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New Decade’s Message for the 2020s – Gennady Stolyarov II

New Decade’s Message for the 2020s – Gennady Stolyarov II

Gennady Stolyarov II


As 2019 draws to a close, Gennady Stolyarov II, Chairman of the United States Transhumanist Party / Transhuman Party and Editor-in-Chief of The Rational Argumentator, expresses hope that humankind will emerge from the “Crazy Years” and offers ten concrete resolutions for human achievement during the 2020s. This message was recorded on December 31, 2019, and is available for viewing here.

As 2019 draws to a close, let us bid farewell and good riddance to a decade which could, in retrospect be referred to using the prophetic Robert Heinlein term, “The Crazy Years” – a turbulent, conflicted decade during which, while glimmers of hope appeared on multiple fronts of technological advancement, society and culture have clearly declined due to the rise of incivility, tribalism, authoritarianism, identity politics, and mass breakdowns of sanity. It is no secret that I had hoped for humankind to have been farther along the path of advancement by now than it has actually come. The great conflict of our decade – between the marvels that have been built by the creative and rational higher faculties of the human mind and the biases, fallacies, vulnerabilities, and atrocities spawned by its darkest evolved recesses – between the Apollonian heights and the Dionysian depths of human nature – will carry on into the 2020s and perhaps beyond. To win this conflict, those of us who desire a brighter future need to advocate for more progress, faster innovation, greater rationality, higher standards of civility and morality, and a long-term outlook that seeks to cultivate the best in human beings.

As the winds of fortune shift, some of us individually will rise, and others will fall. This certainly was the case this past decade. In so many respects, for me, it has been marked by colossal achievements and improvements, but also tectonic shifts in my own life which were not of my initiative – to which I needed to respond and adapt and preserve what I valued in the aftermath. Reflecting back on the end of 2009, and comparing it to today, I realize that absolutely everything about the circumstances of my life is now different… and yet I myself am essentially the same. I believe that it is this core of myself, this fundamentally constant and consistent identity, which has carried me through the crises and enabled me to defy adversity and arise stronger every time – to pursue new endeavors and take on new roles while remaining the same essential individual, to learn from the empirical evidence before me while maintaining the same convictions and understanding of the good. The events of the 2010s have illustrated for me that, indeed, peace and stability in life must ultimately come from within – although it is not a matter of withdrawal into the self or mere self-affirmation, as some popular creeds would claim. Rather, it is the self that must devise and implement solutions to the crises of the day while pursuing consistent improvement in as many dimensions as possible, and preserving that essential core intact.

It is beyond our power to live a decade over again, but we can harness the best of its aftermath and turn the coming decade into a superior and more rational one. Some of us will create resolutions as individuals, and then pursue plans of varying degrees of specificity and likelihood of success. But perhaps it is best to consider the resolutions we would wish to have for humankind as a whole. It is all well and good, of course, to wish for progress and prosperity, but it is also well-known that the resolutions which have the greatest likelihood of succeeding are those which are accompanied by concrete indicators of fulfillment. Therefore, I propose the following ten resolutions for humankind during the decade of the 2020s, which will enable us to empirically identify whether or not they have been fulfilled at the decade’s end.

  1. Construct the next world’s tallest building – because humankind must always reach higher.
  2. Build a base on the Moon – because it is time to colonize other worlds.
  3. Land a human on Mars – because it is time to expand beyond our orbit.
  4. Establish the first fully operational seastead communities – because it is time for human habitation to expand beyond land and for jurisdictional experimentation to resume in earnest.
  5. Have at least one person live beyond 120 years again – mathematically possible given that 10 of today’s supercentenarians are 114 or older; it is time to begin to approach Jeanne Calment’s longevity record of 122 years once more.
  6. Cut all world nuclear-weapon stockpiles in half – more than this has been done before, and so this is really quite a modest goal, but it is imperative to reverse the trajectory of the current arms race. Complete nuclear disarmament by all powers would, of course, be preferable, to finally dispel the “MAD” cloud of annihilation looming over our species.
  7. Compose 100 tonal symphonies – because it is time to rediscover beauty.
  8. Develop medically effective cures for every type of cancer – because, really, it is decades past time.
  9. End the decade with 50 percent of all vehicles on the road at level 2 autonomy or greater – because road deaths are a travesty and should become a relic of a barbaric past.
  10. Experience at least one year in which no country is at war with any other, with “war” including armed insurgencies and terrorist attacks – because national, ethnic, religious, and ideological warfare needs to be relegated to the past.

Of course, there are many worthwhile objectives not encompassed above, and it is my hope that efforts to reach those goals will also advance in parallel. You may have a list of ten resolutions for humankind that differs from mine, but they may be compatible nonetheless. The overarching aim, however, is to restore humanity’s much-needed confidence in progress, to emerge from the postmodern swamp of self-doubt and deconstruction and return to the heights of ennobling ambition and creation. Concrete benchmarks to track our progress can also serve the dual purpose of motivating people everywhere to undertake great tasks. A certain President has expressed the desire to make America great again, but I would venture to say that he has not selected the proper means for doing so. I challenge everyone during the next decade to make the world great again and demonstrate that the most impressive achievements and the most lasting solutions to our age-old problems are still to come. This is the message of transhumanism, and I hope that it can become the theme of the next decade – so that when I speak to you again at the decade’s end, we can reflect upon the wonders that have been built.

Dr. Bill Andrews and U.S. Transhumanist Party Chairman Gennady Stolyarov II Discuss Transhumanism and RAADfest at Sierra Sciences

Dr. Bill Andrews and U.S. Transhumanist Party Chairman Gennady Stolyarov II Discuss Transhumanism and RAADfest at Sierra Sciences

Gennady Stolyarov II
Bill Andrews


On October 12, 2019, Brent Nally recorded this discussion between Dr. Bill Andrews – the Biotechnology Advisor of the U.S. Transhumanist Party / Transhuman Party – and U.S. Transhumanist Party / Transhuman Party Chairman Gennady Stolyarov II regarding recent news in the field of longevity (including pet longevity), techniques to slow down the rate of telomere shortening, changes to public perceptions of aging and longevity, transhumanism and technologies of life enhancement, and how to be rigorous and appropriately skeptical when evaluating various ideas and hypotheses in medicine.

Watch this discussion here and be on the lookout for a special visitor from a different species!

Become a member of the U.S. Transhumanist Party / Transhuman Party here for free, no matter where you reside.

Show Notes by Brent Nally

0:35 Dr. Andrews links:

Facebook: https://facebook.com/telomere.bill.andrews;

Linkedin: https://linkedin.com/in/william-h-andrews-5455b45/;

Wikipedia: https://en.wikipedia.org/wiki/William_H._Andrews_(biologist);

Sierra Sciences Website: https://sierrasci.com/;

Sierra Sciences YouTube Channel: https://www.youtube.com/channel/UCB9UFIxyD9VUHjuNQzpLzeA

1:08 Brent’s RAADfest 2019 YouTube playlist. Go to RAADfest primarily to network https://www.raadfest.com/

2:35 USTP concluded its presidential primary elections: watch Gennady Stolyarov II & Johannon Ben Zion at RAADfest 2019; watch Brent interview Mr. Ben Zion at RAADfest 2019; watch Brent interview Mr. Ben Zion and his VP running mate Charlie Kam at RAADfest 2019.

3:10 Bill’s dog Dash makes his cameo appearance.

4:35 Long-distance running and recovery.

7:20 Bill hosted a pet-longevity panel at RAADfest 2019.

12:15 Quacks and charlatans have discredited human longevity for centuries.

13:26 How has the public’s perception of human aging changed in the last decade?

15:10 Buy Bill’s 2 books: Curing Aging and Telomere Lengthening. See Brent’s book review of Telomere Lengthening: Curing all diseases including cancer & aging by Dr. Bill Andrews

15:25 Inflammation is the number one cause of human aging.

16:47 Do fun activities, meditate, practice yoga, eat a healthy diet, reduce stress to decrease the rate of telomere shortening.

18:48 Caldwell Esselstyn – Wikipedia

19:10 Watch Brent’s interview with Dr. Sandy Kaufmann.

21:33 Funding is needed to cure human aging and all chronic diseases.

24:03 Bill is hoping the telomerase gene therapy clinical study by Libella Gene Therapeutics (which is scheduled to start in November 2019) will show age reversal in the human Alzheimer’s patient in every measurable way.

24:18 Mice telomerase gene therapy study by Dr. by Ron DePinho

26:13 Animals age in different ways.

30:35 Life enhancement should be our focus.

33:08 Most humans living in the 1st world have been transhumanists for quite some time.

35:38 Nanobots

38:02 Get involved in the longevity movement in any way you can – follow thought leaders; donate.

39:40 Dr. Jason Williams

40:30 A race to cure human aging is a great idea to educate people.

43:26 Watch Brent’s interview with USTP Presidential candidate Johannon Ben Zion.

45:15 Spinal-cord repair, prosthetics, stem cells, etc.

51:01 Bill is impressed by stem-cell therapies but warns of charlatans. Watch Brent’s playlist on stem cells.

52:38 Use PubMed to do a meta-analysis of scientific peer-reviewed studies.

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018

Gennady Stolyarov II Interviews Ray Kurzweil at RAAD Fest 2018

Gennady Stolyarov II
Ray Kurzweil


The Stolyarov-Kurzweil Interview has been released at last! Watch it on YouTube here.

U.S. Transhumanist Party Chairman Gennady Stolyarov II posed a wide array of questions for inventor, futurist, and Singularitarian Dr. Ray Kurzweil on September 21, 2018, at RAAD Fest 2018 in San Diego, California. Topics discussed include advances in robotics and the potential for household robots, artificial intelligence and overcoming the pitfalls of AI bias, the importance of philosophy, culture, and politics in ensuring that humankind realizes the best possible future, how emerging technologies can protect privacy and verify the truthfulness of information being analyzed by algorithms, as well as insights that can assist in the attainment of longevity and the preservation of good health – including a brief foray into how Ray Kurzweil overcame his Type 2 Diabetes.

Learn more about RAAD Fest here. RAAD Fest 2019 will occur in Las Vegas during October 3-6, 2019.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form.

Watch the presentation by Gennady Stolyarov II at RAAD Fest 2018, entitled, “The U.S. Transhumanist Party: Four Years of Advocating for the Future”.

Andrés Grases Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II on Transhumanism and the Transition to the Next Technological Era

Andrés Grases Interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II on Transhumanism and the Transition to the Next Technological Era

Gennady Stolyarov II
Andrés Grases


Andrés Grases, the publisher of the Transhuman Plus website (http://transhumanplus.com/) interviews U.S. Transhumanist Party Chairman Gennady Stolyarov II at RAAD Fest 2018 in San Diego, CA, on September 23, 2018. During the course of this conversation, both the contemporary state of transhumanist politics and future directions are covered – along with the challenges to reforming the educational system, the need to create open access to academic works, the manner in which the transition toward the next era of technologies will occur, the meaning of transhumanism and its applications in the proximate future – including promising advances that we can expect to see during the next several years.

Watch the video here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Apply online here in less than a minute.

California Transhumanist Party Leadership Meeting – Presentation by Newton Lee and Discussion on Transhumanist Political Efforts

California Transhumanist Party Leadership Meeting – Presentation by Newton Lee and Discussion on Transhumanist Political Efforts

Newton Lee
Gennady Stolyarov II
Bobby Ridge
Charlie Kam


The California Transhumanist Party held its inaugural Leadership Meeting on January 27, 2018. Newton Lee, Chairman of the California Transhumanist Party and Education and Media Advisor of the U.S. Transhumanist Party,  outlined the three Core Ideals of the California Transhumanist Party (modified versions of the U.S. Transhumanist Party’s Core Ideals), the forthcoming book “Transhumanism: In the Image of Humans” – which he is curating and which will contain essays from leading transhumanist thinkers in a variety of realms, and possibilities for outreach, future candidates, and collaboration with the U.S. Transhumanist Party and Transhumanist Parties in other States. U.S. Transhumanist Party Chairman Gennady Stolyarov II contributed by providing an overview of the U.S. Transhumanist Party’s current operations and possibilities for running or endorsing candidates for office in the coming years.

Visit the website of the California Transhumanist Party:http://www.californiatranshumanistparty.org/index.html

Read the U.S. Transhumanist Party Constitution: http://transhumanist-party.org/constitution/

Become a member of the U.S. Transhumanist Party for free: http://transhumanist-party.org/membership/

(If you reside in California, this would automatically render you a member of the California Transhumanist Party.)

Review of Philip Tetlock’s “Superforecasting” – Article by Adam Alonzi

Review of Philip Tetlock’s “Superforecasting” – Article by Adam Alonzi

The New Renaissance Hat
Adam Alonzi
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Alexander Consulting the Oracle of Apollo, Louis Jean Francois Lagrenée. 1789, Oil on Canvas.

“All who drink of this treatment recover in a short time, except those whom it does not help, who all die. It is obvious, therefore, that it fails only in incurable cases.”

-Galen

Before the advent of evidence-based medicine, most physicians took an attitude like Galen’s toward their prescriptions. If their remedies did not work, surely the fault was with their patient. For centuries scores of revered doctors did not consider putting bloodletting or trepanation to the test. Randomized trials to evaluate the efficacy of a treatment were not common practice. Doctors like Archie Cochrane, who fought to make them part of standard protocol, were met with fierce resistance. Philip Tetlock, author of Superforecasting: The Art and Science of Prediction (2015), contends that the state of forecasting in the 21st century is strikingly similar to medicine in the 19th. Initiatives like the Good Judgement Project (GJP), a website that allows anyone to make predictions about world events, have shown that even a discipline that is largely at the mercy of chance can be put on a scientific footing.

More than once the author reminds us that the key to success in this endeavor is not what you think or what you know, but how you think. For Tetlock pundits like Thomas Friedman are the “exasperatingly evasive” Galens of the modern era. In the footnotes he lets the reader know he chose Friedman as target strictly because of his prominence. There are many like him. Tetlock’s academic work comparing random selections with those of professionals led media outlets to publish, and a portion of their readers to conclude, that expert opinion is no more accurate than a dart-throwing chimpanzee. What the undiscerning did not consider, however, is not all of the experts who participated failed to do better than chance.

Daniel Kahneman hypothesized that “attentive readers of the New York Times…may be only slightly worse” than these experts corporations and governments so handsomely recompense. This turned out to be a conservative guess. The participants in the Good Judgement Project outperformed all control groups, including one composed of professional intelligence analysts with access to classified information. This hodgepodge of retired bird watchers, unemployed programmers, and news junkies did 30% better than the “pros.” More importantly, at least to readers who want to gain a useful skillset as well as general knowledge, the managers of the GJP have identified qualities and ways of thinking that separate “superforecasters” from the rest of us. Fortunately they are qualities we can all cultivate.

While the merits of his macroeconomic theories can be debated, John Maynard Keynes was an extremely successful investor during one of the bleakest periods in international finance. This was no doubt due in part to his willingness to make allowance for new information and his grasp of probability. Participants in the GJP display open-mindedness, an ability and willingness to repeatedly update their forecasts, a talent to neither under- nor over-react to new information by putting it into a broader context,  and a predilection for mathematical thinking (though those interviewed admitted they rarely used an explicit equation to calculate their answer). The figures they give also tend to be more precise than their less successful peers. This “granularity” may seem ridiculous at first. I must confess that when I first saw estimates on the GJP of 34% or 59%, I would chuckle a bit. How, I asked myself, is a single percentage point meaningful? Aren’t we just dealing with rough approximations? Apparently not.

Tetlock reminds us that the GJP does not deal with nebulous questions like “Who will be president in 2027?” or “Will a level 9 earthquake hit California two years from now?” However, there are questions that are not, in the absence of unforeseeable Black Swan events, completely inscrutable. Who will win the Mongolian presidency? Will Uruguay sign a trade agreement with Laos in the next six months? These are parts of highly complex systems, but they can be broken down into tractable subproblems.

Using numbers instead of words like “possibly”, “probably”, “unlikely”, etc., seems unnatural. It gives us wiggle room and plausible deniability. They also cannot be put on any sort of record to keep score of how well we’re doing. Still, to some it may seem silly, pedantic, or presumptuous. If Joint Chiefs of Staff had given the exact figure they had in mind (3 to 1) instead of the “fair chance” given to Kennedy, the Bay of Pigs debacle may have never transpired. Because they represent ranges of values instead of single numbers, words can be retroactively stretched or shrunk to make blunders seem a little less avoidable. This is good for advisors looking to cover their hides by hedging their bets, but not so great for everyone else.

If American intelligence agencies had presented the formidable but vincible figure of 70% instead of a “slam dunk” to Congress, a disastrous invasion and costly occupation would have been prevented. At this point it is hard not to see the invasion as anything as a mistake, but even amidst these emotions we must be wary of hindsight. Still, a 70% chance of being right means there is a 30% chance of being wrong. It is hardly a “slam dunk.” No one would feel completely if an oncologist told them they are 70% sure the growth is not malignant. There are enormous consequences to sloppy communications. However, those with vested interests are more than content with this approach if it agrees with them, even if it ends up harming them.

When Nate Silver put the odds of the 2008 election in Obama’s favor, he was panned by Republicans as a pawn of the liberal media. He was quickly reviled by Democrats when he foresaw a Republican takeover of the Senate. It is hard to be a wizard when the king, his court, and all the merry peasants sweeping the stables would not know a confirmation bias from their right foot. To make matters worse, confidence is widely equated with capability. This seems to be doubly true of groups of people, particularly when they are choosing a leader. A mutual-fund manager who tells his clients they will see great returns on a company is viewed as stronger than a Poindexter prattling on about Bayesian inference and risk management.

The GJP’s approach has not spread far — yet. At this time most pundits, consultants, and self-proclaimed sages do not explicitly quantify their success rates, but this does not stop corporations, NGOs, and institutions at all levels of government from paying handsomely for the wisdom of untested soothsayers. Perhaps they have a few diplomas, but most cannot provide compelling evidence for expertise in haruspicy (sans the sheep’s liver). Given the criticality of accurate analyses to saving time and money, it would seem as though a demand for methods to improve and assess the quality of foresight would arise. Yet for the most part individuals and institutions continue to happily grope in the dark, unaware of the necessity for feedback when they misstep — afraid of having their predictions scrutinized or having to take the pains to scrutinize their predictions.

David Ferrucci is wary of the “guru model” to settling disputes. No doubt you’ve witnessed or participated in this kind of whimpering fracas: one person presents a Krugman op-ed to debunk a Niall Ferguson polemic, which is then countered with a Tommy Friedman book, which was recently excoriated  by the newest leader of the latest intellectual cult to come out of the Ivy League. In the end both sides leave frustrated. Krugman’s blunders regarding the economic prospects of the Internet, deflation, the “imminent” collapse of the euro (said repeatedly between 2010 and 2012) are legendary. Similarly, Ferguson, who strongly petitioned the Federal Reserve to reconsider quantitative easing, lest the United States suffer Weimar-like inflation, has not yet been vindicated. He and his colleagues responded in the same way as other embarrassed prophets: be patient, it has not happened, but it will! In his defense, more than one clever person has criticized the way governments calculate their inflation rates…

Paul Ehrlich, a darling of environmentalist movement, has screeched about the detonation of a “population bomb” for decades. Civilization was set to collapse between 15 and 30 years from 1970. During the interim 100 to 200 million would annually starve to death, by the year 2000 no crude oil would be left, the prices of raw materials would skyrocket, and the planet would be in the midst of a perpetual famine. Tetlock does not mention Ehrlich, but he is, particularly given his persisting influence on Greens, as or more deserving of a place in this hall of fame as anyone else. Larry Kudlow continued to assure the American people that the Bush tax breaks were producing massive economic growth. This continued well into 2008, when he repeatedly told journalists that America was not in a recession and the Bush boom was “alive and well.” For his stupendous commitment to his contention in the face of overwhelming evidence to the contrary, he was nearly awarded a seat in the Trump cabinet.

This is not to say a mistake should become the journalistic equivalent of a scarlet letter. Kudlow’s slavish adherence to his axioms is not unique. Ehrlich’s blindness to technological advances is not uncommon, even in an era dominated by technology. By failing to set a timeline or give detailed causal accounts, many believe they have predicted every crash since they learned how to say the word. This is likely because they begin each day with the same mantra: “the market will crash.”  Yet through an automatically executed routine of psychological somersaults, they do not see they were right only once and wrong dozens, hundreds, or thousands of times. This kind of person is much more deserving of scorn than a poker player who boasts about his victories, because he is (likely) also aware of how often he loses. At least he’s not fooling himself. The severity of Ehrlich’s misfires is a reminder of what happens when someone looks too far ahead while assuming all things will remain the same. Ceteris paribus exists only in laboratories and textbooks.

Axioms are fates accepted by different people as truth, but the belief in Fate (in the form of retroactive narrative construction) is a nearly ubiquitous stumbling block to clear thinking. We may be far removed from Sophocles, but the unconscious human drive to create sensible narratives is not peculiar to fifth-century B.C. Athens. A questionnaire given to students at Northwestern showed that most believed things had turned out for the best even if they had gotten into their first pick. From an outsider’s perspective this is probably not true. In our cocoons we like to think we are in the right place either through the hand of fate or through our own choices. Atheists are not immune to this Panglossian habit. Our brains are wired for stories, but the stories we tell ourselves about ourselves seldom come out without distortions. We can gain a better outside view, which allows us to see situations from perspectives other than our own, but only through regular practice with feedback. This is one of the reasons groups are valuable.

Francis Galton asked 787 villagers to guess the weight of an ox hanging in the market square. The average of their guesses (1,197 lbs) turned out to be remarkably close to its actual weight (1,198 lbs). Scott Page has said “diversity trumps ability.” This is a tad bold, since legions of very different imbeciles will never produce anything of value, but there is undoubtedly a benefit to having a group with more than one point of view. This was tested by the GJP. Teams performed better than lone wolves by a significant margin (23% to be exact). Partially as a result of encouraging one another and building a culture of excellence, and partially from the power of collective intelligence.

“No battle plan survives contact with the enemy.”

-Helmuth von Moltke

“Everyone has a plan ’till they get punched in the mouth.”

-Mike Tyson

When Archie Cochrane was told he had cancer by his surgeon, he prepared for death. Type 1 thinking grabbed hold of him and did not doubt the diagnosis. A pathologist later told him the surgeon was wrong. The best of us, under pressure, fall back on habitual modes of thinking. This is another reason why groups are useful (assuming all their members do not also panic). Organizations like the GJP and the Millennium Project are showing how well collective intelligence systems can perform. Helmuth von Moltke and Mike Tyson aside, a better motto, substantiated by a growing body of evidence, comes from Dwight  Eisenhower: “plans are useless, but planning is indispensable.”

Adam Alonzi is a writer, biotechnologist, documentary maker, futurist, inventor, programmer, and author of the novels A Plank in Reason and Praying for Death: A Zombie Apocalypse. He is an analyst for the Millennium Project, the Head Media Director for BioViva Sciences, and Editor-in-Chief of Radical Science News. Listen to his podcasts here. Read his blog here.

U.S. Transhumanist Party Q&A Session – October 21, 2017

U.S. Transhumanist Party Q&A Session – October 21, 2017

G. Stolyarov II
Martin van der Kroon
Sean Singh
B.J. Murphy


In this interactive question-and-answer session, which occurred at 1 p.m. U.S. Pacific Time on Saturday, October 21, 2017, U.S. Transhumanist Party Officers provided an updated view of the Transhumanist Party’s projects, operations, and achievements, in response to audience questions. Because October is Longevity Month, this Q&A session had a life-extension theme but also delved into various other areas, including how to address conspiracy theories and various approaches toward diet, nutrition, and cultural norms regarding food consumption. The Q&A session has been archived on YouTube here.

The following U.S. Transhumanist Party Officers took part in this Q&A session:

– Gennady Stolyarov II, Chairman
– Martin van der Kroon, Director of Recruitment
– Sean Singh, Director of Applied Innovation
– B.J. Murphy, Director of Social Media

The YouTube question/comment chat for this Q&A session has been archived here and is also provided below.

Visit the U.S. Transhumanist Party website here.

Visit the U.S. Transhumanist Party Facebook page here.

See the U.S. Transhumanist Party FAQ here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside.

Become a Foreign Ambassador for the U.S. Transhumanist Party.

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I am the Lifespan – Video by G. Stolyarov II

I am the Lifespan – Video by G. Stolyarov II

G. Stolyarov II


Gennady Stolyarov II, Chairman of the United States Transhumanist Party, discusses why longevity research is crucial, and how our generation stands on the threshold of finally dealing a decisive blow to the age-old enemies of aging and death, which have destroyed great human minds since the emergence of our species.

This video is part of the #IAmTheLifespan campaign, coordinated by Lifespan.io and the Life Extension Advocacy Foundation (LEAF) for Longevity Month, October 2017. Read more about this campaign here.

Become a member of the U.S. Transhumanist Party for free, no matter where you reside. Fill out our Membership Application Form here.

Become a Foreign Ambassador for the U.S. Transhumanist Party. Apply here.

Visit the website of the U.S. Transhumanist Party here.

Charlie Gard’s Parents Are Forced to Stop Fighting for Their Dying Baby – Article by Marianne March

Charlie Gard’s Parents Are Forced to Stop Fighting for Their Dying Baby – Article by Marianne March

The New Renaissance Hat
Marianne March
July 27, 2017
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I cannot imagine the pain Charlie Gard’s parents are feeling now, as they savor their last moments with their precious child. Charlie is 11 months old and he’s dying.

Chris and Connie have been fighting for months to get treatment for Charlie, ever since he was diagnosed with a rare genetic condition, mitochondrial DNA depletion syndrome. But they have been forced to give up that fight.

I can’t imagine their pain, but I can imagine their fury because I share it.

From the Hospital to the Courts

Charlie is not mine. I’ve never met him or anyone who knows him. Yet I am furious with the British government for refusing to allow his parents to take their dying son to the United States for treatment: a therapy trial, his last and only hope.

No further recourse was available in the UK, but an American doctor was ready to try to help him at Columbia University Medical Center. Charlie’s parents raised £1.4 million through crowdfunding; they had the money to take him to the US by air ambulance.

But doctors at Great Ormond Street Hospital in London didn’t like that idea. They said it wouldn’t help, that the American therapy was experimental. They said the baby’s life support should just stop.

On April 11th, a British High Court judge ruled with the doctors, empowering them to turn off Charlie’s life-support machines. His mother screamed “no” when she heard the verdict.

There was a petition with more than 110,000 names on it. People wrote letters to the Prime Minister, calling on her to release Charlie from Great Ormond Street’s care. The pope said he was praying for Charlie’s parents, “hoping that their desire to accompany and care for their own child to the end is not ignored.”

And now Charlie is out of time.

Even US President Trump tweeted that “If we can help little #CharlieGard, as per our friends in the U.K. and the Pope, we would be delighted to do so.”

Charlie’s parents challenged the decision in the Court of Appeals, the Supreme Court, and the European Court of Human Rights.

All to no avail. The Courts would not allow them to try to save their baby’s life.

Who Can Call This Justice?

And now Charlie is out of time. According to the BBC, “US neurologist Dr. Michio Hirano had said he was no longer willing to offer the baby experimental therapy after he saw the results of a new MRI scan last week.”

It’s possible that Charlie’s doctors were right, that experimental treatment wouldn’t have helped (although his parents don’t think so, nor do American and Italian doctors). But what harm could it have done when he’s dying anyway? And if his parents had the means to give him one last chance, why shouldn’t they exercise their right to do so? They belong to Charlie just as he belongs to them, and no one but Chris and Connie should get the final say on his medical care.

I never really knew what people meant by the phrase “death panels” before. It was just a term bandied about by talking heads and political personalities. It’s chilling how well it applies in this instance: a group of bureaucrats that sits around deciding who is worthy of medical care.

I don’t know how the power slipped away from the individual, whether taken by force or given away with applause, but this is outrageous. And it’s wrong.

Read with a Box of Tissues

I will leave you with the words of Connie Yates, Charlie’s mom:

Due to the deterioration in his muscles, there is now no way back for Charlie. Time that has been wasted. It is time that has sadly gone against him.

We want people to realise that we have been speaking to parents whose children were just like Charlie before starting treatment and now some of them are walking around like normal children. We wanted Charlie to have that chance too.

All we wanted to do was take Charlie from one world renowned hospital to another world renowned hospital in the attempt to save his life and to be treated by the world leader in mitochondrial disease. We feel that we should have been trusted as parents to do so but we will always know in our hearts that we did the very best for Charlie and I hope that he is proud of us for fighting his corner.

Charlie had a real chance of getting better. It’s now unfortunately too late for him but it’s not too late for others with this horrible disease and other diseases. We will continue to help and support families of ill children and try and make Charlie live on in the lives of others. We owe it to him to not let his life be in vain.

Despite the way that our beautiful son has been spoken about sometimes, as if he not worthy of a chance at life, our son is an absolute WARRIOR and we could not be prouder of him and we will miss him terribly. One little boy has brought the world together and whatever people’s opinions are, no one can deny the impact our beautiful son has had on the world and his legacy will never ever die.

We are now going to spend our last precious moments with our son Charlie, who unfortunately won’t make his 1st birthday in just under 2 weeks’ time, and we would ask that our privacy is respected at this very difficult time.

Mummy and Daddy love you so much Charlie, we always have and we always will and we are so sorry that we couldn’t save you.”

Marianne March is a recent graduate of Georgia State University, where she majored in Public Policy, with a minor in Economics. Follow her on twitter @mari_tweets.

This article was published by The Foundation for Economic Education and may be freely distributed, subject to a Creative Commons Attribution 4.0 International License, which requires that credit be given to the author. Read the original article.

An Interview with Kelsey Moody of Ichor Therapeutics, Bringing a SENS Therapy for Macular Degeneration to the Clinic – Article by Reason

An Interview with Kelsey Moody of Ichor Therapeutics, Bringing a SENS Therapy for Macular Degeneration to the Clinic – Article by Reason

The New Renaissance HatReason
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As I mentioned last week, earlier this year Fight Aging! invested a modest amount in the Ichor Therapeutics initiative to develop a treatment for macular degeneration, joining a number of other amateur and professional investors in helping to get this venture started. The approach taken here is based on the results of research carried out at the Methuselah Foundation and SENS Research Foundation over much of the past decade, funded by philanthropists and the support of our community of longevity science enthusiasts. This is how we succeed in building the future: medical science in the laboratory leads to medical development in startup companies, each new stage bringing treatments capable of repairing specific forms of age-related molecular damage that much closer to the clinic.

Ichor Therapeutics is one of a growing number of success stories to emerge from the SENS rejuvenation research community. Young scientists, advocates, and donors involved in earlier projects – years ago now – have gone on to build their own ventures, while retaining an interest in stepping up to do something meaningful to help bring an end to aging. Back in 2010, Kelsey Moody worked on the LysoSENS project to find ways to break down damaging metabolic waste in old tissues; fast-forward six years, and he is the now the CEO of a successful small biotechnology company with a great team, taking that very same technology and putting it to good use. I recently had the chance to ask Kelsey a few questions about the future of SENS rejuvenation research, as well as how the Ichor scientists intend to construct a new class of therapy for macular degeneration, one based on removing one of the root causes of the condition.

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Who are the people behind Ichor Therapeutics? How did you meet and decide that this was the thing to do? Why macular degeneration as a target?

People have always been the focus of Ichor. Since day one we have worked to create a positive environment that cultivates a product-oriented research focus and emphasizes autonomy and personal accountability for work. As a result, ambitious self-starters tend to find their way to Ichor and remain here. However, we recognized early on that just filling a lab with a bunch of blue-eyed bushy tailed young up-and-comers is not sufficient to develop a robust, mature, translational pipeline. We have augmented our team with a number of critical staff members who are seasoned pharma operators, including our Quality Assurance Director and General Counsel.

Age-related macular degeneration (AMD) was chosen as a target because we believe it is the closest SENS therapy to the clinic. While we obviously have an interest in providing cures for the patients suffering from AMD and are attracted to the large market opportunities such a treatment could bring, our broader interest is in validating the entire SENS paradigm. We believe that Aubrey de Grey continues to receive excessive criticism because nothing spun out of SENS has ever made it into a legitimate pre-clinical pipeline, much less to the bedside. However, this does not mean he is wrong. Our goal is to be the first group to bring a SENS inspired therapy into the clinic and in doing so, silence critics and generate new energy and capital for this cause.

I understand there’s a lengthy origin story for the approach you are taking to treat AMD; it’d be great to hear some of it.

Our approach to treating AMD is based on the hypothesis that cellular junk that accumulates over the lifespan significantly contributes to the onset and progression of AMD. Our goal is to periodically reduce the burden of the junk so it never accumulates to levels sufficient to induce pathology. The strategy to accomplish this calls for the identification of enzymes that can break down the junk in a physiological setting, and the engineering of these enzymes such that they can break down the target in the correct organelle of the correct cell without appreciable collateral damage to healthy cells or tissue.

Methuselah Foundation and SENS Research Foundation did excellent work in establishing this program nearly a decade ago. They successfully identified a number of candidate enzymes that could break down the molecular junk, but reported that the targeting systems evaluated failed to deliver these enzymes to the appropriate organelles and cells. My group reevaluated these findings, and discovered that these findings were flawed. The delivery failure could be entirely attributed to a subtle, yet highly significant difference between how the target cells behave outside of the body as compared to inside the body. It turned out that the approach was in fact valid, it was the cell based assay that had been used that was flawed. This discovery was striking enough that SENS Research Foundation provided Ichor with funding and a material and technology transfer agreement to reassess the technology, and over $700,000 in directed program investments and grants have been received in the last year or two.

You recently completed a round of funding for the AMD work; what is the plan for the next year or so?

The new funds will allow us to develop a portfolio of enzyme therapy candidates to treat AMD. We will obtain critical data necessary to secure follow-on investment including in vitro studies (cell culture studies to confirm mechanism of action and cytotoxicity) and pivotal proof-of-concept in vivo studies, such as toxicity, PK/PD (how long the enzyme stays in the body and where), and efficacy. We will also be restructuring the company (reincorporating an IP holding company in Delaware, ensuring all contracts are up to date and audited) and ensuring our IP position is on solid footing (licensing in several related patents from existing collaborators, and filing several provisional patents from our intramural work). Collectively, we believe these efforts will position us to obtain series A for investigational new drug (IND) enabling pre-clinical studies.

You’ve been involved in the rejuvenation research community for quite some time now. What is your take on the bigger picture of SENS and the goal of ending aging?

This is a loaded question. What I can say is that the medical establishment has made great progress in the treatment of infectious disease through the development of antibiotics, vaccines, and hygiene programs. However, similar progress has not been realized for the diseases of old age, despite exorbitant expenditures. I have chosen to work in this space because I think a different approach is necessary, and it is here that I believe my companies and I can be the most impactful. I think SENS provides a good framework within which to ask and answer questions.

What do you see as the best approach to getting nascent SENS technologies like this one out of the laboratory and into the clinic?

We need more people who fully understand, in a highly detailed way, what a real translational path looks like. To take on projects like this, being a good scientist is not enough. We need people who can speak business, science, medicine, and legal, and apply these diverse disciplines to a well articulated, focused product or problem. There is no shortage of people who partially understand some of these, but the details are not somewhat important – they are all that matter for success in this space.

Another area is for investors. Some of the projects that come across my desk for review are truly abysmal, yet I have seen projects that are clearly elaborate hoaxes or outright scams (to anyone who has stepped foot in a laboratory) get funded to the tune of hundreds of thousands of dollars or more. While it is perfectly reasonable for high net worth individuals to gamble on moon shots in the anti-aging space (and I am ever grateful for the investors who have taken such a gamble on us) even aggressive development strategies should have some basis in reality. This is especially true as more and more high tech and internet investors move into the space.

If this works stupendously well, what comes next for Ichor Therapeutics?

I really want to get back into stem-cell research, but I basically need a blank check and a strong knowledge of the regulatory path to clinic before I feel comfortable moving into the space. A successful AMD exit would accomplish both of these goals, and position us to pivot to cell-based therapies.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries.
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.