend to associate markets with buying and selling, jobs, and making (and losing) money, it’s perhaps understandable that they would think that advocates of the free market must be concerned mainly about business-related stuff: profits and losses, efficiency, and creating and marketing new products.

Indeed, I’ve met quite a few who claim to favor “free-market capitalism” merely because they believe in making as much money as possible in their lifetimes. It’s not surprising that many of these folks do tend to be pro-business and supporters of crony capitalism. I want to ask them not to be on my side.

Connotations aside, the free market encompasses far more than the stuff of business or a money-making scheme. Yes, it does include the essentials of private property, free association, and stable governance. But a dynamic market process that generates widespread material prosperity and promotes the pursuit of happiness would not be possible if it were based solely on the relentless pursuit of one’s narrow self-interest. Markets would not have gotten as far as they have today (with per-capita GDP up more than fiftyfold since 1700) if people didn’t also follow norms of honesty and fair play, trust and reciprocity. Such norms are without question partly the result of self-interest; few would trade with us if we weren’t honest and fair. But, as Adam Smith taught us, these norms also arise in large measure from a sense of sympathy, of fellow-feeling and fairness, that comes from our ability to see others as we see ourselves, and vice versa. This is why in most contexts I usually prefer the term “free society” to “free market.”

Bourgeois Virtue

But I think one good reason the association between business on the one hand and economics and classical liberalism on the other has been so persistent is that business and the free society arose together. That is, the liberal idea—that certain fundamental individual rights exist prior to and apart from the State—sparked one of the most momentous social changes in history: the commercial revolution and the emergence of the modern urban middle class. 

The triumph of liberty, of personal freedom, unleashed the creative potential of people, who found expression in art, religion, literature, but most of all—or at least most visibly—in the Marshallian “ordinary business of life.” The changes that have taken place in the past 500 years—scientific revolutions, religious reformations, political upheavals, artistic rebirths—were driven by the same human propensities as the commercial revolution and fueled by the wealth it produced. Indeed, the social and political changes of the past century—for women, workers, and minorities—would not have been possible without the entrepreneurial pressures of competition and innovation that forced radical changes in conventional thinking and socially conservative attitudes.

Tradition’s Worst Enemy

In short, business is the most dynamic social institution known to mankind. The critical and competitive attitudes that enable business to flourish erode custom and break old ties even as they foster new ones. The products of business tend to offend people whose sensibilities were refined by generations of tradition. The free market is tradition’s worst enemy.

Business has become part of the default mode of modern society. We take it for granted. We don’t realize what a radical, subversive force it is, to the point where it sounds strange to say so. But try to imagine a world without businesses and commerce. A world like the Dark Ages of, say ninth century Western Europe: static, grindingly poor, strictly hierarchical, socially intolerant, and, apart from the occasional battle or beheading, boring like you wouldn’t believe.

So, while it’s still a mistake to think economics and classical liberalism are somehow about studying and promoting business, maybe at a deeper level it’s not such a bad one to make after all. Business is subversive.

Sanford Ikeda is an associate professor of economics at Purchase College, SUNY, and the author of The Dynamics of the Mixed Economy: Toward a Theory of Interventionism.
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This article was originally published by The Foundation for Economic Education.
Oklahoma: The Economic Storm – Article by David J. Hebert

Oklahoma: The Economic Storm – Article by David J. Hebert

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David J. Hebert
May 25, 2013
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A tornado ravaged Oklahoma last week, destroying hundreds of homes, killing dozens, and injuring hundreds more. Unfortunately, it looks like the citizens of Oklahoma are about to be ravaged by another storm brought on by the Oklahoma Attorney General, Scott Pruitt.

According to ABC News, Mr. Pruitt and his staff began “aggressively combing the region for fraud just hours after the tornado … and immediately [found] businesses violating the law. ”

What laws were the businesses accused of violating?  Anti-price-gouging laws. Using powers granted by the Emergency Price Stabilization Act, Mr. Pruitt is hoping to help the people of Oklahoma by preventing businesses from profiting off of the suffering of the townspeople, many of whom just lost their homes. He goes so far as to say, “[the townspeople] never anticipate or expect that someone would take advantage of them right now, but this situation is what criminals prey upon. ”

While Mr. Pruitt no doubt intends to help the local citizens, his misunderstanding of the workings of the price mechanism will lead only to folly and the prolonged suffering of the very people that he is trying to help. What he is effectively arguing for is a price ceiling on basic commodities, such as water (which is reportedly being sold for $40 per case today as opposed to only $3-$4 just a few weeks ago).

This has very predictable results: a shortage.

When prices are held below their market value, the effect is that there will be a large number of people who are willing to purchase water at that price but very few sellers willing to sell the water at that price. This means that people will compete on non-price margins to acquire water, that is, they will queue, sometimes for hours on end. The time that they spend waiting in line, however, is a deadweight cost as it is value that is forgone but is not captured by anyone. So now, instead of contributing towards the reconstruction of the town, the people are stuck waiting in line for water.

The beauty of the price mechanism is what it accomplishes in situations like this, assuming, of course, officials allow it to function properly. In this situation, demand in Oklahoma rises and producers, seeing an opportunity to profit, reroute trucks/planes to Oklahoma, thus increasing the quantity of water supplied in the area that needs it most.

Absent the rise in price, we would have to rely on the benevolence of these companies to help the people in need (and assume that they knew what the people of Oklahoma wanted to begin with).

This isn’t in and of itself terrible. Obviously companies DO send extra water to places that experience disasters, and the Red Cross DOES send volunteers and such. But notice that nothing in the preceding analysis precludes this benevolence. Why rely merely on benevolence when we can also rely on self-interest? If the goal is to help people get clean drinking water, it stands to reason that we ought to incentivize producers as many ways as possible, be they other-regarding, self-regarding or both.

David Hebert is a Ph.D. Fellow at the Mercatus Center at George Mason University.

This article was originally published by The Foundation for Economic Education.