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A Brace of Papers from the Longevity Genetics Community – Article by Reason

A Brace of Papers from the Longevity Genetics Community – Article by Reason

The New Renaissance Hat
Reason
December 29, 2013
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You’ll find quite a few papers on longevity and genetics in the preprint queue of Current Vascular Phamacology at the moment. This is a portion of the output of that part of the research community focused on developing a full understanding of the molecular biology of how aging progresses and varies between individuals and species. Biology is fantastically complex, and obtaining that full understanding will be a much, much more challenging endeavor than merely successfully treating or reversing aging.

Treating and even curing aging are goals that might be achieved without a full understanding of exactly how aging progresses. Consider this: you don’t need anything even close to a full molecular model of the progression of rust to greatly extend the life of metal equipment through scrubbing and protective coating. Exactly the same argument about knowledge and action can be applied to biology and medicine. Knowing what the damage is and having a complete understanding of how that damage progresses to cause the visible symptoms of aging are two very different things, the latter much more complex than the former, and only the former actually needed to produce useful therapies.

Nonetheless, most of the present work and funding in the aging science community is focused on developing an understanding of how degenerative aging progresses, not on damage repair and treatment of aging. So most of the output of the research community looks much along the lines of these first few papers I’m going to point out today.

The Challenges in Moving from Ageing to Successful Longevity

Quote:

During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population. Genetic factors contribute to the variation of human life span by around 25%, which is believed to be more profound after 85 years of age. It is likely that multiple factors influence life span and we need answers to questions such as: 1) What does it take to reach 100?, 2) Do centenarians have better health during their lifespan compared with contemporaries who died at a younger age?, 3) Do centenarians have protective modifications of body composition, fat distribution and energy expenditure, maintain high physical and cognitive function, and sustained engagement in social and productive activities?, 4) Do centenarians have genes which contribute to longevity?, 5) Do centenarians benefit from epigenetic phenomena?, 6). Is it possible to influence the transgenerational epigenetic inheritance (epigenetic memory) which leads to longevity?, 7) Is the influence of nutrigenomics important for longevity?, 8) Do centenarians benefit more from drug treatment, particularly in primary prevention?, and, 9) Are there any potential goals for drug research?

Genes Of Human Longevity: An Endless Quest?

Quote:

Human longevity is a complex trait which genetics, epigenetics, environmental and stochasticity differently contribute to. To disentangle the complexity, our studies on genetics of longevity were, at the beginning, mainly focused on the extreme phenotypes, i.e. centenarians who escaped the major age-related diseases compared with cross sectional cohorts.

In association studies on candidate genes many SNPs, positively or negatively correlated with longevity have been identified. On the other hand, the identification of longevity-related genes does not explain the mechanisms of healthy aging and longevity, but it opens a huge amount of questions on epigenetic contribution, gene regulation and the interactions with essential genomes, i.e. mitochondrial DNA and microbiota.

Centenarian Offspring: a model for Understanding Longevity

Quote:

A main objective of current medical research is the improving of life quality of elderly people as priority of the continuous increase of ageing population. Accordingly, the research interest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype, i.e. the centenarian phenotype. Centenarians have been used as an optimal model for successful ageing. However, it is characterized by several limitations, i.e. the selection of appropriate controls for centenarians and the use itself of the centenarians as a suitable model for healthy ageing. Thus, the interest has been centered on centenarian offspring, healthy elderly people. They may represent a model for understanding exceptional longevity for the following reasons: to exhibit a protective genetic background, cardiovascular and immunological profile as well as a reduced rate of cognitive decline than age-matched people without centenarian relatives.

Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity

Quote:

A change in the lipoprotein profile is a metabolic hallmark of aging and has been the target for modern medical developments. Although pharmaceutical interventions aimed at lipid lowering substantially decrease the risk of cardiovascular disease, they have much less impact on mortality and longevity. Moreover, they have not affected death from other age-related diseases.

In this review we focus on high density lipoprotein (HDL) cholesterol, the levels of which are either elevated or do not decrease as would be expected with aging in centenarians, and which are associated with lower prevalence of numerous age-related diseases; thereby, suggesting a potential HDL-mediated mechanism for extended survival. We also provide an update on the progress of identifying longevity-mediating lipid genes, describe approaches to discover longevity genes, and discuss possible limitations. Implicating lipid genes in exceptional longevity may lead to drug therapies that prevent several age-related diseases, with such efforts already on the way.

It has to be said, however, that some areas of research are close enough to the development of actual rejuvenation treatments – those addressing at least some of the root cause damage of aging rather than downstream consequences – that even the scientific mainstream is coming around to the idea. The impact of cellular senescence on aging is one such field, as several obvious and existing applications of medical technology may aid in removal of the senescent cells that accumulate with age, and early work in mice confirms that such treatments should prove helpful:

Cellular Senescence in Ageing, Age-Related Disease and Longevity

Quote:

Cellular senescence is the state of permanent inhibition of cell proliferation. There is mounting evidence that senescent cells contribute to ageing and age-related disease by generating a low grade inflammation state (senescence-associated secretory phenotype-SASP). Even though cellular senescence is a barrier for cancer it can, paradoxically, stimulate development of cancer via proinflammatory cytokines. There is evidence that senescent vascular cells, both endothelial and smooth muscle cells, participate in atherosclerosis and senescent preadipocytes and adipocytes have been shown to lead to insulin resistance.

Thus, modulation of cellular senescence is considered as a potential pro-longevity strategy. It can be achieved in several ways like: elimination of selected senescent cells, epigenetic reprogramming of senescent cells, preventing cellular senescence or influencing the secretory phenotype. Some pharmacological interventions have already been shown to have promising activity in this field.

 

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 

This work is reproduced here in accord with a Creative Commons Attribution license.  It was originally published on FightAging.org.

Why I Wrote a Children’s Book on Indefinite Life Extension – Article by G. Stolyarov II

Why I Wrote a Children’s Book on Indefinite Life Extension – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
December 21, 2013
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My greatest fear about the future is not of technology running out of control or posing existential risks to humankind. Rather, my greatest fear is that, in the year 2045, I will be 58 years old and already marked by notable signs of senescence, sitting at the kitchen table, drinking my morning coffee, and wondering, “What happened to that Singularity we were promised by now? Why did it not come to pass? Why does the world of 2045 look pretty much like the world of 2013, with only a few cosmetic differences?” My greatest fear is that, as I stare into that mug of coffee, I would recognize that it will all be downhill from there, especially as “kids these days” would pay no more attention to technological progress and life-extension possibilities than their predecessors did. My greatest fear is that they would consider me a quixotic old man, fantasizing about a future that never was, while they struggle to make ends meet in an ever-more hostile economy (which would look much like our own, except farther along in the sequence of gradual decay, because nobody cares), strangled by labyrinthine restrictions arising out of Luddism and change-aversion within the widespread society. In short, my greatest fear is that our present will be our future, except that I and the present generation of longevity activists will lose our youthful vitality and will ourselves be rapidly approaching the abyss of oblivion.

So I needed to do something. I am not a doctor or biologist, but I did vow at the age of five that I would devote my life to the struggle against senescence and death – so I needed to make good on that promise. My articles, videos, and occasional donations to life-extension endeavors are all well and good, but I also wanted to make a unique contribution that could turn the tide of cultural attitudes toward life extension and toward death itself. After years of brainstorming and months of concerted activity on the part of both me and my wife and illustrator Wendy Stolyarov, the result is Death is Wrong – an illustrated children’s book on life extension that is the first of its kind.

Death is Wrong - by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong – available in both paperback and Kindle editions – fills an important void. Virtually everyone learns about death as a child, and the initial reaction is the correct one: bewilderment, horror, and outrage. Yet there has been no resource to validate these completely correct first impressions. Almost immediately, the young ones are met with excuses and rationalizations, so that they might be consoled and return to a semblance of normalcy. Over millennia of facing indeed inevitable demises, humans have constructed elaborate edifices of rationalization, designed to keep thoughts of death from intruding upon their day-to-day lives. While understandable in eras when technological progress could not have been expected to attain radical life extension (see Benjamin Franklin’s famous lament that he was born too soon), today such evasions of the grave wrong of death are among the most counterproductive attitudes imaginable. Now that technological progress could bring us into the bright age of indefinite longevity within our lifetimes, every atavistic remnant of the old death acceptance poses a barrier that must be surmounted. The fewer barriers life-extension progress encounters, the faster indefinite lifespans will arrive for us; the more of us will be preserved from oblivion.

While transhumanists and life-extension advocates have made headway with conveying their aspirations for the future to some of the most technically educated and philosophically inclined adults, the mainstream of society remains pervaded by the old death-acceptance arguments – religious and secular: from the fear of “playing God” to the specter of overpopulation. Every mind held captive by these traditional and Malthusian pro-death prejudices is a mind that will at best not help life-extension progress and at worst hinder it greatly – a higher likelihood for the most intelligent purveyors of the death-acceptance mindset. People who embrace these notions and find them credible (despite the relative ease of debunking them using logic and evidence) largely do so because the fallacies were ingrained into them since childhood, with no counterarguments being presented or even posited as conceivable. So, if the antidote to these fallacies is to be most effective, it must be administered in childhood.

Death is Wrong will be easily understood by most eight-year-olds, though my aim is to encompass as young an audience as possible. The beautiful and detailed illustrations will help keep young minds engaged as they read about long-lived organisms found in nature, as well as the great advocates of life extension from the past and the present (featured in the book are Francis Bacon, Benjamin Franklin, Marquis de Condorcet, Friedrich Nietzsche, Alan Harrington, and Aubrey de Grey). The book discusses successes in animal life extension, along with providing a concise introduction to Dr. de Grey’s SENS program and the seven principal types of damage that must be addressed in order to reverse senescence. Parts of the book are autobiographical: they describe my own experiences as a child finding out about death and vowing to combat it. The book also focuses of refuting the common pro-death rationalizations and presenting young readers with all of the amazing opportunities and possibilities that can only exist if humans live much, much longer than is presently the case. At the end is a call to action and a list of further resources for young readers to find out more and to become involved with the life-extension movement.

Some may question my tactic of assailing death itself directly – an approach that strikes at the very attitudes enabling acceptance of the Dragon-Tyrant in the room (not the elephant, because elephants are largely innocuous). Yet this is not the time for prevarication or for dampening the rhetoric to the point where one only advocates greater “healthspans” or “compression of morbidity” or any incremental stopping place for progress. While the achievement of indefinite lifespans (and functional immortality, through improvements to the safety of humans’ environment and to the institutional incentives to avoid violence) will not come all at once, and incremental discoveries and lifespan extensions will certainly be the process leading to the goal, the goal itself – defeating death – should not be forgotten or dismissed. The grave wrong of death is worse than that of slavery – once a ubiquitous institution that every society took for granted. William Lloyd Garrison, the 19th-century abolitionist, recognized that the way to get slavery to disappear was to emphasize the feasibility and desirability of its complete eradication: “Urge immediate abolition as earnestly as we may, it will, alas! be gradual abolition in the end. We have never said that slavery would be overthrown by a single blow; that it ought to be, we shall always contend.” [1] Truer words were never spoken when it comes to the abolition of innocent human death. For those of us life-extension advocates who cannot participate in the research directly (other than donating money and other services to aid the researchers), the most promising path to follow is the example of William Lloyd Garrison. We should emphasize the urgency, the moral necessity, the undeniable justice of abolishing the death of innocent humans as soon as possible. We need to transform the culture so that it comes to reject death much as it was transformed to reject slavery after millennia of blithe acceptance. Then the research funding will flow, the votes and political rhetoric will follow, and even theologies and philosophies will be reinterpreted to view the fight against death on Earth to be the natural conclusion of every religious faith and secular ideology.

The spread of Death is Wrong to children is just one piece of the strategy of advocating for the abolition of the death of innocents. I would admire and embrace every activist project – including other children’s books – aimed toward this same cultural transformation. For those who have been wondering how they personally could contribute to the prospects of achieving indefinite longevity within our lifetimes, I hope that this book offers inspiration as well as some concrete possibilities for action. Even a single pro-longevity activist in a community could make a tremendous difference by donating copies of Death is Wrong to libraries, schools, bookstores, and children’s activity groups – or directly to children with whom the activist is acquainted.

Perhaps, if enough of today’s children read Death is Wrong, they would not view us life-extension advocates as hopeless oldsters lost in unattainable fantasy, thirty-two years into the future. Rather, they would be young alongside us, working to build a human civilization truly worthy of the name – one that is permeated by peace, prosperity, virtue, and a striving to ceaselessly progress as humankind comes to inhabit, develop, beautify, and ennoble the universe at large.

[1] Quoted in William H. Pease and Jane H. Pease, eds., The Antislavery Argument (Indianapolis: Bobbs-Merrill Co., 1965), p. xxxv.

“Death is Wrong”: Illustrated Children’s Book on Life Extension – Announcement and Short Excerpt – Video by G. Stolyarov II

“Death is Wrong”: Illustrated Children’s Book on Life Extension – Announcement and Short Excerpt – Video by G. Stolyarov II

Death is Wrong is the ambitious new book for children and for life-extension advocates of all ages.

If you have ever asked, “Why do people have to die?” then this book is for you. The answer is that no, death is not necessary, inevitable, or good. In fact, death is wrong. Death is the enemy of us all, to be fought with medicine, science, and technology. This book introduces you to the greatest, most challenging, most revolutionary movement to radically extend human lifespans so that you might not have to die at all.

You will learn about some amazingly long-lived plants and animals, recent scientific discoveries that point the way toward lengthening lifespans in humans, and simple, powerful arguments that can overcome the common excuses for death. If you have ever thought that death is unjust and should be defeated, you are not alone. Read this book, and become part of the most important quest in human history.

This book was written by the philosopher and futurist Gennady Stolyarov II and illustrated by the artist Wendy Stolyarov. It is here to show you that, no matter who you are and what you can do, there is always a way for you to help in humanity’s struggle against death.

The First Edition of Death is Wrong was published by the Rational Argumentator Press.

References

Paperback version on Amazon
Kindle version on Amazon
Paperback version on Createspace

Reviews

“Not too grammatically complex, and not too excruciatingly simplistic, Death is Wrong is a blunt dose of reality, quick to the punch and holding nothing back. This is the book I wish I’d have read as a young child.”

~ B. J. Murphy – The Proactionary Transhumanist. Read the full review.

“I thought the book was fun to read and important in what it tries to accomplish.”

~ Zoltan Istvan – Psychology Today. Read the full review.

 

“Death is Wrong” Reviewed by Zoltan Istvan in “Psychology Today” – Post by G. Stolyarov II

“Death is Wrong” Reviewed by Zoltan Istvan in “Psychology Today” – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
December 17, 2013
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I am pleased to announce some excellent news regarding a development that will hopefully accelerate the spread of life-extension ideas to children and to the general public. Zoltan Istvan’s article on my new children’s book Death is Wrong and his interview with me and my wife Wendy Stolyarov was just published on Psychology Today. You can read it here. Psychology Today is a high-traffic site with a high potential for influencing public outlooks on life, death, and life extension.  I welcome your comments both at the bottom of this post and on the Psychology Today page.

Short Review of New Children’s Book, “Death is Wrong” – Article by B. J. Murphy

Short Review of New Children’s Book, “Death is Wrong” – Article by B. J. Murphy

The New Renaissance Hat
B. J. Murphy
December 14, 2013
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The qualm of death is a very uneasy burden we all suffer from. We dedicate hours of our time, spent in colloquy, discussing the myriad risks of life, though subsequently the tender rage to resist to ensure that life lives on. But then, when do we spend our time in preparing our children – the next generation – for what is to come, what is to discuss, and what is to fight for?

I believe this wonderful children’s book, provided by the Stolyarovs, is a very grand step forward in achieving this. Not too grammatically complex, and not too excruciatingly simplistic, Death is Wrong is a blunt dose of reality, quick to the punch and holding nothing back. This is the book I wish I’d have read as a young child.

As science matures and technology continues growing at an exponential pace, especially in the medical sector, the words written here in this book will not only live on forever via the vast archives of historical literature, they will live on forever through the lives of the indefinitely extended – the cyborgs, the transhumans, the posthumans, etc.

While certainly not religious myself, I believe this loosely correlated – albeit relevant – quote from the Judeo-Christian bible will suffice as final remarks in tribute of this book’s noble message to you, the reader:

“The last enemy that shall be destroyed is death.” – 1 Corinthians 15:26

B. J. Murphy publishes The Proactionary Transhumanist blog, where this review originally appeared

Death is Wrong - by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong – by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Purchase

Kindle Format | Paperback Format (Amazon, CreateSpace)

MILE Activist Contest Entry: Distribution of “Death is Wrong” – by G. Stolyarov II

MILE Activist Contest Entry: Distribution of “Death is Wrong” – by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
December 7, 2013
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This is my entry into the Movement for Indefinite Life Extension (MILE) Activist Contest, regarding how one would spend a hypothetical $5,000 to “inform as many people as possible about the desirability and the prospects for indefinite life extension”.

Death is Wrong (currently available on Amazon and Createspace) is my ambitious new book for children and for life-extension advocates of all ages, concisely introducing the major reasons for the feasibility and desirability of indefinite life extension.

Death is Wrong - by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong – by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

My proposal for the MILE Activist Contest entails spending $5,000 to distribute Death is Wrong to as broad an audience as possible.

As the author, I am able to obtain paperback copies of Death is Wrong at a highly discounted price of $3.79 per copy. 1,000 copies could be obtained at a cost of $3,790. The remaining $1,210 would be set aside to pay shipping costs as needed. The plan for distribution would involve coordinating with other life-extension activists in the United States to bring Death is Wrong to their local areas. For instance, if a life-extension activist desires 25 copies of Death is Wrong to distribute to schools, libraries, or local gatherings, I could ship these copies to the activist, who would be able to identify the most effective local distribution channels and the most receptive audiences. Activists could use the donated copies to conduct public readings, including events that draw an audience of children.

As part of this distribution plan, I would be able to provide a similar arrangement for schools, libraries, and other organizations, particularly those which interact significantly with children. Death is Wrong is written at a level readily comprehensible for children ages 8 and older, though ambitious children of younger ages would be an ideal audience as well. In facilitating the distribution of Death is Wrong, I would encourage life-extension activists to invest in quality. Even a single bright child who shows ample curiosity, interest in, and support for dramatic enhancements in human longevity could become a leading contributor to the Movement for Indefinite Life Extension. Cultivating such a passion extremely early in life could provide the MILE with just the kind of support it needs – a set of energetic, intelligent, talented, and idealistic young people who are equipped and eager to transform the world for the better.

Success would be tracked through steady correspondence with activists and other recipients of donated books, to receive updates as to how many books were distributed and through which venues. The greatest mark of success, though, would be observing new people – both children and adults – entering the life-extension movement as a result of Death is Wrong. Through Amazon book reviews, online searches, and monitoring of life-extension social-networking groups and publications, as well as correspondence addressed to me and other longevity activists, it would be possible to gain an appreciation for how many hearts and minds have been won by this effort.

Death is Wrong – Children’s Book on Life Extension – Written by G. Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong – Children’s Book on Life Extension – Written by G. Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong - by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Death is Wrong – by Gennady Stolyarov II, Illustrated by Wendy Stolyarov

Click on the cover for a high-resolution image that you can download, save, and distribute.

If you have ever asked, “Why do people have to die?” then this book is for you. The answer is that no, death is not necessary, inevitable, or good. In fact, death is wrong. Death is the enemy of us all, to be fought with medicine, science, and technology. This book introduces you to the greatest, most challenging, most revolutionary movement to radically extend human lifespans so that you might not have to die at all.

You will learn about some amazingly long-lived plants and animals, recent scientific discoveries that point the way toward lengthening lifespans in humans, and simple, powerful arguments that can overcome the common excuses for death. If you have ever thought that death is unjust and should be defeated, you are not alone. Read this book, and become part of the most important quest in human history.

This book was written by the philosopher and futurist Gennady Stolyarov II and illustrated by the artist Wendy Stolyarov. It is here to show you that, no matter who you are and what you can do, there is always a way for you to help in humanity’s struggle against death.

Death is Wrong is the ambitious new book for children and for life-extension advocates of all ages.

You can purchase Death is Wrong in the following formats and locations:

Paperback Edition: Amazon – $9.48

Paperback Edition: Createspace – $9.48

Kindle Edition: Amazon – $0.99

The First Edition of Death is Wrong was published by the Rational Argumentator Press in conjunction with Ria University Press.

The Rational Argumentator welcomes your reviews of Death is Wrong. You can submit them to TRA by sending them to gennadystolyarovii@yahoo.com. You are also encouraged to review the book on Amazon and spread the word by reprinting the information on this page or your own comments concerning the book on other media outlets.

Non-commercial distribution of Death is Wrong is welcomed – including lending, public readings, and dissemination to libraries and schools. For commercial distribution options, please contact Mr. Stolyarov at gennadystolyarovii@yahoo.com. Because of Mr. Stolyarov’s desire to maximize the spread of this book, non-exclusivity is a key criterion for any commercial distribution rights.

Life Expectancy is Growing at the Upper End, Too – Video by G. Stolyarov II

Life Expectancy is Growing at the Upper End, Too – Video by G. Stolyarov II

Mr. Stolyarov provides evidence that increasing life expectancy is occurring for the oldest individuals, and that rises in average longevity are not just due to reductions in mortality among infants and young adults.

References
– “Life Expectancy is Growing at the Upper End, Too” – Post by G. Stolyarov II
– “Centenarians are the fastest-growing age segment: Number of 100-year-olds to hit 6 million by 2050” – New York Daily News and The Associated Press – July 21, 2009
– “Living to 100: 80% are women, report shows” – USA Today – December 10, 2012
– “Number of centenarians hits new high in Japan” – Medical Xpress – September 13, 2011
– “Jeanne Calment” – Wikipedia
– “Jiroemon Kimura” – Wikipedia

SENS or Cryonics?: My Answer to a Hypothetical Choice – Video by G. Stolyarov II

SENS or Cryonics?: My Answer to a Hypothetical Choice – Video by G. Stolyarov II

If Mr. Stolyarov had $1 billion to donate to life extension, would he donate it to SENS (Strategies for Engineered Negligible Senescence) or cryonics? Find out his answer.

References:
– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Essay by G. Stolyarov II
– “How Can I Live Forever?: What Does and Does Not Preserve the Self” – Video by G. Stolyarov II
SENS Research Foundation Website
– “Kim Suozzi Cryogenically Preserved After Battle With Brain Cancer” – Huffington Post – January 22, 2013

The Boon to Longevity Progress Will Be Increased Activism, Advocacy, and Lobbying – Article by Franco Cortese

The Boon to Longevity Progress Will Be Increased Activism, Advocacy, and Lobbying – Article by Franco Cortese

The New Renaissance Hat
Franco Cortese
November 17, 2013
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When asked what the biggest bottleneck for progress in life extension is, most thinkers and researchers say funding. Others say the biggest bottleneck is breakthroughs, while still others say it’s our way of approaching the problem (i.e., seeking healthy life extension, a.k.a. “aging gracefully”, instead of more comprehensive methods of radical life extension). But the majority seem to feel that the largest determining factor impacting how long it takes to achieve indefinite lifespans is adequate funding to plug away at developing and experimentally verifying the various alternative technologies and methodologies that have already been proposed (e.g. Robert Freitas’s Nanomedicine [1], Aubrey de Grey’s Strategies for Engineered Negligible Senescence [2, 3, 4], Michael R. Rose’s Evolutionary Longevity [5, 6]). I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy, activism and lobbying.
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This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of indefinite longevity’s feasibility and desirability.

There is no definitive timespan that it will take to achieve radically extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Radically Extended Life, per unit of time or effort, by advocating the desirability, ethicality, and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to life-extension projects and research initiatives.

In order to get funding we need to demonstrate with explicit clarity just how much we want it, and that we can do so while minimizing potentially negative societal repercussions like overpopulation. We must do our best to vehemently invalidate the clichés that promulgate the sentiment that life extension is dangerous or unethical. It needn’t be either, and nor is it necessarily likely to be either.

Some think that spending one’s time deliberating the potential issues that could result from greatly increased lifespans and the ways in which we could mitigate or negate them won’t make a difference until greatly increased lifespans are actually achieved. I disagree. While any potentially negative repercussions of life extension (like overpopulation) aren’t going to happen until life extension is achieved, offering solution paradigms and ways in which we could negate or mitigate such negative repercussions decreases the time we have to wait for it by increasing the degree with which the wider public feels it to be desirable, and that it can very well be done safely and ethically. Those who are against radical life extension are against it either because they think it is infeasible (in which case being “against” it may be too strong a descriptor) or because they have qualms relating to its ethicality or its safety. More people openly advocating against it means a higher public perception of its undesirability. Whether indefinite longevity is eventually achieved via private industry or via government-subsidized research initiatives, we need to create the public perception that it is widely desired before either government or industry will take notice.

The sentiment that the best thing we can do is simply live healthily and wait until progress is made seems to be fairly common as well. People have the feeling that researchers are working on it, that it will happen if it can happen, and that waiting until progress is made is the best course to take. Such lethargy will not help Radical Longevity in any way. How long we have to wait for indefinite lifespans is a function of how much effort we put into it. And in this article I argue that how much funding and attention life extension receives is by and large a function of how widespread the public perception of its feasibility and desirability is.

This isn’t simply about our individual desires to live longer. It might be easier to hold the sentiment that we should just wait it out until it happens if we only consider its impact on the scale of our own individual lives. Such a sentiment may also be aided by the view that greatly longer lives would be a mere advantage, nice but unnecessary. I don’t think this is the case. I argue that the technological eradication of involuntary death is a moral imperative if there ever was one. If how long we have to wait until radical longevity is achieved depends on how vehemently we demand it and on how hard we work to create the public perception that longer life is widely longed-for, then to what extent are  100,000 lives lost potentially needlessly every day while we wait on our hands? One million people will die wasteful and involuntary deaths in the next 10 days. 36.5 million people will die this year from age-correlated causes of functional decline. This puts the charges of inethicality in a ghostly new light. If advocating the desirability, feasibility, and blatant ethicality of life extension can hasten its implementation by even a mere 10 days, then one million lives that would have otherwise been lost will have been saved by the efforts of life-extension advocates, researchers, and fiscal supporters. Seen in this way, working toward radical longevity may very well be the most ethical and selfless way you could spend your time, in terms of the number of lives saved and/or the amount of suffering prevented.

One of the most common and easy-to-raise concerns I come across in response to any effort to minimize the suffering of future beings is that there are enough problems to worry about right now. “Shouldn’t we be worrying about lessening starvation in underdeveloped countries first? They’re starving right now. Shouldn’t we be focusing on the problems of today, on things that we can have a direct impact on?” Indeed. 100,000 people will die, potentially needlessly, tomorrow. The massive number of people that suffer involuntary death is a problem of today! Indeed, it may very well be the most pressing problem of today! What other source of contemporary suffering claims so many lives, and occurs on such a massive scale? What other “problem of today” is responsible for the needless and irreversible involuntary death of one hundred thousand lives per day? Certainly not starvation, or war, or cancer, all of which in themselves represent smaller sources of involuntary death. Longevity advocates do what they do for the same reason that people who try to mitigate starvation, war, and cancer do what they do, namely to lessen the amount of involuntary death that occurs.

This is a contemporary problem that we can have a direct impact on. People intuitively assume that we won’t achieve radically extended life until far in the future. This makes them conflate any lives saved by radically extended lifespans with lives yet to come into existence. This makes them see involuntary death as a problem of the future, rather than a problem of today. But more people than I’ve ever known will die tomorrow, from causes that are physically possible to obviate and ameliorate – indeed, from causes that we have potential and conceptual solutions for today.

I have attempted to show in this article that advocating life-extension should be considered as “working toward it” to as great an extent as directly funding it or performing direct research on it is considered as “working toward it”. Advocacy has greater potential to increase life extension’s widespread desirability than direct work or funding does, and increasing both its desirability and the public perception if its desirability has more potential to generate increased funding and research-attention for life-extension than direct funding or research does. Advocacy thus has the potential to contribute to the arrival of life extension and hasten its implementation just as much, if not more so (as I have attempted to argue in this article), than practical research or direct funding does. This should motivate people to help create the momentous momentum we need to really get the ball rolling. To be a longevity advocate is to be a longevity worker! Involuntary death from age-associated, physically-remediable causes is the largest source of death, destruction and suffering today.  Don’t you want to help prevent the most widespread source of death and of suffering in existence today? Don’t you want to help mitigate the most pressing moral concern not only of today, but of the entirety of human history – namely physically remediable involuntary death?

Then advocate the technological eradication of involuntary death. Advocate the technical feasibility, extreme desirability, and blatant ethicality of radically extending life. Death is a cataclysm. We need not sanctify the seemingly inevitable any longer. We need not tell ourselves that death is somehow a good thing, or something we can do nothing about, in order to live with the “fact” of it any longer. Soon it won’t be a fact of life. Soon it will be an artifact of history. Life may not be ipso facto valuable according to all philosophies of value – but life is a necessary precondition for any sort of value whatsoever. Death is dumb, dummy! An incontrovertible waste convertible into nothing! A negative-sum blight! So if you want to contribute to the solution of problems of today, if you want to help your fellow man today, then stand proud and shout loud “Doom to Arbitrary Duty and Death to  Arbitrary Death!” at every crowd cowed by the seeming necessity of death.

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Franco Cortese is a futurist, author, editor, Affiliate Scholar at the Institute for Ethics & Emerging Technologies, Ambassador at The Seasteading Institute, Affiliate Researcher at ELPIs Foundation for Indefinite Lifespans, Fellow at Brighter Brains Institute, Advisor at the Lifeboat Foundation (Futurists Board Member and Life Extension Scientific Advisory Board Member), Director of the Canadian Longevity Alliance, Activist at the International Longevity Alliance, Canadian Ambassador at Longevity Intelligence Communications, an Administrator at MILE (Movement for Indefinite Life Extension), Columnist at LongeCity, Columnist at H+ Magazine, Executive Director of the Center for Transhumanity, Contributor to the Journal of Geoethical Nanotechnology, India Future Society, Serious Wonder, Immortal Life and The Rational Argumentator. Franco edited Longevitize!: Essays on the Science, Philosophy & Politics of Longevity, a compendium of 150+ essays from over 40 contributing authors.
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References:
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[1]. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, HewardCB, McCarter RJ, Stock G (2002). “Time to Talk SENS: Critiquing the Immutability of Human Aging”. Annals of the New York Academy of Sciences 959: 452–62. PMID 11976218.
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[2]. de Grey, Aubrey (2003). The Mitochondrial Free Radical Theory of Aging. Austin, Texas: Landes Bioscience. ISBN 1-58706-155-4.

[3]. de Grey, Aubrey and Rae, Michael (2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. St. Martin’s Press.

[4]. Laurence D. Mueller, Casandra L. Rauser and Michael R. Rose (2011). Does Aging Stop? Oxford University Press.

[5]. Garland, T., Jr., and M. R. Rose, eds. (2009). Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments. University of California Press.