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The Importance of Zoltan Istvan’s Transhumanist Presidential Campaign – Article by G. Stolyarov II

The Importance of Zoltan Istvan’s Transhumanist Presidential Campaign – Article by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
September 13, 2015
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 Zoltan Istvan – journalist, transhumanist philosopher, and author of the novel The Transhumanist Wager – is currently touring the western United States on his Immortality Bus, spreading the message that indefinite life extension is achievable through the progress of science and technology, and should become a political priority. Istvan is running for President of the United States. He knows that he is almost certainly not going to win the 2016 Presidential election, but he seeks to maximize public awareness of the opportunities and questions posed by emerging technologies, and he has thus far done so on an impressively minimal budget. Istvan has founded the United States Transhumanist Party and has encouraged the formation of State-level parties in order to improve his chances of recognition as a candidate at the federal level. On August 31, 2015, Wendy Stolyarov and I officially formed the Nevada Transhumanist Party and registered it with the Secretary of State. (See the officially filed Constitution and Bylaws here and a searchable version here; also join the Facebook group here, as Allied Membership is open to anyone with a rational faculty and ability to form political opinions.) The Nevada Transhumanist Party Platform adopts and expands upon many of the planks of the United States Transhumanist Party Platform – but also imparts upon them a heightened libertarian and individualistic flavor.

Even while I also do not expect Zoltan Istvan to win the Presidency in 2016, and while I recognize the even greater difficulty of qualifying for ballot access for State-level offices (in Nevada, this would require submitting a petition with the signatures of 5,431 registered voters and is thus not a near-term priority for the Nevada Transhumanist Party), I still unequivocally endorse Istvan’s campaign. Why have I made this decision? I present my reasoning here. Whether or not readers will view Istvan as their preferred choice for President, the motives for his campaign and its impact have a much broader significance that should be considered by all.

NTP-Logo-9-1-20151. Voting should not be about who wins. In fact, much of the sub-optimal equilibrium of the two-party system in the United States arises from a misguided “expectations trap” – where each voter fears expressing his or her principles by voting for the candidate closest to that voter’s actual policy preferences. Instead, voters who are caught in the expectations trap will tend to vote for the “lesser evil” (in their view) from one party, because they tend to think that the consequences of the election of the candidate from the other party will be dire indeed, and they do not want to “take their vote away” from the slightly less objectionable candidate. This thinking rests on the false assumption that a single individual’s vote, especially in a national election, can actually sway the outcome. Given that the probabilities of this occurring are negligible, the better choice – the choice consistent with individual autonomy and the pursuit of principle – is to vote solely based on one’s preference, without any regard for how others will vote or how the election will turn out. One is free to persuade others to vote a certain way, of course, or to listen to arguments from others – but these persuasive efforts, to have merit, should be based on the actual positions and character of the candidates involved, and not on appeals to sacrifice one’s intellectual integrity in order to fulfill the “collective good” of avoiding the victory of the “absolutely terrible” (not quite) candidate from one major party, whose policy choices are likely to be near-identical to the “only slightly terrible” candidate from the other major party. While an individual’s vote cannot actually affect who wins, it can – if exercised according to preference – send a signal as to what issues voters actually care about. Whichever politicians do get elected would see a large outpouring of third-party support as a signal of public discontentment and will perhaps be prompted by this signal to shift their stances on policy issues based on the vote counts they observe. Even a few thousand votes for the Transhumanist Party can send a sufficient signal that many Americans are becoming interested in accelerating technological innovation and the freedom from obstacles posed to it by legacy institutions.

2. Life and liberty necessarily go together. You cannot have liberty if you are not alive, and you cannot live well unless you have liberty. In “Liberty Through Long Life” (2013), I discussed the many emerging technologies that could facilitate dramatic improvements in individual liberty, but also noted that “there is a common requirement for one to enjoy all of these potential breakthroughs, along with many others that may be wholly impossible to anticipate: one has to remain alive for a long time. The longer one remains alive, the greater the probability that one’s personal sphere of liberty would be expanded by these innovations.” In “Liberty or Death: Why Libertarians Should Proclaim That Death is Wrong” (2014), I expressed a corollary to this insight: “If we argue for liberty today, it will still likely take decades of the most ardent advocacy and activism to undo the harms caused by ongoing and escalating infringements of every natural and constitutional right of even the most law-abiding citizens. Therefore, while I support every effort – conventional or radically innovative – to move our societies and governments in the direction of liberty, it is essential to recognize that the success of such efforts will take an immense amount of time. If you do not remain alive during that time, then you will die without having known true liberty.”

Unfortunately, given the current combination of political, economic, and societal conditions – including the decidedly un-libertarian mindsets of the majority of the world’s population today – the transformation of existing societies into libertarian havens will not occur anytime soon. Politics as usual – and even libertarian argumentation as usual – will not get us there in time for us. And yet we should continue to strive to actualize the libertarian ideals; we should do so by championing radical life extension as well as societal transformation by means of emerging technologies, so that the balance of resources and incentives can gradually shift in favor of individualistic, pro-liberty mindsets and behaviors – without violent revolutions or other personally damaging upheavals.

Zoltan Istvan is attempting to do exactly what I have advocated in “The Imperative of Technological Progress: Why Stagnation Will Lead to Disaster and How Techno-Optimism Can Overcome It” (2015): “The key to achieving a freer, more prosperous, and longer-lived future is to educate both elites and the general public to accurately weigh the opportunities and risks of emerging technologies. […] By simply arguing the techno-optimist case and educating people from all walks of life about the tremendous beneficial potential of emerging technologies, we can each do our part to ensure that the 21st century will become known as an era of humankind’s great liberation from its age-old limitations, and not a lurch back into the bog of premodern barbarism.” By becoming a prominent techno-optimist advocate, Istvan has even transcended the typical issue-specific policy debates. I may disagree with some of Istvan’s specific policy stances (for instance, his suggestion that college should be free and mandatory for all) – but these disagreements are greatly outweighed by my support for Istvan’s larger role as a visible champion of a radical acceleration of technological progress – the only path that will enable the libertarian ideal to ever be actualized for us.

3. Zoltan Istvan has successfully and beneficially co-opted politics as a vehicle for techno-optimist discourse. Zoltan Istvan is achieving for the cause of transhumanism – the overcoming of age-old human limitations through science and technology – what Ron Paul achieved for the cause of libertarianism during his Presidential runs in 2008 and 2012 (both of which I supported). Ron Paul also did not win the Presidency (although he became an impressive contender for it), but the educational impact of his campaign was tremendous – particularly raising awareness on the issues of a peaceful foreign policy and respect for civil liberties and social freedoms, but also to some extent on the dangers of central banking and inflationary monetary policy. A new generation of activists for liberty came of age during the Ron Paul campaigns and obtained valuable experience and a platform for advocating meaningful policy changes. While Ron Paul was not the sole influence on the recent decisions in many states to completely decriminalize marijuana, the 2015 legalization of same-sex marriage in the United States, and the United States’ avoidance of war with both Russia and Iran, he certainly helped sway the political climate in the direction of these victories for liberty. The Republicans lost both the 2008 and 2012 Presidential Elections, and deserved to lose, in part because the Republican Party establishment deliberately sidelined Ron Paul and rigged the rules against him. Meanwhile, Ron Paul ended up a longer-term winner – an intellectual inspiration to a growing segment of the American population, many of whom continue to deeply respect his example and unwavering integrity.

Zoltan Istvan is venturing even further in the direction of politics-as-education, completely discarding the damaging notion of politics-as-horse-race. Instead of throwing much of his effort into the task of winning the election – which often requires duplicitous rhetoric, creation of a fake persona, and appeals to the lowest common denominator, hardly recipes for true progress – Istvan holds nothing back in expressing what he actually thinks about the desired directions for politics and government. In particular, he emphasizes issues that other candidates systematically avoid – such as the implications of human genetic modification or the possibilities of radical life extension in the coming decades. By prominently communicating that these technologies are not mere science fiction but proximate opportunities, Istvan may persuade large numbers of people to press for the removal of political and other institutional barriers to these technologies’ development and dissemination. Public awareness of possibilities for tremendous technological improvement may result in a greater groundswell of advocacy for the “Six Libertarian Reforms to Accelerate Life Extension” that I outlined in 2013. Zoltan Istvan is, furthermore, an ardent champion of taking resources away from offensive inter-human wars, which needlessly destroy many innocent lives, and instead devoting those resources to technological innovation – so that we can stand a chance of winning the real war that we should be fighting against the forces of ruin. Even this alone – giving the world a few decades of breathing room from organized slaughter staged by national governments – would have a colossal, salutary effect on progress and human well-being.

4. The most vital political change will be achieved by visionaries on the fringes, who do not care about the winds of popular opinion. Mainstream politicians – particularly officeholders who seek reelection – are most often lagging, rather than leading, indicators of societal change. In order to keep the favor of their constituents, politicians need to either respond to ever-shifting public opinion or to create the illusion of doing so (a more common course of action in the increasingly oligarchic American political system). For good or for ill, third parties have most often been the originators of policy proposals that were eventually adopted by a future political establishment. To successfully advocate principled positions – such as the maximization of individual liberty and the elimination of political barriers to life-extension research and treatments – does not require holding political office, but it does require visibly persuading many people – both ordinary voters and elites – that these positions are correct. Those politicians who mostly care about remaining in office will never drive these changes themselves, but they might find themselves impelled to jump on the bandwagon if enough support accumulates. I hope that, because of what Zoltan Istvan is doing today, major party platforms in the 2020s and 2030s will include at least some favorable mentions of life-extending medical research, if not calls for the removal of legacy institutional barriers to the acceleration of such research.

Because of the first-time Transhumanist political presence, the 2016 US Presidential election will be unlike any other. This time, especially given the completely unpalatable candidates from both the Republican and Democratic Parties, it is time to try a radically different approach. Jettisoning the conventional aims of electoral politics and turning it instead into a peaceful, honest, innovative, and spectacular educational campaign for techno-optimism and longevity, is a promising approach that could bear fruit for advocates of liberty, even many years and decades into the future.

This essay may be freely reproduced using the Creative Commons Attribution Share-Alike International 4.0 License, which requires that credit be given to the author, G. Stolyarov II. Find out about Mr. Stolyarov here.

Third Interview of Gennady Stolyarov II and Wendy Stolyarov by Roen Horn of the Eternal Life Fan Club – May 2, 2015

Third Interview of Gennady Stolyarov II and Wendy Stolyarov by Roen Horn of the Eternal Life Fan Club – May 2, 2015

The New Renaissance Hat
G. Stolyarov II and Wendy Stolyarov
September 6, 2015
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ELFC_DIW_Third_InterviewNote by Mr. Stolyarov: On May 2, 2015, a hot spring day in Roseville, California, Wendy Stolyarov and I visited Roen Horn of the Eternal Life Fan Club and had a lengthy discussion with him on a wide variety of subjects: life extension, our illustrated children’s book Death is Wrong, healthcare policy, criminal punishment, and the political prospects of the Transhumanist Party and third parties in general. This was Roen’s third interview with us (watch the first and second interviews as well), and his skillfully edited recording offers a glimpse into its best segments. This conversation occurred approximately four months before Wendy and I took the step to found the Nevada Transhumanist Party, but my comments in this interview are a good example of the evolution of my thinking in this direction, as I was already inclined toward endorsing Zoltan Istvan’s 2016 Presidential run.

Watch the interview here.

Join the Nevada Transhumanist Party here.

Life Extension Advocacy Foundation Launches Lifespan.io – Press Release by Life Extension Advocacy Foundation

Life Extension Advocacy Foundation Launches Lifespan.io – Press Release by Life Extension Advocacy Foundation

The New Renaissance HatLife Extension Advocacy Foundation
August 28, 2015

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Editor’s Note: Visit and contribute to Lifespan.io’s first crowdfunding research project, the SENS Research Foundation’s MitoSENS Mitochondrial Repair Project, here. I have personally donated $100 and encourage all supporters of life-extension research to assist this effort in reaching its $30,000 funding goal. ~ Gennady Stolyarov II, August 27, 2015

LEAF_1NEW YORK, Aug. 26, 2015 – The Life Extension Advocacy Foundation (LEAF) officially launches Lifespan.io, an online platform designed to bridge the gap between longevity researchers and the public who support breakthroughs happening in this burgeoning field.

Lifespan.io is a website designed to house today’s most promising life extension projects. People are invited to contribute financially to the ones they wish to support. This unique approach to crowdfunding gives the public the opportunity to learn about longevity research, meet the people making it happen, and allows them to be a part of promising, historical breakthroughs in life extension technologies.

Supported by biologists George Church and David Sinclair, who are members of LEAF’s Scientific Advisory Board, Lifespan.io is a collaborative environment that invites projects from a wide variety of sources.  Research organizations, nonprofit institutions, citizen scientists, as well as forprofit entities, may submit their projects. Submissions are evaluated and approved based on the legitimacy, the extent of the focus on extending healthy human lifespan, and the viability of the venture.

Organizations submitting launch projects include Harvard Medical School and the SENS Research Foundation.

LEAF President Keith Comito says, “By inviting the public to participate, the organization is creating an environment where everyone can be involved and have a stake in the results. Equitable distribution of the benefits that life extension technologies have to offer is the key to achieving the results we all want: healthier and longer lives. LEAF welcomes everyone to join us and discover more.”

LEAF also aims to educate and inform the public about longevity research and life-expanding advancements. Lifespan.io has a YouTube Channel, Facebook, and Twitter profile where people can find the latest in lifespan, aging, and longevity news. To participate in and lend support to current projects, visit www.Lifespan.io. Join the conversation with the #CrowdFundtheCure hashtag.

Those wishing to submit a project for funding consideration, or who want additional information about the various methods of promotional and scientific counseling offered by LEAF, are also invited to learn more on the website.

LEAF_2ABOUT LIFE EXTENSION ADVOCACY FOUNDATION

The Life Extension Advocacy Foundation is a nonprofit 501(C)(3) organization dedicated to promoting life extension, longevity, and aging research through crowdfunding and advocacy initiatives. Its mission is to connect the researchers and scientists developing the latest advancements with the people who support them through the Lifespan.io platform. Endorsed by top scientific leaders and experts from multiple disciplines, LEAF’s goal is to make all human life healthier and more vital, as well as longer. For more information, please visit www.Lifespan.io.

Photo – http://photos.prnewswire.com/prnh/20150825/260842

Media Contact: Desireé Duffy, Life Extension Advocacy Foundation, 6614789165, info@lifespan.io

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

SOURCE: Life Extension Advocacy Foundation

How Anti-Individualist Fallacies Prevent Us from Curing Death – Article by Edward Hudgins

How Anti-Individualist Fallacies Prevent Us from Curing Death – Article by Edward Hudgins

The New Renaissance HatEdward Hudgins
July 3, 2015
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Are you excited about Silicon Valley entrepreneurs investing billions of dollars to extend life and even “cure” death?

It’s amazing that such technologically challenging goals have gone from sci-fi fantasies to fantastic possibilities. But the biggest obstacles to life extension could be cultural: the anti-individualist fallacies arrayed against this goal.

Entrepreneurs defy death

 A recent Washington Post feature documents the “Tech titans’ latest project: Defy death. “ Peter Thiel, PayPal co-founder and venture capitalist, has led the way, raising awareness and funding regenerative medicines. He explains: “I’ve always had this really strong sense that death was a terrible, terrible thing… Most people end up compartmentalizing and they are in some weird mode of denial and acceptance about death, but they both have the result of making you very passive. I prefer to fight it.”

Others prefer to fight as well. Google CEO Larry Page created Calico to invest in start-ups working to stop aging. Oracle’s Larry Ellison has also provided major money for anti-aging research. Google’s Sergey Brin and Facebook’s Mark Zuckerberg both have funded the Breakthrough Prize in Life Sciences Foundation.

Beyond the Post piece we can applaud the education in the exponential technologies needed to reach these goals by Singularity U., co-founded by futurist Ray Kurzweil, who believes humans and machines will merge in the decades to become transhumans, and X-Prize founder Peter Diamandis.

The Post piece points out that while in the past two-thirds of science and medical research was funded by the federal government, today private parties put up two-thirds. These benefactors bring their entrepreneurial talents to their philanthropic efforts. They are restless for results and not satisfied with the slow pace of government bureaucracies plagued by red tape and politics.

“Wonderful!” you’re thinking. “Who could object?”

Laurie Zoloth’s inequality fallacy

 Laurie Zoloth for one. This Northwestern University bioethicist argues that “Making scientific progress faster doesn’t necessarily mean better — unless if you’re an aging philanthropist and want an answer in your lifetime.” The Post quotes her further as saying that “Science is about an arc of knowledge, and it can take a long time to play out.”

Understanding the world through science is a never-ending enterprise. But in this case, science is also about billionaires wanting answers in their lifetimes because they value their own lives foremost and they do not want them to end. And the problem is?

Zoloth grants that it is ”wonderful to be part of a species that dreams in a big way” but she also wants “to be part of a species that takes care of the poor and the dying.” Wouldn’t delaying or even eliminating dying be even better?

The discoveries these billionaires facilitate will help millions of people in the long-run. But her objection seems rooted in a morally-distorted affinity for equality of condition: the feeling that it is wrong for some folks to have more than others—never mind that they earned it—in this case early access to life-extending technologies. She seems to feel that it is wrong for these billionaires to put their own lives, loves, dreams, and well-being first.

We’ve heard this “equality” nonsense for every technological advance: only elites will have electricity, telephones, radios, TVs, computers, the internet, smartphones, whatever. Yes, there are first adopters, those who can afford new things. Without them footing the bills early on, new technologies would never become widespread and affordable. This point should be blindingly obvious today, since the spread of new technologies in recent decades has accelerated. But in any case, the moral essential is that it is right for individuals to seek the best for themselves while respecting their neighbors’ liberty to do the same.

Leon Kass’s “long life is meaningless” fallacy

 The Post piece attributes to political theorist Francis Fukuyama the belief that “a large increase in human life spans would take away people’s motivation for the adaptation necessary for survival. In that kind of world, social change comes to a standstill.”

Nonsense! As average lifespans doubled in past centuries, social change—mostly for the better—accelerated. Increased lifespans in the future could allow individuals to take on projects spanning centuries rather than decades. Indeed, all who love their lives regret that they won’t live to see, experience, and help create the wonders of tomorrow.

The Post cites physician and ethicist Leon Kass who asks: “Could life be serious or meaningful without the limit of mortality?”

Is Kass so limited in imagination or ignorant of our world that he doesn’t appreciate the great, long-term projects that could engage us as individuals seriously and meaningfully for centuries to come? (I personally would love to have the centuries needed to work on terraforming Mars, making it a new habitat for humanity!)

Fukuyama and Kass have missed the profound human truth that we each as individuals create the meaning for our own lives, whether we live 50 years or 500. Meaning and purpose are what only we can give ourselves as we pursue productive achievements that call upon the best within us.

Francis Fukuyama’s anti-individualist fallacy

 The Post piece quotes Fukuyama as saying “I think that research into life extension is going to end up being a big social disaster… Extending the average human life span is a great example of something that is individually desirable by almost everyone but collectively not a good thing. For evolutionary reasons, there is a good reason why we die when we do.”

What a morally twisted reason for opposing life extension! Millions of individuals should literally damn themselves to death in the name of society. Then count me anti-social.

Some might take from Fukuyama’s premise a concern that millions of individuals living to 150 will spend half that time bedridden, vegetating, consuming resources, and not producing. But the life extension goal is to live long with our capacities intact—or enhanced! We want 140 to be the new 40!

What could be good evolutionary reasons why we die when we do? Evolution only metaphorically has “reasons.” It is a biological process that blindly adapted us to survive and reproduce: it didn’t render us immune to ailments. Because life is the ultimate value, curing those ailments rather than passively suffering them is the goal of medicine. Life extension simply takes the maintenance of human life a giant leap further.

Live long and prosper

 Yes, there will be serious ethical questions to face as the research sponsored by benevolent billionaires bears fruit. But individuals who want to live really long and prosper in a world of fellow achievers need to promote human life as the ultimate value and the right of all individuals to live their own lives and pursue their own happiness as the ultimate liberty.

Dr. Edward Hudgins directs advocacy and is a senior scholar for The Atlas Society, the center for Objectivism in Washington, D.C.

Copyright, The Atlas Society. For more information, please visit www.atlassociety.org.

Changing the View of Aging: Are We Winning Yet? – Article by Reason

Changing the View of Aging: Are We Winning Yet? – Article by Reason

The New Renaissance Hat
Reason
June 28, 2015
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Peter Thiel, who has invested millions into the SENS rejuvenation research programs over the past decade, has of late been talking much more in public on the topic of treating aging. Having wealth gives you a soapbox, and it is good that he is now using it to help the cause of treating aging as a medical condition. One of Thiel’s recent public appearances was a discussion on death and religion in this context.

In the struggle to produce meaningful progress in rejuvenation research, the tipping point can come from either a very large amount of money, hundreds of millions of dollars at least, dedicated to something very similar to the SENS research programs, or from a widespread shift in the commonplace view of aging. At the large scale and over the long term, medical research priorities reflect the common wisdom, and it is my view that public support is needed to bring in very large contributions to research. The wealthiest philanthropists and largest institutional funding bodies follow the crowd as a rule; they only rarely lead it. They presently give to cancer and stem-cell research precisely because the average fellow in the street thinks that both of these are a good idea.

So it is very important that we reach a point at which research into treating degenerative aging is regarded as a sensible course of action, not something to be ridiculed and rejected. Over the past decade or two a great deal of work has gone into this goal on the part of a small community advocates and researchers. It is paying off; the culture of science and the media’s output on aging research is a far cry from what it was ten years ago. When ever more authorities and talking heads are soberly discussing the prospects of extended healthy life and research into the medical control of aging, it is to be hoped that the public will follow. Inevitably religion is drawn in as a topic in these discussions once you start moving beyond the scientific community:

Quote [Source: “Peter Thiel, N.T. Wright on Technology, Hope, And The End of Death” by Max Anderson – Forbes/Tech – June 24, 2015]:

The Venn diagram showing the overlap of people who are familiar with both Peter Thiel and N.T. Wright is probably quite small. And I think it is indicative of a broader gap between those doing technology and those doing theology. It is a surprise that a large concert hall in San Francisco would be packed with techies eager to hear a priest and an investor talk about death and Christian faith, even if that investor is Peter Thiel.

Thiel has spoken elsewhere about the source of his optimism about stopping and even reversing aging. The idea is to do what we are doing in every other area of life: apply powerful computers and big data to unlock insights to which, before this era, we’ve never had access. Almost everyone I talk with about these ideas has the same reaction. First there is skepticism  – that can’t really happen, right? Second, there is consideration  – well those Silicon Valley guys are weird, but if anyone has the brains and the money to do it, it’s probably them. Finally comes reflection, which often has two parts – 1. I would like to live longer. 2. But I still feel a little uneasy about the whole idea.

The concept of indefinite life extension feels uncomfortable to people, thinks Thiel, because we have become acculturated to the idea that death, like taxes, is inevitable. But, he says, “it’s not like one day you’ll wake up and be offered a pill that makes you immortal.” What will happen instead is a gradual and increasingly fast march of scientific discovery and progress. Scientists will discover a cure for Alzheimer’s and will say, “Do you want that?” Of course our answer will be “Yes!” They will find a cure for cancer and say, “Do you want that?” And again, of course, our answer will be “Yes!” What seems foreign and frightening in the abstract will likely seem obvious and wonderful in the specific. “It seems,” Thiel said, “that in every particular instance the only moral answer is to be in favor of it.”

One of Wright’s objections was to articulate a skepticism about whether the project of life extension really is all that good, either for the individual or for the world. “If [I] say, okay I’ll live to be 150. I’ll still be a sinner. I’ll still be conflicted. I’ll still have wrong emotions. Do I really want to go on having all that stuff that much longer? Will that be helpful to the world if I do?” This roused Thiel. “I really have to disagree with that last formulation…it strikes me as very Epicurean in a way.” For Peter Thiel, Epicureanism is akin to deep pessimism. It means basically giving up. One gets the sense he finds the philosophy not just disagreeable but offensive to his deepest entrepreneurial instincts and life experience. “We are setting our sights low,” he argued, “if we say everyone is condemned to a life of death and suffering.”

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

Rise to Meet the Enemies at the Gates: Join the Battle against Disease and Death – Article by Eric Schulke

Rise to Meet the Enemies at the Gates: Join the Battle against Disease and Death – Article by Eric Schulke

The New Renaissance HatEric Schulke
June 25, 2015
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A lot of your great-grandfathers and great-grandmothers have prepared and gone through the fire of war. This happened time and time again over the centuries. It was nearly routine.

The video “World Battleground, 1000 Years of War in 5 Minutes” adds some good perspective to the frequency of larger-scale conflicts.

If you didn’t have the genes for it, didn’t have it in you to put up a staunch defense or go on a successful offense when necessary, then you and your people didn’t survive as often. It is unfortunate that such a terrible trait has played such a fundamental role in shaping who we are, but that seems to be the way it is.

It is in us to adrenalize in the face of battle and do what it takes to find victory. Most of us don’t directly chase it, and we shy away from it when necessary, but when cornered or challenged, when our towns are burned down or our family and neighbors are murdered on the trails, we draw our weapons and pursue the enemy to the corners of the lands, taking them dead or alive.

Aging and diseases have us cornered. So what are we to do? Should we approach it like it is peacetime? Should we get up in the morning and think of aging and disease as another day at the office or another bill to pay, another fish to be caught for supper or another window to be boarded up for a storm?

When an adjacent empire marches in and demands allegiance to expand its power, with the alternative of impalement or crucifixion for everybody you’ve ever known, you churn out ramparts, build your defenses, get the trenches dug, get the spit and sweat out, and make a stand for life against a bunch of killing scum-bags like you’re supposed to do. There is a time for the industry of peacetime, and there is a time for war.

It is like wartime right now.

In this war against aging, other diseases, and death in general, we don’t need guns, and – it’s incredibly lucky for us – we don’t even need to spill guts. Our enemy causes our guts to be spilled, but these gutless intruders don’t even have them to spill. They are microscopic misalignments, cellular maladjustment, biological disrepair, but they are terrible opponents nonetheless. They snatch our lives away from us. That’s why we put up staunch defenses, and beyond that, prepare a fierce, forceful, battering offense in the form of a worldwide expedition in support of the philosophy and research of indefinite life extension – of extended healthy longevity.

If winning a war involves spilling forth solutions from your head and not guts from people’s bodies, and you won’t do it, then we can only be left to assume that winning isn’t worth it for you unless you can dismantle flesh. That’s not the case, is it? It is catastrophic to the outcome of an urgent fight for life if we can’t recognize that a deadly enemy that doesn’t bleed is still an enemy.

Comanches on the warpath had a lot less to lose than you do, and yet they put up a lot more of a fight. Match them, at the least. You have it in you, and we desperately need you at these front lines of the diseases of aging and general death.

We can’t win this unless we expedite, instill energy, move fast, work hard – work wartime hard. And why shouldn’t we get serious if it means a great shot at winning this? Indifference is one of our biggest obstacles here, and that indifference comes in large part from this phenomenon of the children of warriors not recognizing war without enemy blood. As more battle cries go up around the world, those centuries-old frequencies of battle will begin to ring in the DNA of more brave new life-extension advocate centurions and soldiers like you. With a little time, a great army can be raised up in this showdown with the Grim Reaper and its despicable harbingers of aging, and other forms of diseases and death.

Attack disease and death with this attitude. Get pumped up: it’s the only way to accelerate the pace and save life. Join the battle.

You weren’t bred to back down and wimp out. You are the sum total of the survivors of thousands of years of constant brutal wartime. Respect your ancestors by harnessing that fury and stepping up to this call of duty. Report to your nearest life-extension organization or project. Fight for the Movement for Indefinite Life Extension with everything you’ve got.

Pick your legion, be it Fight Aging, the Methuselah Foundation, Longecity, the SENS Research Foundation, Foresight Nanotech Institute, the California Life Company (Calico), the Institute for Ethics and Emerging Technologies, the Longevity Party, the Transhumanist Party, the Buck Institute, Alcor Life Extension Foundation, the Life Extension Foundation, or another, and report.

The Movement for Indefinite Life Extension supports and lists as many of the core, main organizations as possible on this page.

The world is at stake. We all need you.

This song, not affiliated with this movement (yet. Call us, Rammstein), illustrates the concept well.

Translated lyrics:

Even on the waves there is fighting
Where fish and flesh are woven into sea
One stabs the lance while in the army
Another throws it into the ocean

Ahoy

Arise, arise seaman arise
Each does it in his own way
One thrusts the spear into a man
Another then into the fish

Arise, arise seaman arise
And the waves cry softly
In their blood a spear is lodged
They bleed softly into the ocean

The lance must be drowned in flesh
Fish and man sink to the depths
Where the black soul dwells
There is no light on the horizon

Ahoy

Arise, arise seaman arise
Each does it in his own way
One thrusts the spear into a man
Another then into the fish

Arise, arise seaman arise
And the waves cry softly
In their blood a spear is lodged
They bleed softly into the ocean

Arise, arise seaman arise
And the waves cry softly
In their heart a spear is lodged
They bleed themselves dry on the shore

Eric Schulke was a director at LongeCity during 2009-2013. He has also been an activist with the Movement for Indefinite Life Extension and other causes for over 15 years.

“La mort, c’est mal!” – French Translation of “Death is Wrong” – Translated by Philippe Castonguay – Post by G. Stolyarov II

“La mort, c’est mal!” – French Translation of “Death is Wrong” – Translated by Philippe Castonguay – Post by G. Stolyarov II

The New Renaissance Hat
G. Stolyarov II
May 16, 2015
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La mort, c’est mal! – the French translation of Death is Wrong – is now available for download from The Rational Argumentator. You can obtain your free PDF copy here and may spread it to French-speaking audiences as widely as you wish.

La mort, c’est mal! was generously translated into French by Philippe Castonguay.

Death_is_Wrong_French_CoverPaperback copies of La mort, c’est mal! can be purchased in the following venues:

Createspace – $9.48

Amazon – $9.48

Kindle copies of La mort, c’est mal! can be purchased on Amazon for $0.99.

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Si vous avez déjà demandé « pourquoi les gens doivent-ils mourir? » alors ce livre est pour vous. La vérité est que non, la mort n’est ni bonne, ni nécessaire, ni inévitable. En fait, la mort, c’est mal! La mort est notre ennemie à tous et toutes et doit être combattue par la médecine, la science et la technologie. Ce livre vous introduit au plus grand défi de notre espèce, à son mouvement le plus révolutionnaire; celui d’augmenter radicalement l’espérance de vie humaine pour que vous n’ayez plus à mourir, du tout.

Vous trouverez dans ce livre des plantes et des animaux à la longévité spectaculaire, des découvertes scientifiques récentes pavant le chemin vers l’augmentation de la durée des vies humaines, ainsi que de simples, mais puissants arguments pour affronter ceux en faveur de la mort. Si vous avez déjà pensé que la mort était injuste et qu’elle devrait être vaincue, sachez que vous n’êtes pas seul. Lisez ce livre et prenez part à la plus importante quête de l’histoire de l’humanité.

Ce livre a été écrit par le philosophe et futuriste Gennady Stolyarov II et illustré par l’artiste Wendy Stolyarov. Ici, il vous sera démontré que, peu importe qui vous êtes et peu importe vos habiletés, il vous est toujours possible d’aider l’humanité dans sa lutte contre la mort.

Protein Modification as a Biomarker of Aging – Article by Reason

Protein Modification as a Biomarker of Aging – Article by Reason

The New Renaissance Hat
Reason
April 19, 2015
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The development of fairly consistent, accurate means to measure biological age – as opposed to chronological age – from a tissue sample is an important thread in aging research. Aging is a process of damage accumulation, and rejuvenation would be achieved through damage repair. Research and development aimed at significant extension of healthy life span can only become cost-effective given good ways to measure damage, however. There must be some reliable means to quickly assess the results of a treatment that claims a degree of rejuvenation through the partial repair of a specific form of cellular or molecular damage. In some cases this might seem easy. Take senescent cell clearance, for example: you run the therapy in mice, and compare a range of measures known to scale by senescent cell count in tissue samples before and after the treatment regimen. However, all that really tells you is how well the therapy clears senescent cells. All aspects of biology interact with one another, and age is a global phenomenon. To determine how aged an individual is and how effective a treatment might be when it comes to the practical outcome of additional healthy life span added there is presently little to be done other than wait and see.

The biggest challenge in the development of life-extending therapies is funding and cost. On the one hand there is far too little funding directed towards finding ways to treat aging. On the other hand effectively evaluating an alleged means of treating aging currently requires lifespan studies, and even in mice that takes far too long and costs far too much to be done casually. If there were standardized, quick and easy markers of physiological age that could be assessed before and after a treatment, then this research and development might be able to proceed ten times as rapidly, and evaluation of possible therapies would be open to far more research groups. There are many, many more laboratories with the capacity and funding to carry out a speculative $100,000 study versus a speculative $1,000,000 study.

All of this is to explain why there is considerable interest in developing a cheap biomarker of aging that can reliably assess physiological age from a tissue sample. No-one wants to run a five-year mouse study if there is a ten-minute alternative that produces an answer of about the same accuracy. That ten-minute alternative doesn’t yet exist, but some lines of research seem promising, such as work on DNA methylation patterns that appear to be fairly consistent among individuals over the course of aging. There is also the suggestion that the approach should be to measure the fundamental forms of damage thought to cause aging – but all of them, not just the one being treated by the therapy under consideration. At the present time that might be more onerous than finding a good set of secondary consequences that are reactions to damage, such as epigenetic changes.

The open-access paper linked below covers a fairly wide range of topics. The structures of our cells and tissues are built of proteins, and these proteins are constantly damaged and replaced. Many varied mechanisms toil constantly to remove proteins and cellular components as soon as they show damage or dysfunction. Nonetheless the difference between young tissue and old tissue is that old tissues have far more damage: misfolded proteins, malfunctioning structures inside cells, metabolic waste products such as advanced glycation endproducts (AGEs) gumming together structures in between cells, and so on and so forth. The damage leaks through, and even damage repair mechanisms are not invulnerable; they falter with age due to much the same set of issues as causes dysfunction elsewhere. In the future repair technologies, such as those outlined in the SENS proposals, will bring about rejuvenation by reversing these forms of damage. Since these issues are a part of full set of causes of aging, they are also potential markers of aging.

Protein modification and maintenance systems as biomarkers of ageing

Changes in the abundance and post-translational modification of proteins and accumulation of some modified proteins have been proposed to represent hallmarks of biological ageing. Non-enzymatic protein glycation is a common post-translational modification of proteins in vivo, resulting from reactions between glucose or its metabolites and amino groups on proteins, this process is termed “Maillard reaction” and leads to the formation of advanced glycation endproducts (AGEs). During normal ageing, there is accumulation of AGEs of long-lived proteins such as collagens and several cartilage proteins. AGEs, either directly or through interactions with their receptors, are involved in the pathophysiology of numerous age-related diseases, such as cardiovascular and renal diseases and neurodegeneration.
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Beside protein glycation, it is also well known that levels of oxidised proteins increase with age, due to increased protein damage induced by reactive oxygen species (ROS), decreased elimination of oxidized protein (i.e. repair and degradation), or a combination of both. Since the proteasome is in charge of both general protein turnover and removal of oxidized protein, its fate during ageing has received considerable attention, and evidence has been provided for impairment of the proteasome function with age in different cellular systems. Thus, these protein maintenance systems may also be viewed as potential biomarkers of ageing.
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It is expected that a combination of several biomarkers will provide a much better tool to measure biological age than any single biomarker in isolation. For the most part, the markers based on proteins and their modifications that have been chosen are directly related with mechanistic aspects of the ageing process. Indeed, they are relevant to such important physiological features such as protein homeostasis and glycoprotein secretion that have been previously documented as being altered with age. Therefore, it is expected that they may be less influenced by other factors not necessarily related with ageing.
Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

Tomorrow Will Be Different From Today – Article by Reason

Tomorrow Will Be Different From Today – Article by Reason

The New Renaissance Hat
Reason
April 16, 2015
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We live in an era of very rapid change driven by technological progress. Today’s world is enormously different from that of three or four decades past: consider the pervasive effects of the revolution in communications and computing technologies that has taken place over that time. Yet, human nature being what it is, most of the people who lived through this profound shift in capabilities and culture are nonetheless very skeptical of claims that the future will look radically different from today in any important aspect. It is strange.

In particular the concept of actuarial escape velocity leading to thousand-year life spans is a very hard sell. People look at the large number that is very different from today’s maximum life span and immediately reject it out of hand, no matter the reasonable argument behind it. Any medical technology that produces some rejuvenation in old patients buys extra time to develop better means of rejuvenation. At some point the first pass at rejuvenation treatments will improve such that remaining healthy life expectancy grows at more than a year with each passing year. At that point life spans will become indefinite, limited only by accident or rare medical conditions not yet solved.

It doesn’t help that most of the public has very little knowledge of the present state of medical research in any field, never mind the specific details of how aging might be treated and brought under medical control. The only solution to that issue is to keep on talking: educate, advocate, and spread the word.

Quote:

It is likely the first person who will live to be 1,000 years old is already alive today. This is according to a growing regiment of researchers who believe a biological revolution enabling humans to experience everlasting youthfulness is just around the corner. At the epicentre of the research is Aubrey de Grey, co-founder or the California-based Strategies for Engineered Negligible Senescence (SENS) Research Foundation.

“The first thing I want to do is get rid of the use of this word immortality, because it’s enormously damaging, it is not just wrong, it is damaging. It means zero risk of death from any cause – whereas I just work on one particular cause of death, namely ageing.” de Grey said his research aims to undo the damage done by the wear and tear of life, as opposed to stopping the ageing process altogether. “If we ask the question: ‘Has the person been born who will be able to escape the ill health of old age indefinitely?’ Then I would say the chances of that are very high. Probably about 80 per cent.”

“The therapies that we are working on at the moment are not going to be perfect. These therapies are going to be good enough to take middle age people, say people aged 60, and rejuvenate them thoroughly enough so they won’t be biologically 60 again until they are chronologically 90. That means we have essentially bought 30 years of time to figure out how to re-rejuvenate them when they are chronologically 90 so they won’t be biologically 60 for a third time until they are 120 or 150. I believe that 30 years is going to be very easily enough time to do that.”

Link: http://www.news.com.au/technology/science/researchers-believe-a-biological-revolution-enabling-hu

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.

Peter Thiel on Longevity Research and the Defeat of Aging – Article by Reason

Peter Thiel on Longevity Research and the Defeat of Aging – Article by Reason

The New Renaissance Hat
Reason
April 4, 2015
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It has always been the case that the cause of serious rejuvenation research needs more well-regarded individuals to stand up and talk in public about the road ahead, the prospects for success, and the righteousness of the goal. Just lay out the situation as it is, no need for salesmanship: it is simply the need for this to be a topic not left on the edge of polite society. Aging is by far the greatest cause of suffering and death in the world, and we should all be doing more than we are to help bring an end to all of that pain, disease, and loss. For that to happen, the vast majority of people who never think about aging and rarely think about medical research need to give the topic at least as much thought and approval as presently goes towards the cancer research community.

We find ourselves in a peculiar time. Technological barriers to the successful treatment of aging are next to non-existent; progress is falling out of the woodwork even at low levels of funding and interest; this is an age of revolutionary gains in the tools of biotechnology, and that drives the pace of medicine while the cost of meaningful research plummets. This isn’t a space race situation in which the brute force of vast expenditure was used to wrest a chunk of the 21st century into the 20th and land men on the moon. If following the SENS program aimed at repair of the causes of aging, the cost of implementing the first prototype, working rejuvenation treatments in old mice would by current estimates be only 1-2% of the Apollo Program budget. There was vast popular approval for the space race to match the vast expense. The path to human rejuvenation is in exactly the opposite situation: there is very little support for the goal of treating aging as medical condition, but the costs of doing so successfully are so small that given even a minority of the public in favor those funds would be raised.

This is why advocacy is so very important. This is why people with large soapboxes can help greatly simply by talking on the topic. Investor and philanthropist Peter Thiel has been supporting scientific programs such as SENS and related areas in biotechnology for a decade now, but I notice that he is more vocal and direct in public about this cause now that other organizations such as Google Ventures are making large investments. This is all good; we need a sea change in the level of public support for rejuvenation research, and their understanding of the prospects for the future. Aging is far from set in stone, and a range of the biotechnologies needed to treat aging and bring it under medical control are on the verge of breaking out into commercial development, or just a few years away from that point. All it takes to turn the stream into a rapids is a little more rain.

Peter Thiel’s quest to find the key to eternal life – Washington Post

Quote:

WP: Why aging?

Thiel: I’ve always had this really strong sense that death was a terrible, terrible thing. I think that’s somewhat unusual. Most people end up compartmentalizing, and they are in some weird mode of denial and acceptance about death, but they both have the result of making you very passive. I prefer to fight it. Almost every major disease is linked to aging. One in a thousand get cancer after age 30. Nixon declared war on cancer in 1971, and there has been frustratingly slow progress. One-third of people age 85 and older have Alzheimer’s or dementia, and we’re not even motivated to start a war on Alzheimer’s. At the end of the day, we need to do more.

WP: All your philanthropic projects are founded on the idea that there’s something wrong with the way the current system works. What are the challenges you see in biomedical research?

Thiel: I worry the FDA is too restrictive. Pharmaceutical companies are way too bureaucratic. A tiny fraction of a fraction of a fraction of NIH [National Institutes of Health] spending goes to genuine anti-aging research. The whole thing gets treated like a lottery ticket. Part of the problem is that aging research doesn’t always lend itself to being a great for-profit business, but it’s a very important area for a philanthropic investment. NIH grant-making decisions end up being consensus-oriented, focused on doing things that a peer review committee thinks makes sense. So you end up with a very conservative bias in terms of what gets done. [On the other hand,] the original DARPA [Defense Advanced Research Projects Agency] was phenomenally successful. You had a guy running it, and he just gave out the money. It was more focused on substance and less on the grant-writing process. That’s the direction we should go. I worry that right now, we have people who are very nimble in the art of writing grants who have squeezed out the more creative.

WP: You’re currently funding Cynthia Kenyon, Aubrey de Grey and a number of other researchers on anti-aging. What was it about these individuals and their work that got your attention?

Thiel: They think far outside the conventional wisdom and are far more optimistic about what can be done. I think that’s important to motivate the research.

WP: How long is long enough? Is there an optimal human life span?

Thiel: I believe if we could enable people to live forever, we should do that. I think this is absolute. There are many people who stop trying because they think they don’t have enough time. Because they are 85. But that 85-year-old could have gotten four PhDs from 65 to 85, but he didn’t do it because he didn’t think he had enough time. If it’s natural for your teeth to start falling out, then you shouldn’t get cavities replaced? In the 19th century, people made the argument that it was natural for childbirth to be painful for women and therefore you shouldn’t have pain medication. I think the nature argument tends to go very wrong. . . . I think it is against human nature not to fight death.

WP: Assuming the breakthrough in eternal life doesn’t come in our lifetime, what do you hope to have achieved through your philanthropy before you die? What would you like to be remembered for?

Thiel: I think if we made some real progress on the aging thing, I think that would be an incredible legacy to have. I have been fortunate with my business successes, so I would like to encourage, coordinate and help finance the many great scientists and entrepreneurs that will help bring about the technological future. It’s sort of not important for me to get credit for the specific discoveries, but if I can act as a supporter, mentor and financier, I think that feels like the right thing.

Reason is the founder of The Longevity Meme (now Fight Aging!). He saw the need for The Longevity Meme in late 2000, after spending a number of years searching for the most useful contribution he could make to the future of healthy life extension. When not advancing the Longevity Meme or Fight Aging!, Reason works as a technologist in a variety of industries. 
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This work is reproduced here in accord with a Creative Commons Attribution license. It was originally published on FightAging.org.