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Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
October 4, 2013
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As part of my escalating efforts to advance the prospects of radical life extension through my individual actions, I have donated $50 to an ambitious new crowdfunding project to research longevity-enhancing treatments in mice.

This international project, undertaken by researchers at the Kiev Institute of Gerontology and supported by the Methuselah Foundation and the SENS Research Foundation, has an Indiegogo fundraising page, titled “I am a little mouse and I want to live longer!”, where contributions can be made.

I am proud to donate to this effort to support longevity research through crowdfunding. This project allows those of us who seek longer lifespans, and who wish to advance the science that will get us there, to contribute directly in a manner whereby each of us can make a sizable fraction of the difference for this research effort. I look forward to the great work that this project will accomplish. Achieving statistically significant mouse life extension in the near future could trigger massive public interest and the influx of major research funds to attain increasingly ambitious life-extension goals in higher-order mammals, culminating in us.

The project has already raised $8,673 and has 16 days remaining to reach its $15,000 goal. The Methuselah Foundation will match each $1,000 given with an equivalent donation – so it is possible to double one’s impact by contributing funds to this research effort.

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life.

References
– “Calico and the Paradigm Shift in the War on Death” – Article by G. Stolyarov II
– “Google announces Calico, a new company focused on health and well-being” – Google Press Release – September 18, 2013
– “TIME Feature: CSO Aubrey de Grey on Google’s Newly Launched Anti-Aging Initiative” – SENS Research Foundation – September 18, 2013
– “Google’s Calico: the War on Aging Has Truly Begun” – Aubrey de Grey – TIME Magazine – September 18, 2013
SENS Research Foundation

The Last Generation to Die – Article by Reason

The Last Generation to Die – Article by Reason

The New Renaissance Hat
Reason
September 27, 2013
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The last generation whose members will be forced into death by aging is alive today. It won’t be the youngest of us, born in the past few years – they, most likely, have thousands of years ahead of them. It won’t be the oldest of us either, as even under the plausible best of circumstances we are twenty to thirty years away from a widespread deployment of rejuvenation therapies based on the SENS research program. As to the rest of us, just who is left holding the short straw at the end of the day depends on the speed of progress in medical science: advocacy, fundraising, and the effectiveness of research and development initiatives. Persuasion and money are far more important at this early stage than worrying about how well the researchers are doing their jobs, however.

We live in a world in which the public is only just starting to come around to the idea that aging can be treated, and demonstrations of rejuvenation in the laboratory could be achieved in a crash program lasting ten to twenty years, at a comparatively small cost. But still, most people don’t care about living longer, and most people try not to think about aging, or the future of degeneration and sickness that awaits. They think it is inevitable, but that is no longer true. If you are in early middle age today in the first world, then you have a good shot at living for centuries if the world suddenly wakes up tomorrow and massive funding pours into rejuvenation research. You will age and die on a timescale little different from that of your parents if that awakening persistently fails to happen.

So, roll the dice, or help out and try to swing the odds in your favor. Your choice.

Crowdfunding on Kickstarter and related sites is still the new new thing, the shine not yet worn off. One of the truths that this activity reinforces is that it is far, far easier to raise funding for the next throwaway technological widget than for medical research projects aimed at the betterment of all humanity. Research crowdfunding is a tiny, distant moon orbiting the great mass of comics, games, and devices on Kickstarter, Indiegogo, and others. Hell, it’s easier to crowdfund a short film that points out how close human rejuvenation might be to the present day than it is to crowdfund a project to actually conduct a portion of that research. Is this a reflection of rationality? You decide, though it could be argued either way regarding whether a dollar given to raising awareness is more valuable than a dollar given to the researchers at this point in time. Both research and persuasion need to happen.

The Last Generation To Die – A Short Film

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Set in the future when science first begins to stop aging, a daughter tries to save her father from natural death. The story takes place roughly 30 years in the future at the moment when science has first figured out how to stop aging through genetics. It is framed around the gulf between generations that would occur with the first release of this technology. A daughter who works for a company called Aperion Life – the first to bring this new technology to the public – wants to save her aging father. She starts him on the trials but he soon stops coming. The film continues with the conflict rising between them as she wants him to live on with her while he feels a natural ending is more human.The film centers itself around the natural conflict that would exist at this divide. Upon developing this story, I’ve asked many people and I’ve found a pretty even 50/50 divide of opinions strongly on one side or the other- either they want to die naturally and believe there is beauty in finality, or they want to see what the future holds and have more time to explore and learn more in life. I’d like to turn the question to you… Which side are you on? Would you want to live on or die naturally?

I feel this is a film that needs to be made. Asking these questions in the form of art and story will help start the discussion. Our world is changing very fast and the rate of technology is speeding up. What does all of this mean for humanity? Everything we know, from a book to a play to a song, ends… What does it mean when there is no ending? Would we be more complacent? Would life be as meaningful? Is there more of a beauty in the way it has always been with our passing or is there more beauty in our bodies and minds staying fresh and alive for many, many years to come? What about social justice and overpopulation? Would life become boring after living on indefinitely or would you find it exhilarating to have time to learn new languages, instruments, subjects – to read more books, to love more – to live several lifetimes? Would it be worth it if some of your most loved friends or relatives passed on and wouldn’t live on with you? Are you interested in seeing what the future brings in technology and social evolution or are you happy to have contributed and be a part of it for a short time?

Tim Maupin’s Film, ‘The Last Generation to Die’, to Explore Longevity and Life Extension

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Chicago filmmaker Tim Maupin launched a Kickstarter for a short film titled, “The Last Generation to Die.” Maupin thinks now is a great time to start a conversation about life extension. And he’s right. The idea that within decades a genetic fountain of youth may plausibly reverse the aging process, even indefinitely stave off death, seems to be rising up in pop culture. Maupin’s Kickstarter has so far raised over $15,000 – $6,000 more than its initial funding goal. Encouraged by the positive response, they’re dreaming bigger and hope to fund a stretch goal of $25,000 in the last 10 days of the campaign.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Editor’s Note from G. Stolyarov II: I am proud to have donated $50 to help make the film The Last Generation to Die a success. I encourage all readers to donate during the remaining nine days in which the Kickstarter project is open to accepting funds.

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 19, 2013
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Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life. Unlike the cautious, short-term orientation of many more conventional manufacturers of drugs and medical devices, Google’s philosophy of making investments with possible immense payoffs in the distant future offers tremendous hope that this company will be around through the many years it will take to engage in the search for promising treatments and their subsequent testing.

 Aubrey de Grey, one of the chief strategists and key intellectual innovators in the escalating war on senescence, has written that Calico signals that the war on aging has truly begun. De Grey emphasizes that it is no longer necessary to persuade most of academia that this war is a worthwhile endeavor: “With Google’s decision to direct its astronomical resources to a concerted assault on aging, that battle may have been transcended: once financial limitations are removed, curmudgeons no longer matter.” As with its remarkable advances in autonomous vehicles, mobile operating systems, and wearable computing, Google does not need to ask the permission of the entire world to explore the possibilities. Rather, it can simply achieve the breakthroughs, whose momentum and adoption naysayers would be powerless to halt.

Funding has always been a major bottleneck for true life-extending research, but now the resources of Google, as well as the highly skilled researchers who will surely be recruited by Calico, will enable this bottleneck to be overcome. Few details about the company are yet available, and it is likely that several years will elapse before major discoveries are announced. However, the barrier to mainstream acceptability of the war on senescence has been breached. Once significant successes are announced, other companies will hopefully shed some of their current caution and will seek to profit from the burgeoning field of longevity research. A few other companies still may even try to emulate Calico before any results are announced – just so as to remain competitive with Google and stay ahead of the pack, in their view.

The key to the success of any sustainable enterprise focused on life-extension research is to recognize that the sole pursuit of profits next quarter or next year is not a viable strategy for altering the status quo in radical ways. Great innovations require great leaps outside the norm. Such leaps are not often immediately rewarded financially by the broader market, which is why much of the longevity research to date has been sponsored by non-profit institutions such as the SENS Research Foundation and various universities. However, a prudent, forward-looking pursuit of profit can take the radical alteration of the status quo to the next level, by harnessing the immensely powerful motive of self-interest for the purpose of improving human lives. In this case, the improvement from gains to human longevity – and hopefully the ultimate defeat of senescence altogether – would be so immense as to be humankind’s crowning achievement. Google develops technologies with the eventual intent of marketing them to millions of consumers, and the success of Calico would be a triumph not just for longevity research but for the dissemination of cures to age-related diseases, and perhaps to senescence itself.

While anyone of sufficient intellectual courage can have a long-term vision and projects aimed at advancing that vision, Google has the distinct advantage of an extremely viable business in the present, which continues to bring in short-term revenues so that Calico does not need to be concerned with profits next quarter or next year. Instead, Calico will be able to survive on the profits of Google’s many ongoing operations, while devoting the time and effort of world-class researchers to pursuing all of the explorations, experiments, and tests that are needed to ultimately develop marketable cures. Once the cures are out there, though, the profits could be unprecedented, because life is the most precious, the most fundamental value we humans have. Any entity that discovers a way to transcend the current frailties of old age and push back or remove the current limits on human lifespans will become fabulously wealthy beyond comparison.

May Calico usher in Adam Smith’s invisible hand in the realm of longevity medicine – a hand that pushes back senescence and death and creates a world where health and wealth are ours to enjoy indefinitely.

Aubrey de Grey Comments on the “Hallmarks of Aging” Paper – Article by Reason

Aubrey de Grey Comments on the “Hallmarks of Aging” Paper – Article by Reason

The New Renaissance Hat
Reason
September 8, 2013
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The Hallmarks of Aging paper was published earlier this year. It is an outline by a group of noted researchers that divides up degenerative aging into what they believe are its fundamental causes, with extensive references to support their conclusions, and proposes research strategies aimed at building the means to address each of these causes. This is exactly what we want to see more of in the aging research community: deliberate, useful plans that follow the Strategies for Engineered Negligible Senescence (SENS) model of approaching aging.

Read through the Hallmarks of Aging and you’ll see that it is essentially a more mild-mannered and conservative restatement of the SENS approach to aging – written after more than ten years of advocacy and publication and persuasion within the scientific community by SENS supporters. To my eyes, the appearance of such things shows that SENS is winning the battle of ideas within the scientific community, and it is only a matter of time before it and similar repair-based efforts aimed at human rejuvenation dominate the field. Rightly so, too, and it can’t happen soon enough for my liking. SENS and SENS-like research is the only way we’re likely to see meaningful life extension technologies emerge before those of us in middle age now die, so the more of it taking place the better.

Aubrey de Grey, author of the original SENS proposals and now Chief Science Officer of the SENS Research Foundation that funds and guides rejuvenation research programs, is justifiably pleased by the existence of the Hallmarks of Aging. See this editorial in the latest Rejuvenation Research, for example:

A Divide-and-Conquer Assault on Aging: Mainstream at Last

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On June 6th, a review appeared concerning the state of aging research and the promising ways forward for the field. So far, so good. But this was not any old review. Here’s why: (a) it appeared in Cell, one of the most influential journals in biology; (b) it is huge by Cell’s standards – 24 pages, with well over 300 references; (c) all its five authors are exceptionally powerful opinion-formers – senior, hugely accomplished and respected scientists; (d) above all, it presents a dissection of aging into distinct (though inter-connected) processes and recommends a correspondingly multi-pronged (“divide and conquer”) approach to intervention.

It will not escape those familiar with SENS that this last feature is not precisely original, and it may arouse some consternation that no reference is made in the paper to that prior work. But do I care? Well, maybe a little – but really, hardly at all. SENS is not about me, nor even about SENS as currently formulated (though a depressing number of commentators in the field persist in presuming that it is). Rather, it is about challenging a profound, entrenched, and insidious dogma that has consumed biogerontology for the past 20 years, and which this new review finally – finally! – challenges (albeit somewhat diplomatically) with far more authority than I could ever muster.

Aging has been shown, over several decades, to consist of a multiplicity of loosely linked processes, implying that robust postponement of age-related ill-health requires a divide-and-conquer approach consisting of a panel of interventions. Because such an approach is really difficult to implement, gerontologists initially adopted a position of such extreme pessimism that all talk of intervention became unfashionable. The discovery of genetic and pharmacological ways to mimic [calorie restriction], after a brief period of confused disbelief, was so seductive as a way to raise the field’s profile that it was uncritically embraced as the fulcrum of translational gerontology for 20 years, but finally that particular emperor has been decisively shown to have no biomedically relevant clothes.

The publication of so authoritative a commentary adopting the “paleogerontological” position, that aging is indeed chaotic and complex and intervention will indeed require a panel of therapies, but now combined with evidence-based optimism as to the prospects for implementing such a panel, is a key step in the elevation of translational gerontology to a truly mature field.

In essence, as de Grey points out, work on aging has been following the wrong, slow, expensive, low-yield path for a couple of decades: the path of deciphering the mechanisms of calorie restriction and altering genes and metabolism to slightly slow down aging. This path cannot result in large gains in life expectancy and long-term health, and it cannot result in therapies that will greatly help people who are already old. What use is slowing down the accumulation of the damage of aging if you are already just a little more damage removed from death, and frail and suffering because of it, and the treatment will meaningfully alter none of that? If we want to add decades or more to our healthy life spans before we die, then rejuvenation and repair of damage are what is needed: ways to reverse frailty, remove suffering, and restore youthful function.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Longevitize!: The Master Compendium for the Life-Extension Movement – Post by G. Stolyarov II

Longevitize!: The Master Compendium for the Life-Extension Movement – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 7, 2013
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longevitize2013_med

Longevitize!: Essays on the Science, Philosophy & Politics of Longevity is a new and (literally) vital compilation, edited by Franco Cortese, which assembles perhaps the widest array of resources on radical life extension in one location. You can read a detailed description of the book here. Cortese’s ambitious projects have breathed new life into the transhumanist and immortalist movements, and Longevitize promises to be perhaps his most influential contribution to date, illustrating a thorough grasp of the current state of the efforts to defeat senescence and enable humankind to transcend its primordial limitations.

In addition to 164 articles representing diverse perspectives about the scientific, philosophical, and political aspects and implications of indefinite life extension, this compendium includes an immensity of links to external resources, including books, articles, and videos. I am proud that my Resources on Indefinite Life Extension (RILE) page formed the crux of the book’s Appendix II. Longevitize permits the reader to delve as deeply as can be desired into studying the feasibility, desirability, and possibilities for implementation of the defeat of senescence and involuntary death.

I am proud to have contributed 27 essays to this anthology, spanning 9 years of my thinking and writing on the prospect of indefinite longevity. In addition, the excellent cover was designed by my wife Wendy Stolyarov, incorporating Maxim Vorobiev’s 1842 painting, “Oak fractured by a lightning bolt. Allegory on wife’s death.” Death destroys our irreplaceable individual universes much like that lightning destroyed the tree. It is time to put an end to this travesty, and Longevitize offers an amazing toolkit and intellectual foundation for doing so. Buy this book, read it, and use it in your further intellectual explorations – including your writing, research, argumentation, and activism.

Right now, Longevitize! is available as an e-book for $9.99, both in PDF and MOBI formats, from Amazon. A hard-copy version is currently being prepared.

Life Expectancy is Growing at the Upper End, Too – Post by G. Stolyarov II

Life Expectancy is Growing at the Upper End, Too – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 7, 2013
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I was recently asked whether my advocacy of indefinite life extension may be undermined by considering the growth rate in life expectancy at the upper end – for instance, for the oldest 10,000 people alive at any given time, rather than for the general population. Mortality for infants and younger adults has surely declined over the centuries, due to safer environments and considerable reductions in infectious diseases, but what about expansion of the upper bound of lifespans?

It turns out that there, too, considerable progress is being made. In July 2009, the New York Daily News reported, on the basis of a study from the National Institute on Aging, that “The number of centenarians already has jumped from an estimated few thousand in 1950 to more than 340,000 worldwide today, with the highest concentrations in the U.S. and Japan”. In addition to being further evidence that the US is not such a bad place for longevity (if one manages to avoid bad health habits and death from car accidents, both of which are more prevalent in the US than in Europe), this is evidence that a dramatic expansion in lifespans is underway for all age groups. Indeed, centenarians are the fastest-growing segment of all. The 2010 US Census found that the number of centenarians in the US grew by 5.8% from 2000 to 2010.  In Japan, the number of centenarians rose by 3,300 between 2010 and 2011. This trend shows no sign of abating. While Jeanne Calment, who died in 1997, still holds the greatest longevity record (122 years, 164 days), she was clearly a lucky outlier, and a recent one at that, when one considers a broader historical scale.  Statistically, the chances of living longer rise with each passing year. And among human males, the longest-living verified individual, Jiroemon Kimura, died at age 116 years, 54 days, this year (June 12, 2013). I have great hope that his record will be surpassed in the coming years.

Thus, the promise of indefinite life extension is not undermined when considering trends in the upper end of lifespans. There, as with average life expectancy and life expectancy for adults, the growth is apparent.

Transhumanism as the Logical Extrapolation of Humanism – Post by G. Stolyarov II

Transhumanism as the Logical Extrapolation of Humanism – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 6, 2013
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When discussing the relationship between transhumanism and humanism, some would claim that transhumanism rejects humanism due to the latter’s limiting aspects, while others hold that transhumanism is the logical extrapolation of humanism. I firmly adhere to the latter view.

The Wikipedia definition of humanism is rather broad: “Humanism is a group of philosophies and ethical perspectives which emphasize the value and agency of human beings, individually and collectively, and generally prefers individual thought and evidence (rationalism, empiricism) over established doctrine or faith (fideism).” Historically, the advocacy of human agency and value has often led to humanists resisting static definitions of “human nature” (for instance, as advocated by various premodern religions) in favor of a melioristic view of progress and human potential. My own essay, “Human Nature is Tautological” (also available in video form) is an example of this position.

Indeed, I have often thought that humanism and transhumanism are separated only by the degree of emphasis on human improvability. Transhumanism takes the melioristic aspirations of humanism to a new level by emphasizing the power of technology to radically transform human lives by lifting age-old limitations. But nothing in humanism per se would resist such a radical transformation. Transhumanism, in my view, accepts the core values of humanism and takes them further in light of the recognition of technological possibilities, particularly as regards radical life extension and extension of human reach to both the mega-scale (space colonization and giant construction projects) and to the nano-scale (nanotechnology and its applications to manufacturing and medicine).

Combatting the “Longer Life Will Slow Progress” Criticism – Article by Franco Cortese

Combatting the “Longer Life Will Slow Progress” Criticism – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
September 2, 2013
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We are all still children. As far as the Centenarian is concerned, the only people to have ever lived have been children – and we have all died before our coming of age.

What if humans only lived to age 20? Consider how much less it would be possible to know, to experience, and to do. Most people would agree that a maximum lifespan of 20 years is extremely circumscribing and limiting – a travesty. However, it is only because we ourselves have lived past such an age that we feel intuitively as though a maximum lifespan of 20 years would be a worse state of affairs than a maximum lifespan of 100. And it is only because we ourselves have not lived past the age of 100 that we fail to have similar feelings regarding death at the age of 100. This doesn’t seem like such a tragedy to us – but it is a tragedy, and arguably one as extensive as death at age 20.

Another reason informing our concern with death at age 20 and our relative ease with death at 100 is the notion of living long enough to do enough. Death at age 20 for the most part seems to preclude such experiences as parenthood, to birth a child and watch him grow into personhood, whereas a 100-year-old will have had enough time to have children, to watch them grow, to work and to enjoy the fruits of his or her labor through leisure in retirement. Our ignorance regarding the real scope of possibility, of possible experience and possible modes of existence, also informs our relative unconcern with death at age 100. We feel that there is a limited number of things for one to do in life, or at least things that are qualitatively unique enough to be considered as being truly distinguishable from the rest.

But we couldn’t be more wrong. It’s hard to step outside culture sometimes, and easy to naively look upon a foreign culture as embodying but a very limited number of archetypes and stereotypical caricatures of their true depth and diversity. There are more contemporary cultural traditions and conditions that can be practiced and experienced than there are years to actually do so. Likewise, there is more history to learn about than time available. The current breadth and depth of the world and its past are far too gargantuan to be encompassed by a mere 100 years. If you really think that there are only so many things that can be done in a lifetime, you simply haven’t lived long enough or broadly enough. There is more to the wide whorl of the world than the confines and extents of our own particular cultural narrative and native milieu.

More than this, the startling diversity of the world and stark heterogeneity of history are only set to continue their upward growth into spaces unknown as we move into the plethora of futures before us. More information is being produced than can be kept up with. Culture has always been changing, but today the pace of that change is swifter than ever before. The thought that boredom would ever be an issue to longer-living people is simply laughable. Not only does the world currently contain more than it is possible to know in a single century, but it is accumulating ever more depth and diversity every day, and at an accelerating pace. You couldn’t catch up with history in the first place, and you’re sure to gain more ground to cover than you can possibly encompass, faster than you can get a hold of it, as life expectancy experiences further increases.

Another condition informing our concern with death at 20 and our relative unconcern with death at 100 is the decline of function as we age. Bodily suffering and functional decay increase as one grows with age, and often we look upon the elderly as beings more defined by their encumbrance, by what they have lost, than by what they still possess. What will life be like, we wonder, when bodily motion becomes a battle, and when the simple experience of motion in an embodied world is complimented at every turn and twist by heat, friction, and pain, when living as we once did when young becomes a labor, and leisure is really just that? Or perhaps worse, when our minds begin to fall out from under us, to fail, as we are left to look on in horror from the inside-out, looking in? Lucky for us, we’re wrong; and even if we weren’t, we are still lucky that it is a transient tragedy, a temporary and ultimately remediable one.

How Life Expectancy Soared Since 1841

These men and women are more than the sum of what they have lost. They are living, breathing, thinking and valuing beings. They are! It’s as simple and stunning as that: they exist! To think that they might be better off, happier, in the rest of death and quiet of last breath – to think that they are beings defined most fundamentally by suffering, and by a comparison of what they no longer are, is not only wrong but perverse. They are living, and life so long as it’s lived should never be defined by suffering, by a lack or comparison of what it isn’t, but rather by what it is and still is. There are exceptions, of course; rapidly debilitating disease, unremitting pain, incomprehensible horror at the slow decay of mind. But I would argue confidently that the elderly are not in constant woe of that which they can no longer do. Like living beings, they deal with it and continue on in the business of being. To consider the elderly as “waiting for the rest and peace of death” is a dangerous and ugly notion, and one very far from the truth.

Luckily, functional decline as a correlate of age is on the way out. We will live to 100 not in a period of decline upon hitting our mid-twenties, but in a continuing period of youthfulness. There are no longevity therapies on the table that offer to truly prolong life indefinitely without actually reversing aging. Death and aging are not separate things or processes; death is when aging has won the battle. Aging is slow death, and a truly-indefinite delaying of death ipso facto necessitates a reversal of aging, and a remediation of the physiological conditions that ultimately lead to death (i.e., what we colloquially call aging). To think that we will be prolonging our lives not as youthful beings of whatever physiological age we so desire but instead as elderly, age-ravaged beings patching new holes and bracing old crutches, is to some extent mistake the cause for the symptom. If we prolong life significantly, we will prolong the healthy portion of our lives first and foremost. The centenarians of next century will look as healthy as the 20-year-olds of last.

Thus, one of the impediments preventing us from seeing death at 100 as a tragedy, as dying before one’s time, will be put to rest as well. When we see a 100-year-old die in future, he or she will have the young face of someone who we feel today has died before their time. We won’t be intuitively inclined to look back upon the gradual loss of function and physiological-robustness as leading to and foretelling this point, thereby making it seem inevitable or somehow natural. We will see a terribly sad 20-year-old, wishing they had more time. We will be able to envision with vivid viscerality the bright and buoyant things they could be doing were they not bedridden and stricken with sickness unto death.

Moreover, that gradual decline into visually apprehensible old age also highlights another impediment to seeing the elderly as continually growing beings with a future to look forward to rather than fight against. The gradual decline of our mental faculties makes it seem that we would be accumulating experience and memory at a deficit, cumulatively losing the ability to think, judge, remember, and experience. Thus old age conjures to mind more senility than wisdom for many people.

This, too, is less true than delusive. Again, this type of thinking is engendered by comparing what they seem to be with what they aren’t or once were. In any case, it will be even less true in the future, when longevity therapies restore our mental health to its youthful glory. Then, the prospect of ever-continuing experience and personal growth, ever-accumulating wisdom and knowledge, ever sharper consideration and discernment, is not so intuitively improbable. The claim that we can in fact continue to grow in how smart, ethical, knowledgeable, and deliberative we are will not be so easily balkable when one’s physiological state ceases to be an indicator of one’s chronological age.

Another common criticism of indefinite longevity in regard to the downfalls of old age comes from Max Planck’s statement that science progresses one funeral at a time; that men and women of a given generation become so attached to their theories that they remain attached in the face of contrary evidence, and it takes their very death for new theories to be embraced by new generations unencumbered by the consideration that “after all this time I might actually be wrong after all”. From this sentiment follows the criticism that significantly extending the average human lifespan will slow progress in science by preventing the death those grafted unflinchingly to a given theory. I would argue that such a sentiment stems from the view of the elderly previously defined and defied, namely as beings more defined by what they have lost than by what they have, as beings fighting against the grain of growth. To view the elderly as continually growing beings forces one to see this criticism as somewhat naïve.

Along another line of argumentation, if we assume that this observation is correct and elderly academics refusing to let their own cherished theories die at the hands of the new is a real concern only aggravated by the coming of longevity therapies, then we still have reason to believe that longevity therapies can change the nature of the game by a large enough extent to negate these problematic concerns.

If some people refuse to consider in light of new evidence or perspective that their theory is wrong, refuse to allow the series of thought leading to the realization that all they have worked for is of lesser importance now, the most obvious cause of discontent would seem to be the notion of their own onrushing death. “If my theory is wrong, there isn’t time – or perhaps just youthful vigor – enough to do it all over again from scratch.” Someone worked his lifetime to achieve recognition in his field, and with his death so close around the corner, he faces the prospect of having all that work and worth be devalued by new developments. It is a scary thought, and the notion that people willingly or subconsciously refuse to consider facts that undermine their theory, and its perceived worth in their field, is least conceivable under such conditions. Thusly considered, Planck’s notion doesn’t appear as naïve as it first seemed.

But this is the very concern set to be alleviated by longevity therapies. If the concern with being wrong is most impacted by one’s impeding death, and the fact that one wouldn’t have the time or energy to create another groundbreaking paradigm upheaval in their chosen field should one’s namesake-theory prove to be mistaken, then the arrival of longevity therapies should not only fail to exasperate and aggravate this situation, but indeed may even ameliorate or negate it, allowing people to let their theories go under the comforting thought that they have all the time in the world to do it again.

My friend and peer Gennady Stolyarov II combats this criticism admirably, arguing that such instances occur due to the functional decline that comes with graceless old age, due to senility and a loss of mental flexibility. I think there is definitely some weight and worth to this consideration. And luckily, this, too, is a concern that is alleviated rather than aggravated by the introduction of longevity therapies. Longevity therapies will increase our healthy lifespans rather than stretch out the slow rot of our old age, as remarked earlier. Thus the longevity therapies that many critics argue could exasperate this progress-stalling state of affairs could, along yet another line of argumentation, constitute the very thing that jolts this state of affairs into reform. If senility and loss of mental flexibility contribute to Planck’s notion that life (or more properly the absence of timely death) forestalls scientific progress, then longevity therapies may constitute the source of senility’s demise and mental flexibility’s restoration.

In any case, even if we accept Plank’s notion as true, and conclude that indefinite longevity will aggravate rather than alleviate this state of affairs, faster progress in the sciences or the humanities is no justification for simply doing nothing to negate physically remediable sources of death and disease.

It seems to me a truism that we get smarter, more ethical, and more deliberative as we age. To think otherwise is in many cases derivative of the notion that physiology and experience alike are on the decline once we “peak” in our mid-twenties, downhill into old age – which does undoubtedly happen, and which inarguably does cause functional decline. But longevity therapies are nothing more nor less than the maintenance of normative functionality; longevity therapies would thus not only negate the functional decline that comes with old age, and with it the source of the problem arguably at the heart of the concern that longer life will slow progress even more, but might even constitute the only foreseeable fix to the problem by definition, because indefinite longevity is defined as (or more properly, synonymous with) the maintenance of normative functionality, a.k.a. the indefinite prevention of functional decline. There is no reason to expect that, in a time when we age without functional decline, the ethicality and experience of each human being wouldn’t increase as we age just as they arguably do as we age from two to twenty to thirty.

Increasing longevity will not bring with it prolonged old-age, a frozen decay and decrepit delay, but will instead prolong our youthful lives and make us continually growing beings, getting smarter and more ethical all the time. Indefinite longevity will not slow progress, it will accelerate it! Instead of having thinking, being beings die after ten decades, they can continue to think and be. They can build upon the edifice of their existence and experience continually, reaching heights unheralded in flighty fits and bounds. Moreover, increasingly more and more people may very well be a boon to the momentum of progress. It could be argued that the increasing rate of progress was aided by the increase in global population that preceded it, providing not only more people to have more thoughts, but more people to challenge existing thought and to provide feedback accordingly in forward fashion. Statistically speaking, more people should mean more ideas, and more ideas should mean more good ideas, all else being equal.

Thus indefinite longevity will better progress, not deter it, and will do so on the scale of both self and society. We will continue to grow, to learn, and to yearn. But more than that – we will continue to be – and that in itself is cause for good pause. In all our worry about stalled progress and boredom, we forget that even if indefinite longevity didn’t bring with it a host of advantages and boons to the boom of progress and exalted strife intrinsic to life, the ability to simply continue being is incommunicably better than the alternative, which does nothing but put an end to all other alternatives.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.

Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy – Article by Franco Cortese

Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
August 21, 2013
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When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e., that many are seeking healthy life extension, a.k.a. “aging gracefully”, instead of more comprehensive methods of indefinite life extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally verifying the various, sometimes mutually exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.
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This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.
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There is no definitive timespan that it will take to achieve indefinitely extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely Extended Life, per unit of time or effort, by advocating the desirability, ethicality, and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives.

In order to get funding, we need to demonstrate with explicit clarity just how much we want it, and that we can do so while minimizing potentially negative societal repercussions like overpopulation. We must do our best to vehemently invalidate the Deathist clichés that promulgate the sentiment that Life Extension is dangerous or unethical. It needn’t be either, nor is it necessarily likely to be either.

Some think that spending one’s time deliberating the potential issues that could result from greatly increased lifespans and the ways in which we could mitigate or negate them won’t make a difference until greatly increased lifespans are actually achieved. I disagree. While any potentially negative repercussions of RLE (like overpopulation) aren’t going to happen until RLE is achieved, offering solution paradigms and ways in which we could negate or mitigate such negative repercussions decreases the time we have to wait for it by increasing the degree with which the wider public feels it to be desirable, and that it can very well be done safely and ethically. Those who are against radical life extension are against it either because they think it is infeasible (in which case being “against” it may be too strong a descriptor) or because they have qualms relating to its ethicality or its safety. More people openly advocating against it would mean a higher public perception of its undesirability. Whether RLE is eventually achieved via private industry or via government-subsidized research initiatives, we need to create the public perception that it is widely desired before either government or industry will take notice.

The sentiment that that the best thing we can do is simply live healthily and wait until progress is made seems to be fairly common as well. People have the feeling that researchers are working on it, that it will happen if it can happen, and that waiting until progress is made is the best course to take. Such lethargy will not help Radical Longevity in any way. How long we have to wait for RLE is a function of how much effort we put into it. And in this article I argue that how much funding and attention RLE receives is by and large a function of how widespread the public perception of its feasibility and desirability is.

This isn’t simply about our individual desire to live longer. It might be easier to hold the sentiment that we should just wait it out until it happens if we only consider its impact on the scale of our own individual lives. Such a sentiment may also be aided by the view that greatly longer lives would be a mere advantage, nice but unnecessary. I don’t think this is the case. I argue that the technological eradication of involuntary death is a moral imperative if there ever was one. If how long we have to wait until RLE is achieved depends on how vehemently we demand it and on how hard we work to create the public perception that longer life is widely longed-for, then to what extent are 100,000 lives lost potentially needlessly every day while we wait on our hands? One million people will die a wasteful and involuntary death in the next 10 days: one million real lives. This puts the Deathist charges of inethicality in a ghostly new light. If advocating the desirability, feasibility, and radical ethicality of RLE can hasten its implementation by even a mere 10 days, then one million lives that would have otherwise been lost will have been saved by the efforts of RLE advocates, researchers and fiscal supporters. Seen in this way, working toward RLE may very well be the most ethical and humanitarian way you could spend your time, in terms of the number of lives saved and/or the amount of suffering prevented.

This is a contemporary problem that we can have a direct impact on. People intuitively assume that we won’t achieve indefinitely extended life until far in the future. This makes them conflate any lives saved by indefinitely extended lifespans with lives yet to come into existence. This makes them see involuntary death as a problem of the future, rather than a problem of today. But more people than I’ve ever known will die tomorrow, from causes that are physically possible to obviate and ameliorate – indeed, from causes that we have potential and conceptual solutions for today.
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I have attempted to show in this article that advocating RLE should be considered as “working toward it” to as great an extent as directly funding it or performing direct research on it is considered as “working toward it”. Advocacy has greater potential to increase its widespread desirability than direct work or funding does, and increasing both its desirability and the public perception of its desirability has more potential to generate increased funding and research-attention for RLE than direct funding or research does. Advocacy thus has the potential to contribute to the arrival of RLE and hasten its implementation just as much, if not more so (as I have attempted to argue in this article), than practical research or direct funding does. This should motivate people to help create the momentous momentum we need to really get the ball rolling. To be an RLE advocate is to be an RLE worker. Involuntary death from age-associated, physically remediable causes is the largest source of death, destruction, and suffering today.  Don’t you want to help prevent the most widespread source of death and of suffering in existence today?  Don’t you want to help mitigate the most pressing moral concern not only of today, but of the entirety of human history – namely physically remediable involuntary death?

Then advocate the technological eradication of involuntary death. Advocate the technical feasibility, extreme desirability, and blatant ethicality of indefinitely extending life. Death is a cataclysm. We need not sanctify the seemingly inevitable any longer. We need not tell ourselves that death is somehow a good thing, or something we can do nothing about, in order to live with the “fact” of it any longer. Soon it won’t be fact of life. Soon it will be artifact of history. Life may not be ipso facto valuable according to some philosophies of value – but life is a necessary precondition for any sort of value whatsoever. Death is dumb, dummy! An incontrovertible waste convertible into nothing! A negative-sum blight! So if you want to contribute to the problems of today, if you want to help your fellow man today, then stand proud and shout loud, “Doom to Arbitrary Duty and Death to  Arbitrary Death!” at every crowd cowed by the seeming necessity of death.

Franco Cortese is an editor for Transhumanity.net, as well as one of its most frequent contributors.  He has also published articles and essays on Immortal Life and The Rational Argumentator. He contributed 4 essays and 7 debate responses to the digital anthology Human Destiny is to Eliminate Death: Essays, Rants and Arguments About Immortality.

Franco is an Advisor for Lifeboat Foundation (on its Futurists Board and its Life Extension Board) and contributes regularly to its blog.