Browsed by
Tag: longevity

Longevity Logistics: We Can Manage the Effects of Overpopulation – Article by Franco Cortese

Longevity Logistics: We Can Manage the Effects of Overpopulation – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
November 5, 2013
******************************

This is a more popularly-oriented version of a scholarly article in review for the Journal of Evolution and Technology.

By far the most predominant criticism made against indefinite longevity is overpopulation. It is the first “potential problem” that comes to mind. But fortunately it seems that halting the global mortality rate would not cause an immediate drastic increase in global population; in fact, if the mortality rate dropped to zero tomorrow then the doubling rate for the global population would only be increased by a factor of 1.75 [1], which is smaller than the population growth rate during the post-WWII baby-boom.

Population is significantly more determined by birth rate than by death rate, simply because many people have more than one natural child.

This means that we should not see an unsustainable rise in population following even the complete cessation of death globally for a number of generations. We will run into problems 3 or 4 generations hence – but this leaves us with time enough to plan for overpopulation before we’re forced to resort to more drastic solution-paradigms like procreation-bans and space colonization.

Moreover, there are a number of proposed, and in some cases implemented, solutions to existing, contemporary problems that can be utilized for the purpose of minimizing overpopulation’s detrimental effects on living space and non-renewable resource constraints. These contemporary concerns include climate change and dependence on non-renewable energy sources, and they are only increasing in the amount of public attention they are attracting.

While these concerns and their potential solutions were not created by overpopulation or with overpopulation in mind, the potentially negative effects of an increasing global population can be effectively combated all the same using such contemporary methods and technologies.

Thus we can take advantage of the solution-paradigms developed for such contemporary concerns as climate change and dependence on non-renewable resources, and borrow from such movements as the sustainability movement and the seasteading movement, so as to better mitigate and effectively plan for the negative repercussions of a growing global population caused by the emergence of effective longevity technologies.

In a session with The President’s Council on Bioethics (as it was composed during the Bush Administration), S. Jay Olshansky [2] reported calculations he performed indicating that complete cessation of the global morality rate today would lead to less population growth than resulted from the post-WWII “Baby Boom”:

This is an estimate of the birth rate and the death rate in the year 1000, birth rate roughly 70, death rate about 69.5. Remember when there’s a growth rate of 1 percent, very much like your money, a growth rate of 1 percent leads to a doubling time at about 69 to 70 years. It’s the same thing with humans. With a 1 percent growth rate, the population doubles in about 69 years. If you have the growth rate — if you double the growth rate, you have the time it takes for the population to double, so it’s nothing more than the difference between the birth rate and the death rate to generate the growth rate. And here you can see in 1900, the growth rate was about 2 percent, which meant the doubling time was about five years. During the 1950s at the height of the baby boom, the growth rate was about 3 percent, which means the doubling time was about 26 years. In the year 2000, we have birth rates of about 15 per thousand, deaths of about 10 per thousand, low mortality populations, which means the growth rate is about one half of 1 percent, which means it would take about 140 years for the population to double.

Well, if we achieved immortality today, in other words, if the death rate went down to zero, then the growth rate would be defined by the birth rate. The birth rate would be about 15 per thousand, which means the doubling time would be 53 years, and more realistically, if we achieved immortality, we might anticipate a reduction in the birth rate to roughly ten per thousand, in which case the doubling time would be about 80 years. The bottom line is, is that if we achieved immortality today, the growth rate of the population would be less than what we observed during the post-World War II baby boom.

We would eventually run into problems, of course, a century down the road, but just so you know the growth rates would not be nearly what they were in the post-World War II era, even with immortality today.

In other words we will only have increased the doubling-time of the global population by a factor of 1.75 if we achieved indefinite longevity today (e.g., a doubling time of 140 years in 2000 compared to a doubling time of 80 years). This means that we will have two to four generations worth of time to consider possible solutions to growing population before we are faced with the “hard choice” of (1) finding new space and resources or else (2) limiting or regulating the global birthrate.

An alternate study on the demographic consequences of life extension concluded that “population changes are surprisingly slow in their response to a dramatic life extension”. The study applied “the cohort-component method of population projections to 2005 Swedish population for several scenarios of life extension and a fertility schedule observed in 2005,” concluding that “even for a very long 100-year projection horizon, with the most radical life extension scenario (assuming no aging at all after age 60), the total population increases by 22% only (from 9.1 to 11.0 million)” and that “even in the case of the most radical life extension scenario, population growth could be relatively slow and may not necessarily lead to overpopulation.” [2]. The total population increase due to the complete negation of mortality given by this study is significantly lower than the figure calculated by Olshansky.

Finding innovative solutions to new and old problems is what humanity does. We have a variety of possible viable options to increase the resources and living space available to humanity already. Moreover, there are several other contemporary concerns that are invoking the development of technological and methodological solutions that can be applied to our own concerns regarding the effects of overpopulation. Surely we can conceive of optimal solutions to these problems (and the more pressing a given problem is, the more funding it receives and the faster the solution to it is accomplished) – and take advantage of the growing methodological and technical infrastructure being developed for related and convergent problems – within the time it will take to feel overpopulation’s effect on living space and resources.

We could, for instance, colonize the oceans [3, 4, 5], drawing from the engineering, construction techniques used to build, maintain, and safely inhabit contemporary VLFSs (Very Large Floating Structures). 75% of the Earth’s surface area is, after all, water. This would increase our potential living space 3-fold – and I say “potential” because we surely don’t currently maximize living space on the 25% of the Earth’s surface occupied by land. Furthermore, humanity has as yet barely ventured beyond the surface of the earth – which is a sphere after all. There is nothing to prevent society building higher and building deeper. Indeed, with contemporary and projected advances in materials science and structural engineering, there is no theoretical limit to the height of structures we can safely build – the space elevator being a case in point. And while there will indeed be a maximum size wherein building higher becomes economically prohibitive (a limit determined to a large extent by the materials used), contemporary megastructures [6] indicate that very large structures can be built safety and cost-effectively. Underground living [7, 8, 9, 10] is another potential solution-paradigm as well; underground structures require less energy, are protected from weathering effects and changing temperatures to a much greater extent than structures exposed to the elements, and are less susceptible to damage from natural disasters. Furthermore, there are a number of underground cities in existence today [11], with existing techniques and technologies used to better facilitate contemporary underground living, which we can take advantage of.

In fact, the problem of limited living space is a contemporary problem for certain nations like Japan, and active projects to combat this growing problem have already been undertaken in many cases. This means that there will be an existing host of solutions, with their own technological and methodological infrastructures, which we can benefit from and take advantage of when the problematizing effects of growing global population become immediate. Not only can we take advantage of the existing engineering methodologies developed for use in the construction of VLFSs, but we can also take advantage of the growing body of knowledge pertaining to megastructural engineering and even existing proposals for floating cities [12, 13, 14, 15, 17, 18]. Another possible solution is artificial islands [19].

Furthermore, in recent years the topic of Very Large Floating Structures [21, 22] has experienced a surge of renewed interest occurring in tandem with the increasing interest in seasteading [23, 24], – that is, the creation of very-large-floating-structures for reasons of political sovereignty as well as to allow corporations to get around the laws of a given nation by occupying an area outside of exclusive economic zones. This renewed interest can only increase the amount of attention and funding these concepts receive, in turn increasing the viability of VLFS designs and their underlying structural-engineering and energy-production concerns.

Another contemporary movement that will prove advantageous for our own concerns with the effects of overpopulation on living space, working space, and resource space is the growing green movement and sustainability movement. The problem of resource scarcity is already upon us in many areas, and there exists contemporary motivation for finding more resource-efficient ways of making energy and producing goods, and for lessening our dependency on non-renewable energy sources. Climate change has only become an increasingly predominant concern in international politics, and many incentives exist to lessen our dependence on non-renewable energy sources as well as to lessen the environmental impact of contemporary civilization, which is itself another oft-touted problematic concern possibly resulting from overpopulation. Developments in these areas are only set to continue, for reasons wholly unrelated to the effects of overpopulation, and when those effects come to the fore we will have a collection of existing methodologies that can then be harnessed to lessen the impact of overpopulation on living space and resource scarcity.

The predominance of these problems, as well as the amount of attention and funding they are expected to receive (and thus the viability of their potential solutions), will only increase as we move forward into the future. The solutions we have to the potential problems of overpopulation – namely resource scarcity and lack of living space – will not only increase as the effects of overpopulation get closer, but the technological and methodological infrastructures underlying those solutions will also become more tried, tested, and robust, fueled by contemporary concerns over decreasing living space, climate-change and resource scarcity.

While space colonization is the most frequently proffered technological solution to the possibility of future overpopulation, I think we will turn to various Earth-bound solutions to increasing humanity’s available living space, as well as the space available for agricultural labs, that is the manufacture of food-stuffs, or indoor farming systems [25, 26, 28], before colonizing the cosmos becomes an economically optimal option. I think these sorts of solutions will be employed long before humanity is forced to either regulate the birthrate or move into the cosmos.

Moreover, people who wish to have children will have incentive to support politicians running on policies promoting new solutions to decreasing living space. Consider the number of U.S. taxpayer dollars spent during the Space Race, with no immediate material or scientific benefit (other than to prove it could be done, as well as to maintain rough militaristic equality with the USSR to some extent, as the state of rocket technology was indicative of the state of ballistic technologies like missiles). If humanity is forced to choose between having children and receiving the medical treatments that will keep them from dying, surely people will be motivated to fund initiatives and projects aimed at solving the problems of decreasing living space and increasing resource constraints due to a growing global population.

It is important to remember that the largest increase in life expectancy we have experienced historically was followed by a drastic decrease in birthrate over the next few generations thereafter. Before the Industrial Revolution, English women had on average 6 children. In 2000 the average was less than 2.

Figure 1: Fertility Rates in England, 1540-2000

Note: GRR = Gross Reproduction Rate, NRR = Net Reproduction Rate
Source: Wrigley et al. (1997) p. 614. Office of National Statistics, United Kingdom.

The drop in birthrate following the industrial revolution has several causes. Chief among them is the fact that children were considered to some extent as assets, helping with maintaining the family livelihood, often by doing agricultural work on a family farm or helping with household chores (which were much more extensive then). Another large determining factor is a high rate of child mortality; thus families would have multiple children in anticipation of losing some to death. But with a rise in living conditions, the child mortality rate dropped drastically – and as a result we stopped having more kids in anticipation of some of them dying. Moreover, we started treating children less as assets and more as people to nurture and raise for their own sake. Longer lives, and less susceptibility to death in general, appears to have made us better parents.

Thus it is not only possible but probable that we will see a similar drop in the birthrate as a consequence of a significant future increase in average lifespan, with people having children much later in life, when they are more financially stable and when they have done all the commitment-free things they’ve always wanted to do. Without a looming limit on one’s available reproductive lifespan, there will be no pressing motivation to have children “before it’s too late” – and this alone could very well facilitate an unprecedented decrease in the Total Fertility Rate (TFR) of the global population.

Evidence indicates that the drop in birth rate was neither limited to England, nor an isolated result of the Industrial Revolution. A net drop in the TFR seems to be a longer-term trend concurrent across the globe. It is likely that the drop in the TFR is due to the same factors as the drop in birth rate following the Industrial Revolution – increasing life expectancy and continually improving living conditions allow people to have children without expecting a portion of them to be lost to death, to have them for the sake of having children rather than as assets to aid in maintaining the family livelihood, and to have children later in life due to the increase in one’s reproductive lifespan that comes with increasing life expectancy. The fact that the drop in TFR is not an isolated historical event is advantageous because the global population is affected by birth rate much more than by the mortality rate. Hence we may see a continuing decrease in the TFR occur in tandem with increasing life expectancy, leveling out the imbalance created by a mortality rate of zero by a larger than has been heretofore anticipated. (Source: U.S. Central Intelligence Agency, World Factbook.)

Let us suppose, for a moment, the worst: that indefinite longevity is achieved and we completely ignore (i.e., fail to plan for) overpopulation until its effects start becoming readily apparent. Even in this seeming worst-case scenario, overpopulation is not likely to result in any great tragedies. In such a case we would be forced to limit the global birthrate until we are able to implement the solutions that would allow us to sustainably procreate again. If people have a strong enough desire to continue having children, then they will express their demand and politicians will consequently base their policies upon deliberative initiatives to increase available living and agricultural space – and get elected if the desire to freely procreate is strong and widespread enough. Failing to plan for overpopulation will simply be a wake-up call, letting us know that we should have been planning for its effects from the beginning, and that we had better start planning for them now if we want to continue to freely procreate.

Thus while overpopulation is the most prominent and most credible criticism against continually increasing lifespans, and the one that needs to be planned for the most (because it will eventually happen, but it will lead to sustainability, resource, and living-space problems only if we do nothing about it), it is in no way insoluble, nor particularly pressing in terms of the time available to plan and implement solutions to shrinking living space and resource space (i.e., the space occupied by resources such as food, energy production, workplaces, etc.). We have a host of potential solutions today, ones we can use to increase available living space without regulating the global birthrate, and decades following the achievement of indefinite lifespans to consider the advantages and disadvantages of the various possible solutions, to develop them and to implement them.

So then: where to from here? Overpopulation is still the most prominent criticism raised against indefinite longevity, and if combated, the result could be an increase in public support for the Longevity movement. You might think that the widespread concern with overpopulation due to increasing longevity won’t really matter, if they turn out to be wrong, and overpopulation isn’t so insoluble a problem as one is inclined to first presume. But this misses a crucial point: that the time it takes to achieve longevity is determined by and large by how strongly and in how widespread a manner society and the members constituting it desire and demand it. If we can convince people today that overpopulation isn’t an insoluble problem, then continually increasing longevity might happen much sooner than otherwise. At the cost of 100,000 deaths due to age-correlated causes per day, I think hastening the arrival of indefinite longevity therapies by even a modest amount is somewhat imperative. Hastening its arrival by one month will save 3 million lives, and achieving it one year sooner than otherwise will save an astounding 36.5 Million real, human lives.

Thus, we should work toward putting more concrete numbers to these estimates. How much more living space can be feasibly created by colonizing the oceans? How deep can we really dig, build and live? How high can we safely build? Is there a threshold height or depth where building higher or deeper becomes too economically prohibitive to be worth the added living, working or resource space? What are the parameters (e.g., material strength/cost ratio, specific structural design) determining such a threshold?

First, we need to collect and analyze the feasibility studies that have already been undertaken on floating cities, artificial islands, VLFSs and the new solution-paradigms that are emerging to combat the contemporary concerns of sustainability and resource scarcity. In short, we need to compile data from the feasibility studies that have already been done, and the projects already implemented. Then we need to plan and commission further feasibility studies, undertaken by engineers and geologists, to build upon the work already accomplished in feasibility studies pertaining to existing designs for floating cities and other Very Large Floating Structures. We need to put some numbers to the cost the additional space for food, resources, work and living necessitated by widely available life-extension therapies. We need to do some hard calculations to show that the effects of overpopulation are problems that can be solved using existing megascale engineering and construction techniques and materials, safely and economically. We need to show the world that it has more space than it ever thought it had, and that such solution-paradigms as cosmic colonization and procreative regulation are neither the only ones, nor necessarily the most optimal ones. We need, in short, to show them that, in this case, where there’s a will there’s a way, and that the weight of waiting is too high a price to pay.

Franco Cortese is a futurist, author, editor, Affiliate Scholar at the Institute for Ethics & Emerging Technologies, Ambassador at The Seasteading Institute, Affiliate Researcher at ELPIs Foundation for Indefinite Lifespans, Fellow at Brighter Brains Institute, Advisor at the Lifeboat Foundation (Futurists Board Member and Life Extension Scientific Advisory Board Member), Director of the Canadian Longevity Alliance, Activist at the International Longevity Alliance, Canadian Ambassador at Longevity Intelligence Communications, an Administrator at MILE (Movement for Indefinite Life Extension), Columnist at LongeCity, Columnist at H+ Magazine, Executive Director of the Center for Transhumanity, Contributor to the Journal of Geoethical Nanotechnology, India Future Society, Serious Wonder, Immortal Life and The Rational Argumentator. Franco edited Longevitize!: Essays on the Science, Philosophy & Politics of Longevity, a compendium of 150+ essays from over 40 contributing authors.

References:

  1. Presidents Council for Bioethics: Transcripts (December 12, 2002): Session 2: Duration of Life: Is There a Biological Warranty Period? 01.
  2. L. A. Gavrilov and N.S. Gavrilova. “Demographic Consequences of Defeating Aging”. Rejuvenation Research. 2010 April; 13(2-3): 329–334.
  3. Ibid.
  4. McCullagh, Declan. “Seasteaders” Take First Step Toward Colonizing The Oceans.” CBS News, October 9, 2009. 02
  5. Pasternack, Alex. “Bioengineer aspires to colonize the sea.” CNN, January 12, 2011. 03
  6. Banham, Reyner. Megastructure: urban futures of the recent past. London: Thames and Hudson, 1976.
  7. Tsuchiyama, Ray. “Ocean Colonies as Next Frontier.” Forbes, April 24, 2011. Accessed August 1, 2013. 04
  8. “Inside Underground Cities.” Before Its News. 2013 March. 05
  9. South, D. B., and Freda Parker. “Underground Homes – Good or Bad?” Monolithic, January 22, 2009. 06.
  10. Good Earth Plants & Greenscaped Buildings. “Underground Living.” Last modified May 6, 2013. 07.
  11. Kelly, J. “10 Amazing Underground Cities”. Listverse.com. January 22, 2013. Accessed August 1, 2013. 08
  12. Gammon, Katharine. “Building Artificial Islands That Rise With Sea.” PopSci, June 8, 2012. 09
  13. Cottrell, Claire. “A Survey of Futuristic Floating Cities.” FlavorWire, November 2, 2012. 10
  14. “Cities on the Ocean.” Technology Quarterly – The Economist. Q4 2011.
  15. Bonsor, Kevin. “How the Floating Cities Will Work.” HowStuffWorks. n.d. 11.
  16. DigInfo TV. “GREEN FLOAT – a Floating City in the Sky.” Accessed August 6, 2013. 12.
  17. National Geographic. “Pictures: Floating Cities of the Future.” Accessed August 6, 2013. 13.
  18. Emerging Technology News. “Self-Sufficient Floating Cities Planned for 2025: Japan.” Accessed August 6, 2013. 14.
  19. “An artificial island in Hambantota.” News.LK, August 2, 2013. 15
  20. Goodier, Rob. “The World’s 18 Strangest Man Made Islands.” Popular Mechanics, n.d. 16
  21. E. Watanabe, C.M. Wang, T. Utsunomiya and T. Moan. “Very Large Floating Structures: Applications, Analysis and Design”. CORE Report No. 2004-02. Centre for Offshore Research and Engineering National University of Singapore. 17
  22. C.M. Wang, and Z. Tay. Very Large Floating Structures: Applications, Research and Development. In The Proceedings of the Twelfth East Asia-Pacific Conference on Structural Engineering and Construction — EASEC12. Edited by LAM Heung Fai. Singapore: Department of Civil Engineering, National University of Singapore Kent Ridge, 2011. 18
  23. World Architecture News. “Seasteading, United States.” Accessed August 6, 2013. 19
  24. The Seasteading Institute. The Seasteading Institute Annual Report 2008. Rep. n.p., n.d.
  25. Nagy, Attila. “14 High-Tech Farms Where Veggies Grow Indoors.” Gizmodo, June 17. 20.
  26. Meinhold, Bridgette. “Indoor Vertical Farm ‘Pinkhouses’ Grow Plants Faster With Less Energy.” Inhabitat. Last modified May 23, 2013. 21.
  27. TerraSphere. “Urban farming 2.0: No soil, no sun.” Accessed August 1, 2013. 22.
  28. The Vertical Farm Project – Agriculture for the 21st Century and Beyond. “Vertical Farm Designs.” Accessed August 6, 2013. 23

 

Transhumanism as the Logical Extrapolation of Humanism – Video by G. Stolyarov II

Transhumanism as the Logical Extrapolation of Humanism – Video by G. Stolyarov II

Mr. Stolyarov explains why transhumanism is humanism taken to its full logical extent by recognizing the possibilities unleashed by technology for improving human potential.

References
– “Transhumanism as the Logical Extrapolation of Humanism” – Post by G. Stolyarov II
– “Human Nature is Tautological” – Video by G. Stolyarov II
– “Human Nature is Tautological” – Essay by G. Stolyarov II
– “Humanism” – Wikipedia

Evolution Has No Moral Value; Life Extension Does – Video by G. Stolyarov II

Evolution Has No Moral Value; Life Extension Does – Video by G. Stolyarov II

Mr. Stolyarov responds to two statements by Michael Garfield and makes the case that evolution should not be pursued as a moral goal in itself; rather, the survival and increased longevity of every individual should be pursued, since our rationality, technology, and moral compass allow us to transcend the cruelty of primeval natural selection.

Mr. Stolyarov also refutes the allegation that older people somehow necessarily become resigned to or accepting of their own death. He presents counterexamples of individuals who lived past the age of 80 and who wished to continue living indefinitely.

See Benjamin Franklin’s thoughts on scientific progress and life extension: “The rapid progress true science now makes occasions my regretting sometimes that I was born too soon. It is impossible to imagine the height to which may be carried, in a thousand years, the power of man over matter. We may, perhaps, deprive large masses of their gravity, and give them absolute levity, for the sake of easy transport. Agriculture may diminish its labor and double its produce: all diseases may by sure means be prevented or cured (not excepting even that of old age,) and our lives lengthened at pleasure, even beyond the antediluvian standard. Oh that moral science were in as fair a way of improvement, that men would cease to be wolves to one another, and that human beings would at length learn what they now improperly call humanity.”

References
– “Life as the Origin and Basis of Morality” – Video Series by G. Stolyarov II – Part 1 and Part 2
– “Eliminating Death – Part 1 – Death as Waste” – Video by G. Stolyarov II
– “World’s Oldest Man Wants To Live Forever” – WayOdd
– “Robert Ettinger” – Wikipedia

Radical Life Extension Won’t Cause Resource Shortages – Article by Reason

Radical Life Extension Won’t Cause Resource Shortages – Article by Reason

The New Renaissance Hat
Reason
October 6, 2013
******************************

That overpopulation exists at all is one of the most prevalent delusions in the modern world: thanks to the environmentalist movement, a cause that has ascended near to the status of civic religion, the average fellow in the street thinks that there are too many people alive today, that resources are stretched to breaking point, that the future is one of Malthusian decline, and that horrible poverty in the third world is caused by the existence of too many people. All of these points are flat-out wrong. Humanity is wealthier and has greater access to resources today than at any time in history, the variety and amounts of available resources are growing at an accelerating pace due to technological progress, the earth could support many times more people than are alive today, and where there is poverty it exists due to terrible, predatory governance and the inhumanity of man – it exists due to waste and aggression amidst the potential for plenty.

Even this pro-longevity piece by George Dvorsky subscribes, as many do, to the false idea that somehow we are consuming too many resources and will run out. This is silly: resources are infinite, because through technological progress we constantly develop new ones. People live in an age of change, with each new decade clearly different from the last, and yet live under the assumption that everything will remain the same going forward. Being worried about running out of anything that we use today is like being worried about running out of candle wax in 1810, or running out of room for horse breeding operations in 1840, or running out of food in 1940. All false concerns, and all false for exactly the same reasons: we are not static consumers of resources, we are net producers of resources.

Quote:

Make no mistake, it’ll take us a long, long time to get there, but we’ll eventually find a way to halt the aging process. Owing to advanced medical, regenerative, and cybernetic technologies, future humans will enter into a state of “negligible senescence,” a condition marked by the cessation of aging and the onset of everlasting youth. It sounds utopian, but as biogerontologist Aubrey de Grey has repeatedly noted, it’s simply an engineering problem – one that’s not intractable.

I’ve been debating this issue for the better part of a decade, and I’ve heard virtually every argument there is to be said both in favor of and in condemnation of the possibility. I’m not going to go over all of them here. But without a doubt the single most prominent argument set against radical life extension is the issue of overpopulation and environmental sustainability.

As a final note, there’s a certain inevitability to radical life extension. It’s the logical conclusion to the medical sciences. So rather than futilely argue against it, we should come up with constructive solutions to ensure that it unfolds in the most non-disruptive way possible.

Link: http://io9.com/no-extreme-human-longevity-won-t-destroy-the-planet-1440148751

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

Support the “Little Mouse” Crowdfunded Life-Extension Research Project! – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
October 4, 2013
******************************

As part of my escalating efforts to advance the prospects of radical life extension through my individual actions, I have donated $50 to an ambitious new crowdfunding project to research longevity-enhancing treatments in mice.

This international project, undertaken by researchers at the Kiev Institute of Gerontology and supported by the Methuselah Foundation and the SENS Research Foundation, has an Indiegogo fundraising page, titled “I am a little mouse and I want to live longer!”, where contributions can be made.

I am proud to donate to this effort to support longevity research through crowdfunding. This project allows those of us who seek longer lifespans, and who wish to advance the science that will get us there, to contribute directly in a manner whereby each of us can make a sizable fraction of the difference for this research effort. I look forward to the great work that this project will accomplish. Achieving statistically significant mouse life extension in the near future could trigger massive public interest and the influx of major research funds to attain increasingly ambitious life-extension goals in higher-order mammals, culminating in us.

The project has already raised $8,673 and has 16 days remaining to reach its $15,000 goal. The Methuselah Foundation will match each $1,000 given with an equivalent donation – so it is possible to double one’s impact by contributing funds to this research effort.

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Video by G. Stolyarov II

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life.

References
– “Calico and the Paradigm Shift in the War on Death” – Article by G. Stolyarov II
– “Google announces Calico, a new company focused on health and well-being” – Google Press Release – September 18, 2013
– “TIME Feature: CSO Aubrey de Grey on Google’s Newly Launched Anti-Aging Initiative” – SENS Research Foundation – September 18, 2013
– “Google’s Calico: the War on Aging Has Truly Begun” – Aubrey de Grey – TIME Magazine – September 18, 2013
SENS Research Foundation

The Last Generation to Die – Article by Reason

The Last Generation to Die – Article by Reason

The New Renaissance Hat
Reason
September 27, 2013
******************************

The last generation whose members will be forced into death by aging is alive today. It won’t be the youngest of us, born in the past few years – they, most likely, have thousands of years ahead of them. It won’t be the oldest of us either, as even under the plausible best of circumstances we are twenty to thirty years away from a widespread deployment of rejuvenation therapies based on the SENS research program. As to the rest of us, just who is left holding the short straw at the end of the day depends on the speed of progress in medical science: advocacy, fundraising, and the effectiveness of research and development initiatives. Persuasion and money are far more important at this early stage than worrying about how well the researchers are doing their jobs, however.

We live in a world in which the public is only just starting to come around to the idea that aging can be treated, and demonstrations of rejuvenation in the laboratory could be achieved in a crash program lasting ten to twenty years, at a comparatively small cost. But still, most people don’t care about living longer, and most people try not to think about aging, or the future of degeneration and sickness that awaits. They think it is inevitable, but that is no longer true. If you are in early middle age today in the first world, then you have a good shot at living for centuries if the world suddenly wakes up tomorrow and massive funding pours into rejuvenation research. You will age and die on a timescale little different from that of your parents if that awakening persistently fails to happen.

So, roll the dice, or help out and try to swing the odds in your favor. Your choice.

Crowdfunding on Kickstarter and related sites is still the new new thing, the shine not yet worn off. One of the truths that this activity reinforces is that it is far, far easier to raise funding for the next throwaway technological widget than for medical research projects aimed at the betterment of all humanity. Research crowdfunding is a tiny, distant moon orbiting the great mass of comics, games, and devices on Kickstarter, Indiegogo, and others. Hell, it’s easier to crowdfund a short film that points out how close human rejuvenation might be to the present day than it is to crowdfund a project to actually conduct a portion of that research. Is this a reflection of rationality? You decide, though it could be argued either way regarding whether a dollar given to raising awareness is more valuable than a dollar given to the researchers at this point in time. Both research and persuasion need to happen.

The Last Generation To Die – A Short Film

Quote:

Set in the future when science first begins to stop aging, a daughter tries to save her father from natural death. The story takes place roughly 30 years in the future at the moment when science has first figured out how to stop aging through genetics. It is framed around the gulf between generations that would occur with the first release of this technology. A daughter who works for a company called Aperion Life – the first to bring this new technology to the public – wants to save her aging father. She starts him on the trials but he soon stops coming. The film continues with the conflict rising between them as she wants him to live on with her while he feels a natural ending is more human.The film centers itself around the natural conflict that would exist at this divide. Upon developing this story, I’ve asked many people and I’ve found a pretty even 50/50 divide of opinions strongly on one side or the other- either they want to die naturally and believe there is beauty in finality, or they want to see what the future holds and have more time to explore and learn more in life. I’d like to turn the question to you… Which side are you on? Would you want to live on or die naturally?

I feel this is a film that needs to be made. Asking these questions in the form of art and story will help start the discussion. Our world is changing very fast and the rate of technology is speeding up. What does all of this mean for humanity? Everything we know, from a book to a play to a song, ends… What does it mean when there is no ending? Would we be more complacent? Would life be as meaningful? Is there more of a beauty in the way it has always been with our passing or is there more beauty in our bodies and minds staying fresh and alive for many, many years to come? What about social justice and overpopulation? Would life become boring after living on indefinitely or would you find it exhilarating to have time to learn new languages, instruments, subjects – to read more books, to love more – to live several lifetimes? Would it be worth it if some of your most loved friends or relatives passed on and wouldn’t live on with you? Are you interested in seeing what the future brings in technology and social evolution or are you happy to have contributed and be a part of it for a short time?

Tim Maupin’s Film, ‘The Last Generation to Die’, to Explore Longevity and Life Extension

Quote:

Chicago filmmaker Tim Maupin launched a Kickstarter for a short film titled, “The Last Generation to Die.” Maupin thinks now is a great time to start a conversation about life extension. And he’s right. The idea that within decades a genetic fountain of youth may plausibly reverse the aging process, even indefinitely stave off death, seems to be rising up in pop culture. Maupin’s Kickstarter has so far raised over $15,000 – $6,000 more than its initial funding goal. Encouraged by the positive response, they’re dreaming bigger and hope to fund a stretch goal of $25,000 in the last 10 days of the campaign.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Editor’s Note from G. Stolyarov II: I am proud to have donated $50 to help make the film The Last Generation to Die a success. I encourage all readers to donate during the remaining nine days in which the Kickstarter project is open to accepting funds.

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

Calico and the Paradigm Shift in the War on Death – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 19, 2013
******************************

Finally, the war on human senescence and involuntary death has become mainstream. With Google’s announcement of the formation of Calico, a company specifically focused on combating senescence and the diseases it brings about, a large and influential organization has finally taken a stand on the side of longer life. Unlike the cautious, short-term orientation of many more conventional manufacturers of drugs and medical devices, Google’s philosophy of making investments with possible immense payoffs in the distant future offers tremendous hope that this company will be around through the many years it will take to engage in the search for promising treatments and their subsequent testing.

 Aubrey de Grey, one of the chief strategists and key intellectual innovators in the escalating war on senescence, has written that Calico signals that the war on aging has truly begun. De Grey emphasizes that it is no longer necessary to persuade most of academia that this war is a worthwhile endeavor: “With Google’s decision to direct its astronomical resources to a concerted assault on aging, that battle may have been transcended: once financial limitations are removed, curmudgeons no longer matter.” As with its remarkable advances in autonomous vehicles, mobile operating systems, and wearable computing, Google does not need to ask the permission of the entire world to explore the possibilities. Rather, it can simply achieve the breakthroughs, whose momentum and adoption naysayers would be powerless to halt.

Funding has always been a major bottleneck for true life-extending research, but now the resources of Google, as well as the highly skilled researchers who will surely be recruited by Calico, will enable this bottleneck to be overcome. Few details about the company are yet available, and it is likely that several years will elapse before major discoveries are announced. However, the barrier to mainstream acceptability of the war on senescence has been breached. Once significant successes are announced, other companies will hopefully shed some of their current caution and will seek to profit from the burgeoning field of longevity research. A few other companies still may even try to emulate Calico before any results are announced – just so as to remain competitive with Google and stay ahead of the pack, in their view.

The key to the success of any sustainable enterprise focused on life-extension research is to recognize that the sole pursuit of profits next quarter or next year is not a viable strategy for altering the status quo in radical ways. Great innovations require great leaps outside the norm. Such leaps are not often immediately rewarded financially by the broader market, which is why much of the longevity research to date has been sponsored by non-profit institutions such as the SENS Research Foundation and various universities. However, a prudent, forward-looking pursuit of profit can take the radical alteration of the status quo to the next level, by harnessing the immensely powerful motive of self-interest for the purpose of improving human lives. In this case, the improvement from gains to human longevity – and hopefully the ultimate defeat of senescence altogether – would be so immense as to be humankind’s crowning achievement. Google develops technologies with the eventual intent of marketing them to millions of consumers, and the success of Calico would be a triumph not just for longevity research but for the dissemination of cures to age-related diseases, and perhaps to senescence itself.

While anyone of sufficient intellectual courage can have a long-term vision and projects aimed at advancing that vision, Google has the distinct advantage of an extremely viable business in the present, which continues to bring in short-term revenues so that Calico does not need to be concerned with profits next quarter or next year. Instead, Calico will be able to survive on the profits of Google’s many ongoing operations, while devoting the time and effort of world-class researchers to pursuing all of the explorations, experiments, and tests that are needed to ultimately develop marketable cures. Once the cures are out there, though, the profits could be unprecedented, because life is the most precious, the most fundamental value we humans have. Any entity that discovers a way to transcend the current frailties of old age and push back or remove the current limits on human lifespans will become fabulously wealthy beyond comparison.

May Calico usher in Adam Smith’s invisible hand in the realm of longevity medicine – a hand that pushes back senescence and death and creates a world where health and wealth are ours to enjoy indefinitely.

Aubrey de Grey Comments on the “Hallmarks of Aging” Paper – Article by Reason

Aubrey de Grey Comments on the “Hallmarks of Aging” Paper – Article by Reason

The New Renaissance Hat
Reason
September 8, 2013
******************************

The Hallmarks of Aging paper was published earlier this year. It is an outline by a group of noted researchers that divides up degenerative aging into what they believe are its fundamental causes, with extensive references to support their conclusions, and proposes research strategies aimed at building the means to address each of these causes. This is exactly what we want to see more of in the aging research community: deliberate, useful plans that follow the Strategies for Engineered Negligible Senescence (SENS) model of approaching aging.

Read through the Hallmarks of Aging and you’ll see that it is essentially a more mild-mannered and conservative restatement of the SENS approach to aging – written after more than ten years of advocacy and publication and persuasion within the scientific community by SENS supporters. To my eyes, the appearance of such things shows that SENS is winning the battle of ideas within the scientific community, and it is only a matter of time before it and similar repair-based efforts aimed at human rejuvenation dominate the field. Rightly so, too, and it can’t happen soon enough for my liking. SENS and SENS-like research is the only way we’re likely to see meaningful life extension technologies emerge before those of us in middle age now die, so the more of it taking place the better.

Aubrey de Grey, author of the original SENS proposals and now Chief Science Officer of the SENS Research Foundation that funds and guides rejuvenation research programs, is justifiably pleased by the existence of the Hallmarks of Aging. See this editorial in the latest Rejuvenation Research, for example:

A Divide-and-Conquer Assault on Aging: Mainstream at Last

Quote:

On June 6th, a review appeared concerning the state of aging research and the promising ways forward for the field. So far, so good. But this was not any old review. Here’s why: (a) it appeared in Cell, one of the most influential journals in biology; (b) it is huge by Cell’s standards – 24 pages, with well over 300 references; (c) all its five authors are exceptionally powerful opinion-formers – senior, hugely accomplished and respected scientists; (d) above all, it presents a dissection of aging into distinct (though inter-connected) processes and recommends a correspondingly multi-pronged (“divide and conquer”) approach to intervention.

It will not escape those familiar with SENS that this last feature is not precisely original, and it may arouse some consternation that no reference is made in the paper to that prior work. But do I care? Well, maybe a little – but really, hardly at all. SENS is not about me, nor even about SENS as currently formulated (though a depressing number of commentators in the field persist in presuming that it is). Rather, it is about challenging a profound, entrenched, and insidious dogma that has consumed biogerontology for the past 20 years, and which this new review finally – finally! – challenges (albeit somewhat diplomatically) with far more authority than I could ever muster.

Aging has been shown, over several decades, to consist of a multiplicity of loosely linked processes, implying that robust postponement of age-related ill-health requires a divide-and-conquer approach consisting of a panel of interventions. Because such an approach is really difficult to implement, gerontologists initially adopted a position of such extreme pessimism that all talk of intervention became unfashionable. The discovery of genetic and pharmacological ways to mimic [calorie restriction], after a brief period of confused disbelief, was so seductive as a way to raise the field’s profile that it was uncritically embraced as the fulcrum of translational gerontology for 20 years, but finally that particular emperor has been decisively shown to have no biomedically relevant clothes.

The publication of so authoritative a commentary adopting the “paleogerontological” position, that aging is indeed chaotic and complex and intervention will indeed require a panel of therapies, but now combined with evidence-based optimism as to the prospects for implementing such a panel, is a key step in the elevation of translational gerontology to a truly mature field.

In essence, as de Grey points out, work on aging has been following the wrong, slow, expensive, low-yield path for a couple of decades: the path of deciphering the mechanisms of calorie restriction and altering genes and metabolism to slightly slow down aging. This path cannot result in large gains in life expectancy and long-term health, and it cannot result in therapies that will greatly help people who are already old. What use is slowing down the accumulation of the damage of aging if you are already just a little more damage removed from death, and frail and suffering because of it, and the treatment will meaningfully alter none of that? If we want to add decades or more to our healthy life spans before we die, then rejuvenation and repair of damage are what is needed: ways to reverse frailty, remove suffering, and restore youthful function.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.  

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Longevitize!: The Master Compendium for the Life-Extension Movement – Post by G. Stolyarov II

Longevitize!: The Master Compendium for the Life-Extension Movement – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 7, 2013
******************************

longevitize2013_med

Longevitize!: Essays on the Science, Philosophy & Politics of Longevity is a new and (literally) vital compilation, edited by Franco Cortese, which assembles perhaps the widest array of resources on radical life extension in one location. You can read a detailed description of the book here. Cortese’s ambitious projects have breathed new life into the transhumanist and immortalist movements, and Longevitize promises to be perhaps his most influential contribution to date, illustrating a thorough grasp of the current state of the efforts to defeat senescence and enable humankind to transcend its primordial limitations.

In addition to 164 articles representing diverse perspectives about the scientific, philosophical, and political aspects and implications of indefinite life extension, this compendium includes an immensity of links to external resources, including books, articles, and videos. I am proud that my Resources on Indefinite Life Extension (RILE) page formed the crux of the book’s Appendix II. Longevitize permits the reader to delve as deeply as can be desired into studying the feasibility, desirability, and possibilities for implementation of the defeat of senescence and involuntary death.

I am proud to have contributed 27 essays to this anthology, spanning 9 years of my thinking and writing on the prospect of indefinite longevity. In addition, the excellent cover was designed by my wife Wendy Stolyarov, incorporating Maxim Vorobiev’s 1842 painting, “Oak fractured by a lightning bolt. Allegory on wife’s death.” Death destroys our irreplaceable individual universes much like that lightning destroyed the tree. It is time to put an end to this travesty, and Longevitize offers an amazing toolkit and intellectual foundation for doing so. Buy this book, read it, and use it in your further intellectual explorations – including your writing, research, argumentation, and activism.

Right now, Longevitize! is available as an e-book for $9.99, both in PDF and MOBI formats, from Amazon. A hard-copy version is currently being prepared.